|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Carrying Capacity of Marine Region in Liaoning Province显示文摘Carrying capacity is one of important studies on coordinating development of population,resources,and environment.At present,the researches on it mainly concentrate on the carrying capacity for population and economy,such as the water resources carrying capacity,the land resources carrying capacity,the environment carrying capacity,etc.Based on the related theories and methods,this paper creatively proposed the concept and meaning of carrying capacity of marine region,and formed the appraisal system.According to the developing situation of marine economy of Liaoning Province in recent years,and by employing the method of the state space,this paper also measured the carrying capacity and carrying state of marine region and discussed the sustainable problems of marine economy of Liaoning.The research results show that the carrying state of marine region of Liaoning is in the state of overloading at present,but taking a favorable turn. | Di Qianbin Han Zenglin Liu Guichun Chang Hongwei | 2007 | Chinese Geographical Science2007，17，3： | 10 |
| 2 | CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation显示文摘巨噬细胞在开发,动态平衡,织物修理和免疫起枢轴的作用。巨噬细胞增长被刺激殖民地的因素(M-CSF ) 导致了 Akt 发信号的巨噬细胞支持;然而,这个过程怎么被终止,仍然保持不清楚。这里,我们作为巨噬细胞增长的一个新奇禁止者识别酷蛋白 kinase 2-interacting protein-1 (CKIP-1 ) 。在放松巨噬细胞, CKIP-1 是在由组成地活跃的 GSK3β 的丝氨酸 342 点的 phosphorylated;, Akt 的下游的目标。这 phosphorylation 触发 CKIP-1 的 polyubiquitination 和 proteasomal 降级。在 M-CSF 刺激之上, Akt 被 CSF-1R-PI3K 激活然后使 GSK3β 失去活性;,导致 CKIP-1 和 β 的稳定; -catenin 蛋白质。β -catenin 包括 cyclin D 和 c-Myc 支持增长基因的表示。CKIP-1 与 TRAF6,为连接 K63 的 ubiquitination 要求的 ubiquitin ligase 和 Akt 的血浆膜招募交往,并且终止调停 TRAF6 的 Akt 激活。由这个工具, CKIP-1 在 M-CSF 刺激以后在迟了的阶段明确地禁止巨噬细胞增长。而且, CKIP-1 缺乏在老鼠自发地开发的 vitro 和 CKIP-1 −/− 导致增加的增长和巨噬细胞的减少的 apoptosis 巨噬细胞主导的脾大和 myeloproliferation。一起,这些数据证明 CKIP-1 由禁止调停 TRAF6 的 Akt 激活在巨噬细胞动态平衡的规定起一个关键作用。 | Luo Zhang Yiwu Wang Fengjun Xiao Shaoxia Wang Guichun Xing Yang Li Xiushan Yin Kefeng Lu Rongfei Wei Jiao Fan Yuhan Chen Tao Li Ping Xie Lin Yuan Lei Song Lanzhi Ma Lujing Ding Fuchu He Lingqiang Zhang | 2014 | Cell Research2014，24，6： | 7 |
| 3 | Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway显示文摘Taxus,commonly known as yew,is a well-known gymnosperm with great ornamental and medicinal value.In this study,by assembling a chromosome-level genome of the Himalayan yew(Taxus wallichiana)with 10.9 Gb in 12 chromosomes,we revealed that tandem duplication acts as the driving force of gene family evolution in the yew genome,resulting in the main genes for paclitaxel biosynthesis,i.e.those encoding the taxadiene synthase,P450s,and transferases,being clustered on the same chromosome.The tandem duplication may also provide genetic resources for the nature to sculpt the core structure of taxoids at different positions and subsequently establish the complex pathway of paclitaxel by neofunctionalization.Furthermore,we confirmed that there are two genes in the cluster encoding isoenzymes of a known enzyme in the paclitaxel biosynthetic pathway.The reference genome of the Himalayan yew will serve as a platform for decoding the complete biosynthetic pathway of paclitaxel and understanding the chemodi-versity of taxoids in gymnosperms. | Jian Cheng Xiao Wang Xiaonan Liu Xiaoxi Zhu Zihe Li Huanyu Chu Qian Wang QianQian Lou Bijun Cai Yiqun Yang Xiaoyun Lu Kai Peng Dingyu Liu Yuwan Liu Lina Lu Huan Liu Ting Yang Qijin Ge Chengcheng Shi Guichun Liu Zhiwei Dong Xun Xu Wen Wang Huifeng Jiang Yanhe Ma | 2021 | Molecular Plant2021，14，7： | 6 |
| 4 | Proto-Tethys ophiolitic mélange in SW Yunnan: Constraints from zircon U-Pb geochronology and geochemistry显示文摘An early Paleozoic Proto-Tethys ocean in western Yunnan has long been postulated although no robust geological evidence has been identified.Here we investigated the recently-identified Mayidui and Wanhe ophiolitic mélanges in SW Yunnan,which occurs in a N-S trending belt east of the late Paleozoic Changning-Menglian suture zone.The ophiolites consist mainly of meta-basalts(amphibole schists),meta-(cumulate)gabbros and gabbroic diorites,and meta-chert-shale,representing ancient oceanic crust and pelagic and hemipelagic sediments,respectively.Six samples