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| 1 | Climatic Warming and Humidification in the Arid Region of Northwest China: Multi-Scale Characteristics and Impacts on Ecological Vegetation显示文摘The climatic warming and humidification observed in the arid region of Northwest China(ARNC) and their impacts on the ecological environment have become an issue of concern. The associated multi-scale characteristics and environmental responses are currently poorly understood. Using data from satellite remote sensing, field observations, and the Coupled Model Intercomparison Project phase 6, this paper systematically analyzes the process and scale characteristics of the climatic warming and humidification in the ARNC and their impacts on ecological vegetation. The results show that not only have temperature and precipitation increased significantly in the ARNC over the past 60 years, but the increasing trend of precipitation is also obviously intensifying. The dryness index, which comprehensively considers the effects of precipitation and temperature, has clearly decreased, and the trend in humidification has increased. Spatially, the trend of temperature increase has occurred over the entire region, while 93.4% of the region has experienced an increase in precipitation, suggesting a spatially consistent climatic warming and humidification throughout the ARNC. Long-term trends and interannual changes in temperature and precipitation dominate the changes in climatic warming and humidification. Compared to interannual variations in temperature, the trend change of temperature contributes more to the overall temperature change. However, the contribution of interannual variations in precipitation is greater than that of the precipitation trend to the overall precipitation change. The current climatic warming and humidification generally promote the growth of ecological vegetation. Since the 1980 s,82.4% of the regional vegetation has thrived. The vegetation index has a significant positive correlation with precipitation and temperature. However, it responds more significantly to interannual precipitation variation, although the vegetation response varies significantly under different types of land use. The warming and humidification of the climate in the ARNC are probably related to intensifications of the westerly wind circulation and ascending air motions.They are expected to continue in the future, although the strength of the changes will probably be insufficient to significantly change the basic climate pattern in the ARNC. The results of this study provide helpful information for decision making related to China's 'Belt and Road' development strategies. | Qiang ZHANG Jinhu YANG Wei WANG Pengli MA Guoyang LU Xiaoyun LIU Haipeng YU Feng FANG | 2021 | Journal of Meteorological Research2021，35，1： | 19 |
| 2 | ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer显示文摘The Serine-Glycien-One-Carbon(SGOC)pathway is pivotal in multiple anabolic processes.Expression levels of SGOC genes are deregulated under tumoeigenic condltions,suggesting panicipation of oncogenes in deregulating the SGOC biosynthetic pathway.However,the underlying mechanism remains elusive.Here,we identifed that Interleukin enfiarccer-binding factor 3(ILF3)is overexpressed in primary CRC patient specimens and correlates with poor progroosis.ILF3 is critical in regulating the SGOC pathway by directly regulating the mRNA stability of SGOC genes,thereby increasing SGOC genes expression and facilitating tumor growth.Mehhanktic studies showed that the EGF-MIEK-ERK pathway nnediates ILF3 phosphorylation,which hin ders E3 ligase speckle-type POZ protein(SPOP)-mediated poly-ubiquitination and degradation of ILF3.Sign iftca ntly,combination of SGOC inhibitor and the anti-EGFR monoclonal antibody cetuximab can hinder the growth of patient-derived xenografts that sustain high ERK-ILF3 levels.Taken together,deregutation of ILF3 via the EGF-ERK signaling plays an important role in systemic serine metabolic reprogramming and confers a predilection toward CRC development.Our findings indicate that clinical evaluation of SCOC inhibitor is warranted for CRC patients with ILF3 overexpression. | Kai Li Jian-lin Wu Baifu Qin Zongmin Fan Qin Tang Weisi Lu Haipeng Zhang Fan Xing Manqi Meng Shaomin Zou Wenxia Wei Honglei Chen Jian Cai Huaiming Wang Hui Zhang Jiayue Cai Ling Fang Xiqing Bian Chuangqi Chen Ping Lan Bart Ghesquiere Lekun Fang Mong-Hong Lee | 2020 | Cell Research2020，30，2： | 6 |
