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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Role of Ki-67 as a prognostic factor in gastrointestinal stromal tumors显示文摘AIM:To investigate primarily the prognostic value of Ki-67,as well as other parameters,in gastrointestinal stromal tumors(GISTs).METHODS:Ki-67,c-KIT,platelet-derived growth factor receptor-alpha(PDGFRα),smooth muscle actin(SMA),CD34,S100 were stained for immunohistochemistry which was performed on formalin-fixed,paraffinembeded sections on representative block from each case.Proliferation index counted by Ki-67 antibody was calculated as a number of positive nuclear reaction over 100 cells.Immunoreactivity for c-KIT and PDGFRα was evaluated semiquantitatively(weak,intermediate,strong) and for c-KIT type of reactivity was analyzed(cytoplasmic,membrane and 'dot-like' staining).Immunoreactivity for SMA,CD34 and S100 were was evaluated as positive or negative antigen expression.Pathologic parameters investigated in this study included tumor size,cell type(pure spindle,pured epitheloid mixed spindle and epitheloid),mitotic count,hemorrhage,necrosis,mucosal ulceration.Clinical data included age,gender,primary tumor location and spread of disease.χ 2 test and Student's t-test were used for comparisons of baseline characteristics.The Cox's proportional hazard model was used for univariable and multivariable analyses.Survival rates were calculated by Kaplan-Meier method and statistical significance was determined by the log-rank test.RESULTS:According to the stage of disease,there were 36 patients with localized disease,29 patients with initially localized disease but with its recurrence in the period of follow up,and finally,35 patients had metastatic disease from the very beginning of disease.Tumor originated most commonly in the stomach(41%),small intestine was the second most common location(36%).The mean size of primary tumors was 6.5 cm.The mean duration of follow-up was 60 mo.Multiple parameters were analyzed for their effect on overall survival,but no one reached statistical significance(P = 0.06).Analysis of time to progression/relapse in initially localized disease(univariate analysis),tumor size,mitotic count,Ki-67 and type of d-KIT distribution(cytoplasmic vs membrane/'dot-like') showed statistically significant correlation.In multivariate analysis in the group of patients with localized disease,there were only 2 parameters that have impact on relapse,Ki-67 and SMA(P < 0.0001 and P < 0.034,respectively).Furthermore,Ki-67 was analyzed in localized diseasevs localized with recurrence and metastatic disease.It was shown that there is a strict difference between these 2 groups of patients(median value was 2.5 for localized disease vs 10.0 for recurrent/metastatic disease,P < 0.0001).It was also shown that the cut-off value which is still statistically significant in terms of relapse on the level of 6%.The curves for survival on that cut-off level are significantly different(P < 0.04,Cox F).CONCLUSION:Ki-67 presents a significant prognostic factor for GIST recurrence which could be of great importance in evaluating malignant potential of disease. | Borislav Belev Iva Bri Juraj Prejac Zrna Antunac Golubi Damir Vrbanec Jadranka Bozikov Ivan Aleri Marko Boban Jasminka Jaki Razumovi | 2013 | World Journal of Gastroenterology2013，19，4： | 14 |
| 3 | 水性涂料发展势头良好显示文摘水性涂料市场发展良好,在所有细分市场和地区都有望增长。由于城镇化的推进,建筑涂料成为推动水性涂料需求增长的主要驱动力,而在工业涂料领域的细分市场中,水性涂料也呈现增长态势。过去几年中,水性涂料技术进步已成为趋势。增长主要归功于建筑工程领域的巨大投资,以及对绿色、零VOC或低VOC(水性涂料的特性)涂料需求的不断增长。 | Damir Gagro | 2017 | 中国涂料2017，32，2： | 4 |
| 4 | Is Helicobacter pylori infection a risk factor for disease severity in systemic sclerosis?显示文摘 | Mislav Radi? Du?anka Martinovi? Kaliterna Damir Bonacin Jadranka Morovi? Vergles Josipa Radi? Damir Fabijani? Vedran Kova?i? | 2013 | Rheumatology International2013，，11： | 3 |
