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| 1 | Regulation of AMP-activated protein kinase by natural and synthetic activators显示文摘The AMP-activated protein kinase(AMPK)is a sensor of cellular energy status that is almost universally expressed in eukaryotic cells.While it appears to have evolved in single-celled eukaryotes to regulate energy balance in a cell-autonomous manner,during the evolution of multicellular animals its role has become adapted so that it also regulates energy balance at the whole body level,by responding to hormones that act primarily on the hypothalamus.AMPK monitors energy balance at the cellular level by sensing the ratios of AMP/ATP and ADP/ATP,and recent structural analyses of the AMPK heterotrimer that have provided insight into the complex mechanisms for these effects will be discussed.Given the central importance of energy balance in diseases that are major causes of morbidity or death in humans,such as type 2 diabetes,cancer and inflammatory disorders,there has been a major drive to develop pharmacological activators of AMPK.Many such activators have been described,and the various mechanisms by which these activate AMPK will be discussed.A particularly large class of AMPK activators are natural products of plants derived from traditional herbal medicines.While the mechanism by which most of these activate AMPK has not yet been addressed,I will argue that many of them may be defensive compounds produced by plants to deter infection by pathogens or grazing by insects or herbivores,and that many of them will turn out to be inhibitors of mitochondrial function. | David Grahame Hardie | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 11 |
| 2 | Micro-Channel Heat Sink:A Review显示文摘The method to cool a high heat flux device is an important research direction for the heat exchanger design.Micro-channels are an eflfective heat exchange structure both for single-phase and two-phase flow.In this paper,the heat transfer correlations of single-phase,two-phase and nanofluid in a micro-channel are discussed and analyzed.The correlations of pressure drop for single-phase and two-phase fluids are also presented.Excluding the different working fluids used in the micro-channel,the diameter and aspect ratio,shape and structure,surface roughness,internal and external factor and layout of micro-channel pipe are considered to analyze their influence on the heat transfer performance and pressure drop.Micro-channel technology applications include industry,air-conditioning,solar energy systems,heat pipe technology and computer data center cooling.Compared to the conventional heat exchangers used in these fields,a micro-channel heat sink showed a much better heat transfer coefficient and low volume,indicating that it is a good choice and has huge potential for cooling application.Finally,existing problems and future scopes are described,and drawing up design standard,experimental and simulated methods for evaluating its performance are the urgent actions which need to be carried out.This review paper serves as guidance for researchers to design and predict the performance of micro-channel heat sinks. | ZHOU Jinzhi CAO Xiaoling ZHANG Nan YUAN Yanping ZHAO Xudong HARDY David | 2020 | Journal of Thermal Science2020，29，6： | 9 |
| 3 | Nutritional therapy in patients with acute pancreatitis requiring critical care unit management: A prospective observational study in Australia and New Zealand显示文摘 | Andrew R. Davies Siouxzy S. Morrison Emma J. Ridley Michael Bailey Merrilyn D. Banks David J. Cooper Gil Hardy Kerry McIlroy Andrew Thomson | 2011 | Critical Care Medicine2011，，3： | 2 |
| 4 | Negative Impact of Neutrophil-Lymphocyte Ratio on Outcome After Liver Transplantation for Hepatocellular Carcinoma显示文摘 | Karim J. Halazun Mark A. Hardy Abbas A. Rana David C. Woodland Elijah J. Luyten Suhari Mahadev Piotr Witkowski Abbey B. Siegel Robert S. Brown Jean C. Emond | 2009 | Annals of Surgery2009，，1： | 2 |
