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| 1 | Alcohol,inflammation,and gut-liver-brain interactions in tissue damage and disease development显示文摘Chronic inflammation is often associated with alcoholrelated medical conditions. The key inducer of such inflammation, and also the best understood, is gut microflora-derived lipopolysaccharide (LPS). Alcohol can significantly increase the translocation of LPS from the gut. In healthy individuals, the adverse effects of LPS are kept in check by the actions and interactions of multiple organs. The liver plays a central role in detoxifying LPS and producing a balanced cytokine milieu. The central nervous system contributes to anti-inflammatory regulation through neuroimmunoendocrine actions. Chronic alcohol use impairs not only gut and liver functions, but also multi-organ interactions, leading to persistent systemic inflammation and ultimately, to organ damage. The study of these interactions may provide potential new targets for therapeutic intervention. | H Joe Wang Samir Zakhari M Katherine Jung | 2010 | World Journal of Gastroenterology2010，16，11： | 26 |
| 2 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 3 | Microstructure evolution and mechanical properties of Ti-B-N coatings deposited by plasma-enhanced chemical vapor deposition显示文摘Ternary Ti-B-N coatings were synthesized on AISI 304 and Si wafer by plasma-enhanced chemical vapor deposition (PECVD) technique using a gaseous mixture of TiCl4,BCl3,H2,N2,and Ar.By virtue of X-ray diffraction analysis,X-ray photoelectron spectroscopy,scanning electron microscope,and high-resolution transmission electron microscope,the influences of B content on the microstructure and properties of Ti B N coatings were investigated systematically.The results indicated that the microstructure and mechanical properties of Ti-B-N coatings largely depend on the transformation from FCC-TiN phase to HCP-TiB2 phase.With increasing B content and decreasing N content in the coatings,the coating microstructure evolves gradually from FCC-TiN/a-BN to HCP-TiB2 /a-BN via FCC-TiN+HCP-TiB2/a-BN.The highest microhardness of about 34 GPa is achieved,which corresponds to the nanocomposite Ti-63%B-N (mole fraction) coating consisting of the HCP-TiB2 nano-crystallites and amorphous BN phase.The lowest friction-coefficient was observed for the nanocomposite Ti-41%B-N (mole fraction) coating consisting of the FCC-TiN nanocrystallites and amorphous BN | Jung Ho SHIN Kwang Soo CHOI Tie-gang WANG Kwang Ho KIM Roman NOWAK | 2012 | 中国有色金属学会会刊:英文版2012，22，S3： | 13 |
| 4 | Synthesis and properties of Cr-Al-Si-N films deposited by hybrid coating system with high power impulse magnetron sputtering (HIPIMS) and DC pulse sputtering显示文摘The CrN and Cr-Al-Si-N films were deposited on Si wafer and SUS 304 substrates by a hybrid coating system with high power impulse magnetron sputtering (HIPIMS) and a DC pulse sputtering using Cr and AlSi targets under N2/Ar atmosphere.By varying the sputtering current of the AlSi target in the range of 0-2.5 A,both the Al and Si contents in the films increased gradually from 0 to 19.1% and 11.1% (mole fraction),respectively.The influences of the AlSi cathode DC pulse current on the microstructure,phase constituents,mechanical properties,and oxidation behaviors of the Cr-Al-Si-N films were investigated systematically.The results indicate that the as-deposited Cr-Al-Si-N films possess the typical nanocomposite structure,namely the face centered cubic (Cr,Al)N nano-crystallites are embedded in the amorphous Si3N4 matrix.With increasing the Al and Si contents,the hardness of the film first increases from 20.8 GPa for the CrN film to the peak value of 29.4 GPa for the Cr0.23Al0.14Si0.07 N film,and then decreases gradually.In the meanwhile,the Cr0.23Al0.14Si0.07N film also possesses excellent high-temperature oxidation resistance that is much better than that of the CrN film at 900 or 1000 °C. | Min Su KANG Tie-gang WANG Jung Ho SHIN Roman NOWAK Kwang Ho KIM | 2012 | 中国有色金属学会会刊:英文版2012，22，S3： | 11 |
