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| 1 | High-magnification observation of seminiferous tubules through the tunica albuginea by two-photon laser scanning microscopy显示文摘阴囊的精子抽取广泛地在非妨碍的精子缺乏的情况下在男不孕的治疗被使用。在睾丸以内识别 spermatogenetic foci 为阴囊的精子抽取是批评的。二光子的激光扫描显微镜学(TPLSM ) 是深入地新鲜生活纸巾的在细胞的水平允许观察的一种基于 autofluorescence 的显微镜学技术并且不要求任何组织学的处理(固定或染色) 。以前使用的波长没在精子上显示出 phototoxicity。我们使用了 TPLSM 在新鲜老鼠检测 spermatogenetic foci 没有破坏 tunica albuginea 的阴囊的实质。新鲜通过手术检索的睾丸在抽取以后在 1 h 以内用 TPLSM 被观察。为每个动物的 Contralateral 睾丸用标准组织学被观察。用 TPLSM,我们能通过 tunica albuginea 观察并且测量生精的小管的直径,类似于组织学的控制。在上皮的小管以内的结构也被观察,尽管他们的性质还得被识别。TPLSM 是能检测 spermatogenetic foci 的一种即时显微镜学技术。 | Vincent Achard Pascal Weber Georges Mercier Marie-Pierre Blanchard | 2011 | Asian Journal of Andrology2011，13，5： | 4 |
| 2 | Noninvasive model including right ventricular speckle tracking for the evaluation of pulmonary hypertension显示文摘AIM To find parameters from transthorathic echocardiography(TTE) including speckle-tracking(ST) analysis of the right ventricle(RV) to identify precapillary pulmonary hypertension(PH).METHODS Forty-four patients with suspected PH undergoing right heart catheterization(RHC) were consecutively included(mean age 63.1 ± 14 years, 61% male gender). All patients underwent standardized TTE including ST analysis of the RV. Based on the subsequent TTE-derived measurements, the presence of PH was assessed: Left ventricular ejection fraction(LVEF) was calculated by Simpsons rule from 4Ch. Systolic pulmonary artery pressure(s PAP) was assessed with continuous wave Doppler of systolic tricuspid regurgitant velocity and regarded raised with values ≥ 30 mmH g as a surrogate parameter for RA pressure. A concomitantly elevated PCWP was considered a means to discriminate between the precapillary and postcapillary form of PH. PCWP was considered elevated when the E/e' ratio was > 12 as a surrogate for LV diastolic pressure. E/e' ratio was measured by gauging systolic and diastolic velocities of the lateral and septal mitral valve annulus using TDI mode. The results were then averaged with conventional measurement of mitral valve inflow. Furthermore, functional testing with six minutes walking distance(6MWD), ECG-RV stress signs, NT pro-BNP and other laboratory values were assessed.RESULTS PH was confirmed in 34 patients(precapillary PH, n = 15, postcapillary PH, n = 19). TTE showed significant differences in E/e' ratio(precapillary PH: 12.3 ± 4.4, postcapillary PH: 17.3 ± 10.3, no PH: 12.1 ± 4.5, P = 0.02), LV volumes(ESV: 25.0 ± 15.0 mL, 49.9 ± 29.5 m L, 32.2 ± 13.6 m L, P = 0.027; EDV: 73.6 ± 24.0 mL, 110.6 ± 31.8 mL, 87.8 ± 33.0 mL, P = 0.021) and systolic pulmonary arterial pressure(sP AP: 61.2 ± 22.3 mm Hg, 53.6 ± 20.1 mm Hg, 31.2 ± 24.6 mm Hg, P = 0.001). STRV analysis showed significant differences for apical RV longitudinal strain(RVAS: -7.5% ± 5.6%, -13.3% ± 4.3%, -14.3% ± 6.3%, P = 0.03). NT pro-BNP was higher in patients with postcapillary PH(4677.0 ± 7764.1 pg/m L, precapillary PH: 1980.3 ± 3432.1 pg/mL, no PH: 367.5 ± 420.4 pg/mL, P = 0.03). Patients with precapillary PH presented significantly more often with ECG RV-stress signs(P = 0.001). Receiver operating characteristics curve analyses displayed the most significant area under the curve(AUC) for RVAS(cut-off < -6.5%, AUC 0.91, P < 0.001), sPAP(cut-off > 33 mmH g, AUC 0.86, P < 0.001) and ECG RV stress signs(AUC 0.83, P < 0.001). The combination of these parameters had a sensitivity of 82.8% and a specificity of 17.2% to detect precapillary PH. CONCLUSION The combination of non-invasive measurements allows feasible assessment of PH and seems beneficial for the differentiation between the pre- and postcapillary form of this disease. | Yossra Mahran Robert Schueler Marcel Weber Carmen Pizarro Georg Nickenig Dirk Skowasch Christoph Hammerstingl | 2016 | World Journal of Cardiology2016，8，8： | 4 |
| 3 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 4 | Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes That Infiltrate Atherosclerotic Lesions显示文摘 | Clinton S. Robbins Aleksey Chudnovskiy Philipp J. Rauch Jose-Luiz Figueiredo Yoshiko Iwamoto Rostic Gorbatov Martin Etzrodt Georg F. Weber Takuya Ueno Nico van Rooijen Mary Jo Mulligan-Kehoe Peter Libby Matthias Nahrendorf Mikael J. Pittet Ralph Weisslede | 2012 | Circulation2012，，2： | 2 |
