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| 1 | The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection显示文摘(EV71 ) Entero 病毒 71 引起手,脚,和嘴疾病(HFMD ) 并且偶尔导致严重神经病学的复杂并发症甚至死亡。(SCARB2 ) Scavenger 受体班 B 成员 2 是为 EV71 的功能的受体,调停病毒的附件,成为主观,和 uncoating。然而, SCARB2 上的 EV71 的准确有约束力的地点是未知的。在这研究,我们产生了绑在人然而并非老鼠 SCARB2 的 monoclonal 抗体(mAb ) 。它被称为 JL2,并且它能有效地禁止目标房间的 EV71 感染。用人和老鼠 SCARB2 的一套怪物,我们鉴别包含人的 SCARB2 的残余 77-113 的区域显著地作出贡献到 JL2 绑定。SCARB2-JL2 建筑群的结构表明 JL2 绑在包含 -helices 的 SCARB2 的顶端的区域 2, 5,和 14。我们的结果在 SCARB2 和 EV71 入口的分子的机制上为 EV71 提供新卓见进潜在的有约束力的地点。 | Xuyuan Zhang Pan Yang Nan Wang Jialong Zhang Jingyun Li Hao Guo Xiangyun Yin Zihe Rao Xiangxi wang Liguo Zhang | 2017 | Protein & Cell2017，8，8： | 10 |
| 2 | NanoSIMS analytical technique and its applications in earth sciences显示文摘Despite the significant improvement on spatial resolution,Nano SIMS still preserves relatively high mass resolution,sensitivity,and analytical precision.It has become an important analytical platform to determine chemical compositions of solid materials,and has been widely used in space,earth,life,and materials sciences,etc.By using a Cs+ion beam with a size as small as 50nm scanning over sample surfaces,we are able to obtain high spatial resolution images of up to 7 species simultaneously.When utilizing Faraday cup,high analytical precision of 0.3‰–0.5‰(1SD)for C,O and S isotopic analysis can be achieved.Although this precision level is still lower than that of conventional SIMS,it already meets the major requirements of Earth Sciences.In 2011,the first Nano SIMS of China(Cameca Nano SIMS 50L)was installed at Institute of Geology and Geophysics,Chinese Academy of Sciences.Based on the working mechanism and analytical modes of the instrument,this paper will systematically introduce the analytical methods established with the Nano SIMS and their potential applications in earth sciences.These methods include trace element distribution images in mineral zoning,high spatial resolution(2–5?m)Pb-Pb and U-Pb dating,water content and H isotopic analysis for silicate glass and apatite,C isotopic analysis for diamond and graphite,O isotopic analysis for carbonate,S isotopic analysis for sulfides.In addition,the specific requirements for sample preparation will also be introduced in order to facilitate domestic earth scientists’use. | YANG Wei HU Sen ZHANG JianChao HAO JiaLong LIN YangTing | 2015 | Science China Earth Sciences2015，58，10： | 9 |
| 3 | NanoSIMS imaging method of zircon U-Pb dating显示文摘We report an imaging method of zircon U-Pb dating with NanoSIMS 50 L, which overcomes the significant U-Pb fractionation as the pit was sputtered deeper during conventional spot mode analysis and can be applied to irregular small grains or heterogeneous areas of zircon. The U-Pb and Pb-Pb ages can be acquired simultaneously for 2 μm×2 μm(for small grains) or 1 μm×9 μm(for zoned grains), together with Zr, Y and other trace elements distributions. Using zircon M257 as standard, the U-Pb ages of other zircon standards, including Qinghu, Plesovice, Temora and 91500, were measured to(2σ) as158.8±0.8, 335.9±3.4, 412.0±12 and 1067±12 Ma, respectively, consistent with the recommended values within the analytical uncertainties. Tiny zircon grains in the impact melt breccia of the lunar meteorite SaU 169 were also measured in this study,with a Pb-Pb age of 3912±14 Ma and a U-Pb age of 3917±17 Ma, similar to previous results reported for the same meteorite.The imaging method was also applied to determine U-Pb age of the thin overgrowth rims of Longtan metamorphic zircon, with a Pb-Pb age of 1933±27 Ma and a U-Pb age of 1935±25 Ma, clearly distinct from the Pb-Pb age of 2098±61 Ma and the U-Pb age of 2054±40 Ma for detrital cores. | HU Sen LIN YangTing YANG Wei WANG Wei-(RZ) ZHANG JianChao HAO JiaLong XING WeiFan | 2016 | Science China Earth Sciences2016，59，11： | 2 |
