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| 1 | Improvement of quantitative testing of liver function in patients with chronic hepatitis C after installment of antiviral therapy显示文摘AIM: To investigate if and to what extent antiviral therapy influenced a broad panel of quantitative testing of liver function (QTLF).METHODS: Fifty patients with chronic hepatitis C were either treated with interferon (n = 8), interferon/ribavirin (n = 19) or peg-interferon/ribavirin (n = 23). Quantitative testing of liver function, including aminopyrine breath test (ABT), galactose elimination capacity (GEC), sorbitol clearance (SCI) and indocyanine green clearance (ICG)was performed before and 3 mo after initiation of antiviral therapy.RESULTS: After 3 mo of antiviral treatment, 36 patients showed normal transaminases and were negative for HCV-RNA, 14 patients did not respond to therapy. ABT and GEC as parameters of microsomal and cytosolic liver function were reduced in all patients before therapy initiation and returned to normal values in the 36 therapy responders after 3 mo. Parameters of liver perfusion (SCI and ICG) were not affected by antiviral therapy. In the 14 non-responders,no changes in QTLF values were observed during the treatment period.CONCLUSION: ICG and SCI remained unaffected in patients with chronic hepatitis C, while ABT and GEC were significantly compromised. ABT and GEC normalized in responders to antiviral therapy. Early determination of ABT and GEC may differentiate responders from non-responders to antivJral treatment in hepatitis C. | Matthias Ocker Marion Ganslmayer Steffen Zopf Susanne Gahr Christopher Janson Eckhart G. Hahn Christoph Herold | 2005 | World Journal of Gastroenterology2005，11，35： | 8 |
| 2 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 3 | 急性坏死性胰腺炎的经皮坏死清除术显示文摘本回顾性研究的目的是评价急性坏死性胰腺炎经皮坏死清除治疗的结果。通过搜集放射学、手术和内科资料.选取1992--2004年间所有的经皮坏死清除术治疗的急性坏死性胰腺炎病人。通过复习病例、放射学和手术报告进行病人的例数统计,对实验室、临床和手术的详细过程进行分析。复习CT影像确定CT严重性指数(CTSI)评分。共确认18例病人,入院时中位Ranson评分为2,急性生理学及慢性健康状况(APACHE)Ⅱ级评分的中位数是22,CTSI的中位数是7。 | T. Bruennler J. Langgartner S. Lang N. Zorger T. Herold B. Salzberger 高莉(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 3 |
| 4 | Some challenges in global land cover mapping: An assessment of agreement and accuracy in existing 1 km datasets显示文摘 | M. Herold P. Mayaux C.E. Woodcock A. Baccini C. Schmullius | 2007 | Remote Sensing of Environment2007，，5： | 2 |
| 5 | Role and function of granin proteins in diabetes mellitus显示文摘The granin glycoprotein family consists of nine acidic proteins;chromogranin A(CgA),chromogranin B(CgB),and secretogranin II–VIII.They are produced by a wide range of neuronal,neuroendocrine,and endocrine cells throughout the human body.Their major intracellular function is to sort peptides and proteins into secretory granules,but their cleavage products also take part in the extracellular regulation of diverse biological processes.The contribution of granins to carbohydrate metabolism and diabetes mellitus is a recent research area.CgA is associated with glucose homeostasis and the progression of type 1 diabetes.WE-14,CgA10-19,and CgA43-52 are peptide derivates of CgA,and act as CD4+or CD8+autoantigens in type 1 diabetes,whereas pancreastatin(PST)and catestatin have regulatory effects in carbohydrate metabolism.Furthermore,PST is related to gestational and type 2 diabetes.CgB has a crucial role in physiological insulin secretion.Secretogranins II and III have angiogenic activity in diabetic retinopathy(DR),and are novel targets in recent DR studies.Ongoing studies are beginning to investigate the potential use of granin derivatives as drugs to treat diabetes based on the divergent relationships between granins and different types of diabetes. | Zoltan Herold Marton Doleschall Aniko Somogyi | 2021 | World Journal of Diabetes2021，12，7： | 2 |
| 6 | Increased incidence of early de novo cancer in liver graft recipients treated with cyclosporine: An association with C显示文摘 | Angela S. W. Tjon Jerome Sint Nicolaas Jaap Kwekkeboom Robert A. de Man Geert Kazemier Hugo W. Tilanus Bettina E. Hansen Luc J. W. van der Laan Thanyalak Tha‐In Herold J. Metselaar | 2010 | Liver Transpl2010，，7： | 2 |
| 7 | Monitoring dioxins and PCBs in eggs as sensitive indicators for environmental pollution and global contaminated sites and recommendations for reducing and controlling releases and exposure显示文摘This review compiles information on PCDD/F-and PCB-contaminated eggs from 20 years of global egg monitoring around emission sources in four continents conducted by the International Pollutants Elimination Network(IPEN)and Arnika as well as a compilation of data from scientific literature.IPEN monitored 127 pooled egg samples including samples from 113 chicken flocks at potential PCDD/F-and PCB-contaminated sites around priority sources listed in the Stockholm Convention(e.g.waste incinerators,metal industries,cement plants,and open burning).99(88%)of pooled egg samples were above the EU maximum limits for PCDD/Fs(2.5 pg PCDD/F-TEQ/g fat)or the sum of PCDD/Fs and dioxinlike PCBs(5 pg PCDD/F-PCB-TEQ/g fat).Children consuming such eggs exceed the tolerable weekly intake(TWI).This