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| 1 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 2 | SOD1^(G93A) Induces a Unique PSAP-Dependent Mitochondrial Apoptosis Pathway via Bax-Bak Interaction显示文摘Amyotrophic lateral syndrome(ALS)is a progressive degenerative disorder characterized by motor neuron death and axon degeneration.Mitochondrial dysfunction plays a key role in the pathogenesis of ALS,the mechanism of which remains poorly understood.The B-cell lymphoma-2(Bcl-2)family of proteins that control and mediate mitochondrial function and apoptosis,including the pro-apoptotic members Bcl2-Associated X(Bax),are involved in ALS development.The death receptor 6(DR6)regulates motor neuron death in ALS,and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking DR6.Previous studies demonstrated that PSAP localized to mitochondria and was required for DR6-induced apoptosis.In this study,SOD1^(G93A) was transfected into the motor neuron cell line NSC-34 to serve as an ALS cell model in vitro.The data assessed the role of PSAP in SOD1^(G93A)induced apoptosis and demonstrated that the overexpression of SOD1^(G93A),but not wtSOD1,induced PARP cleavage,caspase-3 activation,cytochrome c release,and Bax translocation.PSAP,Bax,and Bak were necessary for SOD1^(G93A)induced apoptosis,as silencing PSAP inhibited SOD1^(G93A)-mediated cell death that was dependent on Bax-Bak interaction. | HAN NIU XIN CHEN XUEQI FU JINGTIAN ZHANG GUODONG LI YUXIANG WANG JIAYUE SONG XUETING MA CHEN HU XUEMIN XU FUQIANG ZHANG LINLIN ZENG | 2021 | BIOCELL2021，45，4： | 2 |
| 3 | Aflatoxin B1: Toxicity, bioactivation and detoxification in the polyphagous caterpillar Trichoplusia ni显示文摘Trichoplusia ni 毛虫是杂食的 foliage-feeders 并且很少可能遇到黄麴毒素 B1 (AFB1 ) , mycotoxin 由曲霉属菌 flavus 和 A 生产了。parasiticus,在他们的主人植物。决定怎么 T。ni 应付 AFB1,我们评估了 AFB1 的毒性到 T。在不同发展阶段的 ni 毛虫并且发现忍耐显著地与幼虫的开发增加的那 AFB1。在 1 g/g 的 AFB1 的食谱加入完全禁止了最新孵的幼虫,而是 3 g/g 的幼虫的生长和 AFB1 没有的化蛹首先消费这的毛虫的幼虫的生长和化蛹上的明显的有毒的效果在孵化以后加重 10 天。Piperonyl butoxide,细胞色素 P450 monooxygenases (P450s ) 的一个一般禁止者,减少了 AFB1 的毒性,建议那 AFB1 是在 T 的 bioactivated。ni 和这 bioactivation 被 P450s 调停。某植物 allelochemicals 包括象黄酮,象 xanthotoxin 和 imperatorin 那样的 furanocoumarins,和象 visnagin 那样的 furanochromones 那样的 flavonoids,在另外的鳞翅类的幼虫导致 P450s 改善 AFB1 毒性,建议那 P450s 也在 T 涉及 AFB1 detoxification。ni。 | Ren Sen Zeng Zhimou Wen Guodong Niu R. Berenbaum | 2013 | Insect Science2013，20，3： | 1 |
| 4 | Low-cost photoacoustic imaging systems based on laser diode and light-emitting diode excitation显示文摘Photoacoustic imaging,an emerging biomedical imaging modality,holds great promise for preclinical and clinical researches.It combines the high optical contrast and high ultrasound resolution by converting laser excitation into ultrasonic emission.In order to generate photoacoustic signal e±-ciently,bulky Q-switched solid-state laser systems are most commonly used as excitation sources and hence limit its commercialization.As an alternative,the miniaturized semiconductor laser system has the advantages of being inexpensive,compact,and robust,which makes a signi¯cant e®ect on production-forming design.It is also desirable to obtain a wavelength in a wide range from visible to nearinfrared spectrum for multispectral applications.Focussing on practical aspect,this paper reviews the state-of-the-art developments of low-cost photoacoustic system with laser diode and light-emitting diode excitation source and highlights a few representative installations in the past decade. | Qingkai Yao Yu Ding Guodong Liu Lvming Zeng | 2017 | Journal of Innovative Optical Health Sciences2017，，4： | 1 |
| 5 | Improved two-step hydrothermal process for acetic acid production from carbohydrate biomass显示文摘An improved two-step process for converting carbohydrate biomass to acetic acid under hydrothermal conditions is proposed. The first step consists of the production of lactic acid from carbohydrate biomass, and the second step consists of conversion of the lactic acid obtained in the first step to acetic acid using CuO as an oxidant. The results indicated that CuO as an oxidant in the second step can significantly improve the production of high-purity acetic acid from lactic acid, and the maximum yield of acetic acid was 61%, with a purity of 90%. The yield of acetic acid obtained using the improved two-step hydrothermal process from carbohydrate biomass, such as glucose, cellulose and starch, was greater than that obtained using traditional two-step process with H2O2 orO2. In addition, a proposed pathway for the production of acetic acid from lactic acid in the second step with CuO was also discussed. The present study provides a useful two-step process for the production of acetic acid from carbohydrate biomass. | Zhibao Huo Yan Fang Guodong Yao Xu Zeng Dezhang Ren Fangming Jin | 2015 | Journal of Energy Chemistry2015，24，2： | 1 |
