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| 1 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012,22,1: | 155 |
| 2 | Accurate single-observer passive coherent location estimation based on TDOA and DOA显示文摘This paper investigates the problem of target position estimation with a single-observer passive coherent location(PCL) system. An approach that combines angle with time difference of arrival(ATDOA) is used to estimate the location of a target. Compared with the TDOA-only method which needs two steps, the proposed method estimates the target position more directly. The constrained total least squares(CTLS) technique is applied in this approach. It achieves the Cramer–Rao lower bound(CRLB) when the parameter measurements are subject to small Gaussian-distributed errors. Performance analysis and the CRLB of this approach are also studied. Theory verifies that the ATDOA method gets a lower CRLB than the TDOA-only method with the same TDOA measuring error. It can also be seen that the position of the target affects estimating precision.At the same time, the locations of transmitters affect the precision and its gradient direction.Compared with the TDOA, the ATDOA method can obtain more precise target position estimation.Furthermore, the proposed method accomplishes target position estimation with a single transmitter,while the TDOA-only method needs at least four transmitters to get the target position. Furthermore,the transmitters' position errors also affect precision of estimation regularly. | Li Jing Zhao Yongjun Li Donghai | 2014 | Chinese Journal of Aeronautics2014,27,4: | 23 |
| 3 | H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2显示文摘H5N1 流行性感冒病毒的感染在所有流行性感冒病毒之中引起最高的死亡。位于如此的高病毒的致病力下面的机制不完全地被理解。这里,我们报导 H5N1 流行性感冒病毒编码象 microRNA 一样小 RNA, miR-HA-3p,它从茎被处理由 Argonaute 2 的包含环的病毒的 RNA 先锋,和戏在在 H5N1 感染期间提高 cytokine 生产的一个角色。miR-HA-3p poly 指向的机械学的学习表演(rC ) 有约束力的蛋白质 2 (PCBP2 ) 并且压制它的表达式。与 PCBP2 being 一致 RIG-I/MAVS-mediated 抗病毒的天生的免疫的一个重要否定管理者,由 miR-HA-3p 的 PCBP2 表示的抑制在感染 H5N1 的人的巨噬细胞和老鼠支持 cytokine 生产病毒。我们断定 miR-HA-3p 是首先识别的流行性感冒编码病毒的象 microRNA 一样功能的 RNA 碎片和贡献导致 H5N1 的 cytokine 暴风雨和死亡的一个新奇毒力因素。 | Xihan Li Zheng Fu Hongwei Liang Yanbo Wang Xian Qi Meng Ding Xinlei Sun Zhen Zhou Ying Huang Hongwei Gu Limin Li Xi Chen Donghai Li Quan Zhao Fenyong Li Hua Wang Jin Wang Ke Zen Chen-Yu Zhang | 2018 | Cell Research2018,28,2: | 12 |
| 4 | Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis显示文摘 | Wenling Zhang Zhaoyang Zeng Yanhong Zhou Wei Xiong Songqing Fan Lan Xiao Donghai Huang Zheng Li Dan Li Minghua Wu Xiaoling Li Shourong Shen Rong Wang Li Cao Ke Tang Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009,41,5: | 11 |
| 5 | Land-surface processes and summer-cloud-precipitation characteristics in the Tibetan Plateau and their effects on downstream weather:a review and perspective显示文摘Correct understanding of the land-surface processes and cloud-precipitation processes in the Tibetan Plateau(TP)is an important prerequisite for the study and forecast of the downstream activities of weather systems and one of the key points for understanding the global atmospheric movement.In order to show the achievements that have been made,this paper reviews the progress on the observations for the atmospheric boundary layer,land-surface heat fluxes,cloud-precipitation distributions and vertical structures by using ground-and space-based multiplatform,multisensor instruments and the effect of the cloud system in the TP on the downstream weather.The results show that the form drag related to the topography,land-atmosphere momentum and scalar fluxes is an important part of the parameterization process.The sensible heat flux decreased especially in the central and northern TP caused by the decrease in wind speeds and the differences in the ground-air temperatures.Observations show that the cloud and precipitation over the TP have a strong diurnal variation.Studies also show the compressed-air column in the troposphere by the higher-altitude terrain of the TP makes particles inside clouds vary at a shorter distance in the vertical direction than those in the non-plateau area so that precipitation intensity over the TP is usually small with short duration,and the vertical structure of the convective precipitation over the TP is obviously different from that in other regions.In addition,the influence of the TP on severe weather downstream is preliminarily understood from the mechanism.It is necessary to use model simulations and observation techniques to reveal the difference between cloud precipitation in the TP and non-plateau areas in order to understand the cloud microphysical parameters over the TP and the processes of the land boundary layer affecting cloud,precipitation and weather in the downstream regions. | Yunfei Fu Yaoming Ma Lei Zhong Yuanjian Yang Xueliang Guo Chenghai Wang Xiaofeng Xu Kun Yang Xiangde Xu Liping Liu Guangzhou Fan Yueqing Li Donghai Wang | 2020 | National Science Review2020,7,3: | 10 |