demonstrates that close to 90%of these areas were not safe for the production of free-range eggs.Sixteen out of the 113 egg samples(14%)were contaminated above 50 pg TEQ/g fat and exceeded the EU maximum limit more than 10 times.From the 26 pooled egg samples around incinerators 24(92%)exceeded the limit with a mean of 43.1 pg TEQ/g fat(2.6e234 pg TEQ/g).All 21 egg samples around metal industries(4.4e112.6 pg TEQ/g fat)were above limits with mean concentration of 26.0 pg TEQ/g fat.Also all 7 egg samples measured at e-waste recycling sites were above limits(mean 308 pg TEQ/g fat).In 58(51%)pooled egg samples the PCB-TEQ was above 5 pg TEQ/g fat exceeding the EU maximum limit with dioxin-like PCBs alone.This highlights the role of commercial PCBs for global contamination with dioxin-like compounds.It was discovered that around metal industries,shredder plants,open burning sites of e-waste and dump sites,a high share of contamination was caused by dl-PCBs.This clearly shows severe PCB release from the end-of-life management of PCB-containing equipment in developing countries.Also highly contaminated eggs were found at many sites where plastic was incinerated.The highest contaminated egg sample ever measured came from an e-waste site in Ghana and had 856 pg TEQ/g fat plus 300 pg TEQ from brominated dioxins(PBDD/Fs).Other extreme PCDD/F contaminations of eggs were found at a chlor-alkali site(514 pg TEQ/g fat),Agent Orange contaminated areas in Vietnam(490,249 and 246 pg TEQ/g fat)and e-waste sites(568 and 520 pg TEQ/g fat).Where DR CALUX®bioassay revealed higher TEQ compared to measured PCDD/F-PCB-TEQ in IPEN studies,polybrominated PBDD/F were also measured and detected up to 300 pg TEQ/g fat at e-waste sites.One positive outcome from the IPEN studies is that all 10 pooled supermarket eggs in developing countries were below regulatory limit.Policy recommendations are made including:a systematic assessment of areas around PCDD/Fs and PCBs sources;measures for reduction of exposures of populations;urgent control of emission sources including PCB equipment,the open burning of plastic,and the use of plastic as fuel in boilers/incinerators in developing countries without air pollution control.Furthermore,soil limits need to be re-assessed and lowered for free-range poultry. | Jindrich Petrlik Lee Bell Joe DiGangi Serge Molly Allo'o Allo'o Gilbert Kuepouo Griffins Ochieng Ochola Valeriya Grechko Nikola Jelinek Jitka Strakova Martin Skalsky Yuyun Ismawati Drwiega Jonathan N.Hogarh Eric Akortia Sam Adu-Kumi Akarapon Teebthaisong Maria Carcamo Bjorn Beeler Peter Behnisch Claudia Baitinger Christine Herold Roland Weber | 2022 | Emerging Contaminants2022，8，1： | 2 |
| 8 | The spatiotemporal form of urban growth: measurement, analysis and modeling显示文摘 | Martin Herold Noah C. Goldstein Keith C. Clarke | 2003 | Remote Sensing of Environment2003，，3： | 2 |
| 9 | Therapeutic hypothermia and controlled normothermia in the intensive care unit:practical considerations,side effects,and cooling methods显示文摘 | Polderman KH Herold I | 2009 | Crit Care Med2009，37，3： | 1 |
| 10 | Regulation of C-C chemokine production by routine T cells by CD28/B7 costimulation显示文摘 | Herold KC Lu J Rulifson I | 1997 | J Immunol1997，159，： | 1 |
| 11 | The cost of treating relapsed indolent non-Hodgkin's lymphoma in an international setting: retrospective analysis of resource use显示文摘 | Herold M Sacchi S Hieke K | 2002 | Haematologica2002，87，7： | 1 |
| 12 | A new approach to high-speed protection for transmission line based on transient signal analysis using wavelets显示文摘 | Shang L Herold G Jaeger J | 2001 | Developments in Power System Protection IEE 20012001，，： | 1 |
| 13 | Coronary artery calcification and myocardial perfusion in asymptomatic adults显示文摘 | Wang L Jerosch- Herold M Jacobs DR | 2006 | J Am Coll Cardiol2006，48，： | 1 |
| 14 | Residual stress measurements in a thick,dissimilar aluminum alloy friction stir weld 显示文摘 | PRIME M B GNAUPEL- HEROLD T | 2006 | Acta Materialia2006，，54： | 1 |
| 15 | Immunization of pediatric solid-organ transplantation candidates:immunizations in transplant candidates显示文摘 | Campbell AL Herold BC | 2005 | Pediatric Transplantation2005，，05： | 1 |
| 16 | The Drosophila insulator proteins CTCF and CP190 link en- hancer blocking to body patterning显示文摘 | Mohan Man Bartkuhn Marek Herold Martin | 2007 | The EMBO journal2007，26，19： | 1 |
| 17 | Bile salts: natural detergents for the prevent of sexually transmitted diseases显示文摘 | Herold B C Kirkpatrick R Marcellino D | 1999 | Antimicrob Agents Chemother1999，43，4： | 1 |
| 18 | Urotensin-Ⅱ-mediated cardiomyocyte hypertrophy:effect of receptor antagonism and role of inflammatory mediators显示文摘 | Johns DG Ao Z Naselsky D Herold CL Maniscalco K Sarov-Blat L | 2004 | Naunyn Schmiedebergs Arch Pharmacol2004，370，4： | 1 |
| 19 | Regulation of photosynthesis by sink ac-tivity-themissing link显示文摘 | Herold A | 1980 | New Phytologist1980，86，： | 1 |
| 20 | Combined in vitro antitumoral action of tamoxifen and retinoic acid derivatives in hepatoma cells显示文摘 | Herold C Ganslmayer M Ocker M | 2002 | Int J Oncol2002，20，1： | 1 |
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