| 6 | The role of the IRE1 pathway in PBDE-47-induced toxicity in human neuroblastoma SH-SY5Y cells in vitro显示文摘 | Chunyang Jiang Shun Zhang Hongliang Liu Qiang Zeng Tao Xia Yihu Chen Gang Kuang Guodong Zhao Xue Wu Xiaofei Zhang Aiguo Wang | 2012 | Toxicology Letters2012，，3： | 1 |
| 7 | Portable optical-resolution photoacoustic microscopy with a pulsed laser diode excitation显示文摘 | ZENG LVMING LIU GUODONG YANG DIWU | 2013 | Applied Physics Letters2013，102，05： | 1 |
| 8 | Synthesis and Characterization of a Silica-Based Drug Delivery System for Spinal Cord Injury Therapy显示文摘Acute inflammation is a central component in the progression of spinal cord injury(SCI).Anti-inflammatory drugs used in the clinic are often administered systemically at high doses,which can paradoxically increase inflammation and result in drug toxicity.A cluster-like mesoporous silica/arctigenin/CAQK composite(MSN-FC@ARCG)drug delivery system was designed to avoid systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal cord.In this nanosystem,mesoporous silica was modified with the FITC fluorescent molecule and CAQK peptides that target brain injury and SCI sites.The size of the nanocarrier was kept at approximately 100 nm to enable penetration of the blood–brain barrier.Arctigenin,a Chinese herbal medicine,was loaded into the nanosystem to reduce inflammation.The in vivo results showed that MSN-FC@ARC-G could attenuate inflammation at the injury site.Behavior and morphology experiments suggested that MSN-FC@ARC-G could diminish local microenvironment damage,especially reducing the expression of interleukin-17(IL-17) and IL-17-related inflammatory factors,inhibiting the activation of astrocytes,thus protecting neurons and accelerating the recovery of SCI.Our study demonstrated that this novel,silica-based drug delivery system has promising potential for clinical application in SCI therapy. | Guodong Sun Shenghui Zeng Xu Liu Haishan Shi Renwen Zhang Baocheng Wang Changren Zhou Tao Yu | 2019 | Nano-Micro Letters2019，11，2： | 1 |
| 9 | Piezoelectricity in β-phase PVDF crystals: A molecular simulation study显示文摘 | Zhu Guodong Zeng Zhigang Zhang Li | 2008 | Comput Mater Sei2008，44，： | 1 |
| 10 | Aurone derivatives as Vps34 inhibitors that modulate autophagy显示文摘We report in this study the identification of a natural product-like antagonist(1a) of Vps34 as a potent autophagy modulator via structure-based virtual screening. Aurone derivative 1a strongly inhibited Vps34 activity in cell-free and cell-based assays. Significantly, 1a prevents autophagy in human cells induced either by starvation or by an mT OR inhibitor. In silico modeling and kinetic data revealed that 1a could function as an ATP-competitive inhibitor of Vps34. Moreover, it suppressed autophagy in vivo and without inducing heart or liver damage in mice. 1a could be utilized as a new motif for more selective and efficacious antagonists of Vps34 for the potential treatment of autophagy-related human diseases. | Guodong Li Joshua William Boyle Chung-Nga Ko Wu Zeng Vincent Kam Wai Wong Jian-Bo Wan Philip Wai Hong Chan Dik-Lung Ma Chung-Hang Leung | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 1 |
| 11 | Allelochemical induction of cytochrome P450 monooxygenases and amelioration of xenobiotic toxicity in Helicoverpa zea显示文摘 | ZENG R S WEN ZHIMOU NIU GUODONG | 2007 | J Chem Ecol2007，33，： | 1 |
| 12 | Pie- zoelectricity in fl-phase PVDF crystals: a molecular simulation study显示文摘 | ZHU Guodong ZENG Zhigang ZHANG Li | 2008 | Computational Materials Science2008，44，2： | 1 |
