|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 3 | Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C2C12 myoblasts via Toll-like receptor-4 and c-Jun NH2-terminal kinase pathways显示文摘 | FROST R A GERALD J N CHARLES H L | 2004 | American Journal of Physiology Cell Physiology2004，287，： | 1 |
| 4 | Bioassays in the study of allelopathy显示文摘 | Gerald R L | 1984 | J Chem Ecol1984，，10： | 1 |
| 5 | Dielectric theory and bioelectrical measurements显示文摘 | Thompson David R Zechariah Gerald L | 1971 | Transactions of the ASAE1971，14，2： | 1 |
| 6 | The synthesis of some 4-quinolinols and 4-chloroquinolines by the ethoxymethylenemalonic ester method显示文摘 | Byron R Gerald R L Bernard H A | 1946 | J Amer Chem Soc1946，68，： | 1 |
| 7 | The development of a standard method for determining oxidation induction times of hydrocarbon liquids by PDSC 显示文摘 | Pamela L S Gerald H P Alan T R | 1994 | Thermochimica Acta1994，，243： | 1 |
| 8 | Adherence to and effectivehess of positive airway pressure therapy in children with obstructive sleep apnea 显示文摘 | Carole LM Gerald R Sally L | 2006 | Pediatrics2006，117，： | 1 |
| 9 | New aspects of the localization of neuronal nitric oxide synthase in the skeletal muscle:A light and electron microscopic study显示文摘 | Fritz R Kristina L Gerald W | 2005 | Nitric Oxide2005，13，1： | 1 |
| 10 | Central nervous system vasculitis associated with hepatitis C virus infection : a brain MRI - sup- ported diagnosis显示文摘 | Castro Caldas A Geraldes R Neto L | 2014 | J Neural Sci2014，336，12： | 1 |
| 11 | Virtual muscle:a computational approach to understanding the effects of muscle properties on motor control显示文摘 | Davoodi R Brown I E Gerald E L | 2000 | Journal of Neuroscience methods2000，101，6： | 1 |
| 12 | Bioassays in the Study of Allelopathy显示文摘 | GERALD R L | 1984 | Journal of Chemistry Ecology1984，10，2： | 1 |
| 13 | Potentials for exploiting allelopathy to enhance crop production显示文摘 | Frank A E Gerald R L | 1988 | J Chem E col1988，14，10： | 1 |
| 14 | An envgene derived fromaprimary human immunodeficiency virus type 1isolate confershigh in vivo replicative capacity to a chimeric simian/human im-munodeficiency virus in rhesus monkeys显示文摘 | Keith A R John T L Gerald V | 1996 | J Virology1996，70，5： | 1 |
| 15 | Marketing the image of management: the costs and bene- fits of CEO reputation显示文摘 | ANNETTE L RANFT ROBERT ZINKO GERALD R | 2006 | Organizational Dynamics2006，，3： | 1 |
| 16 | Current understanding of food allergy显示文摘 | Samuel B L Rosalia A Gerald R | 2002 | Annals NewYorkAcademyofSciences2002，964，： | 1 |
| 17 | Ischemic brain injury in vitro:protective effects of NMDA receptor antagonists and calmidazolium显示文摘 | Gerald L Becker J | 1990 | Brain Res1990，，： | 1 |
| 18 | Dielectric theory and bioelectrical measurements显示文摘 | David R Thompson Gerald L Zechariah | 1971 | Trans of the ASAE1971，14，2： | 1 |
| 19 | Analysis of C1, C2, and C10 through C33 particle-phase and semi- volatile organic compound emissions from heavy-duty diesel engines显示文摘 | Gerald L Z Berg D R Vasys V N | 2010 | Atmospheric Environment2010，44，8： | 1 |
| 20 | Bioassays in the study of allelopathy 显示文摘 | Gerald R L Frank A E | 1984 | Amer J Bot1984，75，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员