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| 1 | Switched adaptive active disturbance rejection control of variable structure near space vehicles based on adaptive dynamic programming显示文摘Based on the switched nonlinear system, a switched adaptive Active Disturbance Rejection Control(ADRC) law is proposed for the Variable Structure Near Space Vehicle(VSNSV) with unknown uncertainties and external disturbances. The reduced-order Extended State Observers(ESOs) are constructed for the attitude angle system and the angular rate system to estimate the total disturbance in real time. With the extended state introduced to counteract the effects of uncertainties and disturbances, a systematic procedure is presented for the synthesis of the switched adaptive ADRC strategy. Rigorous proof shows that the estimation errors of the reduced-order ESOs would converge to a small neighborhood of zero in finite time, and that the output of the closedloop system can track a given signal stably for a class of switching signals with average dwell time via the proposed approach. The variable gain control strategy based on Adaptive Dynamic Programming(ADP) with the actor-critic structure is also designed to improve the dynamic performance of the system. Simulation results verify the effectiveness and advantage of the proposed control scheme. | Chaoyang DONG Chen LIU Qing WANG Ligang GONG | 2019 | Chinese Journal of Aeronautics2019，32，7： | 10 |
| 2 | An overview of energy and metabolic regulation显示文摘The physiology and behaviors related to energy balance are monitored by the nervous and humoral systems. Because of the difficulty in treating diabetes and obesity, elucidating the energy balance mechanism and identifying critical targets for treatment are important research goals. Therefore, the purpose of this article is to describe energy regulation by the central nervous system(CNS) and peripheral humoral pathway. Homeostasis and rewarding are the basis of CNS regulation. Anorexigenic or orexigenic effects reflect the activities of the POMC/CART or NPY/AgRP neurons within the hypothalamus. Neurotransmitters have roles in food intake, and responsive brain nuclei have different functions related to food intake, glucose monitoring, reward processing. Peripheral gut-or adipose-derived hormones are the major source of peripheral humoral regulation systems. Nutrients or metabolites and gut microbiota affect metabolism via a discrete pathway. We also review the role of peripheral organs, the liver,adipose tissue, and skeletal muscle in peripheral regulation. We discuss these topics and how the body regulates metabolism. | Song Wen Chaoxun Wang Min Gong Ligang Zhou | 2019 | Science China(Life Sciences)2019，62，6： | 8 |
| 3 | Switching disturbance rejection attitude control of near space vehicles with variable structure显示文摘A switching disturbance rejection attitude control law is proposed for a near space vehicle(NSV) with variable structure.The multiple flight modes, system uncertainties and disturbances of the NSV are taken into account based on switched nonlinear systems. Compared with traditional backstepping design methods,the proposed method utilizes the added integrals of attitude angle and angular rate tracking errors to further decrease the tracking errors. Moreover, to reduce the computation complexity, a rapid convergent differentiator is employed to obtain the derivative of the virtual control command. Finally, for disturbance rejection, based on the idea from the extended state observer(ESO), two disturbance observers are designed by using non-smooth functions to estimate the disturbances in the switched nonlinear systems. All signals of the closed-loop system are proven to be uniformly ultimately bounded under the Lyapunov function framework. Simulation results demonstrate the effectiveness of the proposed control scheme. | GONG Ligang WANG Qing DONG Chaoyang | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 2 |
| 4 | The landscape of chromatin accessibility in skeletal muscle during embryonic development in pigs显示文摘Background:The development of skeletal muscle in pigs during the embryonic stage is precisely regulated by transcriptional mechanisms,which depend on chromatin accessibility.However,how chromatin accessibility plays a regulatory role during embryonic skeletal muscle development in pigs has not been reported.To gain insight into the landscape of chromatin accessibility and the associated genome-wide transcriptome during embryonic muscle development,we performed ATAC-seq and RNA-seq analyses of skeletal muscle from pig embryos at 45,70 and 100 days post coitus(dpc).Results:In total,21,638,35,447 and 60,181 unique