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| 1 | Achieving the Goals of Healthy China 2030 Depends on Increasing Smoking Cessation in China:Comparative Findings from the ITC Project in China,Japan,and the Republic of Korea显示文摘Summary Tobacco smoking is the number one preventable cause of disease and death in China as it is globally.Indeed,the toll of smoking in China is much greater than its status as the world’s most populous country.There is a persistent and continuing need for China to implement the measures specified in the global tobacco control treaty,the World Health Organization(WHO)Framework Convention on Tobacco Control(FCTC),which China ratified in 2005. | Geoffrey T.Fong Jiang Yuan Lorraine V.Craig Steve Shaowei Xu Gang Meng Anne C.K.Quah Hong-Gwan Seo Sungkyu Lee Itsuro Yoshimi Kota Katanoda Takahiro Tabuchi | 2021 | China CDC weekly2021，3，22： | 2 |
| 2 | Fed-batch two-phase production of alanineby a metabolically engineered Escherichia coli显示文摘 | Geoffrey M. Smith Sarah A. Lee Kevin C. Reilly Mark A. Eiteman Elliot Altman | 2006 | Biotechnology Letters2006，，20： | 1 |
| 3 | Intravenous flecainide versus Amiedarone fof recent-onset atrial fibrillation显示文摘 | Karl D. Donovan Bradley M. Power Bernard E.F. Hockings Geoffrey J. Dobb K-Y Lee | 1995 | The American Journal of Cardiology1995，，10： | 1 |
| 4 | Cost and Utilization Impact of a Clinical Pathway for Patients Undergoing Pancreaticoduodenectomy显示文摘 | Geoffrey A. Porter MD Peter W. T. Pisters MD Carol Mansyur MA Annette Bisanz MPH Kim Reyna MBA Pam Stanford RN Jeffrey E. Lee MD Douglas B. Evans MD | 2000 | Annals of Surgical Oncology2000，，7： | 1 |
| 5 | Rhinoplasty for cleft and hemangioma-related nasal deformities显示文摘 | Thomas S Geoffrey Lee Schwartz M | 2010 | Head and Neck Surgery2010，18，： | 1 |
| 6 | Cost and Utilization Impact of a Clinical Pathway for Patients Undergoing Pancreaticoduodenectomy显示文摘 | Geoffrey A. Porter Peter W. T. Pisters Carol Mansyur Annette Bisanz Kim Reyna Pam Stanford Jeffrey E. Lee Douglas B. Evans | 2000 | Annals of Surgical Oncology2000，，7： | 1 |
| 7 | Obesity and diabetes accelerate hepatocarcinogenesis via hepatocyte proliferation independent of NF-κB or Akt/mTORC1显示文摘Background:There are strong links between obesity,diabetes and hepatocellular carcinoma(HCC),but molecular mechanisms remain unclear.Aim:We tested the proposed involvement of NF-κB,IL-6/STAT3 and Akt/mTORC1 before onset(at 3 months)and at onset(6 months)of accelerated hepatocarcinogenesis in DEN-injected obese and diabetic foz/foz compared to lean wildtype(Wt)mice,and also studied the hepatocyte proliferative response to DNA damage between the obese and lean lines.Methods:Male foz/foz and Wt littermates fed normal chow were DEN-injected(10mg/kg i.p.)at age 12-15 days.To test the effect of mTOR inhibitor on growth of dysplastic hepatocytes,a separate cohort of DEN-injected foz/foz mice was administered rapamycin(4 mg/kg body weight/day).Results:foz/foz mice developed obesity,hyperinsulinemia,diabetes,adipokine dysregulation and fatty liver,without increased serum or liver TNF-αor serum IL-6.All DEN-injected foz/foz mice developed HCC by 6 mths vs.0/10 lean Wt.At 3 mths,there were more dysplastic hepatocytes in DEN-injected foz/foz than Wt,with increased liver injury(serum ALT),hepatocyte apoptosis(M30-positive cells)and proliferation(cyclin D1,cyclin E,PCNA),but neither NF-κB nor STAT3 activation.foz/foz livers exhibited upregulation of DNA damage sensors ATM and ATR,with inadequate cell cycle checkpoint controls(CHK1,CHK2,p53,p21).Akt and mTORC1 were highly activated in livers from foz/foz vs.Wt mice.Despite such activation,rapamycin failed to reduce growth of dysplastic hepatocytes.Conclusions:Accelerated DEN-induced HCC in obese/diabetic mice is linked to enhanced growth of dysplastic hepatocytes that cannot be attributed to NF-κB or IL-6/STAT3 activation,nor to sustained mTORC1 activation.The critical mechanism for obesity-enhanced hepatocarcinogenesis lies in the disconnection between hepatocellular injury with DNA damage,and an unrestrained proliferative response.Relevance for patients:This study supports the epidemiological data linking obesity,diabetes and fatty liver disease with increased risk for developing HCC.The findings also suggest that mTORC1 inhibition may not be beneficial in the prevention of obesity-related hepatocarcinogenesis. | Evi Arfianti Claire Z Larter Seungsoo Lee Vanessa Barn Geoffrey Haigh Matthew M.Yeh George NIoannou Narci C.Teoh Geoffrey C.Farrell | 2016 | Journal of Clinical & Translational Research2016，2，1： | 1 |