| 6 | Development of a daily soil moisture product for the period of2002–2011 in Chinese mainland显示文摘Soil moisture is an essential climate variable(ECV) concerned widely. Due to its high spatial variability, it is costly to measure soil moisture at tens of kilometers scale. In this study, a ten-year(2002–2011) daily soil moisture dataset at 0.25° spatial resolution for Chinese mainland was produced through assimilating the Advanced Microwave Scanning Radiometer for Earth Observing System(AMSR-E) brightness temperature(TB) data into a land surface model(LSM). The obtained soil moisture data was evaluated against soil moisture-measuring networks deployed in two wet areas and one dry area of the Tibetan Plateau.The results show that for the wet areas the accuracy of the soil moisture product obtained from the assimilation is considerably higher than that of both AMSR-E official soil moisture products and land surface simulation results, and for the dry area their accuracy is comparable to each other. The spatial pattern of the soil moisture from the new product is consistent with that of soil porosity from an independent survey-based dataset, further confirming the credibility of the new product. According to this product, the transition regions in China show stronger seasonal variation of soil moisture than dry and wet regions, and drier regions have stronger inter-annual variability of soil moisture than wetter regions, particularly during transitional seasons(spring and autumn). The soil moisture product is accessible at the National Tibetan Plateau Data Center. | Kun YANG Yingying CHEN Jie HE Long ZHAO Hui LU Jun QIN Donghai ZHENG Xin LI | 2020 | Science China Earth Sciences2020,63,8: | 10 |
| 7 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015,25,1: | 8 |
| 8 | Large-area straight,regular periodic surface structures produced on fused silica by the interference of two femtosecond laser beams through cylindrical lens显示文摘Inhomogeneity and low efficiency are two important factors that limit the application of laser-induced periodic surface structures(LIPSSs),especially on glass surfaces.In this study,two-beam interference(TBI)of femtosecond lasers was used to produce large-area straight LIPSSs on fused silica using cylindrical lenses.Compared with those produced us-ing a single circular or cylindrical lens,the LIPSSs produced by TBI are much straighter and more regular.Depending on the laser fluence and scanning velocity,LIPSSs with grating-like or spaced LIPSSs are produced on the fused silica sur-face.Their structural colors are blue,green,and red,and only green and red,respectively.Grating-like LIPSS patterns oriented in different directions are obtained and exhibit bright and vivid colors,indicating potential applications in surface coloring and anti-counterfeiting logos. | Long Chen Kaiqiang Cao Yanli Li Jukun Liu Shian Zhang Donghai Feng Zhenrong Sun Tianqing Jia | 2021 | Opto-Electronic Advances2021,4,12: | 7 |
| 9 | Parameters Optimization of a Novel 5-DOF Gasbag Polishing Machine Tool显示文摘The research on the parameters optimization for gasbag polishing machine tools, mainly aims at a better kinematics performance and a design scheme. Serial structural arm is mostly employed in gasbag polishing machine tools at present, but it is disadvantaged by its complexity, big inertia, and so on. In the multi-objective parameters optimization, it is very difficult to select good parameters to achieve excellent performance of the mechanism. In this paper, a statistics parameters optimization method based on index atlases is presented for a novel 5-DOF gasbag polishing machine tool. In the position analyses, the structure and workspace for a novel 5-DOF gasbag polishing machine tool is developed, where the gasbag polishing machine tool is