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| 1 | 国际水产品市场法规新趋势——欧盟TraceFish计划显示文摘 | 刘俊荣 Gurún ■afsdóttir | 2005 | 水产科学2005，24，4： | 14 |
| 2 | A long-form α-neurotoxin from cobra venom produces potent opioid-independent analgesia显示文摘Aim:In light of the antinociceptive activity of the short-chain neurotoxin,cobrotoxin,and other acetylcholine antagonists,the antinociceptive activity andmechanisms of cobratoxin(CTX),a long-chain postsynaptic α-neurotoxin,wasinvestigated in rodent pain models.Methods:CTX was administered intraperito-neally(30,45,68 μg/kg),intra-cerebral ventricularly(4.5 μg/kg)or microinjectedinto periaqueductal gray(PAG;4.5 μg/kg).The antinociceptive action was testedusing the hot-plate and acetic acid writhing tests m mice and rats.The involve-ment of the cholinergic system and opioid system in CTX-induced analgesia wasexamined by pretreatment of animals with atropine(0.5 mg/kg,im;or 10 mg/kg,ip)or naloxone(1 and 5 mg/kg,ip).The effect of CTX on motor activity was testedusing the Animex test.Results:CTX exhibited a dose-dependent analgesic ac-tion in mice as determined by both the hot-plate and acetic acid writhing tests.The peak effect of analgesia was seen 3 h after administration.In the mouse aceticacid writhing test,the intra-cerebral ventricular administration of CTX at 4.5 μg/kg(1/12th of a systemic dose)produced marked analgesic effects.Microinjection ofCTX(4.5 μgkg)into the PAG region did not elicit an analgesic action in rats in thehot-plate test.Atropine at 0.5 mg/kg(im)and naloxone at 1 and 5 mg/kg(ip)bothfailed to block the analgesic effects of CTX,but atropine at 10 mg/kg(ip)didantagonize the analgesia mediated by CTX in the mouse acetic acid writhing test.Acetylsalicylic acid(300 mg/kg)did not enhance the analgesic effects of CTX.Atthe highest effective dose of 68 μg/kg the neurotoxin did not change the sponta-neous mobility of mice.Conclusion:CTX has analgesic effects,which are medi-ated in the central nervous system though not through the PAG.The centralcholinergic system but not opioid system appears to be involved in theantinociceptive action of CTX. | Zhi-xin CHEN Hui-ling ZHANG Zhen-lun GU Bo-wen CHEN Rong HAN Paul F REID Laurence N RAYMOND Zheng-hong QIN | 2006 | Acta Pharmacologica Sinica2006，27，4： | 7 |
| 3 | 小胶质细胞介导的神经元周围网络降解促进疼痛显示文摘周围神经损伤后脊髓背角小胶质细胞激活促进疼痛敏化产生。活化的小胶质细胞如何选择性地增强脊髓伤害性感受通路的机制目前尚不清楚。该研究发现在周围神经损伤后,小胶质细胞降解脊髓背角I层细胞外基质结构以及神经元周围网络(PNNs)。位于脊髓背角I层的PNNs选择性地包裹脊髓-臂旁核投射神经元,整合脊髓伤害性感受信息,并向脊髓上脑区传递并诱发疼痛感觉。小胶质细胞对PNNs的降解增强了投射神经元的活动并诱导疼痛相关行为。因此,神经损伤诱导的PNNs降解是小胶质细胞选择性地增加脊髓伤害性感受通路信号输出并引起疼痛敏化的一种机制。 | 袁宝童(译) 高永静(校) Tansley S Gu N Guzman AU | 2022 | 中国疼痛医学杂志2022，28，10： | 3 |
| 4 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 5 | Computational simulation of metal droplet break-up, cooling and solidification during gas atomisation显示文摘 | ZEOLI N GU S | 2008 | Computational Materials Science2008，43，2： | 1 |
| 6 | Activation of the subventricular zone in multiple sclerosis, evidence for early glial progenitors显示文摘 | Nait-Oumesmar B Picard-Riera N Kerninon C Decker L Sell- bean D H~glinger GU | 2007 | Proc Natl Acad Sci U S A2007，104，46： | 1 |
| 7 | Noninvasive positive pressure ventilation via face mask firsfline intervention in patients with acute hypercapnic respiratory failure 显示文摘 | Meduri GU Turner RE Abou-shala N | 1996 | Chest1996，109，1： | 1 |
| 8 | The alphaVbeta6 integrin regulates its own expression with cell crowding: implications for tumour progres- sion显示文摘 | Niu J Gu X Ahmed N | 2001 | Int J Cancer2001，92，： | 1 |
| 9 | Study on detection sim- plification of tomographic gamma scanning using dy- namic grids applied in the emission reconstruction 显示文摘 | Gu W Liu C Qian N | 2013 | Annals of Nuclear Ener:u2013，58，： | 1 |
| 10 | Biosynthesis of an antifungal oligopeptide in Burkholderia contaminans strain MS14显示文摘 | Gu G Smith L Wang N | 2009 | Biochemical and Biophysical Research Communications2009，380，： | 1 |
| 11 | Glutathione monoethyl ester improves functional recovery,enhances neuron survival,and stabilizes spinal cord blood flow after spinal cord injury in rats显示文摘 | Guízar-Sahagún G Ibar ra A Espitia A | 2005 | Neuroscience2005，130，3： | 1 |
| 12 | Prevalence, isolation, and partial sequence analysis of hepatitis E virus from domestic animals in China 显示文摘 | Wang Y C Zhang H Y Xia N S Peng G Lan H Y Zhuang H Zhu Y H Li S W Tian K G Gu W J Lin W J Wu J X Li X Harrison T J | 2002 | Journal of Medical Virology2002，67，4： | 1 |
| 13 | Clinical features of cases of influenza A (H1N1)virus in Osaka prefecture,Japan,May 2009显示文摘 | Komiya N Gu Y Kamiya H | 2009 | Euro Surveill2009，14，19： | 1 |
| 14 | Clinical and expefittmntal study on the long-term effect of dietary gamrna-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production显示文摘 | GU/VERNAU M MEZA N BARIA P | 1994 | Prostaglandins Leukot Essent Fatty Acids1994，51，5： | 1 |
| 15 | In vitro corrosion and biocompatibility of binary magnesium alloys显示文摘 | Gu X N Zheng Y F Cheng Y | 2009 | Biomaterials2009，30，4： | 1 |
| 16 | In vitro corrosion and biocompatibility of binary magnesium alloys显示文摘 | Gu X N Zheng Y F Cheng Y | 2009 | Biomaterials2009，30，4： | 1 |
| 17 | Corrosion fatigue behaviors of two biomedical Mg alloys-AZ9ID and WE43-in simulated body f1uid显示文摘 | Gu X N Zhou W R Zheng Y F | 2010 | Acta Biomaterialia2010，6，12： | 1 |
| 18 | Regulation of XIAP translation and induction by MDM2 following irradiation显示文摘 | Gu L Zhu N Zhang H | | 0，，05： | 1 |
| 19 | Silencing oncogene expression in cervical cancer stem-like cells inhibits their cell growth and self-renewal ability显示文摘 | Gu W Yeo E Mc Millan N | 2011 | Cancer Gene Therapy2011，18，12： | 1 |
| 20 | Corrosion resistance and surface biocompatibility of a microarc oxidation coating on a Mg-Ca alloy显示文摘 | GU X N LI N ZHOU W R | 2011 | Acta Biomaterialia2011，，7： | 1 |
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