of gabbros and gabbroic diorites from 3 profiles(Mayidui,Kongjiao and Yinchanghe)yielded zircon U-Pb ages between 462±6 Ma and 447±9 Ma,constraining the formation of the Mayidui and Wanhe ophiolites to Middle Ordovician.Gabbros from the Mayidui and Kongjiao profiles share similar geochemical characteristics with affinities to tholeiitic series,and are characterized by depleted to slightly enriched LREEs relative to HREEs with(La/Sm)N=0.69-1.87,(La/Yb)N=0.66-4.72.These,along with their predominantly positive wholerock eNd(t)and zircon eHf(t)values,indicate a MORB-like magma source.By contrast,the meta-mafic rocks from the Yinchanghe profile show significantly enriched LREEs((La/Sm)N=0.97-3.33,(La/Yb)N=1.19-14.93),as well as positive whole-rock eNd(t)and positive to negative zircon eHf(t)values,indicating an E-MORB-type mantle source.These geochemical features are consistent with an intra-oceanic setting for the formation of the Mayidui-Wanhe ophiolites.Our data,integrated with available geological evidence,provide robust constraints on the timing and nature of the Mayidui-Wanhe ophiolitic mélange,and suggest that the ophiolites represent remnants of the Proto-Tethys Ocean,which opened through separation of the Indochina and Simao blocks from the northern margin of Gondwana before the Early Cambrian,and evolved through to the Silurian. | Guichun Liu Zaibo Sun Jianwei Zi M.Santosh Tianyu Zhao Qinglai Feng Guangyan Chen Xiaomei Nie Jing Li Shitao Zhang | 2021 | Geoscience Frontiers2021，12，5： | 5 |
| 5 | G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease显示文摘Coronary heart disease(CHD) continues to be the greatest mortality risk factor in the developed world. Estrogens are recognized to have great therapeutic potential to treat CHD and other cardiovascular diseases; however,a significant array of potentially debilitating side effects continues to limit their use. Moreover,recent clinical trials have indicated that long-term postmenopausal estrogen therapy may actually be detrimental to cardiovascular health. An exciting new development is the finding that the more recently discovered G-protein-coupled estrogen receptor(GPER) is expressed in coronary arteries-both in coronary endothelium and in smooth muscle within the vascular wall. Accumulating evidence indicates that GPER activation dilates coronary arteries and can also inhibit the prolif-eration and migration of coronary smooth muscle cells. Thus,selective GPER activation has the potential to increase coronary blood flow and possibly limit the debilitating consequences of coronary atherosclerotic disease. This review will highlight what is currently known regarding the impact of GPER activation on coronary arteries and the potential signaling mechanisms stimulated by GPER agonists in these vessels. A thorough understanding of GPER function in coronary arteries may promote the development of new therapies that would help alleviate CHD,while limiting the potentially dangerous side effects of estrogen therapy. | Guichun Han Richard E White | 2014 | World Journal of Cardiology2014，6，6： | 4 |
| 6 | CKIP-1 suppresses the adipogenesis of mesenchymal stem cells by enhancing HDACl-associated repression of C/EBPα显示文摘 | Dahu Li HengZhu Chao Liang Wenbo Li Guichun Xing Lanzhi Ma Lujing Ding Yi Zhang Fuchu He Lingqiang Zhang | 2014 | Journal of Molecular Cell Biology2014，8，5： | 4 |
| 7 | Analysis of the relationship between water level fluctuation and seismicity in the Three Gorges Reservoir(China)显示文摘The Three Gorges Reservoir is a good site for the further researches on reservoir induced seismicity due to decades' seismic monitoring. After the first water impounding in 2003, seismic activity becomes more frequent than that before water impoundment. In order to quantitatively study, the relationship between the water level fluctuation and earthquakes in TGR, we introduced statistical methods to attain the goal.First of all, we relocated the earthquakes in TGR region with double difference method and divided the earthquakes into 5 clusters with clustering analysis method. Secondly, to examine the impacts of water level fluctuation in different water filling stages on the seismic activity in the 5 clusters, a series of statistical analyses are applied. Pearson