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| 1 | Circular RNA circStag1 promotes bone regeneration by interacting with HuR显示文摘Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of fractures.Recently,circular RNAs(circ RNAs)have been demonstrated to play pivotal roles in regulating bone metabolism.However,the underlying functions of circ RNAs in bone metabolism in postmenopausal osteoporosis remain obscure.Here,we report that circ Stag1 is a critical osteoporosis-related circ RNA that shows significantly downregulated expression in osteoporotic bone marrow mesenchymal stem cells(BMSCs)and clinical bone tissue samples from patients with osteoporosis.Overexpression of circ Stag1 significantly promoted the osteogenic capability of BMSCs.Mechanistically,we found that circ Stag1 interacts with human antigen R(Hu R),an RNA-binding protein,and promotes the translocation of Hu R into the cytoplasm.A high cytoplasmic level of Hu R led to the activation of the Wnt signaling pathway by stabilizing and enhancing low-density lipoprotein receptor-related protein 5/6(Lrp5/6)andβ-catenin expression,thereby stimulating the osteogenic differentiation of BMSCs.Furthermore,overexpression of circ Stag1 in vivo by circ Stag1-loaded adeno-associated virus(circ Stag1-AAV)promoted new bone formation,thereby preventing bone loss in ovariectomized rats.Collectively,we show that circ Stag1 plays a pivotal role in promoting the regeneration of bone tissue via Hu R/Wnt signaling,which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis. | Gaoyang Chen Canling Long Shang Wang Zhenmin Wang Xin Chen Wanze Tang Xiaoqin He Zhiteng Bao Baoyu Tan Jin Zhao Yongheng Xie Zhizhong Li Dazhi Yang Guozhi Xiao Songlin Peng | 2022 | Bone Research2022，10，3： | 7 |
| 2 | Solvothermal-assisted assembly of MoS2 nanocages on graphene sheets to enhance the electrochemical performance of lithium-ion battery显示文摘An ordered hollow M0S2 nanocages/RGO nanocomposite is constructed by a simple solvothermal-assisted assembly method combined with freeze-drying and annealing.In this novel nanostructure,hollow M0S2 nanocages are homogeneously distributed on graphene sheets with a tight bond of C-O-Mo.The nanosized and hollow MoS2 nanocages can effectively accommodate the huge volume change during charge/discharge process and increase the number of electrochemical reaction active sites,accelerating the kinetics of lithiation/delithiation.The tight C-O-Mo bond between graphene and MoS2 further reinforces the structural stability,thus improve the electrical conductivity and substantially enhance the lithium storage performance of M0S2 anode material.As a result,this novel nanocomposite shows a long-cycle stability of 717.4 mAh·g^-1 after 800 cycles at a high current density of 3 A·g^-1,exhibiting great potential as an anode nanocomposite for advanced lithium-ion batteries. | Dafang He Yi Yang Zhenmin Liu Jin Shao Jian Wu Shun Wang Liming Shen Ningzhong Bao | 2020 | Nano Research2020，13，4： | 2 |
| 3 | The Melt Character of Partial Molten Gabbro during Plastic Deformation Process显示文摘 | He Changrong Sang Zunan Jin Zhenmin | 2003 | Chinese Journal of Geophysics2003，46，4： | 1 |
| 4 | Improvement of the microstructure and mechanical properties of M2 cast high speed steel by modification显示文摘 | Li Yanjun Jiang Qichuan Zhao Yuguang and He Zhenmin | 1996 | Journal of Materials Science Letters1996，15，18： | 1 |
| 5 | Experimental Study on The Influence of Water Cement Ratio on The Compressive Strength of Shale Ceramsite Concrete 显示文摘 | Zhenmin Cao Zhigang He Yi Yang | 2012 | Applied Mechanics and Materials2012，，： | 1 |
| 6 | Improvement of the Microstructure and Mechanical Properties of M2 Cast High Speed Steel by Modification显示文摘 | Li Yanjun Jiang Qichuan Zhao Yuguang He Zhenmin | 1996 | Journal of Materials Science Letters1996，18，15： | 1 |
| 7 | Synthesis of 2-Hydroxymalononitrile显示文摘α-Hydroxyl carboxylic acids and their derivatives exist as the key substructures in a variety of biologically active natural products and numerous pharmaceuticals[1-3].Various-COX synthons(X=OH, or the equivalent), which are useful umpolung agents[4-14], have been developed.Recently, Nemoto et al.prepared the masked acyl cyanides[2, HC(CN)2OR3], a-COX synthon that played an important role in the synthesis of α-hydroxyl carboxylic acids and their derivatives[11], from commercially available materials in three steps under mild conditions(Scheme 1).However, 2-hydroxymalononitrile(1) was found unstable, and the purification of compound 1 was unsuccessful because it partially decomposed during column chromatography purification on silica gel.There has been no efficient way to synthesize 2-hydroxymalononitrile till very recently[15]. | YANG Jianxin YIN Yunxing HE Zhenmin ZHANG Zhiliu LIN Xiaojuan MA Rujian | 2015 | Chemical Research in Chinese Universities2015，31，5： | 0 |
| 8 | 2-Hydroxymalonitrile——A Useful Reagent for One-step Synthesis of α-Hydroxy Esters显示文摘α-Hydroxy carboxylic esters and their derivatives are key substructures in a variety of biologically active natural products and numerous pharmaceuticals[1-3].A variety of methods for the synthesis of α-hydroxyesters via homologation of aldehydes or ketones have been developed and frequently used in organic synthesis[4-14].These approaches are generally based on the following routes(Scheme 1). | YANG Jianxin YIN Yunxing HE Zhenmin MA Li LI Xin ZHANG Zhiliu LIN Xiaojuan MA Rujian | 2015 | Chemical Research in Chinese Universities2015，31，3： | 0 |
| 9 | Changes in Global DNA Methylation Intensity and DNMT1 Transcription During the Aging Process of Scallop Chlamys farreri显示文摘DNA methylation is an important epigenetic regulatory mechanism that influences genomic stability, gene activation, X-chromosome inactivation and other factors. A change in DNA methylation is usually associated with aging and cellular senescence. DNA methyltransferase 1(DNMT1) is the most abundant DNA methyltransferase, and it plays an important role in maintaining the established methylation pattern during DNA replication in vertebrates. Although the effect of aging on DNA methylation has been well studied in vertebrates, little research has been conducted in invertebrates, especially in marine bivalves. In this study, we examined global DNA methylation levels in four groups of adult Zhikong scallop Chlamys farreri at different ages. The results showed that both the age and tissue type had a strong effect on the DNA methylation. In addition, a significant decrease in DNA methylation with aging(1–4 years) can be detected in mantle, kidney and hepatopancreas. We further measured the change in DNMT1 transcript abundance using quantitative reverse transcription PCR(q RT-PCR), which revealed that DNMT1 transcription significantly decreased with aging in mantle and hepatopancreas and strongly correlated with DNA methylation(R = 0.72). Our data provided greater insight into the aging-related decline of DNA methylation, which could aid in gaining a better understanding of the relationship between DNA methylation and the aging process in bivalve mollusks. | LIAN Shanshan HE Yan LI Xue ZHAO Bosong HOU Rui HU Xiaoli ZHANG Lingling BAO Zhenmin | 2015 | Journal of Ocean University of China2015，14，4： | 0 |
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