| 13 | Effect of fiber architecture and density on the ablation behavior of carbon/carbon composites modified by Zr–Ti–C显示文摘 | Yi Zeng Xiang Xiong Guodong Li Zhaoke Chen Wei Sun Dini Wang Yalei Wang | 2013 | Carbon2013，，： | 1 |
| 14 | Influence of Hydrodynamic Pore Pressure Damage on the Performance of Hot-Mixed Renewable Asphalt Mixture显示文摘For evaluating the water stability of hot-mixed renewable asphalt mixture(HRM),the traditional methods are all tested under still water conditions.Except for damage in still water conditions,the hydrodynamic pore pressure generated by the tire driving on the surface water has a great impact.Thus,the RAP contents of the HRMs were designed at 0%,30%,45%and 60%with AC-25 gradation.Then,the self-designed evaluation methods of water stability and dynamic modulus were studied.Finally,the mechanism of the influence of hydrodynamic pore pressure damage on HRMs was studied.The results show that the water stability of HRM containing 30%RAP is equivalent to that of 45%RAP,and the water stability of HRM containing 60%RAP decreases significantly.The Contabro test after MIST treatment can be used as an evaluation method for hydrodynamic pore pressure damage on HRM.Low-speed,heavy-load traffic and larger RAP content have greater damage to the mixture after hydrodynamic pore pressure damage.The performance differences between the aged bitumen and pure bitumen,as well as the aged minerals and new minerals,are continuing to be enlarged in hydrodynamic pore pressure conditions,finally affecting the water stability and dynamic modulus of the HRMs. | Guodong Zeng Chao Li Yang Fang Hongming Huang Hao Li Yishen Xu | 2023 | Journal of Renewable Materials2023，11，5： | 0 |
| 15 | Exploring exosomes to provide evidence for the treatment and prediction of Alzheimer’s disease显示文摘Exosomes are extracellular vesicles with a 30–150 nm diameter originating from endosomes.In recent years,scientists have regarded exosomes as an ideal small molecule carrier for the targeted treatment of Alzheimer’s disease(AD)across the blood-brain barrier due to their nanoscale size and low immunogenicity.A large amount of evidence shows that exosomes are rich in biomarkers,and it has been found that the changes in biomarker content in blood,cerebrospinal fluid,and urine are often associated with the onset of AD patients.In this paper,some recent advances in the use of exosomes in the treatment of AD are reviewed,and various exosome markers and some latest detection methods are summarized to provide some evidence for the detection or treatment of AD by exosomes. | XIANGYU QUAN XUETING MA GUODONG LI XUEQI FU JIANGTAO LI LINLIN ZENG | 2023 | BIOCELL2023，47，10： | 0 |
| 16 | A Bayesian belief-rule-based inference multivariate alarm system for nonlinear time-varying processes显示文摘This study considers the multivariate alarm design problem of nonlinear time-varying systems by a Bayesian belief-rule-based(BRB)method.In the method,the series of belief rules are constructed to approximate the relationship between input and output variables.Hence,the method does not require an explicit model structure and is suitable for capturing nonlinear causal relationships between variables.For the purpose of online application,this study further introduces sequential Monte Carlo(SMC)sampling to update the BRB model parameters,which is a fast and efficient method for approximately inferring nonlinear sequence models.Using the model parameters obtained by SMC sampling,the series of output variable tracking errors can be estimated and employed for multivariate alarm design.The case study of a condensate pump verifies the effectiveness of the proposed method. | Xiaobin XU Zhuochen YU Jiusun ZENG Wanqi XIONG Yanzhu HU Guodong WANG | 2021 | Science China(Information Sciences)2021，64，10： | 0 |
