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407篇 您的检索式:作者名="Genta"
    题名 作者 年代 出处 被引量
1Classification and Grading of Gastritis: The Updated Sydney System显示文摘Michael F. Dixon Robert M. Genta John H. Yardley Pelayo Correa 1996The American Journal of Surgical Pathology1996,,10:8
2Autoimmune gastritis:Pathologist's viewpoint显示文摘Western countries are seeing a constant decline in the incidence of Helicobacter pylori-associated gastritis, coupled with a rising epidemiological and clinical impact of autoimmune gastritis. This latter gastropathy is due to autoimmune aggression targeting parietal cells through a complex interaction of auto-antibodies against the parietal cell proton pump and intrinsic factor, and sensitized T cells. Given the specific target of this aggression, autoimmune gastritis is typically restricted to the gastric corpus-fundus mucosa. In advanced cases, the oxyntic epithelia are replaced by atrophic(and metaplastic) mucosa, creating the phenotypic background in which both gastric neuroendocrine tumors and(intestinal-type) adenocarcinomas may develop. Despite improvements in our understanding of the phenotypic changes or cascades occurring in this autoimmune setting, no reliable biomarkers are available for identifying patients at higher risk of developing a gastric neoplasm. The standardization of autoimmune gastritis histology reports and classifications in diagnostic practice is a prerequisite for implementing definitive secondary prevention strategies based on multidisciplinary diagnostic approaches integratingendoscopy, serology, histology and molecular profiling.Irene Coati Matteo Fassan Fabio Farinati David Y Graham Robert M Genta Massimo Rugge 2015World Journal of Gastroenterology2015,21,42:8
3The acidic pathway of bile acid synthesis: Not just an alternative pathway显示文摘Over the last two decades,the prevalence of obesity,and metabolic syndromes(MS)such as nonalcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM),have dramatically increased.Bile acids play a major role in the digestion,absorption of nutrients,and the body's redistribution of absorbed lipids as a function of their chemistry and signaling properties.As a result,a renewed interest has developed in the bile acid metabolic pathways with the challenge of gaining insight into novel treatment approaches for this rapidly growing healthcare problem.Of the two major pathways of bile acid synthesis in the liver,the foremost role of the acidic(alternative)pathway is to generate and control the levels of regulatory oxysterols that help control cellular cholesterol and lipid homeostasis.Cholesterol transport to mitochondrial sterol 27-hydroxylase(CYP27A1)by steroidogenic acute regulatory protein(StarD1),and the subsequent 7a-hydroxylation of oxysterols by oxysterol 7a-hydroxylase(CYP7B1)are the key regulatory steps of the pathway.Recent observations suggest CYP7B1 to be the ultimate controller of cellular oxysterol levels.This review discusses the acidic pathway and its contribution to lipid,cholesterol,carbohydrate,and energy homeostasis.Additionally,discussed is how the acidic pathway's dysregulation not only leads to a loss in its ability to control cellular cholesterol and lipid homeostasis,but leads to inflammatory conditions.William M.Pandak Genta Kakiyama 2019Liver Research2019,3,2:4
4Bangkok to Sendai and Beyond: Implications for Disaster Risk Reduction in Asia显示文摘The recently concluded World Conference on Disaster Risk Reduction(WCDRR) in Sendai, Japan and the Sendai Framework for Disaster Risk Reduction2015–2030(SFDRR) have set renewed priorities for disaster risk reduction(DRR) for the next 15 years. Due to Asia’s high exposure to natural hazards, the implications of the new SFDRR have major significance for the future development of the region. The 6th Asian Ministerial Conference on Disaster Risk Reduction(AMCDRR), held in Bangkok in 2014, was a regional preparatory meeting for the WCDRR, and proposed various targets and indicators for DRR in Asia. The AMCDRR recommended inclusion of these goals in the SFDRR. This study focuses on the WCDRR negotiations, particularly outcomes that affect four major groups: local authorities; children and youth;science and technology; and business and industry. An analysis is undertaken of the overlaps and gaps in the outcomes of the 6th AMCDRR and other preceding conferences that fed into the WCDRR. A set of recommendations has evolved from this examination for consideration at the upcoming 7th AMCDRR in 2016. The areas that merit consideration in the upcoming AMCDRR2016 are:(1) development of baseline data and quantitative indicators for monitoring progress in DRR;(2) creation of a common stakeholder platform;(3) construction of city typologies for consideration in all future local level planning;(4) promotion of a culture of safety by linking large enterprises with small and medium enterprises; and(5) exchange and sharing of information and databases between regions at all scales.Ranit Chatterjee Koichi Shiwaku Rajarshi Das Gupta Genta Nakano Rajib Shaw 2015International Journal of Disaster Risk Science2015,6,2:3