| 5 | Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells显示文摘 | Saiyong Zhu Raiesh Ambasudhan Woong Sun Hyun Jung Kim Maria Talantova Xiaojing Wang Mingliang Zhang Yu Zhang Timothy Laurent James Parker Han-Seop Kim Jeffrey D Zaremba Sofiyan Saleem Sara Sanz-Blasco Eliezer Masliah Scott R McKercher Yee Sook Cho Stuart A Lipton Janghwan Kim Sheng Ding | 2014 | Cell Research2014，24，1： | 6 |
| 6 | Counterintuitive Ballistic and Directional Liquid Transport on a Flexible Droplet Rectifier显示文摘Achieving the directional and long-range droplet transport on solid surfaces is widely preferred for many practical applications but has proven to be challenging.Particularly,directionality and transport distance of droplets on hydrophobic surfaces are mutually exclusive.Here,we report that drain fly,a ubiquitous insect maintaining nonwetting property even in very high humidity,develops a unique ballistic droplet transport mechanism to meet these demanding challenges.The drain fly serves as a flexible rectifier to allow for a directional and long-range propagation as well as self-removal of a droplet,thus suppressing unwanted liquid flooding.Further investigation reveals that this phenomenon is owing to the synergistic conjunction of multiscale roughness,structural periodicity,and flexibility,which rectifies the random and localized droplet nucleation(nanoscale and microscale)into a directed and global migration(millimeter-scale).The mechanism we have identified opens up a new approach toward the design of artificial rectifiers for broad applications. | Lei Wang Jing Li Bo Zhang Shile Feng Mei Zhang Dong Wu Yang Lu Ji Jung Kai Jing Liu Zuankai Wang Lei Jiang | 2020 | Research2020，，1： | 6 |
| 7 | Analysis of structural behavior during collision event accounting for bow and side structure interaction显示文摘The main goal of this study was to investigate the effects of selected ship collision parameter values on the characteristics of the absorbed energy in several ship collision scenarios.Non-linear simulations were performed using a finite element method(FEM)to obtain virtual experiment data.In the present research,the size of the side damage from a collision phenomenon were measured and used to verify the numerical configuration together with the calculation results using an empirical equation.Parameters in the external dynamics of a ship collision such as the location of the contact point and velocity of the striking ship were taken into consideration.The internal energy and deformation size on the side structure were discussed further in a comparative study.The effects of the selected parameters on several structural behaviors,namely energy,force,and damage extent were also observed and evaluated in this section.Stiffener on side hull was found to contribute significantly into resistance capability of the target ship against penetration of the striking bow.Remarkable force during penetration was observed to occur when inner shell was crushed as certain velocity was applied in the striking bow. | Aditya Rio Prabowo Dong Myung Bae Jung Min Sohn Ahmad Fauzan Zakki Bo Cao Qing Wang | 2017 | Theoretical & Applied Mechanics Letters2017，7，1： | 5 |
| 8 | Amylase level in extra hepatic bile duct in adult patients with choledochal cyst plus anomalous pancreatico-biliary ductal union显示文摘AIM: To investigate the relationship between pancreatic amylase in bile duct and the clinico-pathological features in adult patients with choledochal cyst and anomalous pancreatico-biliary ductal union (APBDU).METHODS: From 39 patients who underwent surgery for choledochal cyst between March 1995 and March 2003,we selected 15 adult patients who had some symptoms and were radiologically diagnosed as APBDU, and their clinico-pathological features were subsequently evaluated retrospectively. However, we could not obtain biliary amylase in all the patients because of the surgeon's slip.Therefore, we measured the amylase level in gall bladder of 10 patients and in common bile duct of 11 patients.RESULTS: Levels