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| 1 | An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair显示文摘The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral repair.Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand rabbits.Thus,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the defects.Although both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline cartilage.In conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis. | Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 2 | In vitro antioxidant,antilipoxygenase and antimicrobial activities of extracts from seven climbing plants belonging to the Bignoniaceae显示文摘Objectives: This study aimed to evaluate the in vitro antioxidant capacity, to determine the antiinflammatory effect due to lipoxygenase inhibition and to test the antimicrobial activity of ethanolic extracts from leaves of seven climbing species belonging to the Bignoniaceae family. These species are Adenocalymma marginatum(Cham.) DC., Amphilophium vauthieri DC., Cuspidaria convoluta(Vell.) A. H.Gentry, Dolichandra dentata(K. Schum.) L. G. Lohmann, Fridericia caudigera(S. Moore) L. G. Lohmann,Fridericia chica(Bonpl.) L. G. Lohmann and Tanaecium selloi(Spreng.) L. G. Lohmann.Methods: The antioxidant activity was evaluated using three methods, 2,20-azino-bis(3-ethylbenzothiazo line-6-sulfonic acid)(ABTS), 2,2-diphenyl-1-picrylhydrazyl(DPPH), and ferric reducing antioxidant power. Lipoxygenase-inhibiting activity was assayed spectrophotometrically; the result was expressed as percent inhibition. The antimicrobial activity was assessed using the agar disk diffusion method.Minimal inhibitory concentration(MIC) and minimal bactericidal/fungicidal concentration were also determined for each extract against 12 pathogenic bacterial strains of Staphylococcus aureus and seven fungal strains of the Candida genus. The identification of the major compounds present in the most promising extract was established by high-performance liquid chromatography–tandem mass spectrometry.Results: C. convoluta, F. caudigera, and F. chica exhibited the best antioxidant activity by scavenging DPPH and ABTS+radicals and reducing Fe3+ion. These extracts showed a notable inhibition of lipoxygenase.F. caudigera was found to have the lower MIC value against S. aureus strains and six Candida species.The extracts of F. caudigera and C. convoluta were active even against methicillin-resistant S. aureus.C. convoluta had higher total phenol content, better antioxidant activity and superior antiinflammatory and antimicrobial activity. The main phenolic compounds found in this extract were coumaric and hydroxybenzoic acid derivatives and glycosylated and nonglycosylated flavones.Conclusion: Most of the extracts exhibited antioxidant activity as well as in vitro inhibition of lipoxygenase. The excellent antimicrobial activity of T. selloi and F. chica supports their use in traditional medicine as antiseptic agents. The extracts of F. caudigera and C. convoluta, both with notable biological activities in this study, could be used as herbal remedies for skin care. In addition, this study provides, for the first time, information about phenolic compounds present in C. convoluta. | Carola Analla Torres Cristina Marisel Perez Zamora Maria Beatriz Nunez Ana Maria Gonzalez | 2018 | Journal of Integrative Medicine2018，16，4： | 2 |
| 3 | HLA B27 as Predisposition Factor to Suffer Age Related Macular Degeneration显示文摘研究是否特定的等位基因 HLA 一级(HLA -- A 和 HLA-B ) 并且班 II (HLA 医生) 是风险因素因为年龄的 exudative 类型的发展联系了有斑点的退化(ARMD ) , HLA 抗原与 ARMD 在正常、影响的眼睛两个都被表示。我们设计了未来的控制盒子的研究。我们与主要经典或秘密的 choroidal neovascularization 招募了 75 个病人,对 ARMD 第二等,并且与光力学的治疗对待。超过 55 岁的 250 个病人,没有 ophthalmologic 病理,为分析平淡的检查去了医院的人,被用作控制。数据的分析显示出二个组之间的重要差别。等位基因 HLA-B27 与 ARMD 断然相关(p < 0.0113 ) 。然而,我们没发现等位基因否定地联系了。因此 HLA-B27 是等位基因预先安排承受 ARMD。 | Enrique Villegas Becerril Rafael Gonzalez Fernandez Luis Perula Torres Manuel Santos Lacomba Jose Maria Gallardo Galera | 2009 | Cellular & Molecular Immunology2009，6，4： | 2 |