5Staging and grading of chronic gastritis显示文摘Massimo Rugge Robert M. Genta 2005Human Pathology2005,,3:3
6Modulation of the fecal bile acid profile by gut microbiota in cirrhosis显示文摘Genta Kakiyama William M. Pandak Patrick M. Gillevet Phillip B. Hylemon Douglas M. Heuman Kalyani Daita Hajime Takei Akina Muto Hiroshi Nittono Jason M. Ridlon Melanie B. White Nicole A. Noble Pamela Monteith Michael Fuchs Leroy R. Thacker Masoumeh Sikaro 2013Journal of Hepatology2013,,5:3
7Gastroesophageal reflux among different racial groups in the United States显示文摘Hashem B. El-Serag Nancy J. Petersen Junaia Carter David Y. Graham Peter Richardson Robert M. Genta Linda Rabeneck 2004Gastroenterology2004,,7:2
8Clinical significance of the expression of long non-coding RNA HOTAIRin primary hepatocellular carcinoma显示文摘Masahisa Ishibashi Ryunosuke Kogo Kohei Shibata Genta Sawada Yusuke Takahashi Junji Kurashige Sayuri Akiyoshi Shin Sasaki Takeshi Iwaya Tomoya Sudo Keishi Sugimachi Koshi Mimori Go Wakabayashi Masaki Mori 2013Oncology Reports2013,,3:2
9Topographic patterns of intestinal metaplasia and gastric cancer显示文摘Mauro Cassaro Massimo Rugge Oscar Gutierrez Gioacchino Leandro David Y Graham Robert M Genta 2000The American Journal of Gastroenterology2000,,:2
10OLGA staging for gastritis: A tutorial显示文摘M. Rugge P. Correa F. Di Mario E. El-Omar R. Fiocca K. Geboes R.M. Genta D.Y. Graham T. Hattori P. Malfertheiner S. Nakajima P. Sipponen J. Sung W. Weinstein M. Vieth 2008Digestive and Liver Disease2008,,8:2
11Gastric foveolar metaplasia and gastric heterotopia in the duodenum: no evidence of an etiologic role for Helicobacter pylori显示文摘Robert M. Genta R. Shawn Kinsey Anuradha Singhal Smita Suterwala 2010Human Pathology2010,,:2
12Assessing risks for gastric cancer: New tools for pathologists显示文摘Although the Sydney Systems (original and updated) for the classification of gastritis have contributed substantially to the uniformity of the reporting of gastric conditions, they lack immediacy in conveying to the user information about gastric cancer risk. In this review, we summarize the current understanding of the gastric lesions associated with an increased risk for cancer, and present the rationale for a proposal for new ways of reporting gastritis. In addition to the traditional histopathological data gathered and evaluated according to the Sydney System rules, pathologists could add an assessment expressed as grading and staging of the gastric inflammatory and atrophic lesions and integrate these findings with pertinent laboratory information on pepsinogens and gastrin levels. Such an integrated report could facilitate clinicians’ approach to the management of patients with gastric conditions.Robert M Genta Massimo Rugge 2006World Journal of Gastroenterology2006,12,35:2
13Polyps With Advanced Neoplasia Are Smaller in the Right Than in the Left Colon: Implications for Colorectal Cancer Screening显示文摘Samir Gupta Bijal A. Balasubramanian Tommy Fu Robert M. Genta Don C. Rockey Richard Lash 2012Clinical Gastroenterology and Hepatology2012,,12:2
14Management of Gastric Polyps: An Endoscopy-Based Approach显示文摘Yasser H. Shaib Massimo Rugge David Y. Graham Robert M. Genta 2013Clinical Gastroenterology and Hepatology2013,,:2
15Effect of Sevelamer and Calcium-Based Phosphate Binders on Coronary Artery Calcification and Accumulation of Circulating Advanced Glycation End Products in Hemodialysis Patients显示文摘Takatoshi Kakuta Reika Tanaka Toru Hyodo Hajime Suzuki Genta Kanai Mikako Nagaoka Hiroo Takahashi Nobuhito Hirawa Yoichi Oogushi Toshio Miyata Hiroyuki Kobayashi Masafumi Fukagawa Akira Saito 2011American Journal of Kidney Diseases2011,,3:2
16The role of rebamipide in the management of inflammatory disease of the gastriointestinal tract显示文摘Genta RM 2003Aliment Pharmacol Ther2003,18,1:1
17Development of chemical recycling process for post-consumer PET bottle by methanolysis in supercritical methanol显示文摘Genta M Yano F Kondo Y 0,,1:1
18Staging and grading of chornic gastritis 显示文摘Ragge M Genta R M 2005Hum Pathol2005,36,:1
19Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells显示文摘Genta Narazaki Hideki Uosaki Mizue Teranishi 2008Circulation2008,118,:1
20Production of Acetone–Butanol–Ethanol (ABE) in Direct Fermentation of Cassava by Clostridium saccharoperbutylacetonicum N1-4显示文摘Vu Hong Thang Kohzo Kanda Genta Kobayashi 2010Applied Biochemistry and Biotechnology (-)2010,,1:1
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