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| 1 | Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-Ⅱ显示文摘 | Rosa Montes Gertrudis Ligero Laura Sanchez Purificacidn Catalina Teresa de la Cueva Ana Nieto Gustavo J Melen Ruth Rubio Javier Garcia-Castro Clara Bueno Pablo Menendez | 2009 | Cell Research2009，19，6： | 7 |
| 2 | An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair显示文摘The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral repair.Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand rabbits.Thus,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the defects.Although both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline cartilage.In conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis. | Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 3 | PM_(2.5) chemical composition and health risks by inhalation near a chemical complex显示文摘Particulate matter(PM_(2.5))samples were collected in the vicinity of an industrial chemical pole and analysed for organic and elemental carbon(OC and EC),47 trace elements and around 150 organic constituents.On average,OC and EC accounted for 25.2% and 11.4% of the PM_(2.5) mass,respectively.Organic compounds comprised polycyclic aromatic hydrocarbons(PAHs),alkylated PAHs,anhydrosugars,phenolics,aromatic ketones,glycerol derivatives,aliphatic alcohols,sterols,and carboxyl groups,including aromatic,carboxylic and dicarboxylic acids.Enrichment factors>100 were obtained for Pb,Cd,Zn,Cu,Sn,B,Se,Bi,Sb and Mo,showing the contribution of industrial emissions and nearby major roads.Principal component analysis revealed that vehicle,industrial and biomass burning emissions accounted for 66%,11% and 9%,respectively,of the total PM_(2.5)-bound PAHs.Some of the detected organic constituents are likely associated with plasticiser ingredients and thermal stabilisers used in the manufacture of PVC and other plastics in the industrial complex.Photooxidation products of both anthropogenic(e.g.,toluene)and biogenic(e.g.,isoprene and pinenes)precursors were also observed.It was estimated that biomass burning accounted for 13.8%of the PM_(2.5) concentrations and that secondary OC represented 37.6% of the total OC.The lifetime cancer risk from inhalation exposure to PM_(2.5)-bound PAHs was found to be negligible,but it exceeded the threshold of 10−6 for metal(loi)s,mainly due to Cr and As. | Celia Alves Margarita Evtyugina Estela Vicente Ana Vicente Ismael Casotti Rienda Ana Sanchez de la Campa Mario Tome Iola Duarte | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 4 | The natural history of compensated HCV-related cirrhosis: A prospective long-term study显示文摘 | Eduardo Vilar Gomez Yoan Sanchez Rodriguez Luis Calzadilla Bertot Ana Torres Gonzalez Yadina Martinez Perez Enrique Arus Soler Ali Yasells Garcia Luis Perez Blanco | 2012 | Journal of Hepatology2012，，： | 1 |
| 5 | Thermal testing and numerical simulation of gypsum wallboards incorporated with different PCMs content显示文摘 | Ana M Borreguero Luz Sanchez M Jose Luis Valverde | 2011 | Appl Energy2011，88，3： | 1 |
| 6 | Structure-Property Relationships in Molybdenum Disulfide Intercalates显示文摘 | Guillermo Gonzalez Maria Angelica Santa Ana Englantina Benavente Victor Sanchez Neisy Mirabal | 2002 | Molecular Crystals and Liquid Crystals2002，，： | 1 |
| 7 | Age-dependent reliability model considering effects of maintenance and working conditions显示文摘 | Ebastian Martorell Ana Sanchez Vicente Serradell | 1999 | Reliability Engineering and System Safety1999，6464，1： | 1 |
| 8 | The Role of Nutrient-Based Epigenetic Changes in Buffering Against Stress, Aging, and Alzheimer’s Disease显示文摘 | Simon Chiu Michel A. Woodbury-Fari?a Mujeeb U. Shad Mariwan Husni John Copen Yves Bureau Zack Cernovsky J. Jurui Hou Hana Raheb Kristen Terpstra Veronica Sanchez Ana Hategan Mike Kaushal Robbie Campbell | 2014 | Psychiatric Clinics of North America2014，，4： | 1 |
| 9 | The natural history of compensated HCV-related cirrhosis: A prospective long-term study显示文摘 | Eduardo Vilar Gomez Yoan Sanchez Rodriguez Luis Calzadilla Bertot Ana Torres Gonzalez Yadina Martinez Perez Enrique Arus Soler Ali Yasells Garcia Luis Perez Blanco | 2012 | Journal of Hepatology2012，，： | 1 |
| 10 | Cell therapy stimulates bone neoformation in calvaria defects in rats subjected to local irradiation显示文摘Background:The purpose of the study was to analyze the effect of cell therapy on the repair process in calvaria defects in rats subjected to irradiation.Methods:Bone marrow mesenchymal cells were characterized for osteoblastic phenotype.Calvariae of male Wistar rats were irradiated(20 Gy)and,after 4 weeks,osteoblastic cells were placed in surgically created defects in irradiated(IRC)and control animals(CC),paired with untreated irradiated(IR)and control(C)animals.After 30 days,histological and microtomographic evaluation was performed to establish significant(P<0.05)differences among the groups.Results:Higher alkaline phosphatase detection and activity,along with an increase in mineralized nodules,in the IRC,C and CC groups compared to the IR group,confirmed an osteoblastic phenotype.Histology showed impaired bone neoformation following irradiation,affecting bone marrow composition.Cell therapy in the IRC group improved bone neoformation compared to the IR group.Microtomography revealed increased bone volume,bone surface and trabecular number in IRC group compared to the IR group.Conclusion:Cell therapy may improve bone neoformation in defects created after irradiation. | Ana Luisa Riul Sorio Paula Katherine Vargas‐Sanchez Roger Rodrigo Fernandes Dimitrius Leonardo Pitol Luiz Gustavo de Sousa Adriano Luiz Balthazar Bianchini Geraldo Batista de Melo Selma Siessere Karina Fittipaldi Bombonato‐Prado | 2019 | Animal Models and Experimental Medicine2019，2，3： | 1 |
