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| 1 | Focal depth research of earthquakes in China's Mainland: Implication for tectonics显示文摘Focal depth data of earthquakes in China's Mainland are processed and analyzed in this paper, as well as the relationship between the focal depths and large-scale tectonic structures. As a basic parameter for earthquakes, focal depth is used to investigate deep environment of seis-mogenic regions, tectonic backgrounds for concentration and release of seismic energy, the inner crustal deformation and its mechanic features. Depth data of 31282 ML≥2.0 events with 1st class and 2nd class precision in China's Mainland from Jan. 1, 1970 to May 31, 2000 are used to get spatial features of earthquakes distributed with depth and to provide average depth for each grid area throughout China. Researches show that the average depth (D) for all the earthquakes used in this paper is (16±7) km, and (13±6) km and (18±8) km for the events in eastern China and western China, respectively. The area with the deepest focal depth is located in southwest Xinjiang region, near the western and southwestern ends of the Tarim | ZHANG Guomin WANG Suyun LI Li ZHANG Xiaodong MA Hongsheng | 2002 | Chinese Science Bulletin2002，47，12： | 38 |
| 2 | Aerosol and boundary-layer interactions and impact on air quality显示文摘Air quality is concerned with pollutants in both the gas phase and solid or liquid phases. The latter are referred to as aerosols, which are multifaceted agents affecting air quality, weather and climate through many mechanisms. Unlike gas pollutants, aerosols interact strongly with meteorological variables with the strongest interactions taking place in the planetary boundary layer(PBL). The PBL hosting the bulk of aerosols in the lower atmosphere is affected by aerosol radiative effects. Both aerosol scattering and absorption reduce the amount of solar radiation reaching the ground and thus reduce the sensible heat fluxes that drive the diurnal evolution of the PBL. Moreover, aerosols can increase atmospheric stability by inducing a temperature inversion as a result of both scattering and absorption of solar radiation, which suppresses dispersion of pollutants and leads to further increases in aerosol concentration in the lower PBL.Such positive feedback is especially strong during severe pollution events. Knowledge of the PBL is thus crucial for understanding the interactions between air pollution and meteorology. A key question is how the diurnal evolution of the PBL interacts with aerosols, especially in vertical directions, and affects air quality.We review the major advances in aerosol measurements, PBL processes and their interactions with each other through complex feedback mechanisms, and highlight the priorities for future studies. | Zhanqing Li Jianping Guo Aijun Ding Hong Liao Jianjun Liu Yele Sun Tijian Wang Huiwen Xue Hongsheng Zhang Bin Zhu | 2017 | National Science Review2017，4，6： | 37 |
| 3 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 4 | Hyperthermic intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis:A multicenter propensity scorematched cohort study显示文摘Objective:Systemic chemotherapy has limited efficacy in the treatment of peritoneal metastasis(PM)in gastric cancer(GC).Hyperthermic intraperitoneal chemotherapy(HIPEC)combined with complete cytoreductive surgery(CRS)has shown promising outcomes but remains controversial.The present study aimed to evaluate the safety and efficacy of HIPEC without CRS in GC patients with PM.Methods:This retrospective propensity score-matched multicenter cohort study included GC patients with PM treated with either chemotherapy alone(Cx group)or with HIPEC combined with chemotherapy(HIPEC-Cx group)in four Chinese high-volume gastric medical centers between 2010 and 2017.The primary outcomes were median survival time(MST)and 3-year overall survival(OS).Propensity score matching was performed to compensate for controlling potential confounding effects and selection bias.Results:Of 663 eligible patients,498 were matched.The MST in the Cx and HIPEC-Cx groups was 10.8 and 15.9 months,respectively[hazard ratio(HR)=0.71,95%confidence interval(95%CI),0.58-0.88;P=0.002].The 3-year OS rate was 10.1%(95%CI,5.4%-14.8%)and 18.4%(95%CI,12.3%-24.5%)in the Cx and HIPEC-Cx groups,respectively(P=0.017).The complication rates were comparable.The time to first flatus and length of hospital stay for patients undergoing HIPEC combined with chemotherapy was longer than that of chemotherapy alone(4.6±2.4 d vs.2.7±1.8 d,P<0.001;14.2±5.8 d vs.11.4±7.7 d,P<0.001),respectively.The median follow-up period was 33.2 months.Conclusions:Compared with standard systemic chemotherapy,HIPEC combined with chemotherapy revealed a statistically significant survival benefit for GC patients with PM,without compromising patient safety. | Ziying Lei Jiahong Wang Zhi Li Baozhong Li Jiali Luo Xuejun Wang Jin Wang MingchenBa Hongsheng Tang Qingjun He Quanxing Liao Xiansheng Yang Tianpei Guan Han Liang Shuzhong Cui | 2020 | Chinese Journal of Cancer Research2020，32，6： | 11 |