| 4 | Autocatalytic reduction-assisted synthesis of segmented porous PtTe nanochains for enhancing methanol oxidation reaction显示文摘Morphology engineering has been developed as one of the most widely used strategies for improving the performance of electrocatalysts.However,the harsh reaction conditions and cumbersome reaction steps during the nanomaterials synthesis still limit their industrial applications.Herein,one-dimensional(1D)novel-segmented PtTe porous nanochains(PNCs)were successfully synthesized by the template methods assisted by Pt autocatalytic reduction.The PtTe PNCs consist of consecutive mesoporous architectures that provide a large electrochemical surface area(ECSA)and abundant active sites to enhance methanol oxidation reaction(MOR).Furthermore,1D nanostructure as a robust sustaining frame can maintain a high mass/charge transfer rate in a long-term durability test.After 2,000 cyclic voltammetry(CV)cycles,the ECSA value of PtTe PNCs remained as high as 44.47 m^(2)·gPt^(-1),which was much larger than that of commercial Pt/C(3.95 m^(2)·gPt^(-1)).The high catalytic activity and durability of PtTe PNCs are also supported by CO stripping test and density functional theory calculation.This autocatalytic reduction-assisted synthesis provides new insights for designing efficient low-dimensional nanocatalysts. | Qiqi Zhang Tianyu Xia He Huang Jialong Liu Mengyuan Zhu Hao Yu Weifeng Xu Yuping Huo Congli He Shipeng Shen Cong Lu Rongming Wang Shouguo Wang | 2023 | Nano Research Energy2023，2，1： | 1 |
| 5 | Fabrication of C@MoxTi1-xO2-δ nanocrystalline with functionalized interface as efficient and robust PtRu catalyst support for methanol electrooxidation显示文摘A core shell structured C@MoxTi1-xO2-δnanocrystal with a functionalized interface(C@MTNC-FI)was fabricated via the hydrothermal method with subsequent annealing derived from tetrabutyl orthotitanate.The formation of anatase TiO2 was inhibited by the simultaneous presence of the hydrothermal etching/regrowth process,infiltration of Mo dopants and carbon coating,which endows the C@MTNC-FI with an ultrafine crystalline architecture that has a Mo-functionalized interface and carbon-coated shell.Pt Ru nanoparticles(NPs)were supported on C@MTNC-FI by employing a microwave-assisted polyol process(MAPP).The obtained Pt Ru/C@MTNC-FI catalyst has 2.68 times higher mass activity towards methanol electrooxidation than that of the un-functionalized catalyst(Pt Ru/C@TNC)and 1.65 times higher mass activity than that of Pt Ru/C catalyst with over 25%increase in durability.The improved catalytic performance is due to several aspects including ultrafine crystals of TiO2 with abundant grain boundaries,Mofunctionalized interface with enhanced electron interactions,and core shell architecture with excellent electrical transport properties.This work suggests the potential application of an interface-functionalized crystalline material as a sustainable and clean energy solution. | Jialong Li Lei Zhao Xifei Li Sue Hao Zhenbo Wang | 2020 | Journal of Energy Chemistry2020，29，1： | 1 |
| 6 | Disruption of LEAF LESION MIMIC 4 affects ABA synthesis and ROS accumulation in rice显示文摘Lesion mimic mutants(LMMs) are advantageous materials for studying programmed cell death(PCD).Although some rice LMM genes have been cloned, the diversity of functions of these genes indicates that the mechanism of cell death regulation in LMMs needs further study. In this study, we identified a rice light-dependent leaf lesion mimic mutant 4(llm4) that showed abnormal chloroplast structure, photoinhibition, reduced photosynthetic protein levels, massive accumulation of reactive oxygen species(ROS), and PCD. Map-based cloning and complementation testing revealed that LLM4 encodes zeaxanthin epoxidase(ZEP), an enzyme involved in the xanthophyll cycle, which functions in plant photoprotection,ROS scavenging, and carotenoid and abscisic acid(ABA) biosynthesis. The ABA content was decreased,and the contents of 24 carotenoids differed between the llm4 mutant and the wild type(WT). The llm4mutant showed reduced dormancy and greater sensitive to ABA than the WT. We concluded that the mutation of LLM4 resulted in the failure of xanthophyll cycle, in turn causing ROS accumulation. The excessive ROS accumulation damaged chloroplast structure and induced PCD, leading eventually to the formation of lesion mimics. | Hao Wu Gaoxing Dai Rao Yuchun Kaixiong Wu Junge Wang Peng Hu Yi Wen Yueying Wang Lixin Zhu Bingze Chai Jialong Liu Guofu Deng Qian Qian Jiang Hu | 2023 | The Crop Journal2023，11，5： | 0 |
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