advantaged by its simple structure, lower inertia and bigger workspace. In the kinematics analyses, several kinematics performance evaluation indices of the machine tool are proposed and discussed, and the global kinematics performance evaluation atlases are given. In the parameters optimization process, considering the assembly technique, a design scheme of the 5-DOF gasbag polishing machine tool is given to own better kinematics performance based on the proposed statistics parameters optimization method, and the global linear isotropic performance index is 0.5, the global rotational isotropic performance index is 0.5, the global linear velocity transmission performance index is 1.012 3 m/s in the case of unit input matrix, the global rotational velocity transmission performance index is 0.102 7 rad/s in the case of unit input matrix, and the workspace volume is 1. The proposed research provides the basis for applications of the novel 5-DOF gasbag polishing machine tool, which can be applied to the modern industrial fields requiring machines with lower inertia, better kinematics transmission performance and better technological efficiency. | LI Yanbiao TAN Dapeng WEN Donghui JI Shiming CAI Donghai | 2013 | Chinese Journal of Mechanical Engineering2013,26,4: | 7 |
| 10 | Geological Controls on the CBM Productivity of No.15 Coal Seam of Carboniferous–Permian Taiyuan Formation in Southern Qinshui Basin and Prediction for CBM High-yield Potential Regions显示文摘Coalbed methane(CBM) resources in No.15 coal seam of Taiyuan Formation account for 55% of the total CBM resources in southern Qinshui Basin(SQB), and have a great production potential. This study aims at investigating the CBM production in No.15 coal seam and its influence factors. Based on a series of laboratory experiments and latest exploration and development data from local coal mines and CBM companies, the spatial characteristics of gas production of No.15 coal seam were analyzed and then the influences of seven factors on the gas productivity of this coal seam were discussed, including coal thickness, burial depth, gas content, ratio of critical desorption pressure to original coal reservoir pressure(RCPOP), porosity, permeability, and hydrogeological condition. The influences of hydrological condition on CBM production were analyzed based on the discussions of four aspects: hydrogeochemistry, roof lithology and its distribution, hydrodynamic field of groundwater, and recharge rate of groundwater. Finally, a three-level analytic hierarchy process(AHP) evaluation model was proposed for predicting the CBM potentials of the No.15 coal seam in the SQB. The best prospective target area for CBM production of the No.15 coal seam is predicted to be in the districts of Panzhuang, Chengzhuang and south of Hudi. | ZHANG Zheng QIN Yong ZHUANG Xinguo LI Guoqing LIU Donghai | 2018 | Acta Geologica Sinica(English Edition)2018,92,6: | 5 |
| 11 | Investigating the spectral characteristic and humification degree of dissolved organic matter in saline-alkali soil using spectroscopic techniques显示文摘 | Qiang LI Xujing GUO Lu CHEN Yunzhen LI Donghai YUAN Benlin DAI Sisi WANG | 2017 | Frontiers of Earth Science2017,11,1: | 5 |
| 12 | “Three essential elements”of the primary health care system:A comparison between California in the US and Guangdong in China显示文摘The primary health care system(PHCS)is the portal and basis for the national health delivery system.There are a number of elements which comprise the PHCS,but the system cannot be established and developed without the support of“three essential elements,”including general practitioners(GPs),health insurance,and government health investment.Through comparative analysis of the“three essential elements”of the PHCS between California in the US and Guangdong in China,this article indicates that there are three important aspects in developing a PHCS in China,as follows:training qualified GPs;establishing a diversified health insurance system to strengthen the policy connections between health insurance and the PHCS thereby increasing government health investment;and broadening health financing channels. | Minfang Huang Donghai Wei Louis Rubino Lianshen Wang Dazhuang Li Bofeng Ding Gan Li | 2015 | Family Medicine and Community Health2015,3,1: | 5 |