| 11 | Biometric identification through hand geometry measurements 显示文摘 | Raul Sanchez Carmen Sanchez-Avila Ana Gonzalez-Marcos | 2000 | IEEE Transactions on Pattern Analysis and Machine Intelligence2000，22，10： | 1 |
| 12 | The natural history of compensated HCV-related cirrhosis: A prospective long-term study显示文摘 | Eduardo Vilar Gomez Yoan Sanchez Rodriguez Luis Calzadilla Bertot Ana Torres Gonzalez Yadina Martinez Perez Enrique Arus Soler Ali Yasells Garcia Luis Perez Blanco | | Journal of Hepatology0，，： | 1 |
| 13 | Detection of QTL affecting fatty acid composition in the pig显示文摘 | Alex Clop Cristina Ovilo Miguel Perez-Enciso Albert Cercos Anna Tomas Ana Fernandez Agustina Coll Josep M. Folch Carmen Barragan Isabel Diaz Maria A. Oliver Luis Varona Luis Silio Armand Sanchez Jose L. Noguera | 2003 | Mammalian Genome2003，，9： | 1 |
| 14 | Respiration rate response of four baby leaf Brassica species to cutting at harvest and fresh - cut washing 显示文摘 | Ascension Martnez -Sanchez Ana Allende Yolanda Cortes -Galera | 2008 | Postharvest Biology and Technology2008，，47： | 1 |
| 15 | Fluorescence in situ hybridization analysis of aneuploidization patterns in monoclonal gammopathy of undetermined significance versus multiple myeloma and plasma cell Leukemia显示文摘 | Rasillo Ana Tabernero M D Sanchez M L | 2003 | Cancer2003，97，3： | 1 |
| 16 | Intraexaminer repeatability and agreement in stereoacuity measurements made in young adults显示文摘AIM: To determine the repeatability and agreement of stereoacuity measurements made using some of the most widely used clinical tests: Frisby, TNO, Randot and Titmus.METHODS: Stereoacuity was measured in two different sessions separated by a time interval of at least 24 h but no longer than 1wk in 74 subjects of mean age 20.6y using the four methods. The study participants were divided into two groups: subjects with normal binocular vision and subjects with abnormal binocular vision.RESULTS: Best repeatability was shown by the Frisby and Titmus [coefficient of repeatability(COR): ±13 and±12s arc respectively] in the subjects with normal binocular vision though a clear ceiling effect was noted.In the subjects with abnormal binocular vision, best repeatability was shown by the Frisby(COR: ±69s arc)and Randot(COR: ±72s arc). In both groups, the TNO test showed poorest agreement with the other tests.CONCLUSION:Therepeatabilityofstereoacuitymeasures was low in subjects with poor binocular vision yet fairly good in subjects with normal binocular vision with the exception of the TNO test. The reduced agreement detected between the tests indicates they cannot be used interchangeably. | Beatriz Antona Ana Barrio Isabel Sanchez Enrique Gonzalez Guadalupe Gonzalez | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 1 |
| 17 | Nat Methods:利用CRISPR-Cas9组合筛选发现癌症弱点显示文摘导致癌症的基因突变也会削弱癌细胞,从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性(synthetic lethality)”,这是因为这些药物仅对发生突变的(或者说合成的)细胞是致命性的。在一项新的研究中。来自美国加州大学圣地亚哥分校、加州大学旧金山分校、斯坦福大学和癌细胞图谱项目(Cancer Cell Map Initiative)的研究人员开发出一种新的方法来寻找合成致死性的基因组合。 | John Paul Shen, Ana Bojorquez-Gomez, Katherine Licon, Kristin Klepper, Daniel Pekin, Alex N Beckett, Kyle Salinas Sanchez, Jason F Kreisberg, Trey Ideker John Paul Shen, Trey Ideker, Prashant Mali John Paul Shen, Dongxin Zhao, Dan Du, Assen Roguev, Jason F Kreisberg, Nevan Krogan, Lei Qi, Trey Ideker, Prashant Mali Dongxin Zhao, Chih-Chung Kuo, Prashant Mali Roman Sasik, Amanda Birmingham, Aaron N Chang, Trey Ideker Jens Luebeck, Alex Thomas Alex Thomas, Chih-Chung Kuo, Nathan E Lewis Dan Du Assen Roguev, Nevan Krogan Nathan E Lewis Lei Qi | 2017 | 现代生物医学进展2017，17，17： | 1 |
| 18 | Effect of non‐surgical periodontal therapy on clinical and immunological response and glycaemic control in type 2 diabetic patients with moderate periodontitis显示文摘 | Ana BelénNavarro‐Sanchez RicardoFaria‐Almeida AntonioBascones‐Martinez | 2007 | Journal of Clinical Periodontology2007，，10： | 1 |
| 19 | Statistical models to predict type 2 diabetes remission after bariatric surgery 预测2型糖尿病患者减肥手术后缓解情况的统计学模型显示文摘 | Ana M. Ramos‐Levi Pilar Matia Lucio Cabrerizo Ana Barabash Andres Sanchez‐Pernaute Alfonso L. Calle‐Pascual Antonio J. Torres Miguel A. Rubio | 2014 | Journal of Diabetes2014，，： | 1 |
| 20 | Fractionated ionizing radiation accelerates loss of amplified MDR1 genes harbored by extrachromosomal DNA in tumor cells显示文摘 | Ana M Sanchez JTB Patricia VS | 1998 | Cancer Res1998，58，： | 1 |
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