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| 1 | Exercise as a prescription for patients with various diseases显示文摘A growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy.Because each sport has its own set of characteristics and physiological complications that tend to occur during exercise training,the effects and underlying mechanisms of exercise remain unclear.Thus,the first step in probing the effects of exercise on different diseases is the selection of an optimal exercise protocol.This review summarizes the latest exercise prescription treatments for 26 different diseases:musculoskeletal system diseases(low back pain,tendon injury,osteoporosis,osteoarthritis,and hip fracture),metabolic system diseases(obesity,type 2 diabetes,type 1 diabetes,and nonalcoholic fatty liver disease),cardio-cerebral vascular system diseases(coronary artery disease,stroke,and chronic heart failure),nervous system diseases(Parkinson’s disease,Huntington’s disease,Alzheimer’s disease,depression,and anxiety disorders),respiratory system diseases(chronic obstructive pulmonary disease,interstitial lung disease,and after lung transplantation),urinary system diseases(chronic kidney disease and after kidney transplantation),and cancers(breast cancer,colon cancer,prostate cancer,and lung cancer).Each exercise prescription is displayed in a corresponding table.The recommended type,intensity,and frequency of exercise prescriptions are summarized,and the effects of exercise therapy on the prevention and rehabilitation of different diseases are discussed. | Xin Luan Xiangyang Tian Haixin Zhang Rui Huang Na Li Peijie Chen Ru Wang | 2019 | Journal of Sport and Health Science2019，8，5： | 61 |
| 2 | Trend of declining stroke mortality in China:reasons and analysis显示文摘Introduction There is a downward trend of stroke-related mortality in the USA.By reviewing all published articles on stroke mortality in China,we analysed its trend and possible factors that have influenced the trend.Methods Both English and Chinese literatures were searched on the mortality of stroke or cerebrovascular diseases in China.Potential papers related to this topic were identified from PubMed,Medline,Embase,Cochrane Library,Wanfang Database,SINOMED and China National Knowledge Infrastructure databases.Results Comparing the results from the most recent population-based epidemiological survey and databank from the national Center for Disease Control and Prevention,the age-adjusted stroke mortality rate has shown a downward trend among both urban and rural population in the past 30 years in China.Comparing with 30 years ago,the rate of stroke mortality has decreased by more than 31%in urban/suburban population and 11%in rural population.In men,the age-adjusted stroke mortality rate decreased by 18.9%and in women by 24.9%between 1994 and 2013.Factors that may have contributed to the trend of decreased stroke mortality rate include(1)improved healthcare coverage and healthcare environment;(2)improved treatment options and medical technology;(3)support by government to educate the public on stroke and stroke prevention;and(4)improved public knowledge on stroke.Conclusions The age-adjusted stroke mortality rate in China has shown a downward trend among both urban and rural population in the past 30 years.The major influencing factors that helped in reducing stroke mortality in China included improved healthcare coverage,healthcare environment,the updated treatment options and modern medical technology. | Wenzhi Wang David Wang Hongmei Liu Haixin Sun Bin Jiang Xiaojuan Ru Dongling Sun Zhenghong Chen Yongjun Wang | 2017 | Stroke & Vascular Neurology2017，2，3： | 52 |
| 3 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 4 | Drag prediction method of powered-on civil aircraft based on thrust drag bookkeeping显示文摘A drag prediction method based on thrust drag bookkeeping(TDB) is introduced for civil jet propulsion/airframe integration performance analysis.The method is derived from the control volume theory of a powered-on nacelle.Key problem of the TDB is identified to be accurate prediction of velocity coefficient of the powered-on nacelle.Accuracy of CFD solver is validated by test cases of the first AIAA Propulsion Aerodynamics Workshop.Then the TDB method is applied to thrust and drag decomposing of a realistic aircraft.A linear relation between the computations assumed free stream Mach number and the velocity coefficient result is revealed.The thrust losses caused by nozzle internal drag and pylon scrubbing are obtained by the isolated nacelle and mapped on to the in-flight whole configuration analysis.Effects of the powered-on condition are investigated by comparing through-flow configuration with powered-on configuration.The variance on aerodynamic coefficients and pressure distribution is numerically studied. | Zhang Yufei Chen Haixin Fu Song Zhang Miao Zhang Meihong | 2015 | Chinese Journal of Aeronautics2015，28，4： | 11 |
