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| 1 | The adult human testis transcriptional cell atlas显示文摘Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation,alongside complex germ cell-niche interactions,to ensure long-term fertility and faithful genome propagation. Here,we performed single-cell RNA sequencing of -6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig,myoid,Sertoli,endothelial,macrophage),and observed germline-niche interactions and key human-mouse differences. Spermatogenesis,including meiosis,was reconstructed computationally,revealing sequential coding,non-coding,and repeat-element transcriptional signatures. Interestingly,we identified five discrete transcriptional/developmental spermatogonial states,including a novel early SSC state,termed State 0. Epigenetic features and nascent transcription analyses suggested developmental plasticity within spermatogonial States. To understand the or丨gin of State 0,we profiled testicular cells from infants,and identified distinct similarities between adult State 0 and infant SSCs. Overall,our datasets describe key transcriptional and epigenetic signatures of the normal adult human testis,and provide new insights into germ cell developmental transitions and plasticity. | Jingtao Guo Edward J. Grow Hana Mlcochova Geoffrey J. Maher Cecilia Lindskog Xichen Nie Yixuan Guo Yodai Takei Jina Yun Long Cai Robin Kim Douglas T. Carrell Anne Goriely James M. Hotaling Bradley R. Cairns | 2018 | Cell Research2018，28，12： | 12 |
| 2 | Two Potent α3/5 Conotoxins from Piscivorous Conus achatinus显示文摘每个锥蜗牛生产不同 conotoxins 的混合物并且分泌他们使他们的猎物和食肉动物不能调动。α 3 /5 Conotoxins,从狩猎鱼的锥蜗牛孤立,目标肌肉烟碱的醋胆素受体。从食鱼的 Conus achatinus 的α 3 /5 conotoxin 的结构和功能没被学习。我们综合了二 pentadecamer 肽, Ac1.1a 和 Ac1.1b 与适当二硫化物结合,基于α 3 /5 conotoxinsfrom C 的 cDNA 序列。achatinus。Ac1.1a 和 Ac1.1b 由一仅仅氨基酸残余不同。他们分别地在堵住在 Xenopus laevisoocytes 表示的 recombinant 老鼠肌肉醋胆素受体上有类似的力量,与 36 nM 和 26 nM 的 IC_(50 ) 价值。为 Ac1.1b,开始的三 N 终端氨基酸的删除没改变它的活动,显示 N 终点不涉及和它的受体的相互作用。而且,我们的实验显示两毒素强烈在老鼠肌肉上比较喜欢α _1- δ子单元接口而不是α _1- γ结合部位烟碱的醋胆素受体。这些肽为结构的学习和烟碱的受体的功能提供另外的工具。 | Li LIU Geoffrey CHEW Edward HAWROT Chengwu CHI Chunguang WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，6： | 5 |
| 3 | <ce:link locator='fx1'/> Lamivudine Plus Low-Dose Hepatitis B Immunoglobulin to Prevent Recurrent Hepatitis B Following Liver Transplantation显示文摘 | Edward J. Gane Peter W. Angus Simone Strasser Darrell H.G. Crawford John Ring Gary P. Jeffrey Geoffrey W. McCaughan | 2007 | Gastroenterology2007，，3： | 2 |
| 4 | Chemical synthesis and characterization of two α4/7-conotoxins显示文摘-Conotoxins 是对烟碱的醋胆素受体(nAChRs ) 的特定的子类型作为有势力和选择对手起作用的小抑制二硫化物的肽。我们以前从食虫的 Conus leopardus 从 molluscivorous Conus marmoreus 和 Lp1.4 克隆二 -conotoxins, Mr1.1。他们俩有 -conotoxins 的亚科的典型 4/7-type 框架 neuronal nAChRs 上的那行为。在这个工作,我们化学上综合了这二毒素并且描绘了他们的功能的性质。合成 Mr1.1 能首先禁止唤起的醋胆素(ACh ) 水流 reversibly 在表示卵母细胞的老鼠 7 nAChR,而 Lp1.4 是老鼠的意外特定的 blocker 胎儿的肌肉 11 受体。尽管他们的抑制亲密关系是相对低的,他们的唯一的受体识别侧面为毒素受体相互作用研究使他们成为珍贵工具。Mr1.1 能也压制煽动性的反应在 vivo 伤害,建议它应该进一步关于它在为疼痛的治疗的痛觉缺失和它的机制或治疗学的目标的分子的角色被调查。 | Can Peng Weihua Chen Tanya Sanders Geoffrey Chew Jing Liu Edward Hawrot Chengwu Chi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，10： | 2 |
| 5 | Event-related potential studies of attention 显示文摘 | Luck Steven J Woodman Geoffrey F Vogel Edward K | 2000 | Trends in Cognitive Sciences2000，4，11： | 1 |
| 6 | Lamivudine Plus Low-Dose Hepatitis B Immunoglobulin to Prevent Recurrent Hepatitis B Following Liver Transplantation显示文摘 | Edward J. Gane Peter W. Angus Simone Strasser Darrell H.G. Crawford John Ring Gary P. Jeffrey Geoffrey W. McCaughan | 2007 | Gastroenterology2007，，3： | 1 |
| 7 | Bone marrow stem cells for urologic tissue engineering显示文摘 | Dave Shukla Geoffrey N. Box Robert A. Edwards Darren R. Tyson | 2008 | World Journal of Urology2008，，4： | 1 |