| 5 | Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo显示文摘 | Amelia Bartholomew Cord Sturgeon Mandy Siatskas Karen Ferrer Kevin McIntosh Sheila Patil Wayne Hardy Steve Devine David Ucker Robert Deans Annemarie Moseley Ronald Hoffman | 2002 | Experimental Hematology2002，，1： | 2 |
| 6 | New frontiers in food enzymology: recombinant lipoxygenases显示文摘 | Casey R West S I Hardy D David S Robinson Zecai W u Richard K Hughes | 1999 | Trends in Food Science & Technology1999，10，： | 1 |
| 7 | How (Un)Useful is the Pelvic Ring Stability Examination in Diagnosing Mechanically Unstable Pelvic Fractures in Blunt Trauma Patients?显示文摘 | Gil Z. Shlamovitz William R. Mower Jonathan Bergman Kenneth R. Chuang Jonathan Crisp David Hardy Martine Sargent Sunil D. Shroff Eric Snyder Marshall T. Morgan | 2009 | The Journal of Trauma: Injury, Infection, and Critical Care2009，，3： | 1 |
| 8 | The Combined Organ Effect: Protection Against Rejection?显示文摘 | Abbas Rana Susanne Robles Mark J. Russo Karim J. Halazun David C. Woodland Piotr Witkowski Lloyd E. Ratner Mark A. Hardy | 2008 | Annals of Surgery2008，，5： | 1 |
| 9 | Remote sensing of coral reefs and their physical environment显示文摘 | Peter J. Mumby William Skirving Alan E. Strong John T. Hardy Ellsworth F. LeDrew Eric J. Hochberg Rick P. Stumpf Laura T. David | 2003 | Marine Pollution Bulletin2003，，3： | 1 |
| 10 | ErbB/EGF Signaling and EMT in Mammary Development and Breast Cancer显示文摘 | Katharine M. Hardy Brian W. Booth Mary J. C. Hendrix David S. Salomon Luigi Strizzi | 2010 | Journal of Mammary Gland Biology and Neoplasia2010，，2： | 1 |
| 11 | Negative Impact of Neutrophil-Lymphocyte Ratio on Outcome After Liver Transplantation for Hepatocellular Carcinoma显示文摘 | Karim J. Halazun Mark A. Hardy Abbas A. Rana David C. Woodland Elijah J. Luyten Suhari Mahadev Piotr Witkowski Abbey B. Siegel Robert S. Brown Jean C. Emond | 2009 | Annals of Surgery2009，，1： | 1 |
| 12 | Bioavailability of Zinc in Several Sources of Zinc Oxide,Zinc Sulfate,and Zinc Metal 显示文摘 | Hardy M Edwards Ⅲ David H Baker | 1999 | J Anim Sci1999，77，： | 1 |
| 13 | Interleukin 16 and its function as a CD4 ligand显示文摘 | David M. Center Hardy Kornfeld William W. Cruikshank | 1996 | Immunology Today1996，，10： | 1 |
| 14 | Biomimetic spinning of recombinant silk protein显示文摘 | DAVID Keerl HARDY John G THOMAS Scheibel | | 0，，： | 1 |
| 15 | Negative Impact of Neutrophil-Lymphocyte Ratio on Outcome After Liver Transplantation for Hepatocellular Carcinoma显示文摘 | Karim J. Halazun Mark A. Hardy Abbas A. Rana David C. Woodland Elijah J. Luyten Suhari Mahadev Piotr Witkowski Abbey B. Siegel Robert S. Brown Jean C. Emond | 2009 | Annals of Surgery2009，，1： | 1 |
| 16 | ErbB/EGF Signaling and EMT in Mammary Development and Breast Cancer显示文摘 | Katharine M. Hardy Brian W. Booth Mary J. C. Hendrix David S. Salomon Luigi Strizzi | 2010 | Journal of Mammary Gland Biology and Neoplasia2010，，2： | 1 |
| 17 | Coral reef habitat discrimination using multivariate spectral analysis and satellite remote sensing显示文摘 | Cal K A John T Hardy David O Wallin | 2003 | International Journal of Remote Sensing2003，24，13： | 1 |
| 18 | Negative Impact of Neutrophil-Lymphocyte Ratio on Outcome After Liver Transplantation for Hepatocellular Carcinoma显示文摘 | Karim J. Halazun Mark A. Hardy Abbas A. Rana David C. Woodland Elijah J. Luyten Suhari Mahadev Piotr Witkowski Abbey B. Siegel Robert S. Brown Jean C. Emond | 2009 | Annals of Surgery2009，，1： | 1 |
| 19 | The velocity description of deformation,Paper 1:Theory 显示文摘 | DAVID W HARDY S | 1995 | Marine and Petroleum Geology1995，22，： | 1 |
| 20 | Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo显示文摘 | Amelia Bartholomew Cord Sturgeon Mandy Siatskas Karen Ferrer Kevin McIntosh Sheila Patil Wayne Hardy Steve Devine David Ucker Robert Deans Annemarie Moseley Ronald Hoffman | 2002 | Experimental Hematology2002，，1： | 1 |
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