| 5 | Prediction of separation flows around a 6:1 prolate spheroid using RANS/LES hybrid approaches显示文摘这篇论文论述混合平均 Reynolds 的 Navier 司烧(RANS ) 并且为在在 6:1 附近的攻击的高角度的分开的流动的 large-eddy-simulation (LES ) 方法延长球状体。在这个工作学习的 RANS/LES 混合方法基于 Spalart Allmaras ( S A )包括分开的旋涡模拟( DES ), Menter 的 k ω
shear-stress-transport ( SST )和有弱非线性的旋涡粘性明确的表达的 k ω
(威尔科克斯Durbin+,WD+)模型和 zonal-RANS/LES 方法基于 SST 和WD+模型。从到在核心流动区域的 LES 的墙附近的 RANS 的开关通过为带的混合方法混合功能的一个流动依赖者的实现是光滑的。所有混合方法被设计为依附的流动有一个 RANS 模式并且为分开的流动有 LES 行为。这篇论文的主要目的是使用混合方法因为高级雷纳兹数字在延长球状体附近分开了流动在高发生。有第四顺序的人工的粘性的一个第四顺序的中央计划被申请空间 differencing。充分含蓄更低上面对称 -- 有假时间亚重复的高斯 Seidel 作为时间的区别被拿。有可得到的大小的比较为速度的压力分发,皮肤磨擦,和侧面被执行,等等。对实验的合理同意,为格子和基本骚乱上的效果的财务当模特儿,为分离流动被获得。 | Zhixiang Xiao Yufei Zhang Jingbo Huang Haixin Chen Song Fu School of Aerospace Engineering,Tsinghua University,Beijing 100084,China | 2007 | Acta Mechanica Sinica2007，23，4： | 10 |
| 6 | Carrier frequency offset and impulse noise estimation for underwater acoustic orthogonal frequency division multiplexing显示文摘The carrier frequency offset(CFO)and impulse noise always affect the performance of underwater acoustic communication_systems.The CFO and impulse noise could be estimated by using the null subcarriers to cancel the effects of the two types of interference.The null subcarriers estimation methods include optimal separate estimation and joint estimation.The separate estimation firstly estimates the CFO value and then estimates the impulse noise value.However,the CFO and impulse noise always affect each other when either of them is estimated separately.The performance could be improved by using the joint estimation.The results of simulations and experiments have showed that these two optimization methods have good performance and the joint estimation has better performance than the separate estimation method.There is 3 dB performance gain at the BER value of 10^(-2)when using the joint estimation method.Thus these methods could improve the system robustness by using the CFO compensation and impulse noise suppression. | SUN Haixin XU Xiaoka MA Li KUAI Xiaoyan CHENG En CHEN En | 2014 | Chinese Journal of Acoustics2014，33，3： | 8 |
| 7 | An analysis of the Circumferential Grooves Casing Treatment for transonic compressor flow显示文摘The stall mechanism of the NASA Rotor 37 is investigated through the analysis of the critical flow structures near the stall under the transonic condition. The performance of the rotor with Circumferential Grooves Casing Treatment (CGCT) is also studied based on the Reynolds-Averaging Navier-Stokes approach. The study finds that stall margin improvement can be achieved without significant penalty on the efficiency for the two CGCT configurations applied. The effects of circumferential grooves on the critical flow structures are studied through the analysis of the tip leakage mass and momentum transport that further re-veal the CGCT mechanism. | HUANG XuDong,CHEN HaiXin,SHI Ke & FU Song School of Aerospace,Tsinghua University,Beijing 100084,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，2： | 7 |
| 8 | A Karman-Vortex Generator for passive separation control in a conical diffuser显示文摘Flow separation in a conical diffuser with large divergence angle(29.14°) and large area ratio(3.533) is eliminated by a novel passive flow control device called Karman-Vortex Generator(KVG).The effect of the KVG is verified and investigated by the URANS,DES and DDES methods based on the SST model.CFD results show that the performance coefficient of the diffuser can be doubled by the KVG,and the total pressure recovery coefficient can be improved by about 1.2%.DES and DDES results show that the KVG can introduce a Karman-vortex street frequency in the diffuser.This frequency decays rapidly,and could not be detected in the ending plane of the expansion section.Different KVG configurations with different locations and dimensions are numerically simulated and compared.Some suggestions are provided. | ZHANG YuFei CHEN HaiXin FU Song | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，5： | 7 |