of amylase in common bile duct and gall bladder ranged from 11 500 to 212 000 IU/L, and the younger the patients, the higher the biliary amylase level (r= -0.982, P<0.01). Pathologically, significant correlation was found between the size of choledochal cyst and the grade of inflammation (r= 0.798,P<0.01). And, significant correlation was found between the level of amylase in gall bladder and the grade of hyperplasia. On the other hand, there was no correlation to the age of symptomatic onset or inflammatory grade (r = 0.743, P<0.05). Level of lipase was elevated from 6 000 to 159 000 IU/L in bile duct and from 14 400 to 117 000 IU/L in the gall bladder;however, there was no significant correlation with age or clinico-pathological features.CONCLUSION: The results support the notion that amylase has a particular role in the onset of symptoms, and suggest that a large amount of biliary amylase induces early onset of symptom, thereby making early diagnosis possible. | In-Ho Jeong Yong-Sik Jung Hong Kim Bong-Wan Kim Jung-Woon Kim Jeong Hong Hee-Jung Wang Myung-Wook Kim Byung-Moo Yoo Jin-Hong Kim Jae-Ho Han Wook-Hwan Kim | 2005 | World Journal of Gastroenterology2005，11，13： | 5 |
| 9 | Two-step accelerated mineral carbonation and decomposition analysis for the reduction of CO_2 emission in the eco-industrial parks显示文摘Carbon dioxide(CO2) emissions are a leading contributor to the negative effects of global warming. Globally, research has focused on effective means of reducing and mitigating CO2 emissions. In this study, we examined the efficacy of eco-industrial parks(EIPs) and accelerated mineral carbonation techniques in reducing CO2 emissions in South Korea.First, we used Logarithmic Mean Divisia Index(LMDI) analysis to determine the trends in carbon production and mitigation at the existing EIPs. We found that, although CO2 was generated as byproducts and wastes of production at these EIPs, improved energy intensity effects occurred at all EIPs, and we strongly believe that EIPs are a strong alternative to traditional industrial complexes for reducing net carbon emissions. We also examined the optimal conditions for using accelerated mineral carbonation to dispose of hazardous fly ash produced through the incineration of municipal solid wastes at these EIPs. We determined that this technique most efficiently sequestered CO2 when micro-bubbling, low flow rate inlet gas, and ammonia additives were employed. | Seok Jung Li Pang Wang Gjergj Dodbiba Toyohisa Fujita | 2014 | Journal of Environmental Sciences2014，26，7： | 4 |
| 10 | Longitudinal evaluation of time related femoral neck narrowing after metal-on-metal hip resurfacing显示文摘AIM: To track the short-term neck narrowing changes in Birmingham metal-on-metal hip resurfacing(MOMHR) patients. METHODS: Since 2001, the Center for Hip and Knee Replacement started a registry to prospectively collect data on hip and knee replacement patients. From June 2006 to October 2008, 139 MOMHR were performed at our center by two participate surgeons using Birmingham MOMHR prosthesis(Smith Nephew, United States). It is standard of care for patients to obtain low, anteriorposterior(LAP) pelvis radiographs immediately after MOMHR procedure and then at 3 mo, 1 year and 2 year follow up office visits. Inclusion criteria for the present study included patients who came back for follow up office visit at above mentioned time points and got LAP radiographs. Exclusion criteria include patients who missed more than two follow up time points and those with poor-quality X-rays. Two orthopaedic residency trained research fellows reviewed the X-rays independently at 4 time points, i.e., immediate after surgery, 3 mo, 1 year and 2 year. Neck-to-prosthesis ratio(NPR) was used as main outcome measure. Twenty cases were used as subjects to identify the reliability between two observers. An intraclass correlation coefficient at 0.8 was considered as satisfied. A paired t-test was used to evaluate the significant difference between different time points with P < 0.05 