| 13 | Genome-wide dissection of segregation distortion using multiple inter-subspecific crosses in rice显示文摘Mendelian inheritance can ensure equal segregation of alleles from parents to offspring, which provides fundamental basis for genetics and molecular biology. Segregation distortion(SD) leads to preferential transmission of certain alleles from generation to generation. Such violation of Mendelian genetic principle is often accompanied by reproductive isolation and eventually speciation. Although SD is observed in a wide range of species from plants to animals, genome-wide dissection of such biased transmission of gametes is rare. Using nine inter-subspecific rice crosses, a genome-wide screen for SD loci is performed, which reveals 61 single-locus quantitative trait loci and 194 digenic interactions showing distorted transmission ratio, among which 24 new SD loci are identified. Biased transmission of alleles is observed in all nine crosses, suggesting that SD exists extensively in rice populations. 72.13% distorted regions are repeatedly detected in multiple populations, and the most prevalent SD hotspot that observed in eight populations is mapped to chromosome 3. Xian alleles are transmitted at higher frequencies than geng alleles in inter-subspecific crosses, which change the genetic composition of the rice populations. Epistatic interaction contributes significantly to the deviation of Mendelian segregation at the whole-genome level in rice, which is distinct from that in animals. These results provide an extensive archive for investigating the genetic basis of SD in rice, which have significant implications in understanding the reproductive isolation and formation of inter-subspecific barriers during the evolution. | Guangwei Li Jiye Jin Yan Zhou Xufeng Bai Donghai Mao Cong Tan Gongwei Wang Yidan Ouyang | 2019 | Science China(Life Sciences)2019,62,4: | 4 |
| 14 | On transitioning from PID to ADRC in thermal power plants显示文摘This paper focuscs on the recent progress in the adoption of active disturbance rejection control(ADRC)in thermal pro-cesses as a viable alternative to proportional-_integral-derivative(PID),especially in coa-fired power plants.The profound interpretation of this paradigm shift,with backward compatibility,is discussed in detail.A few fundamental issues associated with ADRC's applications in thermal processes are discussed,such as implementation,tuning,and the structural changes.Examples and case studies are presented,encompassing coal-fired power plants,gas turbines and nuclear power plants,as well as highlighting results of field applications.Also discussed are future research opportunities brought by ADRC's entry as the baseline control technology in thermal processes. | Zhenlong Wu Zhiqiang Gao Donghai Li YangQuan Chen Yanhong Liu | 2021 | Control Theory and Technology2021,19,1: | 4 |
| 15 | Functional MRI activation of primary and secondary motor areas in healthy subjects显示文摘BACKGROUND: Functional MRI (fMRI) demonstrates the localization of hand representation in the motor cortex,thereby providing feasible noninvasive mapping of functional activities in the human brain. OBJECTIVE: To observe cortical activation within different cortical motor regions during repetitive hand movements in healthy subjects through the use of fMRI. DESIGN: An observational study,with each subject acting as his own control. SETTING: Department of Radiology,the First Affiliated Hospital of Nanchang University. PARTICIPANTS: Seven healthy volunteers,4 males and 3 females,aged 19 to 38 years,participated in the study. All subjects were right-handed,with no neurological or psychological disorders. Informed written consent was obtained from all subjects,and the study was approved by the Institutional Review Board of the First Affiliated Hospital of Nanchang University. METHODS: The study was performed at the Department of Radiology between June-August 2005. A 1.5 Tesla Siemens MRI scanner (Symphony,Germany) was used to acquire T1-weighted structural images,which were oriented parallel to the line running through the anterior and the posterior commissures. Subjects were instructed on a task and were allowed to practice briefly prior to the imaging procedure. The motor activation task consisted of the right hand performing a clenching movement. The T1-W images were acquired from six alternating epochs of rest and activation from all seven healthy subjects. Data were collected with echoplanar imaging of