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| 1 | Olmutinib(HM61713) reversed multidrug resistance by inhibiting the activity of ATPbinding cassette subfamily G member 2 in vitro and in vivo显示文摘Overexpressing of ATP-binding cassette(ABC) transporters is the essential cause of multidrug resistance(MDR), which is a significant hurdle to the success of chemotherapy in many cancers.Therefore, inhibiting the activity of ABC transporters may be a logical approach to circumvent MDR.Olmutinib is an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor(TKI), which has been approved in South Korea for advanced EGFR T790 M-positive non-small cell lung cancer(NSCLC). Here,we found that olmutinib significantly increased the sensitivity of chemotherapy drug in ABCG2-overexpressing cells. Furthermore, olmutinib could also increase the retention of doxorubicin(DOX) and rhodamine 123(Rho 123) in ABC transporter subfamily G member 2(ABCG2)-overexpressing cells. In addition, olmutinib was found to stimulate ATPase activity and inhibit photolabeling of ABCG2 with [^(125) I]-iodoarylazidoprazosin(IAAP). However, olmutinib neither altered ABCG2 expression at protein and m RNA levels nor blocked EGFR, Her-2 downstream signaling of AKT and ERK. Importantly,olmutinib enhanced the efficacy of topotecan on the inhibition of S1-MI-80 cell xenograft growth. All the results suggest that olmutinib reverses ABCG2-mediated MDR by binding to ATP bind site of ABCG2 and increasing intracellular chemotherapeutic drug accumulation. Our findings encouraged to further clinical investigation on combination therapy of olmutinib with conventional chemotherapeutic drugs in ABCG2-overexpressing cancer patients. | Zhiqiang Zhang Xiaoran Guo Kenneth K.W.To Zhen Chen Xiaona Fang Min Luo Chunling Ma Jianhua Xu Shirong Yan Liwu Fu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 9 |
| 2 | Cloning and functional characterization of Rht8,a“Green Revolution”replacement gene in wheat显示文摘Dear Editor,Wheat(Triticum aestivum)is a major staple crop in the world and provides~20%of the food calories for human consumption(Appels et al.,2018).During the 1960s and 1970s,the introduction of two semi-dwarfing genes Rht-B1b and Rht-D1b in wheat varieties strikingly improved lodging resistance and harvest index,and therefore substantially increased grain yield,resulting in the well-known'Green Revolution'(Peng et al.,1999).However,plants carrying Rht-B1b and Rht-D1b suffer from several drawbacks. | Hongchun Xiong Chunyun Zhou Meiyu Fu Huijun Guo Yongdun Xie Linshu Zhao Jiayu Gu Shirong Zhao Yuping Ding Yuting Li Jiazi Zhang Ke Wang Xuejun Li Luxiang Liu | 2022 | Molecular Plant2022，15，3： | 7 |
| 3 | Proteomic analysis of heat stress resistance of cucumber leaves when grafted onto Momordica rootstock显示文摘Various biotic and abiotic stresses threaten the cultivation of future agricultural crops.Among these stresses,heat stress is a major abiotic stress that substantially reduces agricultural productivity.Many strategies to enhance heat stress tolerance of crops have been developed,among which is grafting.Here,we show that Momordica-grafted cucumber scions have intrinsically enhanced chlorophyll content,leaf area,and net photosynthetic rate under heat stress compared to plants grafted onto cucumber rootstock.To investigate the mechanisms by which Momordica rootstock enhanced cucumber scions heat stress tolerance,comparative proteomic analysis of cucumber leaves in response to rootstock-grafting and/or heat stress was conducted.Seventy-seven differentially accumulated proteins involved in diverse biological processes were identified by two-dimensional electrophoresis(2-DE)in conjunction with matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry(MALDI-TOF/TOF MS).The following four main categories of proteins were involved:photosynthesis(42.8%),energy and metabolism(18.2%),defense response(14.3%),and protein and nucleic acid biosynthesis(11.7%).Proteomic analysis revealed that scions grafted onto Momordica rootstocks upregulated more proteins involved in photosynthesis compared to scions grafted onto cucumber rootstocks under heat stress and indicated enhanced photosynthetic capacity when seedlings were exposed to