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| 1 | FOLFIRI联合西妥昔单抗或贝伐珠单抗治疗晚期结直肠癌:随机临床试验FIRE-3的最终生存及符合方案分析显示文摘背景:在FIRE-3研究中,与贝伐珠单抗+FOLFIRI相比,西妥昔单抗+FOLFIRI可提高KRAS野生型转移性结直肠癌(mCRC)的总生存率,但是未发现相应的无进展生存获益。本研究目的在于分析RAS野生型结直肠癌接受一线FOLFIRI治疗的可评价疗效患者中,与贝伐珠单抗相比,西妥昔单抗是否可改善治疗反应和生存情况,同时分析原发肿瘤部位对预后的影响。方法:意向治疗人群包括593例KRAS第2外显子野生型mCRC患者。进一步检测确认400名患者为全RAS野生型肠癌,其中352名(88%)患者接受了至少3个周期的治疗和至少1次基线后的影像检查以评估疗效,并纳入符合方案的患者(西妥昔单抗组169名,贝伐珠单抗组183名)。 | 何婉 HEINEMANN V VON WEIKERSTHAL L F DECKER T | 2021 | 结直肠肛门外科2021，27，1： | 11 |
| 2 | The menopause ration scale(MRS) as outcome measure for hormone treatment? A validation study显示文摘 | HEINEMANN L A J DOMINH T STRELOW F | 2004 | Health and Quality of Life Outcomes2004，2，： | 1 |
| 3 | Houdriforming reactions catalytic mechanism显示文摘 | MILLS G A HEINEMANN H MILLIKEN T H OBLAD A G | 1953 | Ind Eng Chem1953，45，： | 1 |
| 4 | Regulation of cell function by methionine oxidation and reduction显示文摘 | Hoshi T Heinemann S | 2001 | J Physiol2001，531，1： | 1 |
| 5 | Plasma cell mucositis with oral and genital involvement-successful treatment with topical cy- closporin显示文摘 | Heinemann C Fischer T Barta U | 2006 | J Eur Acad Dermatol Venereol2006，20，6： | 1 |
| 6 | Clinical relevance of EGFR and KRAS status in coloreetal cancer patients treated with monoclonal antibodies directed against the EGFR 显示文摘 | Heinemann V Stintzing S Kirchner T | 2009 | Cancer Treat Rev2009，35，： | 1 |
| 7 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 8 | Molecular neurobiology and genetics:investigation of neural function and dysfunction显示文摘 | Green T Heinemann SF Gusella JF | 1998 | Neuron1998，20，： | 1 |
| 9 | influence ofcontinuous combinedestradiol-norethiserone acetate preparations on insulinsensitivity in postmenopausal nondiabetic women显示文摘 | Kimmerle R Heinemann L Heise T | 1999 | Menopause1999，6，1： | 1 |
| 10 | Influence of continuous combined estradiol-norethisterone acetate preparations on insulin sensitivity in postmenopausal nondiabetic women显示文摘 | Kimmerle R Heinemann L Heise T | 1999 | Menopause1999，6，1： | 1 |
| 11 | Comparison of a neuraI network and traditional classifier for machine vision in spection of potatoes显示文摘 | Deck S H Morrow C T Heinemann P H el al | 1995 | Applied Engineering in Agricuhure1995，11，2： | 1 |
| 12 | FOLFIRI plus cetuximab versus FOLFIRI plus beva-cizumab as first-line treatment for patients with metastaticcolorectal cancer (FIRE-3): a randomised, open-label,phase 3 trial显示文摘 | Heinemann V von Weikersthal LF Decker T | 2014 | Lancet Oncol2014，15，10： | 1 |
| 13 | FOLFIRI plus cetuximab versus FOLFIRI plus beva- cizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3) :a randomised,open-label, phase 3 trial显示文摘 | Heinemann V Von Weikersthal LF Decker T | 2014 | Lancet Oncol2014，15，10： | 1 |
| 14 | Action profile of the rapid acting insulin analogue:human insulin B28Asp显示文摘 | Heinemann L Heise T Jorgensen LN | | 0，，： | 1 |
| 15 | Determinatin of spatial water requirements at county and regional levels using crop models and GIS: An example for the State of Parana, Brazil显示文摘 | Heinemann A B Hoogenboom G Daria R T | 2002 | Agricultural Water Management2002，52，： | 1 |
| 16 | Clinical relevance of EGFR and KRAS status in colorectal cancer pa- tients treated with monoclonal antibodies directed against the EGFR 显示文摘 | Heinemann V Stintzing S Kirehner T | 2009 | Cancer Treatment Rev2009，35，： | 1 |
| 17 | Characterization and regional distribution of nitric oxide synthase in the human brain during normal aging显示文摘 | Heinemann T Lan J | 1999 | Brain Res1999，834，12： | 1 |
| 18 | Sensors for Glucose Monito- ring: Technical and Clinical Aspects 显示文摘 | Koschinsky T Heinemann L | 2001 | Diabetes/Metab- olism Research & Reviews2001，17，2： | 1 |
| 19 | Phase Ⅱ trial of mapatumumab,a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-indu cing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer显示文摘 | Trarbaeh T Moehler M Heinemann V | 2010 | Br J Cancer2010，102，3： | 1 |
| 20 | Molecular neurobiology and genetics: investigation of neural function and dysfunction显示文摘 | Green T Heinemann SF Gusella JF | 1998 | Neuron1998，20，： | 1 |
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