| 4 | Effects of different carbon sources on the synthesis of pectinase by Aspergillus niger in submerged and solid state fermentations显示文摘 | S Sol-Pereira E Favela Torres G Viniegra Gonzalez | 1993 | Applied Microbiology and Biotechnology1993，39，1： | 1 |
| 5 | Levels of HBV-DNA and HBsAg after acute liver allograft rejection treatment by corticoids and OKT3显示文摘 | Gonzalez RA de la Mata M de la Torre J | 2000 | Clin Transplant2000，14，3： | 1 |
| 6 | Energymanagement strategy for plug-in hybrid electric vehicles:A comparative study显示文摘 | TORRES J GONZALEZ R GIMENEZ A | 2014 | Applied Energy2014，113，： | 1 |
| 7 | Disparity for the minor histocompatibility antigen HA-1 is associated with an increased risk of acute graft-versus-host disease(GvHD)but it does not affect chronic GvHD incidence,disease-free survival or overall survival after allogeneic human leucocyte antigen-identical sibling donor transplantation显示文摘 | Arostegui JI Balas A Torres A Caballero D Carreras E Brunet S Jimenez A Mataix R Serrano D Vallejo C Sanz G Solano C Rodriguez-Luaces M Marin J Baro J Sanz C Roman J Gonzalez M Martorell J Sierra J Martin C de la Camara R Granena A | 2001 | Br J Haematol2001，114，4： | 1 |
| 8 | Novel angiotensin I-converting enzyme inhibitorypeptides produced in fermented milk by specific wild Lactococcuslactis strains显示文摘 | Rodriguez -Figueroa JC Gonzalez -Cordova AF Torres -Llanez MJ^ | 2012 | Journal of Dairy Science2012，95，： | 1 |
| 9 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 10 | Energy management strategy for plug-in hybrid electric vehi- cles: A comparative study 显示文摘 | Torres J L Gonzalez R Gimenez A | 2014 | Applied Energy2014，113，： | 1 |
| 11 | The natural history of compensated HCV-related cirrhosis: A prospective long-term study显示文摘 | Eduardo Vilar Gomez Yoan Sanchez Rodriguez Luis Calzadilla Bertot Ana Torres Gonzalez Yadina Martinez Perez Enrique Arus Soler Ali Yasells Garcia Luis Perez Blanco | 2012 | Journal of Hepatology2012，，： | 1 |
| 12 | Bacterial colonization as a potential source of nosocomial respiratory infections in two types of Spirometer显示文摘 | Burgos F Torres A Gonzalez J | 1996 | Eur Respir J1996，9，： | 1 |
| 13 | In vivo real-time confocal reflectance microscopy:a noninvasive guide for Mohs micrographic surgery facilitated by aluminum chloride,an excellent contrast enhancer显示文摘 | Tannous Z Torres A Gonzalez S | 2003 | Dermatol Surg2003，29，8： | 1 |
| 14 | Collagen I upregulatesextra cellular matrixgene expressionandseeretion of TGF- beta 1 By cultured humanme sangial cells 显示文摘 | Ortega VR Gonzalez RM Ruiz - Torres MP | 2004 | Am J Physiol Cell Physio12004，286，6： | 1 |
| 15 | Particle size distribution soft-sensor for a grinding circuit显示文摘 | CASALI A GONZALEZ G TORRES F | 1998 | Powder Technology1998，99，1： | 1 |
| 16 | Quantitative cultures of endotracheal aspirates for the diagnosis of ventilator-associated pneumonia显示文摘 | el-Ebiary M Torres A Gonzalez J | 1993 | Am Rev Respir Dis1993，，： | 1 |
| 17 | Matrix-effects of vegetable commodities in elec-tron capture detection applied to pesticide multiresidue analysis显示文摘 | GONZALEZ F J E TORRES M E H LOPEZ E A | 2002 | Journal of Chromatography A2002，966，12： | 1 |
| 18 | Rifampin and isoniazid resistance associated mutations in mycobacterium tuberculosis clinical isolates in Seville,Spain显示文摘 | Torres MJ Criado A Gonzalez N | 2002 | Int J Tuber Lung Dis2002，6，2： | 1 |
| 19 | A LED-based smart illumination system for studying plant growth 显示文摘 | Olvera Gonzalez E Alaniz Lumbreras D Torres Arguelles V | 2014 | Lighting Research & Technoolgy2014，46，2： | 1 |
| 20 | Optimization of Nonlinear Bioteehnological Processes with Linear Programming: Application to Citric Acid Production by Aspergillus niger 显示文摘 | Torres N V Voit E O Gonzalez - Alcon C | 1996 | Biotechnology and Bioengineering1996，49，： | 1 |
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