|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors显示文摘AIM: To evaluate the efficacy of lower esophageal sphincter(LES)-electrical stimulation therapy(EST) in a subgroup of patients that reported only partial response to proton pump inhibitors(PPIs) therapy, compared to a group of patient with complete response.METHODS: Bipolar stitch electrodes were laparoscopically placed in the LES and connected to an implantable pulse generator(EndoS tim BV, the Hague, the Netherlands), placed subcutaneously in the anterior abdominal wall. Stimulation at 20 Hz, 215 μsec, 3-8 m Amp in 30 min sessions was delivered starting on day 1 post-implant. Patients were evaluated using gastroesophageal reflux disease(GERD)-HRQL, symptom diaries; esophageal p H and esophageal manometry before and up to 24 mo after therapy and results were compared between partial and complete responders.RESULTS: Twenty-three patients with GERD on LESEST were enrolled and received continuous per-protocol stimulation through 12 mo and 21 patients completed 24 mo of therapy. Of the 23 patients, 16(8 male, mean age 52.1 ± 12 years) had incomplete response to PPIs prior to LES-EST, while 7 patients(5 male, mean age 52.7 ± 4.7) had complete response to PPIs. In the sub-group with incomplete response to PPIs, median(IQR) composite GERD-HRQL score improved significantly from 9.5(9.0-10.0) at baseline on-PPI and 24.0(20.8-26.3) at baseline off-PPI to 2.5(0.0-4.0) at 12-mo and 0.0(0.0-2.5) at 24-mo follow-up(P < 0.05 compared to on-and off-PPI at baseline). Median(IQR) % 24-h esophageal pH < 4.0 at baseline in this sub-group improved significantly from 9.8%(7.8-11.5) at baseline to 3.0%(1.9-6.3) at 12 mo(P < 0.001) and 4.6%(2.0-5.8) at 24 mo follow-up(P < 0.01). At their 24-mo follow-up, 9/11 patients in this sub-group were completely free of PPI use. These results were comparable to the sub-group that reported complete response to PPI therapy at baseline. No unanticipated implantation or stimulation-related adverse events, or any untoward sensation due to stimulation were reported in either group and LES-EST was safely tolerated by both groups. CONCLUSION: LES-EST is safe and effective in controlling symptoms and esophageal acid exposure in GERD patients with incomplete response to PPIs. These results were comparable to those observed PPI responders. | Edy Soffer Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Manoel G Neto Michael D Crowell | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 4 |
| 2 | Paclobutrazol and Its Use in Fruit Production:A Review显示文摘There are documentary records referring to paclobutrazol(PBZ)as a growth bioregulator that inhibits the gibberellin synthesis and its application increases yields in fruit and vegetable crop productions.Its agronomic management includes it as an emerging technology to reduce vigour,promote flower induction and flower development in fruit trees with increased economic returns.Its use is banned in some countries because of concerns about residues that can cause harmful effects on the environment.Therefore,the aim of this article was to collect,analyse and summarise relevant information on the use of PBZ in fruit tree production and its possible risks to the environment.The results obtained indicated that the application of PBZ can be effective in solving some problems related to flowering if it is applied in the right amount and at the right time.However,it is necessary to elucidate the physiological processes with which it is associated and its response to be taken into account to increase yield.PBZ is currently used in fruit trees such as mango,lime,apple and guava,increasing their productivity.However,some studies have shown its residual effect on the environment.Therefore,PBZ is a viable strategy,because it presents a series of advantages in the production of fruit trees.However,it is vital to generate protocols that seek its regulation with a rational and sustainable approach. | Laura Raquel Orozco-Meléndez Ofelia Adriana Hernández-Rodríguez Oscar Cruz-Álvarez Loreto Robles-Hernández Graciela Dolores Avila-Quezada Esteban Sánchez Chavez DamiánAarón Porras-Flores Dámaris Leopoldina Ojeda-Barrios | 2022 | Phyton-International Journal of Experimental Botany2022，91，1： | 2 |