brain oxygen level dependent (BOLD) sequence. Each series comprised six cycles of task performance (30 seconds),alternating with rest (30 seconds) periods,and 3-second time intervals. The differences between active and baseline fMRI imaging were calculated using the student t-test. Differential maps were overlaid on the high resolution T1-W structural image for neuroanatomical correlation of activation areas. MAIN OUTCOME MEASURES: The omega-shaped hand knobs were recognized on T1-W structural images. Active signal changes in the primary (M1) and secondary motor (M2) areas,as well as the relationship between the hand knobs and M1 area activation,were analyzed. Region of interest was selected for signal change quantitative graphic analysis. RESULTS: All 7 enrolled volunteers were included in the final analysis. In the present study,hand knob structures were recognized on T1-weighted images in all subjects and were omega-shaped in the axial plane. Significant functional activations were observed in the contralateral primary motor area of all subjects. Activation signals were distributed mainly in the central sulcus around the hand knob. The contralateral primary sensory (S1) cortex was activated in most cases,and ipsilateral M1 was activated in 3 subjects. Contralateral or bilateral supplementary motor area (SMA) was also activated in 6 cases. Premotor area,or super parietal lobe,was activated in two subjects. Three-dimensional reconstruction demonstrated that the active signal of M1 was primarily located at the middle-lateral surface of the contralateral precentral gyrus in Brodman's area 4,and the signal of SMA activation was located in the mesial surface of the premotor area. CONCLUSION: The knob structure of the precentral gyrus is the representative motor area for hand movement. The cerebral cortical motor network was extensively activated during voluntary hand movements in normal subjects. In alert,conscious human subjects,the activated fMRI signal safely and non-invasively localized and lateralized the motor cortical activity associated with simple voluntary repetitive hand movements. Whether higher cognitive functions,such as perception and speech,can be similarly mapped using the fMRI technique and the BOLD method remains to be determined in future well-designed human studies. | Donghai Li Honghan Gong Xiangzuo Xiao Jinhua Wan | 2008 | Neural Regeneration Research2008,3,2: | 3 |
| 16 | A novel rat model of cardiopulmonary bypass for deep hypothermic circulatory arrest without blood priming显示文摘 | Zhang Weihua Zhang Yanbo Liu Donghai Zhu Yaobin Qiao Chenhui Wang Jiaxiang Xu Yulin Liu Yang Li Bin Yang Yao | 2014 | Chinese Medical Journal2014,,7: | 3 |
| 17 | Permian-Triassic magmatic evolution of granitoids from the southeastern Central Asian Orogenic Belt:Implications for accretion leading to collision显示文摘Many orogenic belts in the world exhibit accretionary and collisional orogenic phases to varying extents.How accretion evolves into collision of the Central Asian Orogenic Belt(CAOB),the largest Phanerozoic accretionary orogenic belt,is an intriguing question.In this paper,we present new U-Pb age,geochemical and isotopic data for Permian-Triassic granitoids from middle Inner Mongolia,Northern China in the southeastern CAOB,and delineate the magmatic transition from subduction to(soft)collision.The magmatic record of soft collision is identified and characterized by thickened lower crust-derived high Sr/Y granitoids with a sub-linear distribution along the Solonker suture zone.Granitoids from Early Permian to Late Permian became more enriched in whole-rock Nd and zircon Hf isotopic compositions(εNd(t)values from 2.4 to-19.5,εHf(t)values from 11.6 to-33.7),indicating increasing incorporation of old crust.The change in peak timing of magmatism from west(ca.264 Ma)to east(ca.251 Ma)along the Solonker suture zone implies'scissor-like'closure of the Paleo-Asian Ocean.Integrated with previous studies,a three-stage tectonic model from the Permian to Triassic by accretion leading to collision on the south-eastern margin of CAOB is proposed.(1)Early Permian(>ca.285 Ma):Juvenile magmatism on an active continental margin with double-sided subduction of the Paleo-Asian Ocean;(2)Middle Permian to Middle Triassic(ca.285–235 Ma):Magma source transition from juvenile to old crust induced by a tectonic switch from arc to'scissor-like'closure and subsequent intracontinental orogenic contraction;(3)Late Triassic( | Didi WU Shan LI David CHEW Tieyi LIU Donghai GUO | 2021 | Science China Earth Sciences2021,64,5: | 3 |