| 9 | Pressure distribution guided supercritical wing optimization显示文摘Pressure distribution is important information for engineers during an aerodynamic design process. Pressure Distribution Oriented(PDO) optimization design has been proposed to introduce pressure distribution manipulation into traditional performance dominated optimization.In previous PDO approaches, constraints or manual manipulation have been used to obtain a desirable pressure distribution. In the present paper, a new Pressure Distribution Guided(PDG) method is developed to enable better pressure distribution manipulation while maintaining optimization efficiency. Based on the RBF-Assisted Differential Evolution(RADE) algorithm, a surrogate model is built for target pressure distribution features. By introducing individuals suggested by suboptimization on the surrogate model into the population, the direction of optimal searching can be guided. Pressure distribution expectation and aerodynamic performance improvement can be achieved at the same time. The improvements of the PDG method are illustrated by comparing its design results and efficiency on airfoil optimization test cases with those obtained using other methods. Then the PDG method is applied on a dual-aisle airplane's inner-board wing design. A total drag reduction of 8 drag counts is achieved. | Runze LI Kaiwen DENG Yufei ZHANG Haixin CHEN | 2018 | Chinese Journal of Aeronautics2018，31，9： | 5 |
| 10 | Optimization design of airfoils under atmospheric icing conditions for UAV显示文摘Natural ice accretion on the lifting surface of an aircraft is detrimental to its aerodynamic performance, as it changes the effective streamlined body. The main focus of this work considers the optimization design of airfoils under atmospheric icing conditions for the Unmanned Aerial Vehicle(UAV). The ice formation process is simulated by the Eulerian approach and the three-dimensional Myers model. A three-equation turbulence model is implemented to accurately predict the stall performance of the iced airfoil. In recognition of the real atmospheric variability in the icing parameters, the medium volume diameter of supercooled water droplets is treated as an uncertainty with an assumed probability density function. A technique of polynomial chaos expansion is used to propagate the input uncertainty through the deterministic system. The numerical results show that the multipoint/multiobjective optimization strategy can efficiently improve both the ice tolerance and the cruise performance of an airfoil. The reason for the focus on robust optimization is that the ice angle of the optimized airfoil becomes less critical to the incoming flow.The optimized airfoils are applied to a UAV platform, in which the performance improvement and the relevant key flow feature are both preserved. | Haoran LI Yufei ZHANG Haixin CHEN | 2022 | Chinese Journal of Aeronautics2022，35，4： | 4 |
| 11 | Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population显示文摘Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10^(-7), and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10^(-8), including 4 previously reported loci: rs145063132(7 p21.2, ETV1/DGKB), rs548030386(7 q31.2, ST7 near CAV1/CAV2), rs7047871(9 p24.2, GLIS3), and rs2472494(9 q31.1, ABCA1/SLC44 A1). Of the 17 newly identified loci, five were reported to have ocular related phenotypes: PTCH2(rs7525308 in 1 p34.1), LRIF1/DRAM2(rs1282146 in 1 p13.3), COLEC11(rs201143466 in 2 p25.3),SPTBN1(rs4514918 in 2 p16.2), and CRK(rs11078446 in 17 p13.3). The genetic loci identified in this study not only increase our understanding of the genes involved in intraocular pressure but also provide important genetic markers to improve future genetic screening and drug discovery for intraocular pressure disorders. | Lulin Huang Yuhong Chen Ying Lin Pancy O.S.Tam Yilian Cheng Yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang Yi Yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao Dean-Yao Lee Chi-Pui Pang Xinghuai Sun Zhenglin Yang | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 12 | Involvement of acid-sensing ion channel 1a in gastric carcinoma cell migration and invasion显示文摘酸的微型环境,特别地酸察觉到的离子隧道 1a (ASIC1a ) ,被报导了象移植一样支持癌房间增长。在这研究,我们在胃的癌(GC ) 的移植和侵略上探索了 ASIC1a 的效果。ASIC1a 表示层次被 immunohistochemistry 从 16 个病人在配对的 GC 和邻近的正常纸巾检验。反向的抄写即时 PCR 和 immunoblotting 被进行与 ASIC1a 小发卡 RNA (shRNA ) 在 transfection 以后在 GC 房间线 AGS 估计 ASIC1a 表示层次。创伤愈合和 transwell 侵略试金被利用检测转移和侵略追随者 ASIC1a silencing。肿瘤形成被用来在 vivo 在 tumorigenicity 检测 ASIC1a 的角色。ASIC1a 表示水平在与非转移相比显示出手术后的转移的 GC 纸巾和非肿瘤纸巾是显著地更高的,这被发现。而且,有 shRNA 的 ASIC1a 的 silencing 显著地下面调整的 ASIC1a 表示和减少的 GC 房间移植和侵略。中等酸的细胞外的环境禁止了 GC 房间生存能力。而且, ASIC1a shRNA 在 vivo 引起了 tumorigenicity 的抑制。我们的学习是 attenuating 的第一份报告在 vitro 并且在由压制 ASIC1a 的 vivo 的 GC 的恶意的显型,并且建议一条新奇途径学习在 ASIC 和 GC 房间移植和侵略之间的关系。 | Xin Chen Xue Sun Zhe Wang Xiaojun Zhou Lu Xu Feng'e Li Xingding Zhang Ji'an Pan Lin Qi Haixin Qian Zhongqi Mao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 3 |
