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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma显示文摘 | Deirdre T Helen C Andrew G J | 2008 | Vaccine2008，26，35： | 1 |
| 3 | A new approach to defining func- tional ability in ankylosing spondylitis 显示文摘 | Andrei C Sarah G Helen WL | 1994 | The journal of Rheumetology1994，21，： | 1 |
| 4 | Analysis of nitrosamines in cosmetics显示文摘 | KANE I K-ETH G M HELENE C | 1990 | J Soc Cosmet Chem1990，41，： | 1 |
| 5 | Ytterbium trifluoromethanesulfonate as a novel catalyst for the allylation of aldehydes 显示文摘 | HELEN C A ANDREW F B NICHOLAS G | 1994 | Tetrahedron Letters1994，35，26： | 1 |
| 6 | A new approach to defining functional ability in ankylosing spondylitis:The development of the bath ankylosing spondylitis functional index显示文摘 | Andrei C Sarab G Helen WL | 1994 | The Journal of Rheumatology1994，21，12： | 1 |
| 7 | Benchmark radar targets for the validation of computational electromagnetics problems显示文摘 | Woo Alex C Wang Helen T G Schuh Michael J Sandeers Michael L | 1993 | IEEE Antennas and Propagation Magazine1993，35，1： | 1 |
| 8 | Aporphinoid alkaloids, Ⅲ 显示文摘 | Helene G Michel L Andre C | 1983 | J Nat Prod1983，46，6： | 1 |
| 9 | Characterization of the timing and prevalence of receptor tyrosine kinase expression changes in oesophageal carcinogenesis显示文摘 | Anna L Paterson Maria O’Donovan Elena Provenzano Liam J Murray Helen G Coleman Brian T Johnson Damian T McManus Marco Novelli Laurence B Lovat Rebecca C Fitzgerald | 2013 | J Pathol2013，，1： | 1 |
| 10 | Analysis of T and B cell epitopes of the Schistosoma mansoni p28 antigen in the rat model by using synthetic peptides显示文摘 | Auriault C Helene G M Wolowczuk I | 1988 | J Immunol1988，141，5： | 1 |
| 11 | Extraction of plant RNA 显示文摘 | Michael G S Helen E C | 2007 | Methods in Molecular Biology2007，362，： | 1 |
| 12 | Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson’s disease: a dose escalation, open-label, phase 1/2 trial显示文摘 | Stéphane Palfi Jean Marc Gurruchaga G Scott Ralph Helene Lepetit Sonia Lavisse Philip C Buttery Colin Watts James Miskin Michelle Kelleher Sarah Deeley Hirokazu Iwamuro Jean Pascal Lefaucheur Claire Thiriez Gilles Fenelon Cherry Lucas Pierre Brugières Ina | 2014 | The Lancet2014，，： | 1 |
| 13 | Experimental Af- rican HEV infection in cynomolgus macaques (Macaca fascicularis) 显示文摘 | HELENE C G REBECCA C T JFFREY D C | 1998 | J Med Viro1998，55，： | 1 |
| 14 | Ultra-pressure liquid chromatography-electrospry tandem mass spectrometry for multiresidue determination of pesticides in water显示文摘 | GERVAIS G BROSILLON S LAPLANCHE A HELEN C | 2008 | J Chromatogr:A2008，1202，2： | 1 |
| 15 | Benchmark Radar Targets for the Validation of Computational Electromagnetics Programs显示文摘 | John L Volakls Alex C Woo Helen T G Wang | 1993 | IEEE Antennas and Propagation Magazine1993，35，1： | 1 |
| 16 | Long-lived intestinal tuft cells serve as colon cancer-initiating cells显示文摘 | Westphalen C Benedikt Asfaha Samuel Hayakawa Yoku Takemoto Yoshihiro Lukin Dana J Nuber Andreas H Brandtner Anna Setlik Wanda Remotti Helen Muley Ashlesha Chen Xiaowei May Randal Houchen Courtney W Fox James G Gershon Michael D Quante Mich | 2014 | Journal of Clinical Investigation2014，，3： | 1 |
| 17 | Impact of vertical atmospheric structure on Beijing aerosol distribution 显示文摘 | Benjamin G Jean-Claude R Helene C | 2006 | Atmospheric Environment2006，40，27： | 1 |
| 18 | Cloning, bacterial expression, purification and structural characterization of N-terminal-repetitive domain of γ-Gliadin显示文摘 | Claudia G Benitez C Helene R | 2006 | Protein Expression and Purification2006，，46： | 1 |
| 19 | Modular chiral polyether podands and their lanthanide complexes显示文摘 | Helen C Aspinall Nicholas Greeves Edward G McIver | 2003 | Tetrahedron2003，59，10： | 1 |
| 20 | A nonsynony- mous mutation in the transcriptional regulator lbh is associat- ed with cichlid craniofacial adaptation and neural crest cell development显示文摘 | Powder K E Helene C Mclinden G P | 2014 | Mol Biol Evol2014，31，12： | 1 |
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