| 5 | The effect of melt overheating on the melt structure transition and solidified structures of Sn-Bi40 alloy显示文摘Evolution of the electrical resistivity of Sn-40wt%Bi melt with time under different overheating temperatures during isothermal experiments has been studied, and the relationship between different melt state, solidification behavior and solidified structure has also been investigated. The results show that the melt structure transition revealed by the abnormal change of resistivity would take place within a certain holding time just when the holding temperature is above a certain critical, and that the higher the temperature above the critical, the shorter the 'incubation period' of the melt structure transition, and the faster the transition speed. The results of solidification experiments suggest that the melt structure transition caused by different holding time at the same temperature can lead to a higher so-lidification undercooling degree, finer grain size and change of microscopic pattern. Further exploration indicates that the solidification undercooling degree can come to a head when the melt is held at the specific temperature for a given time. The functionary mechanism of the phenomena above is also discussed briefly. | CHEN HongSheng ZU FangQiu CHEN Jie ZOU Li DING GuoHua HUANG ZhongYue | 2008 | Science China(Technological Sciences)2008，51，9： | 11 |
| 6 | Characteristics of Boundary Layer Structure during a Persistent Haze Event in the Central Liaoning City Cluster, Northeast China显示文摘The characteristics of boundary layer structure during a persistent regional haze event over the central Liaoning city cluster of Northeast China from 16 to 21 December 2016 were investigated based on the measurements of particulate matter(PM) concentration and the meteorological data within the atmospheric boundary layer(ABL). During the observational period, the maximum hourly mean PM_(2.5) and PM10 concentrations in Shenyang, Anshan, Fushun, and Benxi ranged from 276 to 355 μg m–3 and from 378 to 442 μg m–3, respectively, and the lowest hourly mean atmospheric visibility(VIS) in different cities ranged from 0.14 to 0.64 km. The central Liaoning city cluster was located in the front of a slowly moving high pressure and was mainly controlled by southerly winds. Wind speed(WS) within the ABL(< 2 km) decreased significantly and WS at 10-m height mostly remained below 2 m s–1 during the hazy episodes, which was favorable for the accumulation of air pollutants. A potential temperature inversion layer existed throughout the entire ABL during the earlier hazy episode [from 0500 Local Time(LT) 18 December to 1100 LT 19 December], and then a potential temperature inversion layer developed with the bottom gradually decreased from 900 m to 300 m. Such a stable atmospheric stratification further weakened pollutant dispersion. The atmospheric boundary layer height(ABLH) estimated based on potential temperature profiles was mostly lower than 400 m and varied oppositely with PM_(2.5) in Shenyang. In summary, weak winds due to calm synoptic conditions, strong thermal inversion layer, and shallow atmospheric boundary layer contributed to the formation and development of this haze event.The backward trajectory analysis revealed the sources of air masses and explained the different characteristics of the haze episodes in the four cities. | Xiaolan LI Yangfeng WANG Lidu SHEN Hongsheng ZHANG Hujia ZHAO Yunhai ZHANG Yanjun MA | 2018 | Journal of Meteorological Research2018，32，2： | 10 |
