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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure显示文摘 | Pfluger P T Kirchner H Günnel S | | 0，，03： | 1 |
| 3 | Molecular genetic aberrations of ovarian and uterine carcinosarcomas: a CGH and FISH study显示文摘 | Schipf A Mayr D Kirchner T | 2008 | Virchows Arch2008，452，3： | 1 |
| 4 | Thymic cyst with initial maignant transformation显示文摘 | Morresi-Hauf A Wockel W Kirchner T | 2008 | Pathologe2008，29，4： | 1 |
| 5 | Metaplasia, intraepithelial neoplasia and early cancer of the stomach are related to dedifferentiated epithelial cells defined by eytokeratin-7 expression in gastritis显示文摘 | Kirchner T Muller S Hattori T | 2001 | Virch Arch2001，439，4： | 1 |
| 6 | Mucinous neoplasms of the vermi form appendix,Pseudomyxoma peritonei and the new WHO clas- sification显示文摘 | Reu S Neumann J Kirchner T | 2012 | Pathologe2012，33，1： | 1 |
| 7 | Clinical relevance of EGFR and KRAS status in coloreetal cancer patients treated with monoclonal antibodies directed against the EGFR 显示文摘 | Heinemann V Stintzing S Kirchner T | 2009 | Cancer Treat Rev2009，35，： | 1 |
| 8 | The first experimental observation of stable H4+ ions显示文摘 | Kirchner N J Gilbert J R Bowers M T | | 0，，1： | 1 |
| 9 | Metaplasia,intraepithelial neoplasia and early cancer of the stomach are related to dedifferentiated epithelial cells defined by cytokeratin-7 expression in gastritis显示文摘 | Kirchner T Muller S Hattori T | 2001 | Virchows Arch2001，439，4： | 1 |
| 10 | Evaluation of prognostic features in thymic epithelial tumors显示文摘 | Schalke B Marx A | 1989 | Thymus1989，14，： | 1 |
| 11 | Cytotoxicity ol colloidal CdSe and CdSe/ZnS nanoparticles 显示文摘 | Kirchner C Liedl T Kudera S | 2005 | Nano Lett2005，5，2： | 1 |
| 12 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 13 | Cytotoxicity of colloidal CdSe and CdSeFZnS nanoparlicles显示文摘 | KIRCHNER C LIEDI T KUDERA S | 2005 | Nano Letters2005，5，2： | 1 |
| 14 | Effects of tepoxalin,a dual inhibitor of cyclooxygenase/5-lipoxygenase,on events associated with NSAID-induced gastrointestinal inflammation显示文摘 | Aparicio B Argentieri DC | 1997 | Prostaglandins Leukot Essent Fatty Acids1997，56，6： | 1 |
| 15 | Hepatitis B显示文摘 | Lin KW Kirchner J T | 2004 | Am Fam Physician2004，69，1： | 1 |
| 16 | Impact of ELISA and immunoblot as diagnostic tools one year after eradication of helicobacter pylori in a multicentre treatment study显示文摘 | Kist M Strobel S Kirchner T | 1999 | FEMS Immunol Med Microbiol1999，24，2： | 1 |
| 17 | The impact of microRNAs on color- ectal cancer显示文摘 | Faber C Kirchner T Hlubek F | 2009 | Virchows Arch2009，454，4： | 1 |
| 18 | Hepatitis B 显示文摘 | Lin K W Kirchner J T | 2004 | Am Fam Physician2004，69，1： | 1 |
| 19 | Depression in Children and Adolescent显示文摘 | Son S E kirchner J T | | 0，，10： | 1 |
| 20 | A study of cyano- tetrazole oxides and derivatives thereof显示文摘 | Boneber F Kirchner A KlapOtke T M | 2013 | Chem Asian J2013，8，： | 1 |
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