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| 1 | Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks显示文摘Avian infectious bronchitis virus(IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopathological lesions were observed in the tracheal mucosa at 3–5days post inoculation(dpi) and in the kidney at 8 dpi, with heavy viral loads at 1–11 and 1–28 dpi,respectively. The expression of m RNAs encoding Toll-like receptor(TLR) 3 and TLR7 were upregulated at 3–8 dpi, and that of TIR-domain-containing adapter-inducing interferon(IFN) β(TRIF) was upregulated at 21 dpi in the trachea and kidney. Myeloid differentiation primary response protein 88(My D88) was upregulated in the trachea during early infection. Tumor necrosis factor receptor-associated factor(TRAF) 3 and TRAF6 were upregulated expression in both tissues.Moreover, melanoma differentiation-associated protein 5(MDA5), laboratory of genetics and physiology 2(LGP2), stimulator of IFN genes(STING), and mitochondrial antiviral signaling protein(MAVS), as well as TANK binding kinase 1(TBK1), inhibitor of kappa B kinase(IKK) ?, IKKα, IKKβ,IFN regulatory factor(IRF) 7, nuclear factor of kappa B(NF-κB), IFN-α, IFN-β, various interleukins(ILs), and macrophage inflammatory protein-1β(MIP-1β) were significantly upregulated in the trachea and downregulated in the kidney. These results suggested that the TLR and MDA5 signaling pathways and innate immune cytokine were induced after IBV infection. Additionally,consistent responses to IBV infection were observed during early infection, with differential and complicated responses in the kidney. | Yining He Zhiwen Xie Jinglong Dai Yanjie Cao Jinlian Hou Yansheng Zheng Tianchao Wei Meilan Mo Ping Wei | 2016 | Virologica Sinica2016，31，1： | 14 |
| 2 | Electrochemical incineration of dimethyl phthalate by anodic oxidation with boron-doped diamond electrode显示文摘The anodic oxidation of aqueous solutions containing dimethyl phthalate (DMP) up to 125 mg/L with sodium sulfate (Na2SO4) as supporting electrolyte within the pH range 2.0-10.0 was studied using a one-compartment batch reactor employing a boron-doped diamond (BDD) as anode. Electrolyses were carried out at constant current density (1.5-4.5 mA/cm2). Complete mineralization was always achieved owing to the great concentration of hydroxyl radical (.OH) generated at the BDD surface. The effects of pH, apparent current density and initial DMP concentration on the degradation rate of DMP, the specific charge required for its total mineralization and mineralization current efficiency were investigated systematically. The mineralization rate of DMP was found to be pH-independent and to increase with increasing applied current density. Results indicated that this electrochemical process was subjected, at least partially, to the mass transfer of organics onto the BDD surface. Kinetic analysis of the temporal change of DMP concentration during electrolysis determined by High Performance Liquid Chromatography (HPLC) revealed that DMP decay under all tested conditions followed a pseudo first-order reaction. Aromatic intermediates and generated carboxylic acids were identified by Gas Chromatography-Mass Spectrometry (GC-MS) and a general pathway for the electrochemical incineration of DMP on BDD was proposed. | HOU Yining QU Jiuhui ZHAO Xu LIU Huijuan | 2009 | Journal of Environmental Sciences2009，21，10： | 5 |
| 3 | Species transformation and structure variation of fulvic acid during ozonation显示文摘The species transformation and structure variation of fulvic acid (FA) during ozonation were investi- gated in this study. The molecular weight (MW) distribution, the species of intermediate products and the variation of polar functional groups were studied by ultrafiltration, gas chromatography/mass spectrometry (GC/MS) and titration analyses respectively. The average MW of FA decreased signifi- cantly during ozonation. The amount of polar functional groups (carboxylic and phenolic (ph-OH) groups) per unit DOC (mol/kg C) increased with increasing ozonation time. Furthermore, GC/MS ex- periments demonstrated the formation of polar species (e.g., hexadecanoic acid, benzoic acid and oc- tadecanoic alcohol) and less-polar species (e.g., aliphatic hydrocarbons and butanedioic acid, bis(2-methylpropyl) ester). Electron spin resonance (ESR) measurements proved the presence of ·OH radicals in the ozonation system. Based on our experimental results, it appears that the oxidations by ozone molecule and ·OH radicals were responsible for the transformation of organics (FA and its oxi- dation products) during ozonation. These two oxidants showed significant influence on organics transformation and exhibited different mechanisms contributing to these processes. | LI Jing QU JiuHui LIU HuiJuan LIU RuiPing ZHAO Xu HOU YiNing | 2008 | Science China Chemistry2008，51，4： | 4 |