| 8 | Consensus Statement on Natural Orifice Transluminal Endoscopic Surgery and Single-Incision Laparoscopic Surgery: Heralding a New Era in Urology?显示文摘 | Matthew T. Gettman Geoffrey Box Timothy Averch Jeffrey A. Cadeddu Edward Cherullo Ralph V. Clayman Mihr Desai Igor Frank Indebir Gill Mantu Gupta Georges-Pascal Haber Mitchell Humphreys Jihad Kaouk Jaime Landman Estevao Lima Lee Ponsky | 2008 | European Urology2008，，6： | 1 |
| 9 | Reconstituted human oral and esophageal mucosa in culture显示文摘 | Dolphine Oda Christopher E. Savard Lydia Eng John Sekijima Geoffrey Haigh Sum P. Lee | 1998 | In Vitro Cellular & Developmental Biology - Animal1998，，1： | 1 |
| 10 | Stability and surface activity of lactate dehydrogenase in spray-dried trehalose显示文摘 | Lee Geoffrey | 1999 | Journal of Pharmaceutical Sciences1999，2，88： | 1 |
| 11 | The mechanisms of flow ofof pulp Suspensions in pipes显示文摘 | Geoffrey G Duffy A L Titchener P F W Lee | 1976 | Appita1976，29，5： | 1 |
| 12 | Self-adhesive thin films for topical delivery of 5-aminolevulinic acid 显示文摘 | Sonja Lieb Rolf-Markus Szeimie Geoffrey Lee | 2002 | European Journal of Pharmaceutics and Biopharmaceutics2002，，53： | 1 |
| 13 | Hepatic free fatty acids accumulate in experimental steatohepatitis: Role of adaptive pathways显示文摘 | Claire Z. Larter Matthew M. Yeh W. Geoffrey Haigh Jacqueline Williams Sandie Brown Kim S. Bell-Anderson Sum P. Lee Geoffrey C. Farrell | 2008 | Journal of Hepatology2008，，4： | 1 |
| 14 | Reconstituted human oral and esophageal mucosa in culture显示文摘 | Dolphine Oda Christopher E. Savard Lydia Eng John Sekijima Geoffrey Haigh Sum P. Lee | 1998 | In Vitro Cellular & Developmental Biology - Animal1998，，1： | 1 |
| 15 | Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials显示文摘 | Jonathan Emberson Kennedy R Lees Patrick Lyden Lisa Blackwell Gregory Albers Erich Bluhmki Thomas Brott Geoff Cohen Stephen Davis Geoffrey Donnan James Grotta George Howard Markku Kaste Masatoshi Koga Ruediger von Kummer Maarten Lansberg Richard I Lindley | 2014 | The Lancet . 2014 (9958)2014，，： | 1 |
| 16 | Outcome After Curative Resection for Locally Recurrent Rectal Cancer显示文摘 | Isabelle Bedrosian M.D. Geoffrey Giacco M.S. Lee Pederson M.D. Miguel A. Rodriguez-Bigas M.D. Barry Feig M.D. Kelly K. Hunt M.D. Lee Ellis M.D. Steven A. Curley M.D. Jean Nicolas Vauthey M.D. Marc Delclos M.D. Christopher H. Crane M.D. Nora Janjan M.D. Jo | 2006 | Diseases of the Colon & Rectum2006，，2： | 1 |
| 17 | Development of a model-based clinical sepsis biomarker for critically ill patients显示文摘 | Jessica Lin Jacquelyn D. Parente J. Geoffrey Chase Geoffrey M. Shaw Amy J. Blakemore Aaron J. LeCompte Christopher Pretty Normy N. Razak Dominic S. Lee Christopher E. Hann Sheng-Hui Wang | 2010 | Computer Methods and Programs in Biomedicine2010，，2： | 1 |
| 18 | Transosseous Equivalent Rotator Cuff Repair: A Systematic Review on the Biomechanical Importance of Tying the Medial Row显示文摘 | Nathan A. Mall Andrew S. Lee Jaskarndip Chahal Geoffrey S. VanThiel Anthony A. Romeo Nikhil N. Verma Brian J. Cole | 2012 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2012，，： | 1 |
| 19 | Analysis of microbial diversity in oligotrophic microbial fuel cells using 16S rDNA sequences显示文摘 | Nguyet Thu Phung Jiyoung Lee Kui Hyun Kang In Seop Chang Geoffrey Michael Gadd Byung Hong Kim | 2004 | FEMS Microbiology Letters2004，，1： | 1 |
| 20 | Reconstituted human oral and esophageal mucosa in culture显示文摘 | Dolphine Oda Christopher E. Savard Lydia Eng John Sekijima Geoffrey Haigh Sum P. Lee | 1998 | In Vitro Cellular & Developmental Biology - Animal1998，，1： | 1 |
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