| 3 | Safety and survival outcomes of transanal natural orifice specimen extraction using prolapsing technique for patients with middle-to low-rectal cancer显示文摘Objective:The transanal approach to specimen collection,combined with the prolapsing technique,is a wellestablished and minimally invasive surgery for treating rectal cancer.However,reports on outcomes for this approach are sparse.We compared short-and long-term outcomes of conventional laparoscopic surgery(CLS)vs.transanal natural orifice specimen extraction(NOSE)using the prolapsing technique for patients with middle-to low-rectal cancer.Methods:From January 2013 to December 2017,we enrolled consecutive patients with middle-to low-rectal cancer undergoing laparoscopic anterior resection.Totally,50 patients who underwent transanal NOSE using the prolapsing technique were matched with 50 patients who received CLS.Clinical parameters and survival outcomes between the two groups were compared.Results:Estimated blood loss(29.70±29.28 vs.52.80±45.09 mL,P=0.003),time to first flatus(2.50±0.79 vs.2.86±0.76,P=0.022),time to liquid diet(3.62±0.64 vs.4.20±0.76 d,P<0.001),and the need for analgesics(22%vs.48%,P=0.006)were significantly lower for the NOSE group compared to the CLS group.The incidences of overall complications and fecal incontinence were comparable in both groups.After a median follow-up of 44.52 months,the overall local recurrence rate(6%vs.5%,P=0.670),3-year disease-free survival(86.7%vs.88.0%,P=0.945)and 3-year overall survival(95.6%vs.96.0%,P=0.708),were not significantly different.Conclusions:For total laparoscopic rectal resection,transanal NOSE using the prolapsing technique is effective and safe,and associated with less trauma and pain,a faster recovery,and similar survival outcomes compared to CLS. | Zhao Lu Haipeng Chen Mingguang Zhang Xu Guan Zhixun Zhao Zheng Jiang Zheng Liu Zhaoxu Zheng Xishan Wang | 2020 | Chinese Journal of Cancer Research2020，32，5： | 6 |
| 4 | Changes of Extreme Precipitation and its Associated Mechanisms in Northwest China显示文摘Characterized by scarce water resources and fragile ecosystems,Northwest China(NWC)has experienced a climate shift from warm-dry to warm-wet conditions since the 1980s that has garnered extensive concern in recent years.In this study,the variability in extreme precipitation(EP)during 1961-2016 in different climate zones of NWC and the possible mechanisms for this variation are investigated.The results show that the EP trends significantly increased in most of the westerly zone(WZ)and plateau zone(PZ),while the EP trends did not significantly decrease in the monsoon zone(MZ).The start dates of extreme precipitation(SDEP)and end dates of extreme precipitation(EDEP)advanced and were postponed,respectively,in the WZ and PZ,while the opposite occurred in the MZ.Summer atmospheric circulation,water vapor transport,and atmospheric instability over NWC varied greatly with the interdecadal shift in EP before and after 1986.During 1986-2016,upper-level divergence and lower-level convergence occurred in the MZ and PZ,which strengthened ascending flow.In addition,the summer water vapor and atmospheric instability increased in the WZ and PZ.These characteristics created favorable conditions for increased occurrences of EP in the WZ and PZ in summer.Conversely,the upper-level convergence and lower-level divergence in the MZ strengthened descending flow.Decreases in summer water vapor and atmospheric instability occurred in the MZ after 1986.Hence,the environmental conditions in the MZ may have prevented the occurrence and development of EP in summer during 1986-2016. | Shan LU Zeyong HU Haipeng YU Weiwei FAN Chunwei FU Di WU | 2021 | Advances in Atmospheric Sciences2021，38，10： | 4 |