heat stress.Furthermore,the expression of photosynthesis-related genes in plants grafted onto Momordica rootstocks significantly increased in response to heat stress.In addition,increased high-temperature tolerance of plants grafted onto Momordica rootstock was associated with the accumulation of ribulose-1,5-bisphosphate carboxylase/oxygenase(Rubisco)and oxygen-evolving enhancer protein 1(OEE1).Taken together,the data indicated that Momordica rootstock might alleviate growth inhibition caused by heat stress by improving photosynthesis,providing valuable insight into enhancing heat stress tolerance in the global warming epoch. | Ye Xu Yinghui Yuan Nanshan Du Yu Wang Sheng Shu Jin Sun Shirong Guo | 2018 | Horticulture Research2018，5，1： | 6 |
| 4 | Metamerism Appreciation of Jadeite-Jade Green under the Standard Light Sources D_(65),A and CWF显示文摘We tested 288 pieces of the polished cabochon jadeite-jade with high quality green and smooth surfaces using the colorimeter Color i5 based on the CIE 1976 L~*a~*b~* uniform color space. The color changes after alternating three CIE standard light sources D_(65),A and CWF were compared,and the degree of metamerism was evaluated. The results show that the CIE standard light sources D_(65),A and CWF increase the chroma of green and turn bluish green into vivid green,which are similar or to nearly colorless and transparent glass-like samples with fine textures. When the three light sources were individually alternated,the lightness of the jadeite-jades showed little change,but the tone changed significantly. Metamerism occurred only in 3 pairs among the 16 samples that were selected by cluster analysis for quality,and the metamerism colors were highly consistent of L~*D_(65)∈(43.47,46.75),C~*D_(65)∈(65.20,68.80) and ho~*D_(65)∈(138.10,140.23). We can conclude that the jadeite-jade green gradually turns to blue when the color temperature of the light source increases. But when considering both the light sources and the samples,D_(65) is more suitable to be the light source of jadeite-jade green when compared with the light sources CWF and A. Compared with the CIE standard green and high chroma green,high-quality jadeite-jade green has a slight yellow tone,low lightness and high chroma. The special metamerism index decreased to 1 when the light source alternated among D_(65),A and CWF. Therefore,the color of jadeite-jade green might be slightly influenced by alternating of the light sources. | GUO Ying WANG Huan LI Xiang DONG Shirong | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 5 |
| 5 | Adaptation of Asia-Pacific forests to climate change显示文摘Climate change is a threat to the stability and productivity of forest ecosystems throughout the AsiaPacific region. The loss of forests due to climate-induced stress will have extensive adverse impacts on biodiversity and an array of ecosystem services that are essential for the maintenance of local economies and public health. Despite their importance, there is a lack of decision-support tools required to evaluate the potential effects of climate change on Asia-Pacific ecosystems and economies and to aid in the development of regionally appropriate adaptation and mitigation strategies. The project Adaptation of AsiaPacific Forests to Climate Change, summarized herein,aims to address this lack of knowledge and tools and to provide support for regional managers to develop effective policy to increase the adaptive capacity of Asia-Pacific forest ecosystems. This objective has been achieved through the following activities:(1) development of a highresolution climate downscaling model, Climate AP, applicable to any location in the region;(2) development of climate niche models to evaluate how climate change might affect the distribution of suitable climatic conditions for regionally important tree species;(3) development and application of forest models to assess alternative management strategies in the context of management objectives and the projected impacts of climate change;(4) evaluation of models to assess forest fire risk and the relationship between forest fire and climate change;(5) development of a technique to assess ecosystem carbon storage using Li DAR; and(6) evaluation of how vegetation dynamics respond to climate change using remote sensing technology. All project outputs were developed with a focus on communication and extension to facilitate the dissemination of results to regional forest resource managers to support the development of effective mitigation and adaptation policy. | Guangyu Wang Tongli Wang Haijun Kang Shari Mang Brianne Riehl Brad Seely Shirong Liu Futao Guo Qinglin Li John L.Innes | 2016 | Journal of Forestry Research2016，27，3： | 2 |
