|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B显示文摘AIM: To evaluate the clinical efficacy of salvianolic acidB (SA-B) on liver fibrosis in chronic hepatitis B.METHODS: Sixty patients with definite diagnosis of liverfibrosis with hepatitis B were included in the trial.Interferon-γ (IFN-γ) was used as control drug. Thepatients took orally SA-B tablets or received muscularinjection of IFN-γ in the double blind randomized test,The complete course lasted 6 months. The histologicalchanges of liver biopsy specimen before and after thetreatment were the main evidence in evaluation, incombination with the results of contents of serum HA,LN, Ⅳ-C, P-Ⅲ-P, liver ultrasound imaging, andsymptoms and signs.RESULTS: Reverse rate of fibrotic stage was 36.67 % inSA-B group and 30.0 % in IFN-γgroup. Inflammatoryalleviating rate was 40.0 % in SA-B group and 36.67 %in IFN-γ group. The average content of HA and Ⅳ-Cwas significantly lower than that before treatment. Theabnormal rate also decreased remarkably. Overallanalysis of 4 serological fibrotic markers showedsignificant improvement in SA-B group as comparedwith the IFN-γgroup. Score of liver ultrasound imagingwas lower in SA-B group than in IFN-γgroup (HA 36.7 %vs80 %,Ⅳ-C 3.3 % vs23.2 %). Before the treatment,ALT AST activity and total bilirubin content of patientswho had regression of fibrosis after oral administrationof SA-B, were significantly lower than those of patientswho had aggravation of fibrosis after oraladministration of SA-B. IFN-γ showed certain sideeffects (fever and transient decrease of leukocytes,occurrence rates were 50 % and 3.23 %), but SA-Bshowed no side effects.CONCLUSION: SA-B could effectively reverse liverfibrosis in chronic hepatitis B. SA-B was better than IFN-γ in reduction of serum HA content, overall decrease of4 serum fibrotic markers, and decrease of ultrasoundimaging score. Liver fibrosis in chronic hepatitis B withslight liver injury was more suitable to SA-B in anti-fibrotic treatment. SA-B showed no obvious side effects. | Ping Liu Yi-Yang Hu Cheng Liu Hui-Ming Xue Zhi-Qiang Xu Lie-Ming Xu Cheng-Hai Liu Hong-Tu Gu Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China Da-Yuan Zhu Shanghai Institute of Metaria Medica,Chinese Academy of Sciences,Shanghai 200031,China Zhi-Qing Zhang the 4~(th) Hualyin City Hospital,Hualan City,223000,JiangSu Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 85 |
| 2 | Effect of intracoronary administration of anisodamine on slow reflow phenomenon following primary percutaneous coronary intervention in patients with acute myocardial infarction显示文摘许多基本、临床的研究证明了那 anisodamine 的背景能在减轻 microvascular 痉挛上生产重要效果,改进并且挖出冠的 microcirculation。它可能对为尖锐心肌的梗塞( AMI )跟随经皮的冠的干预(一种总线标准)的慢回流现象( SRP )的改进有益我们调查了的 .So 梗塞的 SRP 上的 anisodamine 的 intracoronary 管理的效果联系了在病人跟随主要一种总线标准,圣片断提高了的动脉( IRA )尖锐心肌的梗塞( STEAMI ) .Methods 有从 148 个 STEAMI 病人的一个总数的 SRP 的 21 个病人相信主要一种总线标准从9月被注册进这研究当 SRP 发生了时,硝化甘油(200 g ) 是“大丸药”第一注入了 IRA 排除 epicardial 动脉的痉挛并且识别 SRP 以及一个基线和克制代理人追随者一种总线标准。十分钟以后,当冠的 angiography (CAG ) 被拿在前并且在时, anisodamine 的 1000 g 在 200 g/s 与 SRP 被注入 IRA 第一,第 10 分别地在硝化甘油或 anisodamine 的管理以后纪录的第三 and。改正的 TIMI 框架计数(cTFC ) , TIMI 心肌的灌注等级(TMPG ) 和 IRA 的直径被吉布森的 TIMI 框架计数方法用量的计算机 angiography (QCA ) 计算并且分析在冠的流动和容器腔上评估 anisodamine 的影响的系统。同时, intracoronary 和全身的动脉和心电图(ECG )( 收缩、心脏舒张、吝啬的压力) 的侵略血液动力学的参数被测量并且监视。室的性能参数和不利反应的变化被评估并且在在 cTFCs 和 TMPG 的重要变化都没被发现在的 1 月 post-PCI.Results 跟随起来第一,第 10 作为与基线控制(P0.05 ) 相比在硝化甘油的 intracoronary 管理以后纪录的第三 and。cTFCs 被 58.3% , 56.2% ,和 54.6% 减少,分别地(P0.001 ) ,并且 TMPG 从 1.13 被增加 ??????????? 呃 ???????? 偓 ?? 吗? | FU Xiang-hua FAN Wei-ze GU Xin-shun WEI Yong-yun JIANG Yun-fa WU Wei-li LI Shi-qiang HAO Guo-zhen WEI Qing-min XUE Ling | 2007 | Chinese Medical Journal2007，，14： | 37 |
