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| 1 | DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway显示文摘Gastric cancer is a common malignancy worldwide.The occurrence of multidrug resistance(MDR)is the major obstacle for effective gastric cancer chemotherapy.In this study,the in-depth molec-ular mechanism of the DJ-1-induced MDR in SGC7901 gastric cancer cells was investigated.The results showed that DJ-1 expression level was higher in MDR variant SGC7901NCR cells than that in its parental SGC7901 cells.Moreover,DJ-1 overexpression conferred the MDR phenotype to SGC7901 cells,while DJ-1 knockdown in SGC7901NCR cells induced re-sensitization to adriamycin,vincristine,cisplatin,and 5-fluorouracil.These results suggested that DJ-1 mediated the develop-ment of MDR in SGC7901 gastric cancer cells.Importantly,further data revealed that the activation of PI3k/Akt and Nrf2 signaling pathway were required for the DJ-1-induced MDR phenotype in SGC7901 gastric cancer cells.Meanwhile,we found that Pl3k/Akt pathway was activated probably through DJ-1 directly binding to and negatively regulating PTEN,consequently resulting in Nrf2 phosphorylation and activation,and thereby inducing Nrf2-dependent P-glycoprotein(P-gp)and Bcl-2 expressions in the DJ-1-mediated MDR of SGC7901 gastric cancer cells.Overall,these results revealed that activating PTEN/PI3K/Akt/Nrf2 pathway and subsequently upregulating P-gp and Bcl-2 expression could be a critical mechanism by which DJ-1 mediates the development of MDR in SGC7901 gastric cancer cells.The new findings may be helpful for understanding the mechanisms of MDR in gastric cancer cells,prompting its further investigation as a molecular target to overcome MDR. | Lejia Qiu Zhaoxia Ma Xiaoran Li Yizhang Deng Guangling Duan Le Zhao Xingwang Xu Lin Xiao Haoyue Liu Zhengming Zhu Heping Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 5 |
| 2 | Chemical characterization and sources of PM2.5 at 12-h resolution in Guiyang, China显示文摘The increasing emission of primary and gaseous precursors of secondarily formed atmospheric particulate matter due to continuing industrial development and urbanization are leading to an increased public awareness of environmental issues and human health risks in China.As part of a pilot study, 12-h integrated fine fraction particulate matter(PM_(2.5) filter samples were collected to chemically characterize and investigate the sources of ambient particulate matter in Guiyang City, Guizhou Province, southwestern China. Results showed that the 12-h integrated PM_(2.5) concentrations exhibited a daytime average of 51 ± 22 lg m^(-3)(mean ± standard deviation) with a range of 17–128 lg m^(-3) and a nighttime average of55 ± 32 lg m~(^(-3)) with a range of 4–186 lg m^(-3). The 24-h integrated PM_(2.5) concentrations varied from 15 to157 lg m~(^(-3)), with a mean value of 53 ± 25 lg m^(-3), which exceeded the 24-h PM_(2.5) standard of 35 lg m^(-3) set by USEPA, but was below the standard of 75 lg m^(-3), set by China Ministry of Environmental Protection. Energy-dispersive X-ray fluorescence spectrometry(XRF) was applied to determine PM_(2.5) chemical element concentrations. The order of concentrations of heavy metals in PM_(2.5) were iron(Fe) [ zinc(Zn) [ manganese(Mn) [ lead(Pb) [ arsenic(As) [ chromium(Cr). The total concentration of 18 chemical elements was 13 ± 2 lg m^(-3),accounting for 25% in PM_(2.5), which is comparable to other major cities in China, but much higher than cities outside of China. | Longchao Liang Na Liu Matthew S. Landis Xiaohang Xu Xinbin Feng Zhuo Chen Lihai Shang Guangle Qiu | 2018 | Acta Geochimica2018，37，2： | 4 |
| 3 | Calibration of the linear optics in the SSRF storage ring显示文摘PhaseⅠcommissioning of the SSRF storage ring at 3.0 GeV was ended with encouraging results. Distortions and calibrations of the linear optics during the storage ring commissioning are discussed in this paper.The calibration procedure has reduced sextupole-additional focusing effects by minimizing closed orbit deviation and corrected quadrupole magnetic coefficients with the linear optics from closed orbit (LOCO) technique.After fitting the closed orbit response matrix,linear optics of the storage ring is substantially corrected,and the measured parameters agree well with the design.Four optics modes were commissioned,and relevant machine physics studies were carried out.Their results are summarized. | TIAN Shunqiang LIU Guimin ZHANG Wenzhi LI Haohu ZHANG Manzhou HOU Jie CHEN Guangling | 2008 | Nuclear Science and Techniques2008，19，5： | 2 |