| 6 | Proteomic study participating the enhancement of growth and salt tolerance of bottle gourd rootstock-grafted watermelon seedlings显示文摘 | Yanjuan Yang Liping Wang Jing Tian Jing Li Jin Sun Lizhong He Shirong Guo Takafumi Tezuka | 2012 | Plant Physiology and Biochemistry2012，，： | 2 |
| 7 | Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis-associated cancer显示文摘Background:Mitochondria are key regulators in cell proliferation and apoptosis.Alterations in mitochondrial function are closely associated with inflammation and tumorigenesis.This study aimed to investigate whether mitochondrial transcription factor A(TFAM),a key regulator of mitochondrial DNA transcription and replication,is involved in the initiation and progression of colitis-associated cancer(CAC).Methods:TFAM expression was examined in tissue samples of inflammatory bowel diseases(IBD)and CAC by immunohistochemistry.Intestinal epithelial cell(IEC)-specific TFAM-knockout mice(TFAM^(△IEC))and colorectal cancer(CRC)cells with TFAM knockdown or overexpression were used to evaluate the role of TFAMin colitis and the initiation and progression ofCAC.The underlying mechanisms of TFAMwere also explored by analyzingmitochondrial respiration function and biogenesis.Results:The expression of TFAM was downregulated in active IBD and negatively associated with the disease activity.The downregulation of TFAM in IECs was induced by interleukin-6 in a signal transducer and activator of transcription 3(STAT3)/miR-23b-dependent manner.In addition,TFAM knockout impaired IECturnover to promote dextran sulfate sodium(DSS)-induced colitis inmice.Of note,TFAMknockout increased the susceptibility of mice to azoxymethane/DSSinduced CAC and TFAM overexpression protected mice from intestinal inflammation and colitis-associated tumorigenesis.By contrast,TFAM expression was upregulated in CAC tissues and contributed to cell growth.Furthermore,it was demonstrated that β-catenin induced the upregulation of TFAM through c-Myc in CRC cells.Mechanistically,TFAMpromoted the proliferation of both IECs and CRC cells by increasing mitochondrial biogenesis and activity.Conclusions:TFAM plays a dual role in the initiation and progression of CAC,providing a novel understanding of CAC pathogenesis. | Shirong Yang Xianli He Jing Zhao Dalin Wang Shanshan Guo Tian Gao Gang Wang Chao Jin Zeyu Yan Nan Wang Yongxing Wang Yilin Zhao Jinliang Xing Qichao Huang | 2021 | Cancer Communications2021，41，8： | 2 |
| 8 | Using elevated CO 2 to increase the biomass of a Sorghum vulgare × Sorghum vulgare var. sudanense hybrid and Trifolium pratense L. and to trigger hyperaccumulation of cesium显示文摘 | Huibin Wu Shirong Tang Ximei Zhang Junkang Guo Zhengguo Song Shuai Tian Donald L. Smith | 2009 | Journal of Hazardous Materials2009，，2： | 1 |
| 9 | Local perceptions of the conversion of cropland to forestland program in Jiangxi, Shaanxi, and Sichuan, China显示文摘Numerous land-use policies have been implemented in China in recent decades for ecological restoration and conservation to reduce environmental disasters and promote environmental sustainability.Many of these policies follow a top-down approach to implementation and as such,emphasize the hierarchical control within government structures.An understanding of local perceptions of land-use policies is important if the disconnect between policy makers and the target population is to be reduced and if program support is to improve.This study aimed to help improve local implementation,attitude toward,and engagement by examining the influence of socio-economic characteristics on the target population’s(local farmers)perception of the conversion of cropland to forestland program(CFPP)land use policy in Jiangxi,Sichuan,and