| 5 | Sentinel-1 EW mode dataset for Antarctica from 2014–2020 produced by the CASEarth Cloud Service Platform显示文摘Antarctica plays an important role in research on global change,and its unique geography,ocean,climate,and environment pro-vide an ideal place for humankind to understand Earth’s evolution.Remote sensing provides an effective means to monitor and observe large-scale processes on the continent.Synthetic aperture radar(SAR)in particular provides the capability for all-weather Earth observation.The Sentinel-1A and Sentinel-1B SAR satellites have ideal ground coverage and imaging frequency for observing Antarctica.This study developed a dataset of 69,586 Sentinel-1 EW mode satellite images of the Antarctic ice sheet from October 2014 to December 2020.The dataset was processed with the European Space Agency Sentinel Application Platform(SNAP)and a Python batch scheduling tool on the Big Earth Data Cloud Service Platform of the Chinese Academy of Sciences Big Earth Data Science Engineering Program(CASEarth).Several data processing operations were implemented to process the raw dataset,including radiometric calibration,invalid edge removal,geocoding,data reprojection to an Antarctic projection,data compression to TIFF format,and construction of image pyramids.The dataset is avail-able at http://gffzza4c772bdab62464fhx5kfbvqcvnfk6npc.ffgz.tsg.suse.edu.cn/10.11922/sciencedb.j00076.00085. | Dong Liang Huadong Guo Lu Zhang Haipeng Lia Xuezhi Wang | 2022 | Big Earth Data2022，6，4： | 3 |
| 6 | Phase-selection and metastable phase formation in highly undercooled eutectic Ni_(78.6)Si_(21.4)alloys显示文摘在冷却下面大的 A (250 K ) 在最容易溶解的 Ni 78.6 Si 21.4 由熔融眼镜的 denucleation 并且周期的过热的联合融化。在在凉下来的最容易溶解的 Ni 78.6 Si 21.4 融化被调查。随增加在冷却下面,在最容易溶解的 Ni 78.6 Si 21.4 融化并且这些亚稳的阶段的部分能在房间温度被保留通过慢团结以后。在下面在冷却,亚稳的阶段 b2-Ni3Si, Ni31Si12 和 Ni3Si2 下面大被识别。特别, Ni3Si2 阶段在最容易溶解的 Ni 78.6 Si 21.4 合金第一次。基于最小的免费精力和短暂 uncleation 理论的原则,团结行为融化关于亚稳的阶段形成被分析 melts 什么时候高度在在下面,使状态凉下来。 | LU Yiping YANG Gencang YANG Changlin WANG Haipeng ZHOU Yaohe | 2006 | Progress in Natural Science:Materials International2006，16，3： | 3 |
| 7 | Composition,Microstructure,Phase Constitution and Fundamental Physicochemical Properties of Low-Melting-Point Multi-Component Eutectic Alloys显示文摘Low-melting-point alloys have an extensive applications in the fields of materials processing, phase change energy storage, electronic and electrical automatic control, continuous casting simulation, welding, etc.Specifically, the eutectic compositions make up a large number of low-melting-point alloys that are exploited because of their desirable features like single melting peaks, excellent operational reliability, and casting fluidity. However, the fundamental physicochemical properties from the current available literature on low-melting-point multi-component eutectic alloys(LMP-MCEAs) are rather rare and lowly accurate, including the exact melting temperatures and compositions, constituent phases, microstructures and morphologies, melting enthalpies, specific heats, densities, and so on. This lack of information seriously limits the development and application of low-melting-point multi-component eutectic alloys.In this paper, the low-melting-point multi-component eutectic alloys composed of Bi, Cd, Sn, Pb, and In elements synthesized by high vacuum induction melting and fundamental data were investigated by scanning electron microscopy(SEM), energy dispersive spectrometry(EDS), X-ray diffraction(XRD), differential scanning calorimetry(DSC), and density analysis instrument. Most of the LMP-MCEAs with complex eutectic morphology structures and XRD diffraction patterns could be explained with the fact that they were three-phase eutectic alloys with mixed growth way. Generally, LMP-MCEAs present an extremely low melting point between 48.3 and 124 °C and high density between 8 and 10 g/cm3. | Kaiyao Zhou Zhongyi Tang Yiping Lu Tongmin Wang Haipeng Wang Tingju Li | 2017 | Journal of Materials Science & Technology2017，33，2： | 3 |