considered to be statistically significant.RESULTS: The mean NPRs were 0.852 ± 0.056, 0.839 ± 0.052, 0.835 ± 0.051, 0.83 ± 0.04 immediately, 3 mo, 1 year and 2 years post-operatively respectively. At 3 mo, NPR was significantly different from immediate postoperative X-ray(P < 0.001). There was no difference between 3 mo and 1 year(P = 0.14) and 2 years(P = 0.53). Femoral neck narrowing(FNN) exceeding 10% of the diameter of the neck was observed in only 4 patients(5.6%) at two years follow up. None of these patients developed a femoral neck fracture(FNF). CONCLUSION: Femoral neck narrowing after MOMHR occurred as early as 3 mo postoperatively, and stabilized thereafter. Excessive FNN was not common in patients within the first two years of surgery and was not correlated with risk of FNF. | Wenbao Wang Jeffrey A Geller Rohit Hasija Jung Keun Choi David A Patrick Jr. William Macaulay | 2013 | World Journal of Orthopedics2013，4，2： | 4 |
| 11 | A numerical investigation into the long-term behaviors of Fukushima-derived ^(137)Cs in the ocean显示文摘The Fukushima nuclear accident in 2011 released large amounts of radionuclides, including ^(137)Cs, into the Pacific Ocean. A quasi-global ocean radioactive transport model with horizontal grid spacing of 0.5°×0.5° and 21 vertical layers was thereafter established to study the long-term transport of the Fukushima-derived ^(137)Cs in the ocean.The simulation shows that the plume of ^(137)Cs would be rapidly transported eastward alongside the Kuroshio Current and its extensions. Contaminated waters with concentrations lower than 2 Bq/m3 would reach the west coast of North America 4 or 5 years after the accident. The ^(137)Cs tends to be carried, despite its very low concentration, into the Indian and South Pacific Oceans by 2016 via various branches of ocean currents.Meanwhile, the ^(137)Cs concentrations in the western part of the North Pacific Ocean decrease rapidly with time. Up to now the highly contaminated waters have remained in the upper 400 m, showing no evidence of significant penetration to deeper layers. | ZHAO Chang WANG Gang QIAO Fangli WANG Guansuo JUNG Kyung-Tae XIA Changshui | 2015 | Acta Oceanologica Sinica2015，34，12： | 3 |
| 12 | Case study on the three-dimensional structure of meso-scale eddy in the South China Sea based on a high-resolution model显示文摘Meso-scale eddies are important features in the South China Sea(SCS). The eddies with diameters of 50–200 km can greatly impact the transport of heat, momentum, and tracers. A high-resolution wave-tide-circulation coupled model was developed to simulate the meso-scale eddy in the SCS in this study. The aim of this study is to examine the model ability to simulate the meso-scale eddy in the SCS without data assimilations The simulated Sea Surface Height(SSH) anomalies agree with the observed the AVISO SSH anomalies well. The simulated subsurface temperature profiles agree with the CTD observation data from the ROSE(Responses of Marine Hazards to climate change in the Western Pacific) project. The simulated upper-ocean currents also agree with the main circulation based on observations. A warm eddy is identified in winter in the northern SCS. The position and domain of the simulated eddy are confirmed by the observed sea surface height data from the AVISO. The result shows that the model has the ability to simulate the meso-scale eddy in the SCS without data assimilation.The three-dimensional structure of the meso-scale eddy in the SCS is analyzed using the model result. It is found that the eddy center is tilted vertically, which agrees with the observation. It is also found that the velocity center of the eddy does not coincide with the temperature center of the eddy. The result shows that the model has the ability to simulate the meso-scale eddy in the SCS without data assimilations. Further study on the forming mechanism and the three-dimensional structure of the meso-scale eddies will be carried out using the model result and cruise observation data in the near future. | XIA Changshui JUNG Kyung Tae WANG Guansuo YIN Xunqiang GUO Jingsong | 2016 | Acta Oceanologica Sinica2016，35，2： | 3 |
