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| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years显示文摘 | Stephanos J. Hadziyannis Nicolaos C. Tassopoulos E. Jenny Heathcote Ting–Tsung Chang George Kitis Mario Rizzetto Patrick Marcellin Seng Gee Lim Zachary Goodman Jia Ma Carol L. Brosgart Katyna Borroto–Esoda Sarah Arterburn Steven L. Chuck | 2006 | Gastroenterology2006，，6： | 3 |
| 3 | Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years显示文摘 | Stephanos J. Hadziyannis Nicolaos C. Tassopoulos E. Jenny Heathcote Ting–Tsung Chang George Kitis Mario Rizzetto Patrick Marcellin Seng Gee Lim Zachary Goodman Jia Ma Carol L. Brosgart Katyna Borroto–Esoda Sarah Arterburn Steven L. Chuck | 2006 | Gastroenterology2006，，6： | 2 |
| 4 | A system for the stlrgical staging of musculoskeletal sarcoma显示文摘 | Enneking WF Spanier SS Goodman MA | 1980 | Clinical Orthopaedics Related Research1980，153，1： | 1 |
| 5 | A system for the surgical staging of the musculoskeletal sarcoma 显示文摘 | Enneking WF Spanier SS Goodman MA | 1980 | Clin Orthop1980，153，1： | 1 |
| 6 | Health effects assessment for environmental perchlorate contamination:the dose response for inhibition of thyroidal radioiodine uptake in humans显示文摘 | Greer MA Goodman G Pleus RC | | 0，，： | 1 |
| 7 | A system for the surgecl staging of musculoskeletal sarcoma显示文摘 | Enneking WF Spanier SS Goodman MA | 1980 | Clin Orthop1980，153，： | 1 |
| 8 | A system for the surgical staging of musculoskeletal sarcoma: 1980 显示文摘 | Enneking WF Spanier SS Goodman MA | 2003 | Clin Orthop Relat Res2003，，415： | 1 |
| 9 | Chondroblastoma of the temporal bone:Case report and literature review显示文摘 | Varvares MA Cheney ML Goodman ML | 1992 | Ann Otol Rhinol Laryngol1992，101，9： | 1 |
| 10 | Structure and mechanics of integrin-based cell adhesion 显示文摘 | Amaout MA Goodman SL Xiong JP | 2007 | Curr Opin Cell Biol2007，19，5： | 1 |
| 11 | A system for the surgical staging of musculoskeletal sarcomas显示文摘 | Enneking WF Spiner SS Goodman MA | 1980 | Clin Orthop1980，153，： | 1 |
| 12 | Circulating mutant DNA to assess tumor dynam-ics显示文摘 | DIEHL F SCHMIDT K CHOTI MA ROMANS K GOODMANS LI M | 2008 | Nature medicine2008，14，9： | 1 |
| 13 | The classic: a system for the surgical staging of musculoskeletal sarcoma显示文摘 | Enneking WF Spanier SS Goodman MA | 2003 | Clinical Orthopaedics & Related Research2003，415，： | 1 |
| 14 | A system for thesurgical staging of musculoskeletal sarcoma显示文摘 | Enneking WF Spanier SS Goodman MA | | 0，，： | 1 |
| 15 | Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide显示文摘 | Laia Alemany Ma?lle Saunier Isabel Alvarado‐Cabrero Beatriz Quirós Jorge Salmeron Hai‐Rim Shin Edyta C. Pirog Núria Guimerà Gustavo Hernandez‐Suarez Ana Felix Omar Clavero Belen Lloveras Elena Kasamatsu Marc T. Goodman Brenda Y. Hernandez Jan Laco Leopold | 2015 | Int. J. Cancer2015，，1： | 1 |
| 16 | Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years显示文摘 | Stephanos J. Hadziyannis Nicolaos C. Tassopoulos E. Jenny Heathcote Ting–Tsung Chang George Kitis Mario Rizzetto Patrick Marcellin Seng Gee Lim Zachary Goodman Jia Ma Carol L. Brosgart Katyna Borroto–Esoda Sarah Arterburn Steven L. Chuck | 2006 | Gastroenterology2006，，6： | 1 |
| 17 | COX-2 selective NSAID decreases bone ingrowth in vivo 显示文摘 | GOODMAN S MA T TRINDADE M | 2002 | J Orthop Res2002，20，6： | 1 |
| 18 | A system for the surgi- cal staging of musculoskeletal sarcoma 显示文摘 | Enneking WF Spanier SS Goodman MA | 1980 | Clin Orthop Relat Res1980，，153： | 1 |
| 19 | Alcoholic disease in nonalcoholies:A clinical and histologie comparlson with alcohol-induced liver injury显示文摘 | Dlehl MA Goodman Z 1 shak KG | 1988 | Gastroenterol1988，95，： | 1 |
| 20 | A system for the surgical staging of musculoskeletal sarcoma显示文摘 | Enneking WF Spanier SS Goodman MA | 2003 | Clin Orthop Res2003，415，： | 1 |
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