| 5 | Ultrasound reliability in detection of retinal tear in acute symptomatic posterior vitreous detachment with vitreous hemorrhage显示文摘Cross-sectional study of 75 consecutive patients presenting with acute symptomatic posterior vitreous detachment(ASPVD) and vitreous hemorrhage was conducted at University Eye Clinic,University Hospital 'Sveti Duh',Zagreb,Croatia.To check ultrasound reliability in detecting retinal tears in patients with ASPVD,transpalpebral ultrasound of the eye and the orbit was performed followed by fundus examination initially and in 6 wk period.In 13(17%) patients membranous lesion with ultrasound characteristics of retinal tear was detected.Ophthalmoscopy confirmed the diagnosis in 8/13 patients.In 62/75 patients neither ultrasound nor clinical examination revealed retinal tear.Sensitivity of ultrasound examination was 100%,specificity 92%,positive predictive value 62% and negative predictive value 100%.Ultrasound proved to be a reliable and accurate method for detection of retinal tears in ASPVD.Given the high sensitivity and negative predictive value,negative result on B-scan ultrasound excludes the probability of the retinal tear with a high degree of certainty. | Biljana Kuzmanovic Elabjer Mladen Busic Ana Biscan Tvrdi Daliborka Miletic Damir Bosnar Mirjana Bjelos | 2017 | International Journal of Ophthalmology(English edition)2017，10，12： | 3 |
| 6 | Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-Like Receptor-2显示文摘 | Thimoteus Speer Lucia Rohrer Przemyslaw Blyszczuk Rukshana Shroff Kira Kuschnerus Nicolle Kr?nkel Gabriela Kania Stephen Zewinger Alexander Akhmedov Yi Shi Tina Martin Damir Perisa Stephan Winnik Maja F. Müller Urban Sester Gabriel Wernicke Andreas Jung U | 2013 | Immunity2013，，： | 2 |
| 7 | Renal aspergillosis in a liver transplant patient: A case report and review of literature显示文摘BACKGROUND Aspergillosis is a frequent invasive fungal infection in liver recipients(affecting 1%-9.2% of all patients), second only to candidiasis. Significant risk factors for invasive aspergillosis in liver recipients include corticosteroid therapy, neutropenia, T-cell dysfunction, renal failure and requirement for renal replacement therapy. Aspergillus infection usually affects the lungs of liver recipients, with hematogenous dissemination occurring in 50%-60% of cases. Renal involvement is rare and is considered to occur in 0.4% of all cases of invasive aspergillosis.CASE SUMMARY This paper describes a case of a liver recipient presenting with a newly formed renal mass a year after liver transplantation. The patient underwent liver transplantation due to alcoholic liver cirrhosis, with preoperative corticosteroid therapy and postoperative immunosuppressants(tacrolimus and mycophenolate mofetil). His 1-year follow-up was uneventful, with a satisfying graft function and lack of any symptoms. During a routine follow-up abdominal ultrasound, he was diagnosed with a renal tumor. The renal ima-ging findings were inconclusive(with a differential diagnosis to renal cell carcinoma), while the computed tomography(CT) of the chest showed scar tissue in the lungs suggestive of previous inflammation. The patient underwent radical nephrectomy, with histopathological analysis showing renal aspergilloma, yielding postoperative treatment with voriconazole. His follow up was uneventful, and the chest CT did not show any change in pulmonary lesions. This case illustrates the possibility of aspergillosis affecting the lungs of liver recipients, subsequently affecting the kidney and forming an aspergilloma.CONCLUSION Clinicians should be aware of aspergilloma mimicking solid organ tumors in organ recipients. | Brigita Smolovic Batric Vukcevic Damir Muhovic Marina Ratkovic | 2018 | World Journal of Clinical Cases2018，6，16： | 2 |