| 8 | Low Cost and Reusability of Launch Vehicle显示文摘This paper analyzes the launch price of the launch vehicles, domestic and abroad, studies the status and trend of the low cost launch vehicles, and introduces two measures to reduce the cost by means of evolved and disruptive technologies, utilizing the concept of low cost manufacturing and operating modes as well. This paper also analyzes the launch strategies for small satellites such as piggyback, networking launch, and single launch with a small launch vehicle(SLV). Finally, the development trend of reusable launch vehicles is discussed as well as the development prospects for China's reusable launch vehicle. | LU Yu QIN Xudong CHEN Haipeng | 2016 | Aerospace China2016，17，2： | 2 |
| 9 | A Model for Agglomeration in Bio-fuel Fired Fluidized Bed显示文摘A mathematical model has been developed to describe the agglomeration process in bio-fuel fired fluidized bed combustor.Based on the balance mechanism of the adhesive force caused by liquid bonding between two particles and the breaking force induced by bubbles in the fluidized bed,the model considers modified Urbain model and chemical equilibrium calculations using FactSage modeling.This model prediction accounts for the evolvement of the adhesive and breaking forces,and clearly demonstrates that the different composition of ash,the increasing liquid phase matter and the fluidization velocity cause defluidization in fluidized bed.In this model,it is the first time to hypothesize that the bonding stress between two particles is proportional to mass fraction of liquid phase and inversely proportional to the diameter of particles and viscosity of liquid phase.The defluidization time calculated by this model shows good agreement with that from the experimental data. | Shiyuan Li Linlin Shang Haipeng Teng Qinggang Lu | 2010 | Journal of Thermal Science2010，19，5： | 2 |
| 10 | Optimization of Out-of-Plane Vibration Energy Harvesters Employing Electret显示文摘This paper investigated the dependence of out-of-plane electret-based vibration energy harvesters’output power,frequency bandwidth,and resonance frequency on surface charge density and load resistance.As the external acceleration amplitude and electret size were held constant,the following results are predicted by the numerical investigation:(1)An optimum value exists in the surface charge density to maximize the output power.As the surface charge density is increasing,electrostatic forces are enhanced,which emphasizes that the soft spring effect widens the frequency bandwidth and lowers the resonance frequency.(2)Different surface charge densities correspond to different optimum initial air gaps,resonance frequency,and optimum load resistance.(3)With the attenuation of the surface potential,the output power,frequency drift,and frequency bandwidth decreased.(4)An optimum value exists in the load resistance to maximize the output power.As the load resistance is decreasing,electrostatic force is enhanced,which lowers the resonance frequency.(5)A maximum frequency bandwidth exists with further load resistance increasing,and the initial air gap is smaller,the greater the frequency bandwidth. | Chunhui Gao Shiqiao Gao Haipeng Liu Lei Jin Junhu Lu | 2017 | Journal of Beijing Institute of Technology2017，26，3： | 1 |
| 11 | Composite aerogels based on dialdehyde nanocellulose and collagen for potential applications as wound dressing and tissue engineering scaffold显示文摘 | Tianhong Lu Qing Li Wenshuai Chen Haipeng Yu | 2014 | Composites Science and Technology2014，，： | 1 |
| 12 | 查看详情显示文摘 | Wu Mengqiang Zhang Qiyi Lu Haipeng Chen Ai | | 0，，： | 1 |
| 13 | Nanocrystalline orthorhombic LiMnO2 cathode materials synthesized by a two-step liquid-phase thermal process显示文摘 | Wu Mengqiang Zhang Qiyi Lu Haipeng | 2004 | Solid State Ionics2004，2004，169： | 1 |
| 14 | A numerical study on the axial crushing response of hybrid puhruded and ±45° braided tubes 显示文摘 | Han Haipeng Taheri Farid Pegg Neil Lu You | 2007 | Composite Structures2007，80，2： | 1 |
| 15 | Effects of landscape structure, habitat and human disturbance on birds: A case study in East Dongting Lake wetland显示文摘 | Yujie Yuan Guangming Zeng Jie Liang Xiaodong Li Zhongwu Li Chang Zhang Lu Huang Xu Lai Lunhui Lu Haipeng Wu Xun Yu | 2014 | Ecological Engineering2014，，： | 1 |