| 13 | Numerical study of a supercritical airfoil/wing with variable-camber technology显示文摘Variable-camber technology is considered an effective way to adaptively improve the aerodynamic performance of aircraft under various flight conditions.This paper studies the aerodynamic characteristics of the trailing-edge variable-camber technology by means of Computational Fluid Dynamics(CFD)and a drag decomposition method.Trailing-edge variable-camber technology can be simply realized by the continuous deflection of the flaps and ailerons of a wing.A supercritical airfoil is used to study the two-dimensional effect of variable-camber technology,and a wide-body airplane model is used to validate the three-dimensional improvement in the wing’s airfoil made by variable-camber technology.An optimization strategy for airfoil that incorporates variable-camber technology is proposed.The optimization results demonstrate that the proposed method can obtain better results than the traditional segregated shape optimization. | Wei NIU Yufei ZHANG Haixin CHEN Miao ZHANG | 2020 | Chinese Journal of Aeronautics2020，33，7： | 3 |
| 14 | Hetero-nanostructure of silver nanoparticles on MO_x(M=Mo,Ti and Si) and their applications显示文摘This paper reviews the recent research progress in the hetero-nanostructure of silver nanoparticles on MOx (M=Mo, Ti and Si). It describes the general synthesis of hetero-nanostructure of silver nanoparticles on MOx, and then outlines the interesting catalytic and sensing properties found in these hetero-nanostructures of silver nanoparticles on MOx. | DONG WenJun ZHAO HaiXin LI ChaoRong MEI Jie CHEN BeYong TANG WeiHua SHI Zhan FENG ShouHua | 2011 | Science China Chemistry2011，54，6： | 3 |
| 15 | Navier-Stokes simulations for transport aircraft wing-bodycombinations with deployed high-lift systems显示文摘 | CHEN Haixin | 2003 | Journal of Aircraft2003，5，： | 1 |
| 16 | Numerical investigation of the casing treatment mechanism with a single circumferential groove显示文摘The paper investigates the effect of a single circumferential groove casing treatment(CGCT) on a transonic compressor rotor numerically.In particular,the effect of the groove at different axial locations on the flow field is studied in detail and stall margin improvement is also discussed.The present results show that the groove close to the leading edge plays a crucial role in stabilizing the near stall flow structures and,hence,improves the stall margin.The groove at the mid-chord-section of the blade can help exchange and transfer momentums between different directions,and suppress the flow unsteadiness,leading to increased efficiency in rotor performance and extended operation range.The groove located near the blade trailing edge has limited effects on stall margin improvement and may cause additional penalty in efficiency.Through comparison with the recent work on CGCT,some common flow physics can be observed. | SHI Ke CHEN HaiXin FU Song | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 1 |
| 17 | Living biobank-based cancer organoids: prospects and challenges in cancer research显示文摘Biobanks bridge the gap between basic and translational research.Traditional cancer biobanks typically contain normal and tumor tissues,and matched blood.However,biospecimens in traditional biobanks are usually nonrenewable.In recent years,increased interest has focused on establishing living biobanks,including organoid biobanks,for the collection and storage of viable and functional tissues for long periods of time.The organoid model is based on a 3D in vitro cell culture system,is highly similar to primary tissues and organs in vivo,and can recapitulate the phenotypic and genetic characteristics of target organs.Publications on cancer organoids have recently increased,and many types of cancer organoids have been used for modeling cancer processes,as well as for drug discovery and screening.On the basis of the current research status,more exploration of cancer organoids through technical advancements is required to improve reproducibility and scalability.Moreover,given the natural characteristics of organoids,greater attention must be paid to ethical considerations.Here,we summarize recent advances in cancer organoid biobanking research,encompassing rectal,gastric,pancreatic,breast,and glioblastoma cancers.Living cancer biobanks that contain cancerous tissues and matched organoids with different genetic backgrounds,subtypes,and individualized characteristics will eventually contribute to the understanding of cancer and ultimately facilitate the development of innovative treatments. | Haixin Li Hongkun Liu Kexin Chen | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 18 | Method for searching bridge in IR images显示文摘 | Haixin Chen Zhenkang Shen Jianjun Shen | 1998 | IEEE Aerospace and Electronics Systems Magazine1998，13，7： | 1 |
| 19 | Numerical investigation of fire smoke transport in the tsinghua university sports center ts- inghua显示文摘 | CHEN Jianguo CHEN Haixin FU Song | 2005 | Science and Technology2005，5，： | 1 |
| 20 | Method for searching bridge in IR images显示文摘 | Chen Haixin Shen Zhenkang Shen Jianjun | | 0，，13： | 1 |
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