| 17 | Biochar-supported nano-scale zerovalent iron activated persulfate for remediation of aromatic hydrocarbon-contaminated soil:an in-situ pilot-scale study显示文摘Biochar supported nano-scale zerovalent iron(nZVI/BC)for persulfate(PS)activation has been studied extensively for the degradation of pollutants on the lab scale,but it was rarely applied in practical soil remediation in the field.In this research,we developed a facile ball-milling method for the mass production of nZVI/BC,which was successfully applied to activate persulfate for the remediation of organic polluted soil on an in-situ pilot scale.In-situ high-pressure injection device was developed to inject nZVI/BC suspension and PS solution into the soil with a depth of 0-70 cm.The removal efficiency of target pollutants such as 2-ethylnitrobenzene(ENB,1.47-1.56 mg/kg),biphenyl(BP,0.19-0.21 mg/kg),4-(methylsulfonyl)toluene(MST,0.32-0.43 mg/kg),and 4-phenylphenol(PP,1.70-2.46 mg/kg)at different soil depths was 99.7%,99.1%,99.9%and 99.7%,respectively,after 360 days of remediation.The application of nZVI/BC significantly increased the degradation rates of contaminants by 11-322%,ascribed to its relatively higher efficiency of free radical generation than that of control groups.In addition,it was found that nZVI/BC-PS inhibited soil urease and sucrase enzyme activities by 1-61%within 55 days due to the oxidative stress for microbes induced by free radicals,while these inhibition effects disappeared with remediation time prolonged(>127 days).Our research provides a useful implementation case of remediation with nZVI/BC-PS activation and verifies its feasibility in practical contaminated soil remediation. | Yu Zeng Tai Li Yingzhi Ding Guodong Fang Xiaolei Wang Bo Ye Liqiang Ge Juan Gao Yujun Wang Dongmei Zhou | 2022 | Biochar2022，4，1： | 0 |
| 18 | Clinical Characteristics of BK Virus Infection in Renal Transplant Recipients显示文摘 | Gang Huang Lei Zhang Changxi Wang Jiguang Fei Jiang Qiu Suxiong Deng Jun Li Guodong Chen Qian Fu Wentao Zeng Lizhong Chen | 2010 | 器官移植内科学杂志2010，5，3： | 0 |
| 19 | CNN-Based Broad Learning for Cross-Domain Emotion Classification显示文摘Cross-domain emotion classification aims to leverage useful information in a source domain to help predict emotion polarity in a target domain in a unsupervised or semi-supervised manner.Due to the domain discrepancy,an emotion classifier trained on source domain may not work well on target domain.Many researchers have focused on traditional cross-domain sentiment classification,which is coarse-grained emotion classification.However,the problem of emotion classification for cross-domain is rarely involved.In this paper,we propose a method,called convolutional neural network(CNN)based broad learning,for cross-domain emotion classification by combining the strength of CNN and broad learning.We first utilized CNN to extract domain-invariant and domain-specific features simultaneously,so as to train two more efficient classifiers by employing broad learning.Then,to take advantage of these two classifiers,we designed a co-training model to boost together for them.Finally,we conducted comparative experiments on four datasets for verifying the effectiveness of our proposed method.The experimental results show that the proposed method can improve the performance of emotion classification more effectively than those baseline methods. | Rong Zeng Hongzhan Liu Sancheng Peng Lihong Cao Aimin Yang Chengqing Zong Guodong Zhou | 2023 | Tsinghua Science and Technology2023，28，2： | 0 |
| 20 | A H_(4)SiW_(12)O_(40)-catalyzed three-component tandem reaction for the synthesis of 3,3-disubstituted isoindolinones显示文摘A H_(4)SiW_(12)O_(40)-catalyzed three-component tandem reaction of 2-acylbenzoic acids,primary amines and phosphine oxides to form 3,3-disubstituted isoindolinones was developed.By employing A H_(4)SiW_(12)O_(40)as the catalyst and dimethyl carbonate(DMC)as the solvent,a diverse range of 2-acylbenzoic acid derivatives and primary amines worked well to give the C3-phosphinoyl-functionalized 3,3-disubstituted isoindolinones with the yield range of 61%-87%.Advantages of this transformation include green catalyst and solvent,available starting materials,broad substrate scope,high efficiency and operational simplicity with water as the sole by-product.The strategy achieved an efficient and green molecular fragment assembly to access isoindolinones,which would provide opportunities for the synthesis of potential biologically active molecules in a green manner. | Yufeng Liu Guodong Zeng Yutao Cheng Lei Chen Yunhai Liu Yongge Wei Guoping Yang | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
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