Shaanxi provinces.It uses logistical regression models,with robust aspects of perception including confidence,support,transparency,prospects,fairness,and willingness to participate.Results indicate that social aspects as well as economic aspects are most important in influencing farmers’perceptions towards the CFPP.The farmers who have received technical support,rural male habitants,educated,and non-middle-aged farmers exhibit more positive perceptions of the program and are much more likely to support it,whereas farmers without any technical support or formal education,and female and middle-aged farmers are less likely to support the program.Importantly,this study also reveals the differences in responses,experiences and perceptions of the farmers living across different provinces.These empirical results provide insight into the influence of socio-economic characteristics on the perception of farmers towards land-use policies,which has important implications for designing targeted policy instruments and increasing farmer support for these policies.This knowledge can be harnessed and further evaluated in future research to improve citizen engagement,support,and understanding in order to help ecological restoration and conservation objectives be more effectively achieved. | Guangyu Wang Oliver Z.Ma Liguo Wang Anil Shrestha Baozhang Chen Feng Mi Shirong Liu Xiaomin Guo Sarah Eshpeter John L.Innes | 2019 | Journal of Forestry Research2019，30，5： | 1 |
| 10 | Effects of exogenous nitric oxide on growth, active oxygen species metabolism, and photosynthetic characteristics in cucumber seedlings under NaCl stress显示文摘 | Huaifu Fan Shirong Guo Yansheng Jiao Runhua Zhang Juan Li | 2007 | Frontiers of Agriculture in China2007，，3： | 1 |
| 11 | Spatial and temporal patterns of the sensitivity of radial growth response by Picea schrenkiana to regional climate change in the Tianshan Mountains显示文摘Climate change significantly impacts forest ecosystems in arid and semi-arid regions.However,spatiotemporal patterns of climate-sensitive changes in individual tree growth under increased climate warming and precipitation in north-west China is unclear.The dendrochronological method was used to study climate response sensitivity of radial growth of Picea schrenkiana from 158 trees at six sites during 1990-2020.The results show that climate warming and increased precipitation significantly promoted the growth of trees.The response to temperature first increased,then decreased.However,the response to increased precipitation and the self-calibrating Palmer Drought Severity Index(scPDSI)increased significantly.In most areas of the Tianshan Mountains,the proportion of trees under increased precipitation and scPDSI positive response was relatively high.Over time,small-diameter trees were strongly affected by drought stress.It is predicted that under continuous warming and increased precipitation,trees in most areas of the Tianshan Mountains,especially those with small diameters,will be more affected by precipitation. | Zhongtong Peng Yuandong Zhang Liangjun Zhu Mingming Guo Qingao Lu Kun Xu Hui Shao Qifeng Mo Shirong Liu | 2023 | Journal of Forestry Research2023，34，6： | 1 |
| 12 | Evaluation of leaf morphology, structure and biochemical substance of balloon flower ( Platycodon grandiflorum (Jacq.) A. DC.) plantlets in vitro under different light spectra显示文摘 | Mengxi Liu Zhigang Xu Shirong Guo Canming Tang Xiaoying Liu Xuelei Jao | 2014 | Scientia Horticulturae2014，，： | 1 |
| 13 | Cytokinin plays a critical role in bitter gourd rootstock-induced thermotolerance of cucumber显示文摘Plants,as sessile in nature,are constantly confronted with diverse biotic and abiotic stresses throughout their life cycle in the changing environment.As a result,plants evolved root-shoot communications to optimize plant growth and development,and regulate responses to environmental stresses.Here,we examined the roles of root-sourced cytokinin(CTK)response to heat stress in grafted cucumber seedlings.Cucumber plants grafted onto cucumber roots and bitter gourd(Momordica charantia)roots were exposed to heat to examine their heat tolerance by assessing the levels of photosynthetic capacity,CTK contents,chlorophyll-a/b-binding