| 3 | Effect of multidisciplinary team treatment on outcomes of patients with gastrointestinal malignancy显示文摘AIM: To evaluate the effect of multidisciplinary team (MDT) treatment modality on outcomes of patients with gastrointestinal malignancy in China. METHODS: Data about patients with gastric and colorectal cancer treated in our center during the past 10 years were collected and divided into two parts. Part 1 consisted of the data collected from 516 consecutive complicated cases discussed at MDT meetings in Peking University School of Oncology (PKUSO) from December 2005 to July 2009. Part 2 consisted of the data collected from 263 consecutive cases of resect-able locally advanced rectal cancer from January 2001 to January 2005. These 263 patients were divided into neoadjuvant therapy (NT) group and control group. Patients in NT group received MDT treatment, namely neoadjuvant therapy + surgery + postoperative adjuvant therapy. Patients in control group underwent direct surgery + postoperative adjuvant therapy. The outcomes in two groups were compared. RESULTS: The treatment strategy was altered after discussed at MDT meeting in 76.81% of gastric cancer patients and in 58.33% of colorectal cancer patients before operation. The sphincter-preservation and local control of tumor were better in NT group than in control group. The 5-year overall survival rate was also higher in NT group than in control group (77.23% vs 69.75%, P = 0.049). CONCLUSION: MDT treatment modality can significantly improve the outcomes of patients with gastrointestinal malignancy in China. | Chang-Zheng Du Jie Li Yong Cai Ying-Shi Sun Wei-Cheng Xue Jin Gu | 2011 | World Journal of Gastroenterology2011，17，15： | 31 |
| 4 | Total parathyroidectomy combined with partial autotransplantation for the treatment of secondary hyperparathyroidism显示文摘为长期的肾的失败引起的第二等的甲状腺机能过盛的背景药治疗可能在疾病的早阶段是可得到的,但是它不是为严肃的病人同样有效的。学习的目的是评估通过 2006 年 9 月, parathroidectomy 和自体移植从 1999 年 9 月与第二等的 hyperparathyroidism.Methods 在尿毒症的病人与前臂自体移植相结合的全部的 parathyroidectomy 的效果在 20 个病人被执行。在外科手术前的甲状旁腺的 ultrasonography 和外科的探索的结果之间的连贯被比较。intraoperatively,浆液钙集中和未经触动的甲状旁腺的荷尔蒙(iPTH ) 外科手术前地被监视, 71 增生的甲状旁腺的腺全部的 postoperatively.Results A 是在 20 个病人的 resected。在 B-ultrasonography 和 intraoperative 探索之间的甲状旁腺的本地化的一致率是 94.4% 。平均 iPTH 价值是(110.90 捩瑡潩獮漠捣牵敲 ? 湩㈠瀠瑡敩瑮 ????? 湡 ? 桴牥 ? 慷 ? 潮瀠牥潩数慲楴敶搠慥桴 ? 湯汣獵潩 ? 慌慰潲 ' 盏妻鏂邽惮嫆啼蠹缿?畣敲瑴条 ? 湡 ? 獡楰慲楴湯椠 ? 晥楦楣湥 ? 湡 ? 慳敦映牯氠癩牥爠獥 ' 虡 N 湯 .????? | ZOU Qiang WANG Hong-ying ZHOU Jian LAO Zheng-yin XUE Jun LI Ming-xin LI Hai-ming JIN Yi-ting GU Yong ZHANG Yan-ling | 2007 | Chinese Medical Journal2007，，20： | 22 |
| 5 | Antisense to cyclin D1 reverses the transformed phenotype of human gastric cancer cells显示文摘INTRODUCTIONStudiesonthefunctionsofcelularprotooncogenesandtumorsuppresorgenesindicatethatmostofthesegenesmediatesignaltrans... | CHEN Bing 1, ZHANG Xue Yong 2, ZHANG Yu Jing 3, ZHOU Ping 3, GU Yan 4 and FAN Dai Ming 2 | 1999 | World Journal of Gastroenterology1999，5，1： | 23 |