| 13 | Interface evolution in the platelet-like SiC@C and SiC@ SiO2 monocrystal nanocapsules显示文摘有六角形的像血小板的形态学的碳涂的 SiC@C nanocapsules (NC ) 被简单直接水流(DC ) 制作弧分泌物血浆方法。SiC@C NC 是 monocrystalline,在尺寸的 120-150 nm,和约 50 nm 厚。同样准备的 SiC@C NC 的形成包括了成核截断八面原文如此种子和进在充满碳的气氛的六角形的 nanoplatelets 的种子的随后的各向异性的生长。SiC@C NC 上的混乱的碳层被热处理在 650 楴湯挠浯潰湵獤猠潨敷 ? 牤浡瑡捩污祬映獡整 ? 牤杵爠汥慥敳椠 ? 潭敤慲整祬愠楣楤? 潳畬楴湯琠慨 ? 湩渠略牴污挠湯楤楴湯 ? 湡 ? 硥楨楢整 ? 湥慨据摥琠敨慲数瑵捩攠晦 ' 太 B 愠慧湩瑳琠湥洠摯汥挠湡散 ? 变换成 SiC@SiO 2 NC 的 SiO 2 壳散汬挠汵畴敲 ? 湩愠搠獯 ? 敤数摮湥 ? | Jian Gao Jieyi Yu Lei Zhou Javid Muhammad Xinglong Dong Yinong Wang Hongtao Yu Xie Quan Shaojie Li Youngguan Jung | 2017 | Nano Research2017，10，8： | 3 |
| 14 | Topical imiquimod treatment for human papillomavirus infection in patients with and without cervical/vaginal intraepithelial neoplasia显示文摘 | Cheng-Tao Lin Jian-Tai Qiu Chin-Jung Wang Shuenn-Dyh Chang Yun-Hsin Tang Pei-Ju Wu Shih-Ming Jung Chu-Chun Huang Hung-Hsueh Chou Mei-Shan Jao Chyong-Huey Lai | 2012 | Taiwanese Journal of Obstetrics & Gynecology2012，，4： | 2 |
| 15 | Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease显示文摘 | Wing–Kin Syn Youngmi Jung Alessia Omenetti Manal Abdelmalek Cynthia D. Guy Liu Yang Jiangbo Wang Rafal P. Witek Caitlin M. Fearing Thiago A. Pereira Vanessa Teaberry Steve S. Choi J. Conde–Vancells Gamze F. Karaca Anna Mae Diehl | 2009 | Gastroenterology2009，，4： | 2 |
| 16 | Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice显示文摘 | Bego?a Ochoa Wing‐Kin Syn Igotz Delgado Gamze F. Karaca Youngmi Jung Jiangbo Wang Ana M. Zubiaga Olatz Fresnedo Alessia Omenetti Marzena Zdanowicz Steve S. Choi Anna Mae Diehl | 2010 | Hepatology2010，，： | 2 |
| 17 | Interim analysis of START: Study in asia of the combination of TACE (transcatheter arterial chemoembolization) with sorafenib in patients with hepatocellular carcinoma trial显示文摘 | Young‐Hwa Chung Guohong Han Jung‐Hwan Yoon Jijin Yang Jianhua Wang Guo‐Liang Shao Byung Ik Kim Teng‐Yu Lee Yee Chao | 2012 | Int J Cancer2012，，10： | 2 |
| 18 | Gravity model in the Korean highway显示文摘 | Woo-Sung Jung Fengzhong Wang H. Eugene Stanley | 2008 | EPL (Europhysics Letters)2008，，4： | 2 |
| 19 | Preface to the Special Issue:Towards Improving Understanding and Prediction of Arctic Change and its Linkage with Eurasian Mid-latitude Weather and Climate显示文摘The dramatic changes in the Arctic climate system during recent decades are one of the most prominent features ofglobal climate change. Two most striking and fundamental characteristics are the amplified near-surface warming at a ratetwice the global average since the mid 20th century (e.g., Blunden and Arndt, 2012; Huang et al., 2017), and the rapiddecline of sea-ice extent at a pace of 12.9% (10 yr)-l and thinning of ice thickness by 40% since 1979 (e.g., Kwok andRothrock, 2009; Meier et al., 2012). In conjunction with these changes, the frequency of occurrence of extreme climate andweather events has ostensibly increased across the Northern Hemisphere mid-latitudes, including adverse cold spells, severeheat waves, destructive floods, and persistent droughts (e.g., Coumou and Rahmstorf, 2012). The fact that Arctic climatechanges have coincided with an increase in the frequency of occurrence of extreme events has inspired broad interest inpossible linkages--not only in the climate community, but also the general public, media agencies, and decision makers--inparticular considering the projected future continuation and acceleration of Arctic warming and sea-ice decline (e.g., Zhangand Walsh, 2006; Zhang, 2010; Stroeve et al., 2012; Wang and Overland, 2012). | Xiangdong ZHANG Thomas JUNG Muyin WANG Yong LUO Tido SEMMLER Andrew ORR | 2018 | Advances in Atmospheric Sciences2018，35，1： | 2 |
| 20 | Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing显示文摘 | Y. Jung J. Wang A. Schneider Y.-X. Sun A.J. Koh-Paige N.I. Osman L.K. McCauley R.S. Taichman | 2005 | Bone2005，，4： | 1 |
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