| 18 | Hemodynamic analysis of intracranial aneurysms using phase-contrast magnetic resonance imaging and computational fluid dynamics显示文摘Additional hemodynamic parameters are highly desirable in the clinical management of intracranial aneurysm rupture as static medical images cannot demonstrate the blood flow within aneurysms. There are two ways of obtaining the hemodynamic information—by phase-contrast magnetic resonance imaging(PCMRI) and computational fluid dynamics(CFD). In this paper, we compared PCMRI and CFD in the analysis of a stable patient's specific aneurysm.The results showed that PCMRI and CFD are in good agreement with each other. An additional CFD study of two stable and two ruptured aneurysms revealed that ruptured aneurysms have a higher statistical average blood velocity,wall shear stress, and oscillatory shear index(OSI) within the aneurysm sac compared to those of stable aneurysms.Furthermore, for ruptured aneurysms, the OSI divides the positive and negative wall shear stress divergence at the aneurysm sac. | Xuemei Zhao Rui Li Yu Chen Sheau Fung Sia Donghai Li Yu Zhang Aihua Liu | 2017 | Acta Mechanica Sinica2017,33,2: | 3 |
| 19 | Overview of SMP-CAIL2020-Argmine:The Interactive Argument-Pair Extraction in Judgement Document Challenge显示文摘In this paper we present the results of the Interactive Argument-Pair Extraction in Judgement Document Challenge held by both the Chinese AI and Law Challenge(CAIL)and the Chinese National Social Media Processing Conference(SMP),and introduce the related data set-SMP-CAIL2020-Argmine.The task challenged participants to choose the correct argument among five candidates proposed by the defense to refute or acknowledge the given argument made by the plaintiff,providing the full context recorded in the judgement documents of both parties.We received entries from 63 competing teams,38 of which scored higher than the provided baseline model(BERT)in the first phase and entered the second phase.The best performing system in the two phases achieved accuracy of 0.856 and 0.905,respectively.In this paper,we will present the results of the competition and a summary of the systems,highlighting commonalities and innovations among participating systems.The SMP-CAIL2020-Argmine data set and baseline modelshave been already released. | Jian Yuan Zhongyu Wei Yixu Gao Wei Chen Yun Song Donghua Zhao Jinglei Ma Zhen Hu Shaokun Zou Donghai Li Xuanjing Huang | 2021 | Data Intelligence2021,3,2: | 3 |
| 20 | Lightweight Design of Commercial Vehicle Cab Based on Fatigue Durability显示文摘To better improve the lightweight and fatigue durability performance of the tractor cab,a multi-objective lightweight design of the cab was carried out in this study.First,the finite element model of the cab with counterweight loading was established and then confirmed by the physical testing,and use the inertial reliefmethod to obtain stress distribution under unit load.The cab-frame rigid-flexible couplingmulti-body dynamicsmodelwas built by Adams/car software.Taking the cab airbag mount displacement and acceleration signals acquired on the proving ground as the desired signals and obtaining the fatigue analysis load spectrum through Femfat-Lab virtual iteration.The fatigue simulation analysis is performed in nCode based on the Miner linear fatigue cumulative damage theory.Then,with themass and fatigue damage values as the optimization objectives,the bending-torsional stiffness and first-order bending-torsional mode as constraints,the thickness variables are screed based on the sensitivity analysis.The experimental design was carried out using the Optimal Latin hypercube method,and the multi-objective optimal design of the cab was carried out using theKriging approximationmodel fitting and particle swarmalgorithm.The weight of the optimized cab is reduced by 7.8%on the basis of meeting the fatigue durability performance.Finally,a seven-axis road simulation test rig was designed to verify its fatigue durability.The results show the optimized cab can consider both lightweight and durability. | Donghai Li Jiawei Tian Shengwen Shi Shanchao Wang Jucai Deng Shuilong He | 2023 | Computer Modeling in Engineering & Sciences2023,,7: | 2 |