| 6 | Exome sequencing confirms molecular diagnoses in 38 Chinese families with hereditary spherocytosis显示文摘Hereditary spherocytosis(HS), the most common cause of congenital hemolytic anemia, is caused by deficiency of the erythrocyte membrane proteins. Five causative genes(ANK1, SPTB, SPTA1, SLC4 A1, and EPB42) have been identified. To date,molecular genetic studies have been performed in different populations, including the American, European, Brazilian, Japanese and Korean populations, whereas only a few studies have been described in the Chinese population. Here, by reanalysis of the exome data, we revealed causative mutations and established a definitive diagnosis of HS in all 38 Chinese families. We found 34 novel mutations and four reported mutations in three known HS-causing genes—17 in ANK1, 17 in SPTB and four in SLC4 A1,suggesting that ANK1 and SPTB are the major genes in Chinese patients with HS. All of the ANK1 or SPTB mutations, scattered throughout the entire genes, are non-recurrent; and most of them are null mutations, which might cause HS via a haploinsufficiency mechanism. De novo mutations in ANK1 or SPTB often occur with an unexpected high frequency(87.5% and64.2%, respectively). Our study updates our knowledge about the genetic profile of HS in Chinese and shows that family-based,especially parent-offspring trio, sequencing analysis can help to increase the diagnostic power and improve diagnostic efficiency. | Rongrong Wang Shuanghao Yang Ming Xu Jia Huang Hongyan Liu Weiyue Gu Xue Zhang | 2018 | Science China(Life Sciences)2018，61，8： | 22 |
| 7 | EXPERIMENTAL STUDY OF FLOWFIELD STRUCTURE AROUND AN OGIVE-CYLINDER显示文摘The flowfield structure and their aerodynamic characteristics over an ogive cylinder were studied by means of flow visualization and surface pressure measurement in a water tunnel and a wind tunnel. The existence of multi asymmetric vortices over long slender bodies was experimentally confirmed at large angles of attack and in the subcritical Reynolds number range. The spatial 3 D characteristics of the multi vortices system were analyzed and a physical model was developed. The topological structure of different patterns in cross flow plane was studied and the mechanism governing the formation of asymmetric vortices and multi vortices was discussed from the viewpoint of stability of the topological structure. It was concluded that the maximum in the sectional side force distribution curve are not caused by the shedding of higher position vortex, but by the cross over to the symmetric plane of the lower position vortex. | Ph.D.Candidate:Wang Gang Fluid Mechanics Institute, Beijing University of Aeronautics and Astronautics, Beijing 100083, China,Supervisor: Deng Xue ying (Beijing University of Aeronautics and Astronautics) Members of Dissertation Defense Committee: Tong Bing gang (Graduate School of the Chinese Academy of Sciences),Chairman Gu Zhi fu (Peking University) Yang Qi de (China Aerodynamics Research and Development Center) Lv Zhi yong (Beijing University of Aeronautics and Astronautics) Liu Pei qing (Beijing University of Aeronautics and Astronautics) | 2003 | Journal of Hydrodynamics2003，15，5： | 18 |
| 8 | Droplet deposition and efficiency of fungicides sprayed with small UAV against wheat powdery mildew显示文摘Small unmanned aerial vehicle(UAV),a timely and effective pesticide sprayer,can be used to spray pesticide in a high efficiency without harming the crop,and is especially suitable for spraying for small farms and hills in Asian countries.In recent years,it has been chosen as a key and new technique for pesticide application.This paper studied the impact of UAV(UAV N-3)spraying parameters(different working height and different spraying concentrations)on the deposition