correlation results show that only the 175 m water level fluctuation has significantly positive impacts on the seismic activity in clusters Ⅰ, Ⅱ, Ⅲ and Ⅴ with correlation coefficients of 0.44, 0.38, 0.66 and 0.63. Cross-correlation analysis demonstrates that 0, 1, 0 and 0 month time delay separately for the clusters Ⅰ, Ⅱ, Ⅲ and Ⅴ exists. It illustrated the influences of the water loading and pore pressure diffusion on induced earthquakes. Cointegration tests and impulse response analysis denoted that the 175 m water level only had long term and significant effects just on the seismic events in the intersection region of the Fairy Mount Fault and Nine-brook Fault. One standard deviation shock to175 m water level increased the seismic activity in cluster Ⅴ for the first 3 months, and then the negative influence was shown. After 7 months, the negative impulse response becomes stable. The long-term effect of the 175 m water impoundment also proved the important role of pore pressure diffusion in RIS with time. | Lifen Zhang Jinggang Li Guichun Wei Wulin Liao Qiuliang Wang Chuanfang Xiang | 2017 | Geodesy and Geodynamics2017，8，2： | 4 |
| 8 | Fired Models of Air-gun Source and Its Application显示文摘Air-gun is an important active seismic source.With the development of the theory about air-gun array,the technique for air-gun array design becomes mature and is widely used in petroleum exploration and geophysics.In order to adapt it to different research domains,different combination and fired models are needed.At the present time,there are two fired models of air-gun source,namely,reinforced initial pulse and reinforced first bubble pulse.The fired time,space between single guns,frequency and resolution of the two models are different.This comparison can supply the basis for its extensive application. | Luo Guichun Ge Hongkui Wang Baoshan Hu Ping Mu Hongwang Chen Yong | 2008 | Earthquake Research in China2008，22，2： | 3 |
| 9 | Geochronological and geochemical constraints on the petrogenesis of late Mesoproterozoic mafic and granitic rocks in the southwestern Yangtze Block显示文摘Late Mesoproterozoic igneous rocks in the SW Yangtze Block are important for understanding the role of it in reconstruction of the Rodinia supercontinent.In the present study,we report new geochronological,geochemical,and Nd-Hf isotopic data for the Cuoke plagioclase amphibolites and granites in the SW Yangtze Block.Geochronological results show that the plagioclase amphibolites and granites have similar late Mesoproterozoic zircon U-Pb ages of 1168-1162 Ma,constituting a bimodal igneous assemblage.The plagioclase amphibolites have high and variable TiO2 contents(1.15-4.30 wt.%)and Mg#(34-66)values,similar to the tholeiitic series.They are characterized by enrichment in LREEs and LILEs,and have OIB-like affinities with positive Nb and Ta anomalies.The plagioclase amphibolites have positive whole-rockεNd(t)(+3.2 to+4.3)and zirconεHf(t)(+4.3 to+10.7)values,indicating that they were derived from an OIB-like asthenospheric mantle source.The granites belong to the reduced peralkaline A-type series and have negativeεNd(t)value of-6.0 andεHf(t)values of-5.8 to-13.8,indicating a derivation from the partial melting of ancient mafic lower crust.In combination with the~1.05-1.02 Ga bimodal igneous assemblage in the SW Yangtze Block,we propose that the Cuoke 1168-1162 Ma igneous rocks were likely formed in a continental rift basin and argue against the existance of Grenvillian Orogen in the SW Yangtze Block during the late Mesoproterozoic. | Guichun Liu Jing Li Xin Qian Qinglai Feng Wei Wang Guangyan Chen Shaobin Hu | 2021 | Geoscience Frontiers2021，12，1： | 3 |
