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| 1 | Efficacy and safety evaluation of intravenous infusion of cervus and cucumis polypeptides for treatment of avascular necrosis of the femoral head: a randomized clinical trial显示文摘OBJECTIVE: To investigate the efficacy and safety of intravenous cervus and cucumis polypeptides for treating avascular necrosis of the femoral head(ANFH) in regard to pain and hip function in a randomized clinical trial.METHODS: A total of 96 subjects with ANFH who were recruited at the Orthopaedic Hospital Affiliated with Hebei United University and Qian Hai Femoral Head Hospital of Beijing were assigned by lottery to an intervention group(n = 48) or a control group(n = 48). All subjects underwent physical therapy and rehabilitation exercises. In addition,subjects in the intervention group were given intravenous infusions of cervus and cucumis polypeptides. Visual analogue scale(VAS), Harris hip score,and radiography or magnetic resonance imaging were applied to assess all subjects at the beginning of treatment and 3, 6, and 9 months afterward. All the subjects were followed up for 2 years.RESULTS: At the beginning of treatment, there were no statistically significant differences between the two groups in terms of the general condition of patients or the VAS and Harris hip scores(all P > 0.05). At 3, 6, and 9 months after treatment,however, the VAS score decreased and the Harris hip score increased in all patients, with the improvement of intervention group significantly greater than that of the control group(P < 0.05).The total effectiveness rates for the intervention and control groups were 89.58% and 70.83%, respectively, with the difference being statistically significant(P < 0.05). There was no statistically significant difference between the two groups in terms of the safety of the injections(P > 0.05).CONCLUSION: Intravenous infusion of cervus and cucumis polypeptides relieved pain and improved hip function of subjects with ANFH.Thus, the intravenous infusion of cervus and cucumis polypeptides was a safe, effective treatment for ANFH. | Wei Liyou Zhang Hongwei Li Xinmin Yang Chunyan Wang Guoqiang Zhang Lifeng Cui Mingwu Han Lijun | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 15 |
| 2 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 3 | Study of the varve record from Erlongwan maar lake, NE China, over the last 13 ka BP显示文摘在来自跨越最后 13 ka BP 的 Erlongwan maar 湖的一个沉积序列,二种主要纹泥类型能被认出:源於生物的纹泥(从礼品到 -11.2 ka BP, 0-632 厘米) 并且碎屑状的纹泥(从 -11.2 到 -12.7 ka BP, 632-700 厘米) 。基于在沉积包含的水藻的主导的类型,源於生物的纹泥能被分类进 dinocyst 源於生物的纹泥(0-63 厘米) 并且混合(dinocyst 和硅藻) 源於生物的纹泥(214-632 厘米) 。在这篇论文,纹泥的形成过程和部件被描述,为纹泥在整个记录变化的类型的可能的原因被讨论,一张高分辨率的纹泥年表被建立跨越最后 13 ka BP。尽管进一步的纹泥数和错误评价被需要,这里介绍的结果为学习 Erlongwan maar 湖的 palaeoclimate 记录代表一个稳固的基础。 | YOU HaiTao LIU JiaQi LIU Qiang CHU GuoQiang Patrick RIOUAL HAN JingTai | 2008 | Chinese Science Bulletin2008，53，2： | 9 |
| 4 | Archaeal community structure along a gradient of petroleum contamination in saline-alkali soil显示文摘The response of archaeal communities to petroleum contamination in saline-alkali soil was characterized by analyses of three soil samples with different total petroleum hydrocarbon concentrations.Through the construction and screening of 16S rRNA gene clone libraries based on DNA extracts from these soils,nine distinct phylogenetic groups were identified.Statistical analyses showed that the distribution of archaeal community structures differ significantly along the gradient of petroleum contamination in these three saline- alkali soils.Five phylogenetic groups were dominant in the control soil,two of which were also abundant in the lightly contaminated soil.Four phylogenetic groups were dominant in heavily contaminated soil,one of which was also abundant in the lightly contaminated soil.The halophilic genus of Haloferax and the haloalkaliphilic genus of Natronomonas were more abundant in heavily contaminated soil.These results suggested that the genera of Haloferax and Natronomonas may have a role in the natural attenuation of petroleum- contaminated saline-alkali soil. | Xinxin Wang Zhen Han Zhihui Bai Jingchun Tang Anzhou Ma Jizheng He Guoqiang Zhuang | 2011 | Journal of Environmental Sciences2011，23，11： | 8 |