| 7 | Development strategies for the sea cucumber industry in China显示文摘The sea cucumber, Apostichopus japonicus, is an important marine aquaculture species in China. After nearly thirty years of development, the production of A. japonicus has become commercially lucrative and successful. In this report, current advances in sea cucumber industry are addressed in terms of the basic biology, culturing methods, and health care bene?ts. Next, the challenges restricting development of the sea cucumber industry are discussed, including weaknesses in the basic biological research, the problem of germplasm degradation, environmental stress caused by global climate change, and food safety problems. Finally, several strategies are presented that might contribute to sustainable development of the sea cucumber industry. These strategies include advances in genome studies, behavioral studies, selective breeding, ecological culture technologies, reforms in food safety management, and the development of health care functions based on contemporary medical practices. Thus, our work provides new insights into how to explore the sustainable development of the sea cucumber industry in the future. | RU Xiaoshang ZHANG Libin LI Xiaoni LIU Shilin YANG Hongsheng | 2019 | Journal of Oceanology and Limnology2019，37，1： | 10 |
| 8 | Monte Carlo Method for the Uncertainty Evaluation of Spatial Straightness Error Based on New Generation Geometrical Product Specification显示文摘Straightness error is an important parameter in measuring high-precision shafts. New generation geometrical product specification(GPS) requires the measurement uncertainty characterizing the reliability of the results should be given together when the measurement result is given. Nowadays most researches on straightness focus on error calculation and only several research projects evaluate the measurement uncertainty based on 'The Guide to the Expression of Uncertainty in Measurement(GUM)'. In order to compute spatial straightness error(SSE) accurately and rapidly and overcome the limitations of GUM, a quasi particle swarm optimization(QPSO) is proposed to solve the minimum zone SSE and Monte Carlo Method(MCM) is developed to estimate the measurement uncertainty. The mathematical model of minimum zone SSE is formulated. In QPSO quasi-random sequences are applied to the generation of the initial position and velocity of particles and their velocities are modified by the constriction factor approach. The flow of measurement uncertainty evaluation based on MCM is proposed, where the heart is repeatedly sampling from the probability density function(PDF) for every input quantity and evaluating the model in each case. The minimum zone SSE of a shaft measured on a Coordinate Measuring Machine(CMM) is calculated by QPSO and the measurement uncertainty is evaluated by MCM on the basis of analyzing the uncertainty contributors. The results show that the uncertainty directly influences the product judgment result. Therefore it is scientific and reasonable to consider the influence of the uncertainty in judging whether the parts are accepted or rejected, especially for those located in the uncertainty zone. The proposed method is especially suitable when the PDF of the measurand cannot adequately be approximated by a Gaussian distribution or a scaled and shifted t-distribution and the measurement model is non-linear. | WEN Xiulan XU Youxiong LI Hongsheng WANG Fenglin SHENG Danghong | 2012 | Chinese Journal of Mechanical Engineering2012，25，5： | 10 |
| 9 | NUMERICAL SIMULATION OF FEEDSTOCK MELT FILLING IN A CYLINDRICAL CAVITY WITH SOLIDIFICATION IN POWDER INJECTION MOLDING显示文摘INTRODUCTIONPowderinjectionmolding(PIM)isaprocesingrouteforfabricatingmetalorceramiccomponentswithcomplexshapeandhighperfor?.. | Qu Xuanhui, Li Yimin, Yue Hongsheng, Mao Jinying, Zhu Lei and Huang Baiyun State Key Laboratory for Powder Metallurgy, Central South University of Technology, Changsha 410083, P. R. China | 1998 | 中国有色金属学会会刊:英文版1998，8，4： | 9 |
| 10 | Synthesis of growth-type polycrystalline diamond compact (PDC) using the solvent Fe_(55)Ni_(29)Co_(16) alloy under HPHT显示文摘A growth-type polycrystalline diamond compact (PDC) was synthesized under high temperature and high pressure (HPHT). The infiltration technique was used with an Fe55Ni29Co16 (KOV) alloy as the sintering solvent. The morphology and weight ratio of the PDC were investigated through scanning electron microscopy (SEM) and electron dispersion spectroscopy (EDS). Note that the KOV alloy evenly infiltrated throughout the polycrystalline diamond (PCD) layer and WC-Co substrate in a short sintering time due to its low viscosity and high soakage capability. A transition layer confirmed the presence of the MxC phase near the interface of the PDC, which can make the diamond layer and WC-Co substrate combine as a complex material. X-ray diffraction (XRD) performed on the PCD layer confirmed the presence of cubic diamond, WC, cubic CoCx, the high temperature cubic phase of α-Co, the alloy phase of FeNix, and no graphite phase. Besides, a surface residual stress of the PCD layer, measured with reasonable accuracy using micro-Raman spectroscopy, is found to be a homogeneous compressive stress with an average value of 0.16 GPa, much lower than that of the powders-mixing method. | JIA HongSheng JIA XiaoPeng MA HongAn LI HaiBo | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，8： | 9 |
