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| 1 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 3 |
| 2 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 1 |
| 3 | Positive allosteric regulation of PAC1-R up-regulates PAC1-R and its specific ligand PACAP显示文摘PAC1-R is a recognized preferential receptor for the neuropeptide of pituitary adenylate cyclase-activating polypeptide(PACAP),which mediates neuroprotective and nerve regenerative activities of PACAP.In this study,we found that in both PAC1R-CHO cells with high expression of PAC1R-eGFP and retinal ganglion cells(RGC-5)with the natural expression of PAC1-R,oligo-peptide PACAP(28-38)and the positively charged arginine-rich penetrating peptide TAT,as positive allosteric modulators of PAC1-R,significantly trigger the nuclear translocation of PAC1-R.The chromatin immunoprecipitation(ChIP)-PCR results show that the nuclear translocated PAC1-R binds with the promoter regions of PAC1-R and its specific ligand PACAP.The up-regulated promoter activities of PAC1-R and PACAP induced by PACAP(28-38)or TAT are positively correlative with the increase of the expression levels of PAC1-R and PACAP.Moreover,the nuclear translocation of PAC1-R induced by PACAP(28-38)or TAT is significantly inhibited by the mutation of PAC1-R on Cys25 and the palmitoylation inhibitor 2-bromopalmitate.Meanwhile,the increase in both PAC1-R and PACAP levels and the neuroprotective activities of PACAP(28-38)and TAT in MPPinduced cell model of Parkinson’s disease are synchronously inhibited by 2-bromopalmitate,which are positively correlated with the nuclear translocation of PAC1-R induced by PACAP(28-38)or TAT.Bioinformatics analysis and motif enrichment analysis following ChIP-sequencing show that the transcription factors including SP1,Zic2,GATA1,REST and YY1 may be recruited by nuclear PAC1-R and involved in regulating the promoter activities of PAC1-R and PACAP.ChIP-sequencing and related bioinformatics analysis show that the downstream target genes regulated by the nuclear PAC1-R are mostly involved in the process of cellular stress and related to neuroprotection,neuronal genesis and development. | Guangchun Fan Zhengxin Tao Shang Chen Huahua Zhang Rongjie Yu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，5： | 1 |
| 4 | Improving dynamics of integer-order small-world network models under fractional-order PD control显示文摘The optimal control of dynamics is a popular topic for small-world networks. In this paper, we address the problem of improving the behavior of Hopf bifurcations in an integer-order model of small-world networks. In this study, the time delay is used as the bifurcation parameter. We add a fractional-order proportional-derivative(PD) scheme to an integer-order Newman-Watts(N-W) small-world model to better control the Hopf bifurcation of the model. The most important contribution of this paper involves obtaining the stability of the system and the variation of the conditions of the Hopf bifurcation after a fractional PD controller is added to the integer-order small-world model. The results demonstrate that the designed PD controller can be used to restrain or promote the occurrence of Hopf bifurcations by setting appropriate parameters. We also describe several simulations to verify our research results. | Huaifei WANG Min XIAO Binbin TAO Fengyu XU Zhengxin WANG Chengdai HUANG Jianlong QIU | 2020 | Science China(Information Sciences)2020，63，1： | 1 |
| 5 | Study on the Carbon Stocks of Soils under Five Kinds of Plantations显示文摘Based on the field data and laboratory analysis,we studied the soil organic carbon storage and vertical distribution features about five kinds of plantations in Xuyi,and the results showed that soil carbon density in the five forest types changed greatly,with a range of 0. 8-3. 04 kg / m2 for five soil layers. Furthermore,soil carbon density decreased generally with the depth,as well as carbon content. In the whole soil profile,the range of carbon density in these five forests was from 4. 79 kg / m2 to 5. 62 kg / m2. However,60% carbon was concentrated in40 cm depth of soil. The calculated result of soil organic carbon reserve was as follows: Cupressus lusitanica( 50. 264 t / hm2),hackberry( 47. 859 t/hm2),Populus L.( 53. 216 t/hm2),Red bayberry( 49. 581 t/hm2),Amygdalus persica L.( 58. 202 t/hm2),with the average storage of 51. 824 t / hm2,lower than the national average level,so,people should pay attention to the artificial forest tending and management.According to the above analysis,this paper concluded that the afforestation was the effective measure for increasing the soil organic carbon accumulation,and the effects of planting the indigenous tree species Cupressus lusitanica and Amygdalus persica L. were best. | Tao ZHANG Fuxu WAN Zhengxin TAN | 2015 | Asian Agricultural Research2015，7，4： | 0 |
| 6 | A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson's disease model显示文摘As a neuropeptide pituitary adenylate cyclase-activating polypeptide(PACAP)-preferring receptor,PAC1-R mediates effective neuroprotective activity.Based on the finding that the antibiotic doxycycline(DOX)with clinical neuroprotective activity functions as a positive allosteric modulator(PAM)of neuropeptide PACAP receptor 1(PAC1-R),we use virtual and laboratory screening to search for novel small molecule PAMs of PAC1-R.Virtual screening is carried out using a small-molecule library TargetMol.After two-level precision screening with Glide,the top five compounds with the best predicted affinities for PAC1-R are selected and named small positive allosteric modulator 1-5(SPAM1-5).Our results show that only 4-[4-(4-Oxo-3,4-2-yl)butanamido]methyl)benzoic acid(SPAM1)has stronger neuroprotective activity than DOX in the MPP+PD cell model and MPTP PD mouse model.SPAM1 has a higher affinity for PAC1-R than DOX,but has no antibiotic activity.Moreover,both SPAM1 and DOX block the decrease of PAC1-R level in mouse brain tissues induced by MPTP.The successful screening of SPAM1 offers a novel drug for the treatment of neurodegenerative disease targeting the PAC1-R. | Guangchun Fan Shang Chen Zhengxin Tao Huahua Zhang Rongjie Yu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 0 |
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