of droplets on the wheat canopy and the prevention of powdery mildew.Water sensitive paper was used as the sampler to collect the pesticide droplets and image processing software Deposit Scan was used to compute the coverage rate of droplets on the wheat top layer to acquire the proportional distribution of droplets on the wheat lower layer.The experimental results showed the impact of spraying height on the distribution of droplets on the wheat upper layer was quite significant,when the spraying height was 5.0 m and the spraying speed was 4 m/s,the coverage rate of droplets on the wheat lower layer was the largest,as it was 45.6%of that on the upper layer,the droplets distribution was the most uniform,and the coefficient of variation was 33.13%.450 g/hm^(2)(dosage registered)of triadimefon SC(44%)was sprayed by the UAV,the control efficiency reached 55.1%after applying which was better than 20%and 40%of dosage decreased for each hectare,and the applying effect(35.6%)of 20%dosage decreased for each hectare had no significant difference from the applying effect(34.6%)applied by a knapsack-type electric sprayer.At 10 d after applying,the prevention effect realized by UAV was lower than that realized by a knapsack-type electric sprayer,and it may be correlated to the meteorological condition and water amount in the pesticide sprayed.Thus,when UAV spraying was chosen to prevent wheat powdery mildew under a serious disease situation,an auxiliary agent for spraying could be added to prolong the retention of pesticide on the plant surface to extend the pesticide effect.This study can provide a reference for the optimized design,performance upgrade and reasonable application of small UAV sprayers. | Weicai Qin Xinyu Xue Shaoming Zhang Wei Gu Baokun Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 16 |
| 9 | Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals显示文摘瞄准:在脂肝上评估 osthole 的效果,并且调查可能的机制。方法:有 hyperlipidemic 脂肝的一个鹑模型和有含酒精的脂肝的老鼠模型被分别地喂多脂饮食和白酒建立。这些实验动物然后分别地为 6 wk 与 osthole 5-20 mg/kg 被对待。然后,在浆液的类脂化合物和肝的织物,和肝的重量的系数被测量。结果:胆固醇(TC ) ,甘油三酸酯(TG ) ,更低的密度脂蛋白胆固醇(LDL-C ) ,肝的重量的系数,和肝的织物 TC 和 TG 满足的有浆液的层次总计的 osthole 的术后疗法显著地被减少。在肝的超级氧化物歧化酶(草皮) 的活动被改进。在导致白酒的脂肝老鼠,在肝的 malondialdehyde (MDA ) 的水平被减少。在高导致脂肪的脂肝鹑,在肝的谷胱甘肽过氧化物酶(GSH-PX ) 显著地被改进。肝标本的组织学的评估证明 osthole 戏剧性地减少了类脂化合物累积。结论:这些结果建议 osthole 在酒精和高导致脂肪的脂肝上有治疗学的效果。机制可能与它的反氧化被联系。 | Fang Song Mei-Lin Xie Lu-Jia Zhu Ke-Ping Zhang Jie Xue Zhen-Lun Gu | 2006 | World Journal of Gastroenterology2006，12，27： | 15 |
| 10 | Preventive effects of anisodamine against contrast-induced nephropathy in type 2 diabetics with renal insufficiency undergoing coronary angiography or angioplasty显示文摘 | GENG Wei FU Xiang-hua GU Xin-shun WANG Yan-bo WANG Xue-chao LI Wei JIANG Yun-fa HAO Guo-zhen FAN Wei-ze XUE Ling | 2012 | Chinese Medical Journal2012，，19： | 13 |
| 11 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 12 | Impact of EBV infection and immune function assay for lymphoproliferative disorder in pediatric patients after liver transplantation: A single-center experience显示文摘Background:Post-transplant lymphoproliferative disorder(PTLD)is a lethal complication after pediatric liver transplantation,but information regarding risk factors for the development of PTLD remains unclear.This study was to identify characteristics and risk factors of PTLD.Methods:A total of 705 pediatric patients who underwent liver transplantation between January 2017 and October 2018 were studied.Impact of clinical characteristics and