| 5 | Experimental evaluation of thermolysis-driven gas emissions from LiPF6-carbonate electrolyte used in lithium-ion batteries显示文摘This paper performs an experimental evaluation of thermolysis-driven gases generated by the thermal decomposition of 1 M LiPF6+EC/DMC=1/1 v/v electrolytes at various decomposition temperatures,pyrolysis durations,and oxygen concentrations.Carried out in a home-built autoclave filled with pure helium,the experiment reveals that as the decomposition temperature increases,more types and larger quantities of gases will be released.Specifically,the experimental results demonstrate trends of logistic growth in the volume concentration of CO2,C2H6O,C2H4,CO,and C2H4O2 with the increase of decomposition temperature.With a prolonged pyrolysis duration,while volume concentrations of certain gases,such as CO2,C2H6O,C2H5F,and CO would increase,the concentration of C2H4O2 actually decreases.Moreover,concentrations of both C2H4 and C2H5F will first decrease and reach their minimum values at 1%v/v oxygen concentration,and then they would quickly climb back at higher oxygen concentrations,while the concentrations of C2H6 and C2H3F would decrease monotonically.It is envisioned that the detailed experimental results and findings on the gas generation pattern of 1 M LiPF6+EC/DMC=1/1 v/v electrolytes can facilitate the development of an early warning mechanism of thermal runaway based on gas sensing technology,which can be effectively applied to monitor the potential thermal failures of lithium-ion batteries with the same type of electrolyte and thus promote the thermal safety of battery packs in safety-critical applications. | Zhenghai Liao Shen Zhang Yikun Zhao Zongjia Qiu Kang Li Dong Han Guoqiang Zhang Thomas G.Habetler | 2020 | Journal of Energy Chemistry2020，29，10： | 7 |
| 6 | Room temperature ferromagnetism in ultra-thin van der Waals crystals of 1T-CrTe2显示文摘Although many emerging new phenomena have been unraveled in two dimensional(2D)materials with long-range spin orderings,the usually low critical temperature in van der Waals(vdW)magnetic material has thus far hindered the related practical applications.Here,we show that ferromagnetism can hold above 300 K in a metallic phase of 1T-CrTe2 down to the ultra-thin limit.It thus makes CrTe2 so far the only known exfoliated ultra-thin vdW magnets with intrinsic long-range magnetic ordering above room temperature.An in-plane room-temperature negative anisotropic magnetoresistance(AMR)was obtained in ultra-thin CrTe2 devices,with a sign change in the AMR at lower temperature,with−0.6%and+5%at 300 and 10 K,respectively.Our findings provide insights into magnetism in ultra-thin CrTe2,expanding the vdW crystals toolbox for future room-temperature spintronic applications. | Xingdan Sun Wanying Li Xiao Wang Qi Sui Tongyao Zhang Zhi Wang Long Liu Da Li Shun Feng Siyu Zhong Hanwen Wang Vincent Bouchiat Manuel Nunez Regueiro Nicolas Rougemaille Johann Coraux Anike Purbawati Abdellali Hadj-Azzem Zhenhua Wang Baojuan Dong Xing Wu Teng Yang Guoqiang Yu Bingwu Wang Zheng Han Xiufeng Han Zhidong Zhang | 2020 | Nano Research2020，13，12： | 6 |
| 7 | Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice显示文摘The novel coronavirus SARS-CoV-2 has infected more than 104 million individuals and resulted in more than 2.2 million deaths worldwide as of February 7,2021(http://gffzze7c39cdc9e894ca6sp9ubv0xqqp0o60uk.ffgz.tsg.suse.edu.cn).The COVID-19 pandemic highlights the need for safe and effective vaccines against SARS-CoV-2 infection. | Shihui Sun Lei He Zhongpeng Zhao Hongjing Gu Xin Fang Tiecheng Wang Xiaolan Yang Shaolong Chen Yongqiang Deng Jiangfan Li Jian Zhao Liang Li Xinwang Li Peng He Ge Li Hao Li Yuee Zhao Chunrun Gao Xiaoling Lang Xin Wang Guoqiang Fei Yan Li Shusheng Geng Yuwei Gao Wenjin Wei Zhongyu Hu Gencheng Han Yansong Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 8 | Efficiency of Slit Dam Prevention against Non-Viscous Debris Flow显示文摘This paper describes an experimental work in order to assess the efficiency of slit dam on non-viscous debris flow. Some results have been acquired as