| 8 | Single molecule fluorescence fluctuations of the cyanine dyes linked covalently to DNA显示文摘The intersystem crossing and isomerization dynamics of free-Cy3,Cy3-ssDNA,free-Cy5 and Cy5-ssDNA are obtained through simple analysis of rapid on/off blinking from single molecule fluorescence intensity time-traces and the fluorescence correlation spectroscopy(FCS).The on-and off-times observed in fluorescence time traces of single cyanine dyes are due to the formation of the triplet state and isomerization,where both the interaction with DNA and long central polymethine chain of cyanine dyes increase the barriers of isomerization,leading to long off-time.The results indicate that the single molecule fluorescence fluctuation together with the resulting second autocorrelation analysis are powerful methods for determining the triplet state and isomerization dynamics,which could be the simple techniques and complementary to other spectroscopic techniques,such as fluorescence decay measurement and laser flash photolysis to study the photophysical processes of complex molecules. | AUMILER Damir | 2009 | Science China Chemistry2009，52，8： | 2 |
| 9 | 现代电网的六个基本特性(英文)显示文摘最近的研究表明,世界人口和人均能源消费量在2050年将翻一番。与此同时,根据最近的报告电网正在老化。这就体现出电网现代化的强大动力、必要性和机遇。电网现代化意味着消费者、电网运营商/机构及环境是三赢局面。本文讨论了现代电网的六个基本特性:电子、分形、结构化、容错、弹性和异步。本文提出了一种独特可行的现代电网架构,可通过目前先进的技术实现。我们可以利用先进的电力电子与系统技术在发电、输电、配电和离网储能等方面以最优的管理手段来迎接世界对能源需求的挑战。 | Don Tan Damir Novosel | 2017 | 南方电网技术2017，11，10： | 2 |
| 10 | Absorption of light in InP nanowire arrays显示文摘 | Nicklas Anttu Alireza Abrand Damir Asoli Magnus Heurlin Ingvar Aberg Lars Samuelson Magnus Borgstrom | 2014 | Nano Research2014，7，6： | 2 |
| 11 | The influence of honing process parameters on sur- face quality, productivity, cutting angle and coefficients of friction 显示文摘 | Damir S Vrac | 2012 | Industrial Lubrication and Tribology2012，64，2： | 1 |
| 12 | Effect of high temperature on properties of steel slag aggregate concrete显示文摘 | Ivanka Netinger Damir Varevac Dubravka Bjegovi? Dragan Mori? | 2013 | Fire Safety Journal2013，，： | 1 |
| 13 | Wide-area protection and emergency control显示文摘 | Miroslav Begovic Damir Novosel Daniel Karlsson | 2005 | Proceedings of the IEEE2005，93，5： | 1 |
| 14 | Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease: Role of High-Density Lipoprotein–Proteome Remodeling显示文摘 | Meliana Riwanto Lucia Rohrer Bernd Roschitzki Christian Besler Pavani Mocharla Maja Mueller Damir Perisa Kathrin Heinrich Lukas Altwegg Arnold von Eckardstein Thomas F. Lüscher Ulf Landmesser | 2013 | Circulation2013，，8： | 1 |
| 15 | A new frequency tracking and phasor estimation algorithm for generator protection显示文摘 | Damir Novosel Yi Hu | 1997 | IEEE Trans on Power Delivery1997，12，3： | 1 |
| 16 | Pulsating instability of externally forced premixed counterflow flame显示文摘 | Damir M. Valiev Manqi Zhu Gaurav Bansal Hemanth Kolla Chung K. Law Jacqueline H. Chen | 2013 | Combustion and Flame2013，，2： | 1 |
| 17 | The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice显示文摘 | Hervé Guillou Damir Zadravec Pascal G.P. Martin Anders Jacobsson | 2009 | Progress in Lipid Research2009，，2： | 1 |
| 18 | AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer Cells显示文摘 | Jane O’Hara Damir Vareslija Jean McBryan Fiona Bane Paul Tibbitts Christopher Byrne Ronán M. Conroy Yuan Hao Peadar ó Gaora Arnold D.K. Hill Marie McIlroy Leonie S. Young | 2012 | Clinical Cancer Research2012，，12： | 1 |
| 19 | Improvement of the cogeneration plant economy by using heat accumulator显示文摘 | ?eljko Bogdan Damir Kopjar | 2006 | Energy2006，，13： | 1 |
| 20 | The Anatomy of Temporal Hollowing: The Superficial Temporal Fat Pad显示文摘 | Sharon K Damir M | 2005 | J Craniofac Surg2005，16，5： | 1 |
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