Epstein-Barr virus(EBV)infection on the development of PTLD was evaluated.In addition,ImmuKnow assay was adopted in partial patients to analyze the immune status.Results:Twenty-five(3.5%)patients suffered from PLTD with a median time of 6 months(3–14 months)after transplantation.Extremely high tacrolimus(TAC)level was found in 2 fatal cases at PTLD onset.EBV infection was found in 468(66.4%)patients.A higher peak EBV DNA loads(>9590 copies/mL)within 3 months was a significant indicator for the onset of PTLD.In addition,the ImmuKnow assay demonstrated that overall immune response was significantly lower in patients with EBV infection and PTLD(P<0.0001).The cumulative incidence of PTLD was also higher in patients with lower ATP value(≤187 ng/mL,P<0.05).Conclusions:A careful monitoring of EBV DNA loads and tacrolimus concentration might be supportive in prevention of PTLD in pediatric patients after liver transplantation.In addition,application of the ImmuKnow assay may provide guidance in reducing immunosuppressive agents in treatment of PTLD. | Tian Qin Xiang-Qian Gu Seog-Song Jeong Yan-Yan Song Jin-Chuan Liu Jian-Xin Zheng Feng Xue Qiang Xia | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 8 |
| 13 | Genetic Analysis and Gene-Mapping of Two Reduced-Culm-Number Mutants in Rice显示文摘在现在的学习,以便系统地把米饭(Oryza sativa L.) 的基因机制为超级米饭 ideotype 和分叉的开发的模型系统的 tilling,二乙醇甲烷从 Nippobare 的子孙的导致 sulfonate 的米饭 reduced-culm-number (rcn ) 异种(O。sativa ssp。装饰用的梨树) ,也就是 rcn8 和 rcn9,被使用。Theirmaximum 两个都是不到 4 到 ers 为止。另外, rcn9 有 rust-spottedleaves 的另一个主要特征。在这二异种和七另外的后退的到很少为止异种之间的突变而产生之遗传的测试表明他们以前是未知 loci。基因分析证明 rcn 特点都被一双不同隐性基因控制,分别地指定了为 RCN8 和 RCN9。二张 F2 人口源于在 rcn8 或 rcn9 异种之间的十字, 93-11 被构造。用与出版简单顺序重复标记印射人口的二 rcn F2 的连接分析证明 RCN8 和 RCN9 基因分别地在染色体 1 的长手臂(119.6 厘米) 和染色体 6 的短手臂(63.6 厘米) 上被印射。现在的学习的结果对基于地图的克隆和 RCN8 和 RCN9 基因的功能的分析有益…… | Hua Jiang Long-Biao Guo Da-Wei Xue Da-Li Zeng Guang-Heng Zhang Guo-Jun Dong Ming-Hong Gu Qian Qian | 2006 | Journal of Integrative Plant Biology2006，48，3： | 8 |
| 14 | Procalcitonin could be a reliable marker in differential diagnosis of post-implantation syndrome and infection after percutaneous endovascular aortic repair显示文摘 | Xue Ling Luo Songyuan Luo Jianfang Liu Zhen Gu Mengnan Kang Huiyuan Yang Fan Nie Bingrong Liu Yuan Huang Wenhui Xie Nianjin He Pengcheng Dong Haojian Ni Zhonghan Fan Ruixin Chen Jiyan | 2014 | Chinese Medical Journal2014，，14： | 8 |
| 15 | Cadmium Activates Reactive Oxygen Species-dependent AKT/mT OR and Mitochondrial Apoptotic Pathways in Neuronal Cells显示文摘Objective To examine the role of Cd-induced reactive oxygen species(ROS)generation in the apoptosis of neuronal cells.Methods Neuronal cells(primary rat cerebral cortical neurons and PC12 cells)were incubated with or without Cd post-pretreatment with rapamycin(Rap)or N-acetyl-L-cysteine(NAC).Cell viability was determined by MTT assay,apoptosis was examined using flow cytometry and fluorescence microscopy,and the activation of phosphoinositide 3'-kinase/protein kinase B(Akt)/mammalian target of rapamycin(m TOR)and mitochondrial apoptotic pathways were measured by western blotting or immunofluorescence assays.Results Cd-induced activation of Akt/m TOR signaling,including Akt,m TOR,p70 S6 kinase(p70 S6K),and eukaryotic initiation factor 4E binding protein 1(4E-BP1).Rap,an m TOR inhibitor and NAC,a ROS scavenger,blocked Cd-induced activation of Akt/m TOR signaling and apoptosis of neuronal cells.Furthermore,NAC blocked the decrease of B-cell lymphoma 2/Bcl-2 