| 10 | Geochronological and Geochemical Constraints on the Petrogenesis of Early Paleoproterozoic(2.40–2.32 Ga) Nb-Enriched Mafic Rocks in Southwestern Yangtze Block and Its Tectonic Implications显示文摘Recent geological survey has identified the Early Paleoproterozoic meta-mafic intrusions in the southwestern Yangtze Block.We present geochronological,whole-rock geochemical and Nd isotopic data for these meta-mafic rocks to better address the tectonic evolution of the Yangtze Block during the Early Paleoproterozoic Period.Geochronological data show that the meta-mafic rocks have zircon ages of 2 395-2 316 Ma.They have high TiO_2 contents of 1.40 wt.%-3.66 wt.% and Nb concentrations of 13.7 ppm-45.5 ppm,thus aregrouped as Nb-enriched mafic rocks.These mafic rocks are characterized by tholeiitic compositions with enrichment of LREEs and LILEs,and can be divided into two groups.Group 1 samples display E-MORB-like geochemical characteristics.Group 2 samples have positive ENd(t) values of 4.0-5.0.Geochemical data indicate that all meta-mafic rocks were likely derived from a depleted asthenospheric mantle.REE modeling indicates lower degree of partial melting for Group 2 samples(3%-10%) relative to Group 1 samples(15%-20%).Taking into account contemporaneous post-collisional granitoids in southwestern Yangtze Block,we propose that these meta-mafic rocks were formed in a post-collisional extension setting.These meta-mafic rocks can be compared with those in Africa,South America and Europe,and might be linked with the Arrowsmith orogenic belt. | Guichun Liu Xin Qian Jing Li Jian-Wei Zi Tianyu Zhao Qinglai Feng Guangyan Chen Shaobin Hu | 2020 | Journal of Earth Science2020，31，1： | 3 |
| 11 | Pressure control strategy for pump motor energy transfer unit显示文摘Multi-level pressure source system is a novel hydraulic system with distinct advantage of energy saving. In order to balance each pressure level of the multi-level pressure source system, a pump motor energy transfer unit is usually equipped. However, the pump motor energy transfer has the characteristics of poor starting and low response, which cause long time of pressure adjustment and large pressure jitter when the transformer is switched to system suddenly and the motor-side pressure has pressure impact when rail of the pump-side is switched. To address these problems, this paper proposes a compound control strategy of feedforward compensation control with Fuzzy-PID to improve the controllability of the multi-level pressure source system. A test rig of the pump motor energy transfer unit is built and the controllability of compound controller and PID controller are compared. The experiment results show that, compared with the traditional PID, the adjustment time and the pressure impact are reduced by 20% and 25% with the proposed compound control strategy. Therefore, the presented compound control strategy can be used to improve starting performance and robustness of the pump motor energy transfer unit control system. | 姚静 Zhang Wei Cao Xiaoming Zhao Guichun Sun Menghui | 2019 | High Technology Letters2019，25，3： | 2 |
| 12 | Synthesis and Anti-HIV Activity of a Series of 6-Modified 2',3'-Dideoxyguanosine and 2',3'-Didehydro-2',3'- dideoxyguanosine Analogs显示文摘寻找潜在的 2,3-dideoxyguanosine (ddG ) 和 2,3-didehydro-2,3-dideoxyguanosine (D4G ) prodrugs,一系列 6-modified ddG, D4G 类似物在基于房间的试金为他们的 anti-HIV 活动和 cytotoxities 被综合并且评估。所有类似物显示出低 cytotoxicities,他们中的一些显示了良性的 anti-HIV 活动。在 vivo, ddGTP 和 D4TTP 的活跃 triphosphate 形式,被一个新奇、灵巧的“一个壶”也综合方法。由 Taq, Therminater DNA 聚合酶和在 DNA/RNA 海滨合并的 HIV 反向的 transcriptase (RT ) 的 ddGTP 和 D4TTP 的识别被一个非放射性方法调查, Km 是坚定的。 | Lujia Xie Xiantao Yang Delin Pan Yingli Cao Mou Cao Guichun Lin Zhu Guan Ying Guo Lihe Zhang Zhenjun Yang | 2013 | Chinese Journal of Chemistry2013，31，9： | 2 |
| 13 | DNA damage stress induces the dissociation of Smurf1/2 from MDM2 in a slow manner显示文摘The tumor suppressor p53 locates at the key point of cell growth or apoptosis balance, and the expression level of p53 is tightly controlled by ubiquitin ligases including MDM2. Upon DNA damage stresses, p53 was accumulated and activated, leading to cell cycle arrest or apoptosis. We previously showed that Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by interacting with and stabilizing MDM2, and consequently enhancing MDM2-mediated ubiquitylation of p53. However, it is unclear how the Smurf1-MDM2 interaction is regulated in response to DNA damage stress. Here, we show that in response to etoposide treatment Smurf1 dissociates from MDM2, resulting in MDM2 destabilization and p53 accumulation. The negative regulation of Smurf1 on apoptosis is released. Notably, this dissociation is a slow process rather than a rapid response, implicating high expression of Smurf1 might confer the resistance against p53 activation. Consistent with this notion, we observed that Smurf1/2 ligases are highly expressed in colon cancer, esophageal squamous cell carcinoma and pancreatic cancer tissues, suggesting the oncogenic tendency of Smurf1/2. | NIE Jing LIU Lin ZHAO XiaoHang XIE Ping ZHOU PingKun XING GuiChun LIU XiangJun HE FuChu HAN WeiDong ZHANG LingQiang | 2011 | Chinese Science Bulletin2011，56，30： | 2 |
