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| 1 | The dynamics of the piglet gut microbiome during the weaning transition in association with health and nutrition显示文摘Background: Understanding the composition of the microbial community and its functional capacity during weaning is important for pig production as bacteria play important roles in the pig's health and growth performance. However,limited information is available regarding the composition and function of the gut microbiome of piglets in early-life.Therefore, we performed 16 S rRNA gene and whole metagenome shotgun sequencing of DNA from fecal samples from healthy piglets during weaning to measure microbiome shifts, and to identify the potential contribution of the early-life microbiota in shaping piglet health with a focus on microbial stress responses, carbohydrate and amino acid metabolism.Results: The analysis of 16 S rR NA genes and whole metagenome shotgun sequencing revealed significant compositional and functional differences between the fecal microbiome in nursing and weaned piglets. The fecal microbiome of the nursing piglets showed higher relative abundance of bacteria in the genus Bacteroides with abundant gene families related to the utilization of lactose and galactose. Prevotel a and Lactobacil us were enriched in weaned piglets with an enrichment for the gene families associated with carbohydrate and amino acid metabolism. In addition, an analysis of the functional capacity of the fecal microbiome showed higher abundances of genes associated with heat shock and oxidative stress in the metagenome of weaned piglets compared to nursing piglets.Conclusions: Overal, our data show that microbial shifts and changes in functional capacities of the piglet fecal microbiome resulted in potential reductions in the effects of stress, including dietary changes that occur during weaning.These results provide us with new insights into the piglet gut microbiome that contributes to the growth of the animal. | Robin B.Guevarra Sang Hyun Hong Jin Ho Cho Bo-Ra Kim Jiwon Shin Jun Hyung Lee Bit Na Kang Young Hwa Kim Suphot Wattanaphansak Richard E.Isaacson Minho Song Hyeun Bum Kim | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 16 |
| 2 | Piglet gut microbial shifts early in life:causes and effects显示文摘The gut microbiome has long been known to play fundamentally important roles in the animal health and the well-being of its host. As such, the establishment and maintenance of a beneficial gut microbiota early in life is crucial in pigs, since early gut colonizers are pivotal in the establishment of permanent microbial community structures affecting the health and growth performance of pigs later in life. Emphasizing this importance of early gut colonizers, it is critical to understand the factors impacting the establishment of the piglet gut microbiome at weaning. Factors include, among others, diet, in-feed antibiotics, probiotics and prebiotic administration. The impact of these factors on establishment of the gut microbiome of piglets at weaning includes effects on piglet gut microbial diversity, structure, and succession. In this review, we thoroughly reviewed the most recent findings on the piglet gut microbiome shifts as influenced by weaning, and how these microbiome changes brought about by various factors that have been shown to affect the development of microbiota in piglets. This review will provide a general overview of recent studies that can help to facilitate the design of new strategies to modulate the gut microbiome in order to enhance gastrointestinal health, growth performance and well-being of piglets. | Robin B.Guevarra Jun Hyung Lee Sun Hee Lee Min-Jae Seok Doo Wan Kim Bit Na Kang Timothy J.Johnson Richard E.Isaacson Hyeun Bum Kim | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 13 |
