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| 1 | Optimizing hepatitis C virus treatment through pharmacist interventions: Identification and management of drug-drug interactions显示文摘AIM To quantify drug-drug-interactions(DDIs) encountered in patients prescribed hepatitis C virus(HCV) treatment, the interventions made, and the time spent in this process.METHODS As standard of care, a clinical pharmacist screened for DDIs in patients prescribed direct acting antiviral(DAA) HCV treatment between November 2013 and July 2015 at the University of Colorado Hepatology Clinic. HCV regimens prescribed included ledipasvir/sofosbuvir(LDV/SOF), paritaprevir/ritonavir/ombitasvir/dasabuvir(OBV/PTV/r + DSV), simeprevir/sofosbuvir (SIM/SOF), and sofosbuvir/ribavirin (SOF/RBV). This retrospective analysis reviewed the work completed by the clinical pharmacist in order to measure the aims identified for the study. The number and type of DDIs identified were summarized with descriptive statistics.RESULTS Six hundred and sixty four patients(83.4% Caucasian, 57% male, average 56.7 years old) were identified; 369 for LDV/SOF, 48 for OBV/PTV/r + DSV, 114 for SIM/SOF, and 133 for SOF/RBV. Fifty-one point five per cent of patients were cirrhotic. Overall, 5217 medications were reviewed (7.86 medications per patient) and 781 interactions identified (1.18 interactions per patient). The number of interactions were fewest for SOF/RBV (0.17 interactions per patient) and highest for OBV/PTV/r + DSV (2.48 interactions per patient). LDV/SOF and SIM/SOF had similar number of interactions (1.28 and 1.48 interactions per patient, respectively). Gastric acid modifiers and vitamin/herbal supplements commonly caused interactions with LDV/SOF. Hypertensive agents, analgesics, and psychiatric medications frequently caused interactions with OBV/PTV/r + DSV and SIM/SOF. To manage these interactions, the pharmacists most often recommended discontinuing the medication (28.9%), increasing monitoring for toxicities (24.1%), or separating administration times (18.2%). The pharmacist chart review for each patient usually took approximately 30 min, with additional time for more complex patients. CONCLUSION DDIs are common with HCV medications and management can require medication adjustments and increased monitoring. An interdisciplinary team including a clinical pharmacist can optimize patient care. | Jacob A Langness Matthew Nguyen Amanda Wieland Gregory T Everson Jennifer J Kiser | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 2 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 3 | A mo- dle of cockpit karst landscape, Jamaica显示文摘 | Cyril Fleurant Gregory E T Heather A | 2008 | Geomor phologie : relief processus environment2008，1514，： | 1 |
| 4 | Changes in gene expression by trabecular meshwork cells in response to mechanical stretching显示文摘 | Vittal V Rose A Gregory K E Kelley M J Acott T S | 2005 | Invest Ophthalmol Vis Sci2005，46，： | 1 |
| 5 | Marquis detection of chemical warfare agents using nanostructured metal oxide sensors 显示文摘 | ALEXEY A T GREGORY O | 2005 | Sensors and Actuators B2005，108，： | 1 |
| 6 | Characterization of apparent dehydrogenase isoenzyme 6: A lactate-independent dehydrogenase显示文摘 | Stanley J P Richard A M Gregory A T | 1984 | Clin Chem1984，30，2： | 1 |
| 7 | Electro-optical signatures comparisons of geosynchronous satellites 显示文摘 | PAYNE T E GREGORY S A KIM L | 2006 | Aerospace Conference Proceedings of IEEE2006，，4： | 1 |
| 8 | The crystallization of cordierite glass显示文摘 | GREGORY A G VEASEY T J | 1973 | J Mater Sci1973，8，3： | 1 |
| 9 | Cell wall disassembly during the melting phase of softening in‘Snow Queen’nectarines显示文摘 | Abel O Graham B S Gregory A T | 2010 | Postharvest Biology and Technology2010，58，2： | 1 |
| 10 | Familyconflict in childhood:apredictor of later insomnia显示文摘 | GREGORY A M CAAPI A MOFFITT T E | 2006 | Sleep2006，29，8： | 1 |
| 11 | Analysis of multispectral radiometric signatures from geosynchronous satellites显示文摘 | Payne T E Gregory S A | 2002 | Proceedings of SPIE2002，4847，： | 1 |
| 12 | Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis显示文摘 | Alice T Shaw Beow Y Yeap Benjamin J Solomon Gregory J Riely Justin Gainor Jeffrey A Engelman Geoffrey I Shapiro Daniel B Costa Sai-Hong I Ou Mohit Butaney Ravi Salgia Robert G Maki Marileila Varella-Garcia Robert C Doebele Yung-Jue Bang Kimary Kulig Pauli | 2011 | Lancet Oncology2011，，11： | 1 |
| 13 | The second Hadley Centre coupled ocean-atmosphere GCM:Model description,spinup and validation显示文摘 | Carrell R E Crossley J F Gregory J M Mitchell J F B Senior C A Tett S F B Wood R A | 1997 | Climate Dynamics1997，13，2： | 1 |
| 14 | Optical coherence tomography 显示文摘 | Huang D Swanson E A Lin C P Schuman J S Stinson W G Chang W Hee M R Flotte T Gregory K Puliafito C A Fujimoto J G | 1991 | Science1991，154，5053： | 1 |
| 15 | The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments显示文摘 | Bustin Stephen A Benes Vladimir Garson Jeremy A Hellemans Jan Huggett Jim Kubista Mikael Mueller Reinhold Nolan Tania Pfaffl Michael W Shipley Gregory L Vandesompele Jo Wittwer Carl T | 2009 | Clinical Chemistry2009，，： | 1 |
| 16 | Associations between sleep quality and anxiety and depression symptoms in a sample of young adult twins and siblings 显示文摘 | Gregory A M Buysse D J Wiuis T A | 2011 | J Psychosom Res2011，71，4： | 1 |
| 17 | Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis显示文摘 | Alice T Shaw Beow Y Yeap Benjamin J Solomon Gregory J Riely Justin Gainor Jeffrey A Engelman Geoffrey I Shapiro Daniel B Costa Sai-Hong I Ou Mohit Butaney Ravi Salgia Robert G Maki Marileila Varella-Garcia Robert C Doebele Yung-Jue Bang Kimary Kulig Pauli | 2011 | Lancet Oncology2011，，11： | 1 |
| 18 | Fasting lipid and anticardiolipin antibodies as risk factor for vascular disease in SLE显示文摘 | Mac Gregory A T Dhillon V B Bind A | 1992 | Am Rheum Dis1992，51，： | 1 |
| 19 | Performance characteristics of an optically addressed ferroelectric liquid- crystal spatial light modulator显示文摘 | Hudson T D Worcester R K Gregory D A | 1991 | Application Optics1991，30，20： | 1 |
| 20 | Mechanisms determining the Atlantic thermohaline circulation response to greenhouse gas forcing in a non-flux-adj usted coupled climate model显示文摘 | THORPE A J GREGORY J M JOHNS T C | 2001 | J Climate2001，14，： | 1 |
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