protein(Lhcb2),ribulose-1,5-bisphosphate carboxylase/oxygenase(Rubisco)and its activating enzyme(RCA)content,and the enzyme activity of Rubisco.Bitter gourd rootstock enhanced cucumber scions heat stress tolerance.This enhancement was positively correlated with a higher content of CTK in both leaf and root parts,chlorophyll contents,and Rubisco abundance and activity.In addition,the higher level of CTK and Rubisco content in bitter gourd grafted plants shoots than in cucumber self-gafted plants shoots were attributed to an increase in CTK transport from roots in grafted plants under hightemperature conditions.These results indicated that CTK transfer from bitter gourd rootstock to scion and triggered the accumulation of Rubisco in leaf,thus improving the heat resistance of bitter gourd-grafted plants. | Shaoli Han Sheng Shu Yu Wang Mohammad Shah Jahan Jin Sun Shirong Guo | 2022 | Vegetable Research2022，2，1： | 1 |
| 14 | 显示文摘 | FAN Huaifu GUO Shirong JIAO Yansheng ZHANG Runhua LI Juan College of Horticulture Nanjing Agricultural University Nanjing 210095 China.? Effects of exogenous nitric oxide on growth active oxygen species metabolism and photosynthetic characte | 2007 | Frontiers of Agriculture in China2007，，03： | 1 |
| 15 | RNA-Seq analysis reveals the growth and photosynthetic responses of rapeseed(Brassica napus L.)under red and blue LEDs with supplemental yellow,green,or white light显示文摘Compound light is required for plant growth and development,but the response mechanisms of plants are undercharacterized and not fully understood.The present study was undertaken to evaluate the effect of supplemental light(green light,G;white light,W;yellow light,Y)added to red–blue light(RB)and sole W on the growth and photosynthesis of rapeseed seedlings.The results revealed that supplemental G/W improved the growth and photosynthesis of seedlings,but supplemental Y significantly reduced the photosynthetic rate and palisade tissue layer.Sole W caused similar responses in terms of growth,leaf development,oxidative damage,and antioxidant capability as supplemental Y.In total,449,367,813,and 751 differentially expressed genes(DEGs)were identified under supplemental G,Y,and W and sole W,respectively,compared to RB.The DEGs under different lights were closely associated with pathways such as light stimulus and high-light response,root growth,leaf development,photosynthesis,photosynthesis-antenna proteins,carbohydrate synthesis and degradation,secondary metabolism,plant hormones,and antioxidant capacity,which contributed to the distinct growth and photosynthesis under different treatments.Our results suggest that Y is more likely substituted by other wavelengths to achieve certain effects similar to those of supplemental Y,while G has a more distinctive effect on rapeseed.Taken together,supplementation RB with G/W promotes the growth of rapeseed seedlings in a controlled environment. | Xiaoying Liu Zheng Chen Mohammad Shah Jahan Yixuan Wen Xuyang Yao Haifeng Ding Shirong Guo Zhigang Xu | 2020 | Horticulture Research2020，7，1： | 1 |
| 16 | Biodegradability enhancement of coking wastewater by catalytic wet air oxidation using aminated activated carbon as catalyst 显示文摘 | Chen Honglin Yang Guo Feng Yujun Shi Changli Xu Shirong Cao Weiping Zhang Xiaoming | 2012 | Chemical Engineering Journal2012，198，： | 1 |
| 17 | Proteomics reveal cucumber Spd-responses under normal condition and salt stress 显示文摘 | Li Bin He Lizbong Guo Shirong | 2013 | Plant Physiol Biochem2013，67，： | 1 |
| 18 | DHD4,a CONSTANS-like family transcription factor,delays heading date by affecting the formation of the FAC complex in rice显示文摘Heading date(or flowering time)is one of the most important agronomic traits in rice,influencing its regional adaptability and crop yield.Many major-effect genes for rice heading date have been identified,but in practice they are difficult to be used for rice molecular breeding because of their dramatic effects on heading date.Genes with minor effects on heading date,which are more desirable for fine-tuning flowering time without significant yield penalty,were seldom reported.In this study,we identified a new minor-effect heading date repressor,Delayed Heading Date 4(DHD4).The