| 11 | Performing optical logic operations by a diffractive neural network显示文摘Optical logic operations lie at the heart of optical computing,and they enable many applications such as ultrahighspeed information processing.However,the reported optical logic gates rely heavily on the precise control of input light signals,including their phase difference,polarization,and intensity and the size of the incident beams.Due to the complexity and difficulty in these precise controls,the two output optical logic states may suffer from an inherent instability and a low contrast ratio of intensity.Moreover,the miniaturization of optical logic gates becomes difficult if the extra bulky apparatus for these controls is considered.As such,it is desirable to get rid of these complicated controls and to achieve full logic functionality in a compact photonic system.Such a goal remains challenging.Here,we introduce a simple yet universal design strategy,capable of using plane waves as the incident signal,to perform optical logic operations via a diffractive neural network.Physically,the incident plane wave is first spatially encoded by a specific logic operation at the input layer and further decoded through the hidden layers,namely,a compound Huygens’metasurface.That is,the judiciously designed metasurface scatters the encoded light into one of two small designated areas at the output layer,which provides the information of output logic states.Importantly,after training of the diffractive neural network,all seven basic types of optical logic operations can be realized by the same metasurface.As a conceptual illustration,three logic operations(NOT,OR,and AND)are experimentally demonstrated at microwave frequencies. | Chao Qian Xiao Lin Xiaobin Lin Jian Xu Yang Sun Erping Li Baile Zhang Hongsheng Chen | 2020 | Light(Science & Applications)2020，9，1： | 8 |
| 12 | The plate contact geometry investigation based on earthquake source parameters at the Burma arc subduction zone显示文摘Accurately characterizing the three-dimensional geometric contacts between the crust of the Chinese mainland and adjacent regions is important for understanding the dynamics of this part of Asia from the viewpoint of global plate systems.In this paper,a method is introduced to investigate the geometric contacts between the Eurasian and Indian plates at the Burma arc subduction zone using earthquake source parameters based on the Slab1.0 model of Hayes et al.(2009,2010).The distribution of earthquake focus depths positioned in 166 sections along the Burma Arc subduction zone boundary has been investigated. Linear plane fitting and curved surface fitting has been performed on each section.Three-dimensional geometric contacts and the extent of subduction are defined quantitatively.Finally,the focal depth distribution is outlined for six typical sections along the Burma arc subduction zone,combining focal mechanisms with background knowledge of geologic structure.Possible dynamic interaction patterns are presented and discussed.This paper provides an elementary method for studying the geometric contact of the Chinese mainland crust with adjacent plates and serves as a global reference for dynamic interactions between plates and related geodynamic investigations. | ZHANG LangPing SHAO ZhiGang MA HongSheng WANG XingZhou LI ZhiHai | 2013 | Science China Earth Sciences2013，56，5： | 8 |
| 13 | Effect of moxa smoke produced during combustion of Aiye(Folium Artemisiae Argyi) on behavioral changes in mice inhaling the smoke显示文摘OBJECTIVE: To evaluate the effects that inhalation of the combustion products of the traditional Chinese herb Aiye(Folium Artemisiae Argyi) has on the central nervous system.METHODS: Forty Kunming mice(half male) were randomly assigned(n = 10/group) to a control group(C) or one of three moxa smoke concentration groups(% opacity): low(L1; 0.4%), medium(M1; 2%), and high(H1; 15%). Mice in the latter three groups were exposed to moxa smoke in a dynamic gas exposure cabinet for 20 min per day for7 days. Mice in control group were placed in the same cabinet without any intervention. For the sleep experiments, another 50 mice were divided into five groups of 10 mice each: a saline-injected control group, L1 + pentobarbital sodium(PS)-injected group, M1+PS