follows: ① there are three kinds of blocking type: Total-blocking, opening and part-blocking. The blocking conditions of slit dam are closely link to b/d_ max (the ratio of slit width to maximum diameter of solid matter), as b/d_ max is less than 0.739, the slit dam is total- blocking; and b/d_ max is more than 1.478, the slit dam will be opening; whereas b/d_ max ranges from 0.739 to 1.478, the slit dam is part-blocking. ② Variation of the mean density passing through slit dam is the most obvious as b/d_ max ranges from 0.739 to 1.232. ③ According to experimental results, slit dams have been shown to be effective in reducing debris flow density while slit density ∑b/B (B is slit dam width) ranges from 0.2 to 0.5. | HAN Wenbing OU Guoqiang | 2006 | Wuhan University Journal of Natural Sciences2006，11，4： | 4 |
| 9 | THE DYNAMIC BUCKLING OF ELASTIC-PLASTIC COLUMN SUBJECTED TO AXIAL IMPACT BY A RIGID BODY显示文摘The dynamic buckling of an elastic-plastic column subjected to axial impact by arigid body has been discussed in this paper. The whole traveling process of elastic-plastic wavesunder impact action is analyzed with the characteristics method. The regularity of stress changesin both column ends and the first separating time of a rigid body and column are obtained. Byusing the energy principle and taking into account the propagation and reffection of stress wavesthe lateral disturbance equation is derived and the power series solution is given. In addition,the critical buckling condition can be obtained from the stability analysis of the solution. Bynumerical computation and analysis, the relationship among critical velocity and impact mass,hardening modulus, and buckling time is given. | Han Zhijun Wang Jingchao Cheng Guoqiang Ma Hongwei Zhang Shanyuan | 2005 | Acta Mechanica Solida Sinica2005，18，3： | 4 |
| 10 | Multi-feature Multimodal Biometric Recognition Based on Quaternion Locality Preserving Projection显示文摘This paper proposed Quaternion locality preserving projection(QLPP)for multi-feature multimodal biometric recognition.Multi-features fill the real part or the three imaginary parts of quaternion to constitute the quaternion fusion features.In quaternion division ring,QLPP extracts the local information and finds essential manifold structure of the quaternion fusion features.Deferent from Quaternion principal component analysis(QPCA)and Quaternion fisher discriminant analysis(QFDA),QLPP takes advantage of the optimal linear approximations to find the nonlinear manifold structures.Two experiments are designed:one fuses four features from two biometric modalities,and the other fuses three features from three biometric modalities.The experimental results show the proposed algorithm achieves much better performance than the unimodal biometric algorithms,the traditional feature level fusion methods(weighted sum rule and series rule)and two quaternion representation methods(QPCA and QFDA). | WANG Zhifang ZHEN Jiaqi LI Yanchao LI Guoqiang HAN Qi | 2019 | Chinese Journal of Electronics2019，28，4： | 3 |
| 11 | Mutagenesis reveals that the rice OsMPT3 gene is an important osmotic regulatory factor显示文摘Plant mitochondrial phosphate transporters regulate phosphate transport and ATP synthesis. Determining whether they function in abiotic stress response process would shed light on their response to salt stress. We used the CRISPR/Cas9 gene-editing system to mutagenize two mitochondrial phosphate transporters, OsMPT3;1 and OsMPT3;2, to investigate their regulatory roles under salt stress. Two cas9(CRISPR-associated protein9)-free homozygous mutants, mpt33 and mpt30, were confirmed to be stable. Both OsMPT3;1 and OsMPT3;2 were markedly induced by salt stress, and their mutagenesis strongly inhibited growth and development, especially under salt stress. Mutagenesis sharply reduced the accumulation of ATP, phosphate, calcium, soluble sugar, and proline and increased osmotic potential, malondialdehyde, and Na^+ /K^+ ratio under salt stress. Both mutants demonstrate normal growth and development in the presence of ATP, revealing high sensitivity to exogenous ATP under salt stress. The mutants showed lowered rates of Na^+ efflux but