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| 1 | Autophagy in filamentous fungi显示文摘 | Judith K. Pollack Steven D. Harris Mark R. Marten | 2008 | Fungal Genetics and Biology2008，，1： | 1 |
| 2 | Influence of Age and Gender on the Pharmacokinetics and Pharmacodynamics of Remifentanil: I. Model Development显示文摘 | Charles F. Minto Thomas W. Schnider Talmage D. Egan Elizabeth Youngs Harry J. M. Lemmens Pedro L. Gambus Valerie Billard John F. Hoke Katherine H. P. Moore David J. Hermann Keith T. Muir Jaap W. Mandema Steven L. Shafer | 1997 | Anesthesiology1997，，： | 1 |
| 3 | Parathyroid Hormone and Teriparatide for the Treatment of Osteoporosis: A Review of the Evidence and Suggested Guidelines for Its Use显示文摘 | Anthony B. Hodsman Douglas C. Bauer David W. Dempster Larry Dian David A. Hanley Steven T. Harris David L. Kendler Michael R. McClung Paul D. Miller Wojciech P. Olszynski Eric Orwoll Chui Kin Yuen | 2005 | Endocrine Reviews2005，，5： | 1 |
| 4 | 过量尿嘧啶胁迫下pyrG对维持构巢曲霉胞内尿嘧啶稳定及正常产孢起关键作用显示文摘为减少DNA中尿嘧啶的掺入,细胞内尿嘧啶水平受到严格控制,但其机制尚不清楚.构巢曲霉(Aspergillus nidulans)乳清酸核苷5′-磷酸脱羧酶PyrG催化乳清苷酸(OMP)转化为尿苷酸(UMP)的反应,本研究发现,在过量尿嘧啶存在的情况下,PyrG对维持细胞内较低尿嘧啶浓度具有重要作用.与野生菌株相比,过量尿嘧啶及其代谢物对乳清苷酸脱羧酶缺陷的pyrG89突变体具有更强的抑制作用,并能增强pyrG89突变体的有性发育.通过数字基因表达谱(DGE)分析pyrG89突变体和野生菌株对过量尿嘧啶的转录响应,发现尿嘧啶转录激活pyrG89突变体中有性发育相关的基因.HPLC定量分析显示,在过量尿嘧啶存在的情况下,pyrG89突变体胞内尿嘧啶水平是野生菌株的6.5倍.本研究的结果不仅为细胞内尿嘧啶循环及细胞对过量尿嘧啶的适应机制提供了新内容,还揭示了OMP脱羧酶对真菌生长发育存在潜在影响. | 孙宪昀 朱菊芬 宝丽 胡成成 金城 HARRIS Steven D. 刘宏伟 李少杰 | 2013 | 中国科学:生命科学2013，43，5： | 1 |
| 5 | Analysis of Molecular Markers by Anatomic Tumor Site in Stage III Colon Carcinomas from Adjuvant Chemotherapy Trial NCCTG N0147 (Alliance)显示文摘 | Sinicrope Frank A. Mahoney Michelle R. Yoon Harry H. Smyrk Thomas C. Thibodeau Stephen N. Goldberg Richard M. Nelson Garth D. Sargent Daniel J. Alberts Steven R | 2015 | Clinical Cancer Research2015，，23： | 1 |
| 6 | Quality of Life and Exercise Performance in Patients in Sinus Rhythm Versus Persistent Atrial Fibrillation显示文摘 | Steven N. Singh X. Charlene Tang Bramah N. Singh Paul Dorian Domenic J. Reda Crystal L. Harris Ross D. Fletcher Satish C. Sharma J. Edwin Atwood Alan K. Jacobson H. Daniel Lewis Becky Lopez Dennis W. Raisch Michael D. Ezekowitz | 2006 | Journal of the American College of Cardiology2006，，4： | 1 |
| 7 | Current methods of the U.S. Preventive Services Task Force显示文摘 | Russell P. Harris Mark Helfand Steven H. Woolf Kathleen N. Lohr Cynthia D. Mulrow Steven M. Teutsch David Atkins | 2001 | American Journal of Preventive Medicine2001，，： | 1 |
| 8 | Parathyroid Hormone and Teriparatide for the Treatment of Osteoporosis: A Review of the Evidence and Suggested Guidelines for Its Use显示文摘 | Anthony B. Hodsman Douglas C. Bauer David W. Dempster Larry Dian David A. Hanley Steven T. Harris David L. Kendler Michael R. McClung Paul D. Miller Wojciech P. Olszynski Eric Orwoll Chui Kin Yuen | 2005 | Endocrine Reviews2005，，5： | 1 |
| 9 | pyrG is required for maintaining stable cellular uracil level and normal sporulation pattern under excess uracil stress in Aspergillus nidulans显示文摘Tight control of the intracellular uracil level is believed to be important to reduce the occurrence of uracil incorporation into DNA.The pyrG gene of Aspergillus nidulans encodes orotidine 5'-phosphate decarboxylase,which catalyzes the conversion of orotidine monophosphate(OMP) to uridine monophosphate(UMP).In this study,we found that pyrG is critical for maintaining uracil at a low concentration in A.nidulans cells in the presence of exogenous uracil.Excess uracil and its derivatives had a stronger inhibitory effect on the growth of the pyrG89 mutant with defective OMP decarboxylase activity than on the growth of wild type,and induced sexual development in the pyrG89 mutant but not in wild type.Analysis of transcriptomic responses to excess uracil by digital gene expression profiling(DGE) revealed that genes related to sexual development were transcriptionally activated in the pyrG89 mutant but not in wild type.Quantitative analysis by HPLC showed that the cellular uracil level was 6.5 times higher in the pyrG89 mutant than in wild type in the presence of exogenous uracil.This study not only provides new information on uracil recycling and adaptation to excess uracil but also reveals the potential effects of OMP decarboxylase on fungal growth and development. | SUN XianYun ZHU JuFen BAO Li HU ChengCheng JIN Cheng HARRIS Steven D. LIU HongWei LI ShaoJie | 2013 | Science China(Life Sciences)2013，56，5： | 0 |
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