| 3 | Learning curve for robotic-assisted laparoscopic rectal cancer surgery显示文摘 | Rosa M. Jiménez-Rodríguez José Manuel Díaz-Pavón Fernando Portilla de Juan Emilio Prendes-Sillero Hisnard Cadet Dussort Javier Padillo | 2013 | International Journal of Colorectal Disease2013，，6： | 2 |
| 4 | Cytokine IL-1 beta but not IL-1 alpha promoter polymorphism is associated with Alzheimer disease in a population from the Canary Islands,Spain显示文摘 | Déniz-Naranjo MC Muoz-Fernandez C Alemany-Rodríguez MJ | 2008 | Euro J Neurol2008，15，10： | 1 |
| 5 | Transient receptor potential (TRPC) channels in human sperm:expression,cellular localization and involvement in the regulation of flagellar motility显示文摘 | Castellano LE Trevif(n)o CL Rodríguez D | | 0，，1： | 1 |
| 6 | Chemical characterization of Opuntia dillenii and Opuntia ficus indica fruits显示文摘 | E.M. Díaz Medina E.M. Rodríguez Rodríguez C. Díaz Romero | 2006 | Food Chemistry2006，，1： | 1 |
| 7 | On- line FT - Raman and dispersive Raman spectra database of artists materials ( e - VISART database ) 显示文摘 | Castro K Pe'rez - Alonso M Rodri'guez - Laso M D | 2005 | Anal Bioanal Chem2005，382，： | 1 |
| 8 | The efficacy of laparoscopic surgery in the diagnosis and treatment of peritonitis显示文摘 | J. Cueto O. Díaz D. Garteiz M. Rodríguez A. Weber | 1997 | Surgical Endoscopy1997，，4： | 1 |
| 9 | Understanding the mechanism of protamine in solid lipidnanoparticle-based lipofection: the importance of the entrypathway显示文摘 | Delgado D del Pozo-Rodríguez A Solinís Má | 2011 | Eur J Pharm Biopharm2011，79，3： | 1 |
| 10 | Early recruitment of phagocytes contributes to the vascular inflammation of giant cell arteritis显示文摘 | Foell D Hernández-Rodríguez J Sánchez M | | 0，，： | 1 |
| 11 | Label-free detection of DNA with interdigitated micro-electrodes in a fluidic cell显示文摘 | Berdat D Rodn'guez A C M Herrer F | 2008 | Lab Chip2008，8，： | 1 |
| 12 | Luminescent properties of transparent nanostructured Eu3 + doped SnO2-SiO2 glass-ceramics prepared by the sol-gel method显示文摘 | Del Castillo J Rodríguez V D Yanes A C | 2005 | Nanotechnology2005，16，5： | 1 |
| 13 | Acid Suppressants Reduce Risk of Gastrointestinal Bleeding in Patients on Antithrombotic or Anti-Inflammatory Therapy显示文摘 | Kueiyu Joshua Lin Sonia Hernández–Díaz Luis A. García Rodríguez | 2011 | Gastroenterology2011，，1： | 1 |
| 14 | Laser fabrication of polymer ferroelectric nanostruCtures for nonvolatile organic memory devices显示文摘 | MART NEZ-TONG D E RODR GUEZ-RODR GUEZ A NOGALES A | 2015 | ACS Appl Mater Interfaces2015，7，19： | 1 |
| 15 | The natural products chemistry of West Indian gorgonian octocorals显示文摘 | Rodríguez A D | 1995 | Tetrahedron1995，51，： | 1 |
| 16 | Development and experimental validation of a computational model in order to simulate ice cube production in a thermoelectric ice-maker显示文摘 | RODR(I)GUEZ A VI(A)N J G ASTRAIN D | 2009 | Applied Thermal Engineering2009，29，1415： | 1 |
| 17 | Effectiveness of the EndoActivator System in removing the smear layer after root canal instrumentation显示文摘 | Uroz-Torres D González-Rodríguez MP Ferrer-Luque CM | | 0，，02： | 1 |
| 18 | Optimization of microwave-assisted extraction of hydrocarbons in marine sediments : Comparison with the Soxhlet extraction method显示文摘 | Blanco E V Mahia P L Lorenzo S M Rodr guez D P Fern ndez E F | 2000 | Fresenius Journal of Analytical Chemistry2000，366，： | 1 |
| 19 | Construction strategyfor an internal amplification control for real-time diagnostic assaysusing nucleic acid sequence-based amplification:development andclinical application显示文摘 | RODRíGUEZ D D’AGOSTINO PLA M | 2004 | Journal of Clinical Microbiology2004，42，12： | 1 |
| 20 | Sex hormones and autoimmunity显示文摘 | González DA Díaz BB Rodríguez Pérez Mdel C | 2010 | Immunol Lett2010，133，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员