| 5 | Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial显示文摘 | George L Bakris Pantelis A Sarafidis Matthew R Weir Bj?rn Dahl?f Bertram Pitt Kenneth Jamerson Eric J Velazquez Linda Staikos-Byrne Roxzana Y Kelly Victor Shi Yann-Tong Chiang Michael A Weber | 2010 | The Lancet2010，，9721： | 1 |
| 6 | Quercetin: Synergistic action with carboxyamidotriazole in human breast carcinoma cells显示文摘 | Y. Albert Yen Maria Herenyiova George Weber | 1995 | Life Sciences1995，，13： | 1 |
| 7 | Biomechanical Analysis Comparing Titanium Elastic Nails With Locked Plating in Two Simulated Pediatric Femur Fracture Models显示文摘 | Scott E. Porter George R. Booker Douglas E. Parsell Mark D. Weber George V. Russell James Woodall Michael Wagner Thomas Neubauer | 2012 | Journal of Pediatric Orthopaedics2012，，6： | 1 |
| 8 | Some Monetary Facts显示文摘 | George T McCandless Jr and Warren E Weber | 1995 | Federal Reserve Bank of Min- neapolis Quarterly Review 19(3)1995，1995，： | 1 |
| 9 | The effects of entrepreneurship education显示文摘 | Georg von Graevenitz Dietmar Harhoff Richard Weber | 2010 | Journal of Economic Behavior and Organization2010，，1： | 1 |
| 10 | Dielectric Properties of Ba,( Zr,Ti) O3-Based Ferroelectrics for Capacitor Applications显示文摘 | Ulrich Weber Georg Greuel Ulrich Boettger | | 0，，04： | 1 |
| 11 | The modulation of Amyotrophic Lateral Sclerosis risk by Ataxin-2 intermediate polyglutamine expansions is a specific effect显示文摘 | Suzana Gispert Alexander Kurz Stefan Waibel Peter Bauer Inga Liepelt Christof Geisen Aaron D. Gitler Tim Becker Markus Weber Daniela Berg Peter M. Andersen Rejko Krüger Olaf Riess Albert C. Ludolph Georg Auburger | 2011 | Neurobiology of Disease2011，，1： | 1 |
| 12 | Some Monetary Facts显示文摘 | George T McCandless Jr and Warren E Weber | 1995 | Federal Reserve Bank of Minneapolis Quarterly Review 19(3)1995，1995，： | 1 |
| 13 | Some Mo- netary Facts显示文摘 | George T McCandless Jr and Warren E Weber | 1995 | Federal Reserve Bank of Min- neapo- lis Quarterly Review 19 (3)1995，1995，： | 1 |
| 14 | Comparison of Benazepril Plus Amlodipine or Hydrochlorothiazide in High-Risk Patients With Hypertension and Coronary Artery Disease显示文摘 | George Bakris Alexandros Briasoulis Bjorn Dahlof Kenneth Jamerson Michael A. Weber Roxzana Y. Kelly Allen Hester Tsushung Hua Dion Zappe Bertram Pitt | 2013 | The American Journal of Cardiology2013，，： | 1 |
| 15 | Interactions between osteopontin and vascular endothelial growth factor: Implications for cancer显示文摘 | Divya Ramchandani Georg F. Weber | 2015 | BBA - Reviews on Cancer2015，，： | 1 |
| 16 | Data-driven Bayesian model-based prediction of fatigue crack nucleation in Ni-based superalloys显示文摘This paper develops a Bayesian inference-based probabilistic crack nucleation model for the Ni-based superalloy René88DT under fatigue loading.A data-driven,machine learning approach is developed,identifying underlying mechanisms driving crack nucleation.An experimental set of fatigue-loaded microstructures is characterized near crack nucleation sites using scanning electron microscopy and electron backscatter diffraction images for correlating the grain morphology and crystallography to the location of crack nucleation sites.A concurrent multiscale model,embedding experimental polycrystalline microstructural representative volume elements(RVEs)in a homogenized material,is developed for fatigue simulations.The RVE domain is modeled by a crystal plasticity finite element model.An anisotropic continuum plasticity model,obtained by homogenization of the crystal plasticity model,is used for the exterior domain.A Bayesian classification method is introduced to optimally select informative state variable predictors of crack nucleation.From this principal set of state variables,a simple scalar crack nucleation indicator is formulated. | Maxwell Pinz George Weber Jean Charles Stinville Tresa Pollock Somnath Ghosh | 2022 | npj Computational Materials2022，，1： | 1 |
| 17 | Top Languages: The World' s 10 Most Influential Languages显示文摘 | George Weber | 1997 | Language Today1997，，2： | 1 |
| 18 | Some Mone- tary Facts 显示文摘 | George T McCandless Jr Warren E Weber | 1995 | Federal Reserve Bank of Minneapolis Quar- terly Review1995，，19： | 1 |
| 19 | The metastasis gene osteopontin: a candidate target for cancer therapy显示文摘 | Georg F Weber | 2001 | BBA - Reviews on Cancer2001，，2： | 1 |
| 20 | The effects of entrepreneurship education显示文摘 | Graevenitz Georg Harhoff Dietmar Weber Richard | 2010 | Journal of economic behavior and organization2010，76，1： | 1 |
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