regions(or peaks)were found across the embryos at 45 dpc(LW45),70 dpc(LW70)and 100 dpc(LW100),respectively.More than 91%of the peaks were annotated within−1 kb to 100 bp of transcription start sites(TSSs).First,widespread increases in specific accessible chromatin regions(ACRs)from embryos at 45 to 100 dpc suggested that the regulatory mechanisms became increasingly complicated during embryonic development.Second,the findings from integrated ATAC-seq and RNA-seq analyses showed that not only the numbers but also the intensities of ACRs could control the expression of associated genes.Moreover,the motif screening of stage-specific ACRs revealed some transcription factors that regulate muscle developmentrelated genes,such as MyoG,Mef2c,and Mef2d.Several potential transcriptional repressors,including E2F6,OTX2 and CTCF,were identified among the genes that exhibited different regulation trends between the ATAC-seq and RNA-seq data.Conclusions:This work indicates that chromatin accessibility plays an important regulatory role in the embryonic muscle development of pigs and regulates the temporal and spatial expression patterns of key genes in muscle development by influencing the binding of transcription factors.Our results contribute to a better understanding of the regulatory dynamics of genes involved in pig embryonic skeletal muscle development. | Jingwei Yue Xinhua Hou Xin Liu Ligang Wang Hongmei Gao Fuping Zhao Lijun Shi Liangyu Shi Hua Yan Tianyu Deng Jianfei Gong Lixian Wang Longchao Zhang | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 2 |
| 5 | Closed-loop fault detection for full-envelope fligh vehicle with measurement delays显示文摘A closed-loop fault detection problem is investigated for the full-envelope flight vehicle with measurement delays,where the flight dynamics are modeled as a switched system with delayed feedback signals.The mode-dependent observer-based fault detection filters and state estimation feedback controllers are derived by considering the delays’impact on the control system and fault detection system simultaneously.Then,considering updating lags of the controllers/filters’switching signals which are introduced by the delayed measurement of altitude and Mach number,an asynchronous H∞ analysis method is proposed and the system model is further augmented to be an asynchronously switched time-delay system.Also,the global stability and desired performance of the augmented system are guaranteed by combining the switched delay-dependent Lyapunov–Krasovskii functional method with the average dwell time method(ADT),and the delaydependent existing conditions for the controllers and fault detection filters are obtained in the form of the linear matrix inequalities(LMIs).Finally,numerical example based on the hypersonic vehicles and highly maneuverable technology(Hi MAT)vehicle is given to demonstrate the merits of the proposed method. | Wang Zhaolei Wang Qing Dong Chaoyang Gong Ligang | 2015 | Chinese Journal of Aeronautics2015，28，3： | 2 |
| 6 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 7 | Chemicalcomposition and antifungal activity of the fruit oil of Zanthoxylumbungeanum Maxim,(Rutaceae)from China显示文摘 | GONG Youwen HUANG Yongfu ZHOU Ligang | 2009 | J Essent Oil Res2009，21，2： | 1 |
| 8 | Acousto-optic tunable ultrafast laser with vector-mode-coupling-induced polarization conversion显示文摘Acousto-optic interactions, employed in the ultrafast laser regulation,possess remarkable advantages for fast tuning performance in a wide spectral range. Here, we propose an ultrafast fiber laser whose wideband tunability is provided by an acousto-optic structure fabricated with an etched single-mode fiber. Because of the laser polarization conversion induced by the coupling between the core and cladding vector modes in the etched fiber,a band-pass characteristic of the acousto-optic interaction is achieved to effectively regulate the inner-cavity gain range. Cooperating with a saturable absorber based on single-wall carbon nanotubes (SWCNTs) with polarization robustness,a soliton operating state is achieved in the tunable erbium-doped fiber laser.By controlling the acoustical wave frequency from 1.039 to 1.069 MHz, this soliton laser can be conveniently tuned in a wide spectral range from 1571.52 to 1539.26nm.Meanwhile, the laser pulses have near-transform-limited durations stably maintaining less than 2 ps at different wavelength channels,owing to the broadband nonlinear absorption of SWCNTs. | Yujia Li Ligang Huang Haonan Han Lei Gao Yulong Cao Yuan Gong Wending Zhang Feng Gao Iroegbu Paul Ikechukwu Tao Zhu | 2019 | Photonics Research2019，7，7： | 0 |
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