associated X protein(Bcl-2/Bax)ratio,release of cytochrome c,cleavage of caspase-3 and poly(ADP-ribose)polymerase(PARP),and nuclear translocation of apoptosis-inducing factor(AIF)and endonuclease G(Endo G).Conclusion Cd-induced ROS generation activates Akt/m TOR and mitochondrial pathways,leading to apoptosis of neuronal cells.Our findings suggest that m TOR inhibitors or antioxidants have potential for preventing Cd-induced neurodegenerative diseases. | YUAN Yan WANG Yi HU Fei Fei JIANG Chen Yang ZHANG Ya Jing YANG Jin Long ZHAO Shi Wen GU Jian Hong LIU Xue Zhong BIAN Jian Chun LIU Zong Ping | 2016 | Biomedical and Environmental Sciences2016，29，2： | 8 |
| 16 | JAK-STAT signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients显示文摘以前的研究揭示了那根骨头从病人们早展出了的全身的豺狼座 erythematosus (SLE ) 的髓间充质的干细胞(BM-MSCs ) 老朽签名,它可以参予 SLE 的发展。然而,关于这现象的分子的机制充分没被阐明。在当前的学习,我们试图调查表明发信号的抄写(STAT ) 的变换器和使活跃之物的 Janus kinase (JAK ) 是否调停了从 SLE 病人的 BM-MSCs 的老朽。12 个女 SLE 病人和健康题目在学习被注册。所有 BM-MSCs 被密度坡度 centrifugation 孤立。西方的污点分析被用来测试表明分子的 JAK-STAT 的表示。我们由流动 cytometry 观察了房间,由染色的 F 肌动朊的细胞骨架结构的变化,和房间周期的分发的女郎的活动。从 SLE 病人的 BM-MSCs 显示出表明 transduction, phosphorylated JAK2 的高水平,和 STAT3 的 JAK-STAT 的老朽,和反常激活的突出的特征。在在正常 MSC 的 IFN- 的刺激以后,发信号的 JAK-STAT 被激活。房间体积和联系老朽的牛乳糖的数字(SA -- 女郎) 在 SLE BM-MSCs 积极被增加。细胞骨架的组织是将近混乱的。房间增长的率被减少。AG490, JAK2 的禁止者,并且在 BM-MSCs 的 STAT3 击倒,能显著地颠倒老朽。在摘要,我们的学习显示 JAK-STAT 发信号小径可以在 SLE BM-MSCs 的老朽起一个关键作用。 | Juan Ji Yeqing Wu Yan Meng Lijuan Zhang Guijuan Feng Yunfei Xia Wenrong Xue Shuyang Zhao Zhifeng Gu Xiaoyi Shao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 8 |
| 17 | Nodeless pairing in superconducting copper-oxide monolayer films on BieSreCaCueO8+δ显示文摘 | Yong Zhong Yang Wang Sha Han Yan-Feng Lv Wen-Lin Wang Ding Zhang Hao Ding Yi-Min Zhang Lili Wang Ke He Ruidan Zhong John A. Schneeloch Gen-Da Gu Can-Li Song Xu-Cun Ma Qi-Kun Xue | 2016 | Science Bulletin2016，61，16： | 8 |
| 18 | Associations of egg consumption with incident cardiovascular disease and all-cause mortality显示文摘Eggs are nutrient-dense while also loaded with abundant cholesterol, thus making the public hesitant about their consumption.We conducted the study to investigate if egg consumption is associated with incident cardiovascular disease(CVD) and all-cause mortality. Using the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China, we included 102,136 adults free of CVD and assessed their egg consumption with food-frequency questionnaires. CVD endpoints and all-cause mortality were confirmed during follow-ups by interviewing participants or their proxies and checking hospital records/death certificates.The HRs(95% CIs) were calculated using the cohort-stratified Cox regression models. During 777,163 person-years of followup, we identified 4,848 incident CVD and 5,511 deaths. U-shaped associations of egg consumption with incident CVD and allcause mortality were observed. Compared with consumption of 3–<6/week, the multivariable-adjusted HRs(95% CIs) of <1/week and ≥10/week for incident CVD were 1.22(1.11 to 1.35) and 1.39(1.28 to 1.52), respectively. The corresponding HRs(95% CIs) for all-cause mortality were 1.29(1.18 to 1.41) and 1.13(1.04 to 1.24). Our findings identified that both low and high consumption were associated with increased risk of incident CVD and all-cause mortality, highlighting that moderate egg consumption of 3–<6/week should be recommended for CVD prevention in China. | Xue Xia Fangchao Liu Xueli Yang Jianxin Li Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Yingxin Zhao Xianping Wu Liancheng Zhao Ying Li Jianfeng Huang Xiangfeng Lu Dongfeng Gu | 2020 | Science China(Life Sciences)2020，63，9： | 7 |