| 3 | The adult human testis transcriptional cell atlas显示文摘Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation,alongside complex germ cell-niche interactions,to ensure long-term fertility and faithful genome propagation. Here,we performed single-cell RNA sequencing of -6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig,myoid,Sertoli,endothelial,macrophage),and observed germline-niche interactions and key human-mouse differences. Spermatogenesis,including meiosis,was reconstructed computationally,revealing sequential coding,non-coding,and repeat-element transcriptional signatures. Interestingly,we identified five discrete transcriptional/developmental spermatogonial states,including a novel early SSC state,termed State 0. Epigenetic features and nascent transcription analyses suggested developmental plasticity within spermatogonial States. To understand the or丨gin of State 0,we profiled testicular cells from infants,and identified distinct similarities between adult State 0 and infant SSCs. Overall,our datasets describe key transcriptional and epigenetic signatures of the normal adult human testis,and provide new insights into germ cell developmental transitions and plasticity. | Jingtao Guo Edward J. Grow Hana Mlcochova Geoffrey J. Maher Cecilia Lindskog Xichen Nie Yixuan Guo Yodai Takei Jina Yun Long Cai Robin Kim Douglas T. Carrell Anne Goriely James M. Hotaling Bradley R. Cairns | 2018 | Cell Research2018，28，12： | 12 |
| 4 | Listeria monocytogenes following orthotopic liver transplantation:Central nervous system involvement and review of the literature显示文摘Listeria monocytogene is a well-recognized cause of bacteremia in immunocompromised individuals,including solid organ transplant recipients,but has been rarely reported following orthotopic liver transplantation. We describe a case of listeria meningitis that occurred within a week after liver transplantation. The patient developed a severe headache that mimicked tacrolimus encephalopathy,and was subsequently diagnosed with listeria meningitis by cerebrospinal fluid culture. The infection was successfully treated with three-week course of intravenous ampicillin. Recurrent hepatitis C followed and was successfully treated with interferon alfa and ribavirin. Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. Most reported cases were successfully treated with intravenous ampicillin. There were four cases of listeria meningitis,and the mortality of them was 50%. Early detection and treatment of listeria meningitis are the key to obtaining a better prognosis. | Shugo Mizuno Ivan R Zendejas Alan I Reed Robin D Kim Richard J Howard Alan W Hemming Denise C Schain Consuelo Soldevila-Pico Roberto J Firpi Shiro Fujita | 2007 | World Journal of Gastroenterology2007，13，32： | 2 |
| 5 | Pulmonary function in bronchcpulmonary dysplasia显示文摘 | Robin B Kim YJ Huth J | 2004 | Pediatr Pulmonol2004，37，3： | 1 |
| 6 | Antagonism of the histamine H 4 receptor reduces LPS-induced TNF production in vivo显示文摘 | Jeffery M. Cowden Fuqu Yu Mamatha Challapalli Jing-Feng Huang Sunhwa Kim Wai-Ping Fung-Leung Jing Ying Ma Jason P. Riley Mai Zhang Paul J. Dunford Robin L. Thurmond | 2013 | Inflammation Research2013，，6： | 1 |
| 7 | Synthesis of mechanical driver and power generation configurations(Ⅰ):Optimization framework 显示文摘 | Frank L Del Nogal Jin-Kuk Kim Simon Perry Robin Smith | 2010 | AIChE Journal2010，56，9： | 1 |
| 8 | The effects of IT capabilities and delivery model on cloud computing success and firm per- formance for cloud supported processes and operations 显示文摘 | GARY G ROBIN L W KIM S | 2015 | International Journal of Information Management2015，35，： | 1 |
| 9 | Factors Associated with Early Recurrence after Resection for Hepatocellular Carcinoma and Outcomes显示文摘 | Shimul A. Shah Paul D. Greig Steven Gallinger Mark S. Cattral Elijah Dixon Robin D. Kim Bryce R. Taylor David R. Grant Charles M. Vollmer | 2006 | Journal of the American College of Surgeons2006，，2： | 1 |
| 10 | ASPAN’s Evidence-Based Clinical Practice Guideline for the Promotion of Perioperative Normothermia: Second Edition显示文摘 | Vallire D. Hooper Robin Chard Theresa Clifford Susan Fetzer Susan Fossum Barbara Godden Elizabeth A. Martinez Kim A. Noble Denise O’Brien Jan Odom-Forren Corey Peterson Jacqueline Ross Linda Wilson | 2010 | Journal of PeriAnesthesia Nursing2010，，6： | 1 |
| 11 | Resection of the Liver and Inferior Vena Cava for Hepatic Malignancy显示文摘 | Alan W. Hemming Kristin L. Mekeel Ivan Zendejas Robin D. Kim Jason K. Sicklick Alan I. Reed | 2013 | Journal of the American College of Surgeons2013，，1： | 1 |
| 12 | Estimating historical atmospheric mercury concentrations from silver mining and their legacies in present-day surface soil in Potosí,Bolivia显示文摘 | Hagan N Robins N Hsu Kim H | 2011 | Atmospheric Environment2011，45，40： | 1 |
