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| 1 | Aboveground biomass and its spatial distribution pattern of herbaceous marsh vegetation in China显示文摘Herbaceous marsh is the most widely distributed type of marsh wetland ecosystem,and has important ecological functions such as water conservation,climate regulation,carbon storage and fixation,and sheltering rare species.The carbon sequestration function of herbaceous marsh plays a key role in slowing climate warming and maintaining regional environmental stability.Vegetation biomass is an important index reflecting the carbon sequestration capacity of wetlands.Investigating the biomass of marsh vegetation can provide a scientific basis for estimating the carbon storage and carbon sequestration capacity of marshes.Based on field survey data of aboveground biomass of herbaceous marsh vegetation and the distribution data set of marsh in China,we analyzed the aboveground biomass and its spatial distribution pattern of herbaceous marsh on a national scale for the first time.The results showed that in China the total area of herbaceous marsh was 9.7×10^(4) km^(2),the average density of aboveground biomass of herbaceous marsh vegetation was 227.5±23.0 g C m-2(95%confidence interval,the same below),and the total aboveground biomass was 22.2±2.2 Tg C(1 Tg=1012 g).The aboveground biomass density of herbaceous marsh vegetation is generally low in Northeast China and the Tibetan Plateau,and high in central North China and coastal regions in China.In different marsh distribution regions of China,the average biomass density of herbaceous marsh vegetation from small to large was as follows:temperate humid and semi-humid marsh region(182.3±49.3 g C m^(-2)) | Xiangjin SHEN Ming JIANG Xianguo LU Xingtu LIU Bo LIU Jiaqi ZHANG Xianwei WANG Shouzheng TONG Guangchun LEI Shengzhong WANG Chuan TONG Hangqing FAN Kun TIAN Xiaolong WANG Yuanman HU Yonghong XIE Muyuan MA Shuwen ZHANG Chunxiang CAO Zhichen WANG | 2021 | Science China Earth Sciences2021，64，7： | 4 |
| 2 | Positive allosteric regulation of PAC1-R up-regulates PAC1-R and its specific ligand PACAP显示文摘PAC1-R is a recognized preferential receptor for the neuropeptide of pituitary adenylate cyclase-activating polypeptide(PACAP),which mediates neuroprotective and nerve regenerative activities of PACAP.In this study,we found that in both PAC1R-CHO cells with high expression of PAC1R-eGFP and retinal ganglion cells(RGC-5)with the natural expression of PAC1-R,oligo-peptide PACAP(28-38)and the positively charged arginine-rich penetrating peptide TAT,as positive allosteric modulators of PAC1-R,significantly trigger the nuclear translocation of PAC1-R.The chromatin immunoprecipitation(ChIP)-PCR results show that the nuclear translocated PAC1-R binds with the promoter regions of PAC1-R and its specific ligand PACAP.The up-regulated promoter activities of PAC1-R and PACAP induced by PACAP(28-38)or TAT are positively correlative with the increase of the expression levels of PAC1-R and PACAP.Moreover,the nuclear translocation of PAC1-R induced by PACAP(28-38)or TAT is significantly inhibited by the mutation of PAC1-R on Cys25 and the palmitoylation inhibitor 2-bromopalmitate.Meanwhile,the increase in both PAC1-R and PACAP levels and the neuroprotective activities of PACAP(28-38)and TAT in MPPinduced cell model of Parkinson’s disease are synchronously inhibited by 2-bromopalmitate,which are positively correlated with the nuclear translocation of PAC1-R induced by PACAP(28-38)or TAT.Bioinformatics analysis and motif enrichment analysis following ChIP-sequencing show that the transcription factors including SP1,Zic2,GATA1,REST and YY1 may be recruited by nuclear PAC1-R and involved in regulating the promoter activities of PAC1-R and PACAP.ChIP-sequencing and related bioinformatics analysis show that the downstream target genes regulated by the nuclear PAC1-R are mostly involved in the process of cellular stress and related to neuroprotection,neuronal genesis and development. | Guangchun Fan Zhengxin Tao Shang Chen Huahua Zhang Rongjie Yu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，5： | 1 |