| 14 | Flotation performance of a novel Gemini collector for kaolinite at low temperature显示文摘How to sustainably produce bauxite by effective reverse froth flotation of kaolinite at low temperature is an urgent problem to be solved in the field of mineral processing.In this work,a novel amino-based Gemini surfactant butadiyl-1,4-bis(dimethyl dodecylammonium bromide)(BBDB) was prepared and first utilized as a novel collector for kaolinite flotation.Its flotation performance for kaolinite was compared with that of the common monomolecular surfactant 1-dodecylamine(DDA) by micro-flotation tests.The tests results indicated that 95% kaolinite recovery was obtained using 2.0×10^(-4) mol/L BBDB at 25℃ which was half of the dosage when DDA obtained the maximum kaolinite recovery of81%.At extremely low temperature(0℃),3.0×10^(-4) mol/L BBDB could still collect 91% kaolinite,while DDA showed a frustrating ability.The contact angle tests indicated that BBDB could still significantly improve the hydrophobicity of the kaolinite surface(contact angle 71.7°) than DDA(contact angle only25.8°) at 0℃.The Krafft point comparison tests indicated that BBDB had a much lower Krafft point(below0℃) than DDA.Fourier transform infrared spectroscopy(FTIR)-spectrum analysis and zeta potential measurements showed that BBDB was physically adsorbed on the surface of kaolinite through electrostatic interaction. | Shiyong Zhang Zhiqiang Huang Hongling Wang Rukuan Liu Chen Cheng Shuyi Shuai Yajing Hu Zhiqun Guo Xinyang Yu Guichun He Weng Fu | 2021 | International Journal of Mining Science and Technology2021，31，6： | 2 |
| 15 | Bevacizumab improves the antitumor efficacy of adoptive cytokine-induced killer cells therapy in non-small cell lung cancer models显示文摘 | Leilei Tao Guichun Huang Shujing Shi Longbang Chen | 2014 | Medical Oncology2014，，1： | 2 |
| 16 | Three-dimensional and two-dimensional morphological features of patent foramen ovale revealed by transesophageal echocardiography显示文摘Patent foramen ovale (PFO),a congenital cardiac lesion that persists into adulthood,has become the subject of much clinical interest.PFO has been implicated in several serious clinical syndromes,including paradoxical systemic emboli (which contribute to ischemic stroke),myocardial infarction,and complications of pulmonary embolism.Currently,two-dimensional transesophageal echocardiography (TEE) is the standard procedure for diagnosing PFO.The diameter and contrast score have been used to size the PFO.1 None of these techniques is optimal as they are all indirect ways of measuring PFOs.Few data exist on the relation between stroke risk,anatomical characteristics,and physiological behavior.The purpose of our study therefore was to explore the clinical feasibility of sizing or displaying the morphology and physiological behavior of PFOs using three-dimensional TEE. | Liu Mei Wang Jianhua Ding Guichun Duan Yaqi Sun Pengfei Jian Wenhao | 2014 | Chinese Medical Journal2014，，8： | 2 |
| 17 | Seasonal changes in the effects of free-air CO 2 enrichment (FACE) on dry matter production and distribution of rice ( Oryza sativa L.)显示文摘 | Lianxin Yang Jianye Huang Hongjie Yang Guichun Dong Gang Liu Jianguo Zhu Yulong Wang | 2005 | Field Crops Research2005，，1： | 2 |
| 18 | Quantitative assessment of the association between three polymorphisms in FAS and FASL gene and breast cancer risk显示文摘 | Zexing Wang Jun Gu Weiwei Nie Jing Xu Guichun Huang Xiaoxiang Guan | 2014 | Tumor Biology2014，，： | 1 |
| 19 | Differential regulation of Apak by various DNA damage signals显示文摘 | Shan Wang Chunyan Tian Tingtiang Xiao Guichun Xing Fuchu He Lingqiang Zhang Hong Chen | 2010 | Molecular and Cellular Biochemistry (-)2010，，1： | 1 |
| 20 | Potassium(BKCa) currents are reduced in microvascular smooth muscle cells from insulin-resistant rats显示文摘 | Dimitropouloul C Guichun H Allison W | 2002 | Am J Physiol Heart Circ Physiol2002，282，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员