| 4 | The interaction of phenolic acids with Fe(III) in the presence of citrate as studied by isothermal titration calorimetry显示文摘 | Senpei Yang Guangling Bai Lingli Chen Qun Shen Xianmin Diao Guanghua Zhao | 2014 | Food Chemistry2014，，： | 1 |
| 5 | Excitation curve calibration for the SSRF booster magnets and applications in the commissioning显示文摘The Shanghai Synchrotron Radiation Facility (SSRF) is a low emittance third-generation synchrotron radiation light source under commissioning. The excitation curve calibration for the booster magnets is important to provide the magnet current configurations as reference. Calibration studies give the polynomial coefficients of each type of magnets and provide the magnet current configurations under different beam energies as beam is ramped at speed of 2 Hz. The applications of calibration in booster commissioning which show the accuracy of the magnetic excitation curve calibration are also discussed. | HOU Jie SUN Xiaoying CHEN Guangling ZHOU Xuemei LI Haohu LIU Guimin | 2008 | Nuclear Science and Techniques2008，19，4： | 1 |
| 6 | Preparation and Characteristic of Glass-Ceramics with Super Low Thermal Expansion Coefficient显示文摘The preparation technics of glass-ceramics with super low coefficient of thermal expansion containing β-quartz solid solution as a main crystal phase based on the glass in the system Li2O-Al2O3-SiO2 was introduced. The composition of base glass, technics of melting and heat treatment effecting on characteristic of glass-ceramics was described. Specimens were prepared by melting, anneal and controlled two steps heat treatment. Crystal phase, microstructure and elementary distributing were studied by using XRD, SEM and EDS respectively. Prepared specimens show excellent transparency and super low thermal expansion coefficient of 2×10-8 ·K-1, which reaches international advanced level. | Zhao Chunxia Fan Shigang Chen Guangle Jiang Hui Wang Shengjun Wang Kun | 2006 | Journal of Rare Earths2006，24，z1： | 0 |
| 7 | Studies and Properties of Ceramics with High Thermal Conductivity显示文摘The sintering technology of the AlN ceramics power were discussed. It is discussed that the compound sintering aids is consistent with the enhancement of the the thermal conductivity of AlN ceramics, and sintering technics is helped to the improvement of density. It is analyzed how to sinter machinable AlN ceramics with high thermal conductivity. And the microstructure of compound ceramics based on AlN was studied. | Chen Guangle Fan Shigang Zhao Chunxia Wang Kun Xia Shuqin | 2006 | Journal of Rare Earths2006，24，z1： | 0 |
| 8 | Mercury accumulation,distribution,and isotopic composition in tissues of the Collared Scops Owl(Otus lettia)显示文摘Mercury is a ubiquitous contaminant known to accumulate in wildlife,particularly bird species at higher trophic levels.Knowledge of tissue-specific Hg distributions aids our understanding of Hg bioaccumulation in organisms.In this study,one adult and three juvenile Collared Scops Owls(Otus lettia)were studied to elucidate the bioaccumulation of Hg in body tissues.Six tissues and organs(feathers,nails,heart,liver,gizzard,and muscle),as well as gastric contents,were examined for total Hg(THg)and methylmercury(MeHg)contents,Hg isotopic compositions including mass-dependent fractionation(MDF;δ202Hg)and mass-independent fractionation(MIF;Δ199Hg andΔ201Hg),and C(δ13C)and N(δ15N)isotopic compositions.Tissue-specific THg and MeHg concentrations in the adult were in the ranges of 150–1360 ng/g and17–1060 ng/g,and lower in the juveniles at 91–419 ng/g and 67–350 ng/g,respectively.Theδ^(202)Hg values in the adult were strongly negative at-1.75‰±0.17‰compared with the juveniles at-0.99‰±0.25‰.The adult exhibited lower MIF values than the juveniles,at0.23‰±0.07‰forΔ^(199)Hg and 0.2‰±0.11‰forΔ^(201)Hg,comparedwith0.81‰±0.09‰and0.66‰±0.07‰,respectively.The lower adult MDF and MIF values suggest that the adult tended to accumulate negative Hg isotopes but the juvenile's positive Hg isotopes.Differences between adult and juvenile tissue Hg concentrations indicate that metabolic processes play an important role in Hg accumulation. | Dongya Jia Kang Luo Zhidong Xu Xiaohang Xu Chan Li Hongmei Wu Dawei Wang Hui Ye Gaoen Wu Zhuo Chen Guangle Qiu | 2023 | Acta Geochimica2023，42，4： | 0 |