| 8 | Parainfluenza Virus Infection of Young Children: Estimates of the Population-Based Burden of Hospitalization显示文摘 | Geoffrey A. Weinberg Caroline B. Hall Marika K. Iwane Katherine A. Poehling Kathryn M. Edwards Marie R. Griffin Mary Allen Staat Aaron T. Curns Dean D. Erdman Peter G. Szilagyi | 2009 | The Journal of Pediatrics2009，，5： | 1 |
| 9 | Need satisfaction and the self-regulation of learning显示文摘 | Edward L Deci Richard M Ryan Geoffrey C Williams | | 0，，03： | 1 |
| 10 | Consensus Statement on Natural Orifice Transluminal Endoscopic Surgery and Single-Incision Laparoscopic Surgery: Heralding a New Era in Urology?显示文摘 | Matthew T. Gettman Geoffrey Box Timothy Averch Jeffrey A. Cadeddu Edward Cherullo Ralph V. Clayman Mihr Desai Igor Frank Indebir Gill Mantu Gupta Georges-Pascal Haber Mitchell Humphreys Jihad Kaouk Jaime Landman Estevao Lima Lee Ponsky | 2008 | European Urology2008，，6： | 1 |
| 11 | Individual Differences among Grapheme-Color Synesthetes: Brain-Behavior Correlations显示文摘 | Edward M. Hubbard A. Cyrus Arman Vilayanur S. Ramachandran Geoffrey M. Boynton | 2005 | Neuron2005，，6： | 1 |
| 12 | The ratio of the arithmetic to the geometric mean : A first- order statistical test for muhilook SAR image homogeneity 显示文摘 | Martio Beauchemin Keith P B Thomson Geoffrey Edwards | 1996 | IEEE Trans Geosci Remote Sens1996，34，2： | 1 |
| 13 | Displacement damage analogs to ionizing radiation effects显示文摘 | Geoffrey P Summers Edward A Burke Michael A Xapsos | 1994 | Radiation Measurements1994，，1： | 1 |
| 14 | Characterization of a novel α4/4-conotoxin, Qcl.2, from vermivorous Conus quercinus显示文摘 | Can Peng Weihua Chen Yuhong Han Tanya Sanders Geoffrey Chew Jing Liu Edward Hawrot Chengwu Chi Chunguang Wang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，10： | 1 |
| 15 | Combination Low-Dose Hepatitis B Immune Globulin and Lamivudine Therapy Provides Effective Prophylaxis Against Posttransplantation Hepatitis B显示文摘 | Peter W. Angus Geoffrey W. McCaughan Edward J. Gane Darryl H.G. Crawford Hugh Harley | 2000 | Liver Transplantation2000，，4： | 1 |
| 16 | Need satisfaction and the self-regulation of learning显示文摘 | Edward L. Deci Richard M. Ryan Geoffrey C. Williams | 1996 | Learning and Individual Differences1996，，3： | 1 |
| 17 | Blocked and non-blocked ricin immunotoxins against the CD4 antigen exhibit higher cytotoxic potency than a ricin A chain immunotoxin potentiated with ricin B chain or with a ricin B chain immunotoxin显示文摘 | Edward J. Wawrzynczak Graham J. Watson Alan J. Cumber Raymond V. Henry Geoffrey D. Parnell E. Peter Rieber Philip E. Thorpe | 1991 | Cancer Immunology Immunotherapy1991，，5： | 1 |
| 18 | Where Do We Really Stand With LESS and NOTES?显示文摘 | Matthew T. Gettman Wesley M. White Monish Aron Riccardo Autorino Tim Averch Geoffrey Box Jeffrey A. Cadeddu David Canes Edward Cherullo Mihir M. Desai Igor Frank Indebir S. Gill Mantu Gupta Georges-Pascal Haber Mitchell R. Humphreys Brian H. Irwin Jihad H | 2010 | European Urology2010，，2： | 1 |
| 19 | The physiology of p16INK4A-mediated G1 proliferative arrest显示文摘 | Geoffrey I. Shapiro Christian D. Edwards Barrett J. Rollins | 2000 | Cell Biochemistry and Biophysics2000，，： | 1 |
| 20 | Consensus Statement on Natural Orifice Transluminal Endoscopic Surgery and Single-Incision Laparoscopic Surgery: Heralding a New Era in Urology?显示文摘 | Matthew T. Gettman Geoffrey Box Timothy Averch Jeffrey A. Cadeddu Edward Cherullo Ralph V. Clayman Mihr Desai Igor Frank Indebir Gill Mantu Gupta Georges-Pascal Haber Mitchell Humphreys Jihad Kaouk Jaime Landman Estevao Lima Lee Ponsky | 2008 | European Urology2008，，6： | 1 |
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