| 16 | Identification of a Proteus penneri isolate as the causal agent of red body disease of the cul- tured white shrimp Penaeus vannamei and its control with Bdellov- ibrio baeteriovorus显示文摘 | Cao Haipeng He Shan Lu Liqun | 2014 | Antonie van Leeuwenhoek2014，105，3： | 1 |
| 17 | Engineering organoid microfluidic system for biomedical and health engineering:A review显示文摘In recent years,organoid technology,i.e.,in vitro three-dimensional(3D)tissue culture,has attracted increasing attention in biomedical engineering.Organoids are cell complexes induced by differentiation of stem cells or organ-progenitor cells in vitro using 3D culture technology.They can replicate the key structural and functional characteristics of the target organs in vivo.With the opening up of this new field of health engineering,there is a need for engineering-system approaches to the production,control,and quantitative analysis of organoids and their microenvironment.Traditional organoid technology has limitations,including lack of physical and chemical microenvironment control,high heterogeneity,complex manual operation,imperfect nutritional supply system,and lack of feasible online analytical technology for the organoids.The introduction of microfluidic chip technology into organoids has overcome many of these limitations and greatly expanded the scope of applications.Engineering organoid microfluidic system has become an interdisciplinary field in biomedical and health engineering.In this review,we summarize the development and culture system of organoids,discuss how microfluidic technology has been used to solve the main technical challenges in organoid research and development,and point out new opportunities and prospects for applications of organoid microfluidic system in drug development and screening,food safety,precision medicine,and other biomedical and health engineering fields. | Yifan Xing Junyu Liu Xiaojie Guo Haipeng Liu Wen Zeng Yi Wang Chong Zhang Yuan Lu Dong He Shaohua Ma Yonghong He Xin-Hui Xing | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 1 |
| 18 | On Feedback Control of Delayed Chaotic System显示文摘 | Li Lixiang Peng Haipeng Lu Huibin | 2001 | Chinese Physics2001，10，9： | 1 |
| 19 | C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment显示文摘The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell death.Cell free-double strand DNA(dsDNA)segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic GMP-AMP synthase(cGAS),which triggers robust activation of the innate immune stimulator of interferon genes(STING)pathway and initiate the chronic inflammatory cascade.The decomposition of immunogenic dsDNA and inhibition of the innate immune STING are synergistic immunologic targets for ameliorating neuroinflammation.To combine the anti-inflammatory strategies of STING inhibition and dsDNA elimination,we constructed a DNase-mimetic artificial enzyme loaded with C-176.Nanoparticles are self-assembled by amphiphilic copolymers(P[CL35-b-(OEGMA20.7-co-NTAMA14.3)]),C-176,and Ce^(4+)which is coordinated with nitrilotriacetic acid(NTA)group to form corresponding catalytic structures.Our work developed a new nano-drug that balances the cGAS-STING axis to enhance the therapeutic impact of stroke by combining the DNase-memetic Ce^(4+)enzyme and STING inhibitor synergistically.In conclusion,it is a novel approach to modulating central nervus system(CNS)inflammatory signaling pathways and improving stroke prognosis. | Zhixin Zhu Haipeng Lu Lulu Jin Yong Gao Zhefeng Qian Pan Lu Weijun Tong Pik Kwan Lo Zhengwei Mao Haifei Shi | 2023 | Bioactive Materials2023，，11： | 1 |
| 20 | cAMP-PGC1α途径诱导的抗Warburg效应驱动胶质母细胞瘤细胞分化为星形胶质细胞显示文摘文章简介多形性胶质母细胞瘤(GBM)是人类最具侵袭性的肿瘤之一。虽然分化治疗已被提出作为治疗GBM的潜在方法,但诱导分化的机制仍然很不清楚。在此,课题组利用c AMP激活剂建立了GBM诱导分化模型,该模型特异性地指导GBM分化为星形胶质细胞。 | Fan Xing Yizhao Luan Jing Cai Sihan Wu Jialuo Mai Jiayu Gu Haipeng Zhang Kai Li Yuan Lin Xiao Xiao Jiankai Liang Yuan Li Wenli Chen Yaqian Tan Longxiang Sheng Bingzheng Lu Wanjun Lu Mingshi Gao Pengxin Qiu Xingwen Su Wei Yin Jun Hu Zhongping Chen Ke Sai Jing Wang Furong Chen Yinsheng Chen Shida Zhu Dongbing Liu Shiyuan Cheng 谢志 朱文博 颜光美 | 2018 | 科学新闻2018，0，4： | 1 |
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