| 3 | Experimental study on treatment of electroplating wastewater by nanofihration显示文摘 | Wang Zhi Liu Guangchun Fan Zhifeng | 2007 | Journal of Membrane Science2007，305，12： | 1 |
| 4 | Experimental study on treatment of electroplating wastewater by nanofihration 显示文摘 | Wang Zhi Liu Guangchun Fan Zhifeng | 2007 | Journal of Membrane Science2007，305，12： | 1 |
| 5 | Scaly-sided Merganser(Mergus squamatus)equalizes foraging costs with depth by switching foraging tactics显示文摘Throughout evolutionary history,animals are finely tuned to adjust their behaviors corresponding to environmental variations.Behavioral flexibility represents an important component of a species'adaptive capacity in the face of rapid anthropogenetic environmental change,and knowledge of animal behaviors is increasingly recognized in conservation biology.In aquatic ecosystem,variation of water depth is a key factor affecting the availability of food;thus,the foraging behaviors of many waterbirds,especially piscivores.In this study,we compared the foraging behaviors of the Scaly-sided Merganser(Mergus squamatus),an endangered migratory diving duck endemic to East Asia,in habitats with different water depths(Shallow waters:0–40 cm;Deep waters:40–300 cm),using video camera records obtained from the known wintering sites during three winters from 2018 to 2020.Further,the energy expenditure of foraging behavior profile and energy intake based on fish sizes were calculated to study the foraging energetics.In total,200 effective video footages that contained 1086 min with 17,995 behaviors and 163 events of catching fish were recorded.Results showed that:1)time length for fishing(including eye-submerging,head-dipping,diving and food handling)of M.squamatus in shallow waters was significantly more than in deep waters;2)M.squamatuss spent significantly more time for preparing(including vigilance,preening and swimming)in deep waters than in shallow waters;3)the mean catch rate was 0.28 fish/min in shallow waters,which is significantly higher than the value of 0.13 fish/min in deep waters;4)despite the distinct foraging behavior profiles and energy intakes,M.squamatus showed similar energetics in shallow and deep waters.We concluded that M.squamatus is a good example of behavioral flexibility that aligns with expectations of optimal foraging theory,in that it behaves in accordance to resource availability in different environments,resulting in high foraging efficiency. | Peizhong Liu Meihan Liu Dongyang Xiao Ying He Rong Fan Cai Lu Li Wen Qing Zeng Guangchun Lei | 2023 | Avian Research2023，14，4： | 0 |
| 6 | A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson's disease model显示文摘As a neuropeptide pituitary adenylate cyclase-activating polypeptide(PACAP)-preferring receptor,PAC1-R mediates effective neuroprotective activity.Based on the finding that the antibiotic doxycycline(DOX)with clinical neuroprotective activity functions as a positive allosteric modulator(PAM)of neuropeptide PACAP receptor 1(PAC1-R),we use virtual and laboratory screening to search for novel small molecule PAMs of PAC1-R.Virtual screening is carried out using a small-molecule library TargetMol.After two-level precision screening with Glide,the top five compounds with the best predicted affinities for PAC1-R are selected and named small positive allosteric modulator 1-5(SPAM1-5).Our results show that only 4-[4-(4-Oxo-3,4-2-yl)butanamido]methyl)benzoic acid(SPAM1)has stronger neuroprotective activity than DOX in the MPP+PD cell model and MPTP PD mouse model.SPAM1 has a higher affinity for PAC1-R than DOX,but has no antibiotic activity.Moreover,both SPAM1 and DOX block the decrease of PAC1-R level in mouse brain tissues induced by MPTP.The successful screening of SPAM1 offers a novel drug for the treatment of neurodegenerative disease targeting the PAC1-R. | Guangchun Fan Shang Chen Zhengxin Tao Huahua Zhang Rongjie Yu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 0 |
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