dhd4 mutant shows a slightly earlier flowering phenotype without a notable yield penalty compared with wild-type plants under natural long-day conditions.DHD4 encodes a CONSTANS-like transcription factor localized in the nucleus.Molecular,biochemical,and genetic assays show that DHD4 can compete with 14-3-3 to interact with OsFD1,thus affecting the formation of the Hd3a-14-3-3-OsFD1 triprotein FAC complex,resulting in reduced expression of OsMADS14 and OsMADS15,and ultimately delaying flowering.Taken together,these results shed new light on the regulation of flowering time in rice and provide a promising target for fine-tuning flowering time to improve the regional adaptability of rice. | Maohong Cai Shanshan Zhu Mingming Wu Xiaoming Zheng Jiachang Wang Liang Zhou Tianhui Zheng Song Cui Shirong Zhou Chaonan Li Huan Zhang Juntao Chai Xinyue Zhang Xin Jin Zhijun Cheng Xin Zhang Cailin Lei Yulong Ren Qibing Lin Xiuping Guo Lei Zhao Jie Wang Zhichao Zhao Ling Jiang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 1 |
| 19 | TGase positively regulates photosynthesis via activation of Calvin cycle enzymes in tomato显示文摘Transglutaminases(TGases),which are widespread cross-linking enzymes in plants,play key roles in photosynthesis and abiotic/biotic stress responses;however,evidence concerning the genetics underlying how TGase improves the capability of photosynthesis and the mechanism of TGase-mediated photosynthesis are not clear in this crop species.In this study,we clarified the function of TGase in the regulation of photosynthesis in tomato by comparing wild-type(WT)plants,tgase mutants generated by the CRISPR/Cas9 system and TGase-overexpressing(TGaseOE)plants.Our results showed that increasing the transcript level of TGase resulted in an enhanced net photosynthetic rate(Pn),whereas the tgase mutants presented significantly inhibited Pns and CO2 assimilation compared with the WT.Although the total RuBisCO activity was not affected by TGase,the initial and activation status of RuBisCO and the activity of RuBisCO activase(RCA)and fructose-1,6-bisphosphatase(FBPase)in TGaseOE plants were significantly higher than that in WT plants.Except for RuBisCO small subunit(RbcS),the transcription levels of Benson–Calvin cycle-related genes were positively related to the endogenous TGase activity.Furthermore,TGaseOE plants had higher protein levels of RuBisCO large subunit(RbcL)and RCA than did WT plants and showed a reduced redox status by enhancing the activity of dehydroascorbate reductase(DHAR)and glutathione reductase(GR),which was compromised in TGasedeficient plants.Overall,TGase positively regulated photosynthesis by maintaining the activation states of the Benson–Calvin cycle and inducing changes in cellular redox homeostasis in tomato. | Min Zhong Yu Wang Kun Hou Sheng Shu Jin Sun Shirong Guo | 2019 | Horticulture Research2019，6，1： | 0 |
| 20 | Flexible broadband WS_(2)/Si optical position-sensitive detector with high sensitivity and fast speed显示文摘Si-based optical position-sensitive detectors(PSDs)have stimulated the interest of researchers due to their wide range of practical applications.However,due to the rigidity and fragility of Si crystals,the applications of flexible PSDs have been limited.Therefore,we presented a flexible broadband PSD based on a WS_(2)/Si heterostructure for the first time.A scalable sputtering method was used to deposit WS_(2)thin films onto the etched ultrathin crystalline Si surface.The fabricated flexible PSD device has a broad spectral response in the wavelength range of 450-1350 nm,with a high position sensitivity of~539.8 mV·mm^(−1)and a fast response of 2.3μs,thanks to the strong light absorption,the built-in electrical field at the WS_(2)/Si interface,and facilitated transport.Furthermore,mechanical-bending tests revealed that after 200 mechanical-bending cycles,the WS_(2)/Si PSDs have excellent mechanical flexibility,stability,and durability,demonstrating the great potential in wearable PSDs with competitive performance. | Yunjie Liu Yupeng Wu Fuhai Guo Yingming Liu Shirong Zhao Siqi Li Weizhuo Yu Lanzhong Hao | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，6： | 0 |
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