group, H1(15%)+PS group,and a positive control group(10 mg/kg, chlorpromazine, p.o.). The weight, general activities, locomotor activities, rotarod performance, sleep duration,and sleeping rate induced by a subthreshold dose of pentobarbital sodium were recorded in the mice,and the composition of moxa smoke was analyzed using headspace gas chromatography(GC-HS).RESULTS: A low concentration of smoke significantly decreased the frequency of locomotor activities and the time for which the mice remaining on the rotarod; however, a high smoke concentration significantly prolonged the pentobarbital-induced sleeping time and sleeping rate.CONCLUSION: The concentration-dependent relaxing effects of moxa smoke on the Central Nervous System(CNS) were confirmed. Moreover, GC-HS analysis showed that the component present in the highest concentration in moxa smoke was eucalyp-tol, an essential oil well recognized for its soothing effects on the CNS. This may therefore be accountable for the sedative effects of moxa smoke. | Yang Jia Zheng Xiaojun Jin Ran Han Li Ha Lue Li Jun Wang Lei Liu Ping Chu Zhusheng Huang Chang Chang Hongsheng Lao Lixing Zhao Baixiao | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 8 |
| 14 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 15 | Lamellar orientation control in directionally solidified TiAl intermetallics显示文摘TiAl-based alloys are potentially used as high-temperature structural materials with a high specific strength in the range of^900°C.However,the mechanical properties of TiAl-based alloys are extremely anisotropic with respect to the lamellar orientation of the microstructures.A balance combination of room-temperature ductility and strength can be achieved when the lamellar orientation are aligned parallel to the tensile stress direction.Lamellar orientation control of TiAl-based alloys by directional solidification technique has been widely studied in recent years.Two different directional solidification processes can be used to modify the lamellar orientation.One is a seeding technique and the other is adjusting the solidification path.This paper reviews the principles of the two methods and their progress.The influence of alloy composition and solidification parameters on lamellar orientation control is also discussed. | Su Yanqing Liu Tong Li Xinzhong Chen Ruirun Ding Hongsheng Guo Jingjie Fu Hengzhi | 2014 | China Foundry2014，11，4： | 7 |
| 16 | Optimization Potentials for the Waste Heat Recovery of a Gas-Steam Combined Cycle Power Plant Based on Absorption Heat Pump显示文摘A new waste heat recovery system is presented to recover exhausted steam waste heat from the steam turbine by absorption heat pump(AHP) in a gas-steam combined cycle(GSCC) power plant. The system can decrease energy consumption and further improve the energy utilization. The performance evaluation criteria are calculated, and exergy analysis for key components are implemented in terms of the energy and exergy analysis theory. Besides, the change of these criteria is also revealed before and after modification. The net power output approximately increases by 21738 kW, and equivalent coal consumption decreases by 5.58 g/kWh. A 1.81% and 1.92% increase in the thermal and exergy efficiency is respectively obtained in the new integrated system as the heating load is 401095 kJ at 100% condition. Meanwhile, the appropriate extraction parameters for heating have been also analyzed in the two systems. The proposed scheme can not only save energy consumption but also reduce emission and gain great economic benefit, which is proven to be a huge potential for practical application. | ZHANG Hongsheng ZHAO Hongbin LI Zhenlin HU Eric | 2019 | Journal of Thermal Science2019，28，2： | 6 |
| 17 | Added Value of Quantitative Apparent Diffusion Coefficients for Identifying Small Hepatocellular Carcinoma from Benign Nodule Categorized as LI-RADS 3 and 4 in Cirrhosis显示文摘Background and Aims:Correct identification of small hepa-tocellular carcinomas(HCCs)and benign nodules in cirrhosis remains challenging,quantitative apparent diffusion coeffi-cients(ADCs)have shown potential value in characterization of benign and malignant liver lesions.We aimed to explore the added value of ADCs in the identification of small(≤3 cm)HCCs and benign nodules categorized as Liver Imag-ing Reporting and Data System(LI-RADS)3(LR-3)and 4(LR-4)in cirrhosis.Methods:Ninety-seven cirrhosis patients with 109 small nodules(70 HCCs,39 benign nodules)of LR-3 and 4 LR-4 based on major and ancillary magnetic resonance imaging features were included.Multiparametric