| 13 | Tropical forest canopies and their relationships with climate and disturbance: results from a global dataset of consistent field-based measurements显示文摘Background: Canopy structure, defined by leaf area index(LAI), fractional vegetation cover(FCover) and fraction of absorbed photosynthetically active radiation(f APAR), regulates a wide range of forest functions and ecosystem services. Spatially consistent field-measurements of canopy structure are however lacking, particularly for the tropics.Methods: Here, we introduce the Global LAI database: a global dataset of field-based canopy structure measurements spanning tropical forests in four continents(Africa, Asia, Australia and the Americas). We use these measurements to test for climate dependencies within and across continents, and to test for the potential of anthropogenic disturbance and forest protection to modulate those dependences.Results: Using data collected from 887 tropical forest plots, we show that maximum water deficit, defined across the most arid months of the year, is an important predictor of canopy structure, with all three canopy attributes declining significantly with increasing water deficit. Canopy attributes also increase with minimum temperature, and with the protection of forests according to both active(within protected areas) and passive measures(through topography). Once protection and continent effects are accounted for, other anthropogenic measures(e.g. human population) do not improve the model.Conclusions: We conclude that canopy structure in the tropics is primarily a consequence of forest adaptation to the maximum water deficits historically experienced within a given region. Climate change, and in particular changes in drought regimes may thus affect forest structure and function, but forest protection may offer some resilience against this effect. | marion pfeifer alemu gonsamo william woodgate luis cayuela andrew r.marshall alicia ledo timothy c.e.paine rob marchant andrew burt kim calders colin courtney-mustaphi aida cuni-sanchez nicolas j.deere dereje denu jose gonzalez de tanago robin hayward alvaro lau manuel j.macía pieter i.olivier petri pellikka hamidu seki deo shirima rebecca trevithick beatrice wedeux charlotte wheeler pantaleo k.t.munishi thomas martin abdul mustari philip j.platts | 2018 | Forest Ecosystems2018，5，1： | 1 |
| 14 | Liver Transplantation From Donation After Cardiac Death: A Single Center Experience显示文摘 | Shiro Fujita Shugo Mizuno Takahisa Fujikawa Alan I. Reed Robin D. Kim Richard J. Howard Alan W. Hemming | 2007 | Transplantation2007，，1： | 1 |
| 15 | 采用金属有机骨架材料M(HBTC)(4,4'-bipy)·3DMF(M=Ni,Co,Zn)催化CO_2与环氧丙烷的环加成反应(英文)显示文摘采用溶剂热法合成了三种M(HBTC)(4,4’-bipy)·3DMF(M=Ni,Co,Zn,HBTC=1,3,5-均苯三甲酸,4,4’-bipy=4,4′-联吡啶)结构的支柱层金属有机骨架材料(MOFs).首次采用溶剂热和微波法合成了Zn(HBTC)(4,4’-bipy)·3DMF,并采用多种物理化学方法对其进行了表征.M(HBTC)(4,4’-bipy)·3DMF中包含有M2+离子的蜂窝网格层和BTC单元,BTC单元与4,4’-联吡啶柱进一步交联形成三维多孔骨架材料.在采用烷基铵卤化物作为助催化剂和无溶剂的条件下,所有MOFs材料均对催化固定CO_2与环氧化合物环加成制备环状碳酸酯反应表现出非常好的协同催化性能,其催化活性高低顺序为:Zn>Co>Ni,这可通过酸-碱双功能特性进行解释.采用微波法合成的Zn(HBTC)(4,4’-bipy)·3DMF材料表现出与常规催化剂相似的物理化学性质和催化性能.考察了不同制备参数的影响和材料的重复使用性能。 | Seol-Hee Kim Robin Babu Dong-Woo Kim Wonjoo Lee Dae-Won Park | 2018 | Chinese Journal of Catalysis2018，39，8： | 1 |
| 16 | Liver Transplantation From Donation After Cardiac Death: A Single Center Experience显示文摘 | Shiro Fujita Shugo Mizuno Takahisa Fujikawa Alan I. Reed Robin D. Kim Richard J. Howard Alan W. Hemming | 2007 | Transplantation2007，，1： | 1 |
| 17 | PI-3’ kinase and NF-ΚB cross-signaling in human pancreatic cancer cells显示文摘 | Shimul A. Shah M.D. Michael W. Potter M.D. Mohir H. Hedeshian M.D. Robin D. Kim M.D. Ravi S. Chari M.D. Mark P. Callery M.D. F.A.C.S | 2001 | Journal of Gastrointestinal Surgery2001，，6： | 1 |
| 18 | Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer显示文摘 | Seok Jin Kim Zahid N. Rabbani Fan Dong Robin T. Vollmer Ernst-Gilbert Schreiber Mark W. Dewhirst Zeljko Vujaskovic Michael J. Kelley | 2010 | Medical Oncology2010，，1： | 1 |
| 19 | Role of Magnetic Resonance Cholangiography in Assessing Biliary Anatomy in Right Lobe Living Donors显示文摘 | Robin D. Kim Seisuke Sakamoto Masoom A. Haider Michele Molinari Steven Gallinger Ian D. McGilvray Paul D. Greig David R. Grant Mark S. Cattral | 2005 | Transplantation2005，，10： | 1 |
| 20 | Studies on simultaneous energy and water minimisation—Part I: Systems with no water re-use显示文摘 | Luciana Savulescu Jin-Kuk Kim Robin Smith | 2005 | Chemical Engineering Science2005，，12： | 1 |
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