| 9 | A modeling GUI for accelerator physics of the storage ring at SSRF显示文摘In this paper,we report a MATLAB-based GUI tool,bodgui,which integrates functions of lattice editor,linear match,and nonlinear optimization,and visualized tracking functions for beam optics design.A user can switch his/her design procedures one to another.Flexibilities are provided for adjusting or optimizing the lattice settings in commissioning or operation of the accelerators.The algorithm of the linear match and nonlinear optimization,and the GUI windows including the main functions and running status,are presented.The SSRF storage ring was employed as a test lattice.Several optics modes designed and optimized by the GUI tools were used for commissioning the storage ring.Functions of bodgui tool are machine-independent,and it can be well applied to modern light sources being built in other parts of the world. | CHEN Guangling TIAN Shunqiang LIU Guimin JIANG Bocheng | 2009 | Nuclear Science and Techniques2009，20，2： | 0 |
| 10 | Rice ferredoxin OsFd4 contributes to oxidative stress tolerance but compromises defense against blight bacteria显示文摘Ferredoxins(Fds)in plastids are the most upstream stromal electron receptors shuttling electrons to downstream metabolic systems and function in various physiological processes of dicots,but their roles in monocots’response to stresses are still unclear.In this study,the functions of OsFd4,the major non-photosynthetic type Fd in rice,were characterized under oxidative stress and Xanthomonas oryzae pv.oryzae(Xoo)infection.OsFd4-knockout mutants displayed no defects in key agronomic traits and blast resistance,but were more sensitive to hydrogen peroxide(H2O2)treatment than the wild type.Transient expression of OsFd4 alleviated H2O2-induced rice cell death,suggesting that OsFd4 contributes to rice tolerance to exogenous oxidative stress.Deletion of OsFd4 enhanced rice immune responses against Xoo.OsFd4 formed a complex in vivo with itself and OsFd1,the major photosynthetic Fd in rice,and OsFd1 transcripts were increased in leaf and root tissues of the OsFd4-knockout mutants.These results indicate that OsFd4 is involved in regulating rice defense against stresses and interplays with OsFd1. | Minfeng Lu Jinhui Chen Han Meng Guangling Mo Yunhong Liu Fengping Chen Zonghua Wang Mo Wang | 2023 | The Crop Journal2023，11，6： | 0 |
| 11 | ABI5 promotes heat stress-induced chlorophyll degradation by modulating the stability of MYB44 in cucumber显示文摘The yellowing of leaves caused by the decomposition of chlorophyll(Chl)is a characteristic event during senescence,which can be induced by various environmental stresses.However,the molecular mechanisms of high temperature-induced Chl degradation in horticultural plants remain poorly understood.Here,we found that heat stress induced Chl degradation and the expression of ABI5 and MYB44 in cucumber.Silencing of ABI5 compromised heat stress-induced Chl degradation,and the transcription of pheophytinase(PPH)and pheophorbide a oxygenase(PAO),two key genes in Chl catabolic pathway,but silencing of MYB44 exhibited the opposite results.Furthermore,ABI5 interacted with MYB44 in vitro and in vivo.ABI5 positively regulated heat stress-induced Chl degradation through two pathways.ABI5 directly bound to PPH and PAO promoters to promote their expression,leading to accelerating Chl degradation.On the other hand,the interaction between ABI5 and MYB44 reduced the binding of MYB44 to PPH and PAO promoters and led to the ubiquitination-depended protein degradation of MYB44,thereby alleviating the transcription inhibitory effect of MYB44 on PPH and PAO.Taken together,our findings propose a new regulatory network for ABI5 in regulating heat stress-induced Chl degradation. | Weikang Liu Guangling Chen Mingming He Jianqiang Wu Wenxu Wen Qinsheng Gu Shirong Guo Yu Wang Jin Sun | 2023 | Horticulture Research2023，10，6： | 0 |
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