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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | 阿司匹林及氯吡格雷双抗与阿司匹林单药治疗急性轻度缺血性卒中及高危短暂性脑缺血发作的比较:系统综述及meta分析显示文摘目的为了评估对于急性轻度缺血性卒中及短暂性脑缺血发作(TIA)患者应用联合阿司匹林及氯吡格雷双抗治疗,相较于单用阿司匹林,预防血栓再发及出血事件的有效性及安全性。研究设计对随机、安慰剂对照研究进行系统综述及meta分析。 | Qiukui Hao Malavika Tampi Martin O' Donnell Farid Foroutan Reed AC Siemieniuk Gordon Guyatt 李洁(译) 毛晨晖(校) | 2019 | 英国医学杂志中文版2019，22，5： | 5 |
| 3 | Shoot and root traits in drought tolerant maize(Zea mays L.) hybrids显示文摘This study aimed to investigate the differences in shoot and root traits, and water use and water use efficiency(WUE) in drought tolerant(DT) maize(Zea mays L.) hybrids under full and deficit irrigated conditions. A two-year greenhouse study was conducted with four hybrids(one conventional hybrid, 33D53AM, two commercial DT hybrids, P1151 AM, N75H, and an experimental hybrid, Exp HB) grown under two water regimes(I_(100) and I_(50), referring to 100 and 50% of evapotranspiration requirements). Under water stress, the hybids P1151 AM, N75, and Exp HB showed more drought tolerance and had either greater shoot dry weight or less dry weight reduction than the conventional hybrid(33 D53 AM). However, these three hybrids responded to water stress using different mechanisms. Compared with the conventional hybrid, the two commercial DT hybrids(P1151 AM and N75H) had a smaller leaf area, shoot dry weight, and root system per plant. As a result, these hybrids used less water but had a higher WUE compared with the conventional hybrid. In contrast, the experimental hybrid(ExpHB) produced more shoot biomass by silking stage at both irrigation levels than all other hybrids, but it had relatively lower WUE. The hybrids demonstrated different drought response mechanisms that may require different irrigation management strategies. More investigation and validation are needed under field conditions and in different soil types. | ZHAO Jin XUE Qing-wu Kirk E Jessup HOU Xiao-bo HAO Bao-zhen Thomas H Marek XU Wen-wei Steven R Evett Susan A O'Shaughnessy David K Brauer | 2018 | Journal of Integrative Agriculture2018，17，5： | 3 |
| 4 | Hepatitis C and Alcohol Exacerbate Liver Injury by Suppression of FOXO3显示文摘 | Batbayar Tumurbaatar Irina Tikhanovich Zhuan Li Jinyu Ren Robert Ralston Sudhakiranmayi Kuravi Roosevelt Campbell Gaurav Chaturvedi Ting-Ting Huang Jie Zhao Junfang Hao Maura O’Neil Steven A. Weinman | 2013 | The American Journal of Pathology2013，，6： | 2 |
| 5 | A Simple Method for the Detection and Geneotyping of High-risk Human Papillomavirus Using Seminested Polymerase Chain Reaction and Reverse Hybridization显示文摘 | Hao L Jau-Sung M Yu-Che O | 2005 | Gynecol Oncol2005，96，1： | 1 |
| 6 | Acupuncture anesthesia for open heart surgery in contemporary China 显示文摘 | Zhou J Hao C Tsung O | 2011 | Int J Cardiol2011，150，1： | 1 |
| 7 | Decolorization of wastewater显示文摘 | Hao O Kim H Chiang P | 1999 | Critical Reviews in Environmental Science and Technology1999，30，4： | 1 |
| 8 | Effects of metal additions on sulfate reduction activity in wastewaters 显示文摘 | Hao O J Huang L Chen J M | 1994 | Toxicological and Environmental Chemistry1994，46，4： | 1 |
| 9 | Drastic SOxremoval and influences of various factors in O2/CO2pulverized coal combustion system显示文摘 | Hao L Shiro K Ken O | 2001 | Energy&Fuels2001，15，2： | 1 |
| 10 | Effect of humic substance characteristics on UF performance 显示文摘 | LIN C F HUANG Y J HAO O J | 2000 | Water Res2000，34，4： | 1 |
| 11 | Effect of functional groups of humic substance on UF performance 显示文摘 | LIN C F LIU S H HAO O J | 2001 | Water Res2001，35，10： | 1 |
| 12 | Surface microstructure and mechanical property of WC-6% Co hard alloy irradiation by high current pulsed electron beam 显示文摘 | Xu Y Zhang Y Hao S Z Perroud O Li M C Wang H H Grosdidier T Dong C | 2013 | Applied Sur- face Science2013，279，： | 1 |
| 13 | Extension of sensing distance in a ROTDR with an optimized fiber显示文摘 | Gong Y Michael O L C Hao J | 2007 | Optics Communications2007，280，1： | 1 |
| 14 | AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer Cells显示文摘 | Jane O’Hara Damir Vareslija Jean McBryan Fiona Bane Paul Tibbitts Christopher Byrne Ronán M. Conroy Yuan Hao Peadar ó Gaora Arnold D.K. Hill Marie McIlroy Leonie S. Young | 2012 | Clinical Cancer Research2012，，12： | 1 |
| 15 | Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumour immunity显示文摘 | Hao S Bai O Li F | 2007 | Immunology2007，120，1： | 1 |
| 16 | Effects of humic substance characteristics on UF performance显示文摘 | C Lin T Lin O J Hao | 2000 | Water Research2000，34，4： | 1 |
| 17 | Adsorption characteristics of fluoride onto hydrous aluminum 显示文摘 | Huang C P | 1986 | Environ Eng Div ASCE1986，112，： | 1 |
| 18 | Separation-induced body weight loss, impairment in altematian behavior, and autonomic tone: effects of tyrosine 显示文摘 | Hao S Avraham Y Bonne O et ol | 2001 | Pharmacol Biochem Be2001，68，2： | 1 |
| 19 | A survey on shape correspondence显示文摘 | van Kaick O Zhang Hao Hamarneh G | 2011 | Computer Graphics Forum2011，30，6： | 1 |
| 20 | Microbial chromium (VI) reduction 显示文摘 | CHEN J M HAO O J | 1998 | Critical Reviews in Environmental Science and Technology1998，28，3： | 1 |
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