also of K^+ and Ca^(2+) influx under salt stress. Mutagenesis of OsMPT3;2 altered the enrichment profiles of differentially expressed genes involved mainly in synthesis of secondary metabolites, metabolism of glycolysis, pyruvate, tricarboxylic acid cycle, in response to salt stress. The mutant displayed significant accumulation differences in 14 metabolites involved in 17 metabolic pathways, and strongly up-regulated the accumulation of glutamine, a precursor in proline synthesis, under salt stress. These findings suggest that the OsMPT3 gene modulates phosphate transport and energy supply for ATP synthesis and triggers changes in accumulation of ions and metabolites participating in osmotic regulation in rice under salt stress, thus increasing rice salt tolerance. This study demonstrates the effective application of CRISPR/Cas9 gene-editing to the investigation of plant functional genes. | Shengcai Huang Shichao Xin Guoqiang Xie Jiao Han Zhonglai Liu Bing Wang Shuqing Zhang Qingyu Wu Xianguo Cheng | 2020 | The Crop Journal2020，8，3： | 2 |
| 12 | Influence of Nitrogen Flow Rate on the Microstructure and Properties of N and Me (Me=Cr,Zr) Co-doped Diamond-like Carbon Films显示文摘In this paper,Me (Me=Cr,Zr) and N co-doped diamond like carbon (DLC-MeN) composite films were prepared on cemented carbide substrates by pulsed bias arc ion plating.The effect of nitrogen flow rates on the microstructure and properties of the films were investigated by X-ray photoelectron spectroscopy (XPS),Raman spectra,grazing incident X-ray diffraction (GIXRD),high resolution transmission electron microscopy (HRTEM) and nano-indentation.Raman,GIXRD and HRTEM results show that the deposited films are nanocomposite films with MeN nanocrystalline phase embedded within DLC amorphous matrix,which are vital for the mechanical properties of the films.The nitrogen flow rate has significant effect on the compositions and structures and hence on the hardness and elastic modulus of the films,and increasing nitrogen flow rate decreases drastically the hardness and elastic modulus of the films. | Zhiyun Han,Hongkai Li,Guoqiang Lin and Chuang Dong Key Laboratory for Material Modification by Laser,Ion and Electron Beams,Dalian University of Technology,Dalian 116085,China | 2010 | Journal of Materials Science & Technology2010，26，11： | 2 |
| 13 | Field study on occupants’ thermal comfort and residential thermal environment in a hot-humid climate of China显示文摘 | Jie Han Guoqiang Zhang Quan Zhang Jinwen Zhang Jianlong Liu Liwei Tian Cong Zheng Junhong Hao Jianping Lin Yanhui Liu Demetrios. J. Moschandreas | 2006 | Building and Environment2006，，12： | 1 |
| 14 | HDPE solution crystallization induced by eleetrospun PA66 nanofiber 显示文摘 | HAN Wenjuan ZHENG Guoqiang LIANG Yanyan | 2011 | Colloid Polym Sci2011，289，7： | 1 |
| 15 | Safety evaluation of marine derrick steel structures based on dynamic measurement and updated finite element model显示文摘 | Han Dongying Shi Peiming Zhou Guoqiang | | 0，，： | 1 |
| 16 | Synthesis of (R)-cyanohydrins by crude (R)-oxynitrilasecatalyzed reactions in microaqueous medium 显示文摘 | Han Shiqing Lin Guoqiang Li Zuyi | 1998 | Tetrahedron: Asymmetry1998，9，11： | 1 |
| 17 | Crypt Base Columnar Stem Cells in Small Intestines of Mice Are Radioresistant显示文摘 | Guoqiang Hua Tin Htwe Thin Regina Feldman Adriana Haimovitz–Friedman Hans Clevers Zvi Fuks Richard Kolesnick | 2012 | Gastroenterology2012，，5： | 1 |
| 18 | Field study on occupants' thermal comfort and residential thermal environment in a hot-humid climate of China显示文摘 | Han Jie Zhang Guoqiang Zhang Quan | 2007 | Building and Environment2007，42，12： | 1 |
| 19 | Nano-hybrid shish-kebab: Isotactic polypropylene epitaxial growth on electrospun polyamide 66 nanofibers via isothermal crystallization显示文摘 | Yanyan Liang Guoqiang Zheng Wenjuan Han Chuntai Liu Jingbo Chen Qian Li Baochen Liu Changyu Shen Xiangfang Peng | 2010 | Materials Letters2010，，4： | 1 |
| 20 | Synthesis of (R)- cyanohydrins by crude (R)-oxynitrilasecatalyzed reactions in micro-aqueous medium显示文摘 | Shiqing Han Guoqiang Lin Zuyi Li | 1998 | Tetrahedron: Asymmetry1998，9，11： | 1 |
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