quantitative ADCs of the lesions,including the mean ADC(ADCmean),min-imum ADC(ADCmin),maximal ADC(ADCmax),ADC standard deviation(ADCstd),and mean ADC value ratio of lesion-to-liv-er parenchyma(ADCratio)were calculated.Regarding the joint diagnosis,a nomogram model was plotted using multivariate logistic regression analysis.The performance was assessed using the area under the receiver operating characteristic curve(AUC).Results:The ADCmean,ADCmin,ADCratio,and ADCstd were significantly associated with the identification of small HCC and benign nodules(p<0.001).For the joint diagnosis,the LI-RADS category(odds ratio[OR]=12.50),ADCmin(OR=0.14),and ADCratio(OR=0.12)were identified as independent factors for distinguishing HCCs from benign nodules.The joint nomogram model showed good calibration and discrimination,with a C-index of 0.947.Compared with the LI-RADS category alone,this nomogram model demon-strated a significant improvement in diagnostic performance,with AUC increasing from 0.820 to 0.967(p=0.001).Con-clusions:The addition of quantitative ADCs could improve the identification of small HCC and benign nodules catego-rized as LR-3 and 4 LR-4 in patients with cirrhosis. | Xi Zhong Hongsheng Tang Tianpei Guan Bingui Lu Chuangjia Zhang Danlei Tang Jiansheng Li Shuzhong Cui | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 6 |
| 18 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 19 | Theoretical analysis on the deformation characteristics of coal wall in a longwall top coal caving face显示文摘Against the background of analyzing coal wall stability in 14101 fully mechanized longwall top coal caving face in Majialiang coal mine,based on the torque equilibrium of the coal wall,shield support and the roof strata,an elastic mechanics model was established to calculate the stress applied on the coal wall.The displacement method was used to obtain the stress and deformation distributions of the coal wall.This study also researched the influence of support resistance,protective pressure to the coal wall,fracture position of the main roof and mining height on the coal wall deformation.The following conclusions are drawn:(1) The shorter the distance from the longwall face,the greater the vertical compressive stress and horizontal tensile stress borne by the coal wall.The coal wall is prone to failure in the form of compressive-shear and tension;(2) With increasing support resistance,the revolution angle of the main roof decreases linearly.As the support resistance and protective force supplied by the face guard increases,the maximum deformation of the coal wall decreases linearly;(3) As the face approaches the fracture position of the main roof,coal wall horizontal deformation increases significantly,and the coal wall is prone to instability;and(4) The best mining height of 14101 longwall face is 3.0 m. | Bai Qingsheng Tu Shihao Li Zhaoxin Tu Hongsheng | 2015 | International Journal of Mining Science and Technology2015，25，2： | 5 |
| 20 | Approaches to Census Mapping:Chinese Solution in 2010 Rounded Census显示文摘China still use sketch maps as control devices that guarantees consistency and accuracy of population counting in previous census.Although the rapid advancement of geospatial technologies provides many possible solutions of digital census mapping,existing researches do not answer which solution is suitable to China.Subject to many constraints originated from characteristics of China,a practical solution of census mapping based on remote sensing imagery and auxiliary geographic information was proposed and proved to be feasible through evaluation analysis and a three-stage pilot study.Imagery with 2.5 meters and higher resolution,innovative workflow of census areas delineation,easy-to-use census mapping software packages and training organization all together provide the all-around supports for the 2010 rounded census (the 6th census) mapping activities.A digital census geographic framework detailed at the level of enumeration area was established in the 2010 rounded census which fills in the gaps in the field of modern geospatial census in China.The spatially referenced digital census database,especially the detailed census units,is of great value in successive census,sampling survey and many other census-related fields.Future work including quality evaluation of census areas,census mapping solution in the Tibet Autonomous Region are also discussed. | WANG Yingjie LI Hongsheng YU Zhuoyuan LUO Bin | 2012 | Chinese Geographical Science2012，22，3： | 5 |
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