| 19 | Exosomal piRNA profiling revealed unique circulating piRNA signatures of cholangiocarcinoma and gallbladder carcinoma显示文摘Cholangiocarcinoma(CCA)and gallbladder carcinoma(GBC)are biliary tract cancers with poor five-year survival and high recurrence rates.Both CCA and GBC patients suffer from lack of circulating diagnostic biomarkers at the early stage.Extracellular vesicles,especially exosomes,have been emerged as promising diagnostic sources for cancers due to easy and quick accessibility.Hence,identification of exosomal biomarkers provides a novel strategy for CCA and GBC diagnosis.Here,five CCA patients and four GBC patients were enrolled for exosomal small RNA sequencing.Our data showed that exosomal piwi-interacting RNA(piRNA)populations were altered in the plasma of CCA and GBC patients.In comparison to healthy individuals,694 and 323 piRNAs were upregulated in CCA and GBC,respectively,while 36 and 191 piRNAs were down regulated.Interestingly,sequencing results predicted that piR-2660989,piR-10506469,piR-20548188,piR-10822895,piR-hsa-23209,and piR-18044111 were upregulated in both CCA and GBC plasma.Importantly,we further included blood samples from 50 health individuals,40 CCA patients,and 25 GBC patients and found that piR-10506469 were significantly increased in the exosomes of plasma from both CCA and GBC patients.Moreover,we analyzed the expression levels of differentially expressed exosomal piRNAs in the plasma of CCA and GBC patient before and after surgeries and found that piR-10506469 and piR-20548188 were significantly decreased in patients underwent surgeries.Taken together,our data revealed that exosomal piRNAs those are differentially expressed in CCA and GBC plasma may serve as potential biomarkers for the diagnosis of CCA and GBC. | Xinjin Gu Chen Wang Hui Deng Chong Qing Rong Liu Sanhong Liu Xinying Xue | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 7 |
| 20 | Hybrid CFD/FEM-BEM simulation of cabin aerodynamic noise for vehicles traveling at high speed显示文摘Flow passing a vehicle may lead to the increase of the cabin interior noise level through a variety of mechanisms. These mechanisms include vibrations caused by aerodynamic excitations and reradiation from the glass panels, exterior noise trans-mitted and leaked through door seals including gaps and glass edge, and transmission of airborne noise generated by the interaction of flow with body panels. It is of vital importance to predict both the flow fields and the acoustic sources around the ve-hicle to accurately assess the impact of wind induced noise inside the cabin. In the present study, an unstructured segregated finite volume model was used to calculate the flow fields in which a hexahedron grid is used to simplify the vehicle geometry.A large eddy simulation coupled with a wall function model was applied to predict the exterior transient flow fields. The mean flow quantities were thus calculated along the symmetry plane and the vehicle's side windows. A coupled FEM/BEM method was used to compute the vehicle's interior noise level. The total contribution of the interior noise level due to the body panels of the vehicle was subsequently analyzed. | WANG YiPing ZHEN Xin WU Jing GU ZhengQi XIAO ZhenYi YANG Xue | 2013 | Science China(Technological Sciences)2013，56，7： | 7 |
您所在的机构暂未开通此部分的功能，请联系管理员