| 4 | Removing formaldehyde form gas by TiO2-activated carbon fiber compound materials显示文摘 | Hou Yining Wang An Wang Yang | | 0，，： | 1 |
| 5 | FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway显示文摘CDK4/6 inhibitors are routinely recommended agents for the treatment of advanced HR+HER2-breast cancer.However,their therapeutic effectiveness in triple-negative breast cancer(TNBC)remains controversial.Here,we observed that the expression level of fibrous sheath interacting protein 1(FSIP1)could predict the treatment response of TNBC to CDK4/6 inhibitors.High FSIP1 expression level was related to a poor prognosis in TNBC,which was associated with the ability of FSIP1 to promote tumor cell proliferation.FSIP1 downregulation led to slowed tumor growth and reduced lung metastasis in TNBC.FSIP1knockout caused cell cycle arrest at the G0/G1 phase and reduced treatment sensitivity to CDK4/6 inhibitors by inactivating the Nanog/CCND1/CDK4/6 pathway.FSIP1 could form a complex with Nanog,protecting it from ubiquitination and degradation,which may facilitate the rapid cell cycle transition from G0/G1 to S phase and exhibit enhanced sensitivity to CDK4/6 inhibitors.Our findings suggest that TNBC patients with high FSIP1 expression levels may be suitable candidates for CDK4/6 inhibitor treatment. | Guanglei Chen Lisha Sun Xi Gu Liping Ai Jie Yang Zhan Zhang Pengjie Hou Yining Wang Xunyan Ou Xiaofan Jiang Xinbo Qiao Qingtian Ma Nan Niu Jinqi Xue Hao Zhang Yongliang Yang Caigang Liu | 2023 | Science China(Life Sciences)2023，66，12： | 1 |
| 6 | A new trifilar pendulum approach to identify all inertia parameters of a rigid body显示文摘 | HOU Zhichao LU Yining LAO Yaoxin | 2009 | Mechanism and Machine Theory2009，44，6： | 1 |
| 7 | The electrocatalytic dechlori nation of chloroacetic acids at electrodeposited Pd/Fe-modified carbon paper electrode显示文摘 | Li Angzhen Zhao Xu Hou Yining | 2012 | Applied Catalysis B-Environmental2012，111，62： | 1 |
| 8 | Relationship of energy charge and toxin content of Microcystis aeruginosa in nitrogen-limited or phosphorous-limited cultures显示文摘 | Ruihua Dai Huijuan Liu Jiuhui Qu Xu Zhao Jia Ru Yining Hou | 2007 | Toxicon2007，，4： | 1 |
| 9 | Thermostable Nitrogen-Doped HTiNbO5 Nanosheets with a High Visible-Light Photocatalytic Activity显示文摘做氮的 HTiNbO5 nanosheets 被第一 exfoliating 成功地综合了在 tetrabutylammonium 氢氧化物(TBAOH ) 到的分层的 HTiNbO5 获得 HTiNbO5 nanosheets 然后与脲加热 nanosheets。产生样品被 X 光检查描绘衍射(XRD ) ,传播电子显微镜学(TEM ) ,扫描电子显微镜学(SEM ) ,精力散的 X 光检查(EDX ) , X 光检查光电子光谱学(XPS ) ,紫外力的光谱学和 N2 吸附解吸附作用大小。在分层的结构,内在的 bandgap 变窄和可见轻回答的高得多的 thermostability 结果,被发现那做 N。做的氮原子主要位于 TiNbO5 lamellae 的空隙的地点并且化学上跳了到氢离子。与做 N 的 HTiNbO5 相比,做 N 的 HTiNbO5 nanosheets 由于 titanoniobate nanosheets 的相当松开、不规则的安排有一个大得多的特定的表面区域和更富有的 mesoporosity。做 N 的分层的 HTiNbO5 和 HTiNbO5 nanosheets 为玫瑰精 B (RhB ) 的降级显示出一项很高可见光的 photocatalytic 活动水的答案。而且由于更加更大的表面区域,更富有的 mesoporosity 和更强壮的酸味,做 N 的 HTiNbO5 nanosheets 比做 N 的 HTiNbO5 举办了一项甚至更高的活动,尽管后者在可见区域有更强壮的吸收。染料分子主要被降级到脂肪族的有机化合物并且部分使矿物化到 CO2 或公司,而非简单地被将脱色。photosensitization 的效果是不足道的, RhB 主要经由典型 photocatalytic 反应线路被降级。为在在做 N 的 HTiNbO5 nanosheets 上的可见轻照耀下面的 RhB 的 photodegradation 的二条不同反应线路被建议了。现在的方法能被扩大到有置闰和脱落的特征的很多分层的金属氧化物,因此为高度有效、潜在地实际的可见光的光催化剂的制造提供新机会。 | Zheng Zhai Yucheng Huang Lin Xu Xiaoyan Yang Chenhui Hu Lihong Zhang Yining Fan Wenhua Hou | 2011 | Nano Research2011，4，7： | 1 |
| 10 | Effects of amino acids on microcystin production of the Microcystis aeruginosa显示文摘 | Ruihua Dai Huijuan Liu Jiuhui Qu Xu Zhao Yining Hou | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 11 | A New Trifilar Pendulum Approach to Identify All Inertia Parameters of a Rigid Body or Assembly Rigid Body显示文摘 | Hou Zhichao Lu Yining Lao Yaoxin | | 0，，6： | 1 |
| 12 | Electro-oxidation of diclofenac at boron doped diamond: kinetics and mechanism 显示文摘 | ZHAO Xu HOU Yining LIU Huijuan | 2009 | Electrochimica Acta2009，54，17： | 1 |
| 13 | Structure and function of the membrane microdomains in osteoclasts显示文摘The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases.Strong experimental evidence supports the existence of membrane microdomains in osteoclasts(OCs).However,the potential membrane microdomains and the crucial mechanisms underlying their roles in OCs have not been fully characterized.Membrane microdomain components,such as scaffolding proteins and the actin cytoskeleton,as well as the roles of individual membrane proteins,need to be elucidated.In this review,we discuss the compositions and critical functions of membrane microdomains that determine the biological behavior of OCs through the three main stages of the OC life cycle. | Jialong Hou Jian Liu Zhixian Huang Yining Wang Hanbing Yao Zhenxin Hu Chengge Shi Jiake Xu Qingqing Wang | 2023 | Bone Research2023，11，4： | 0 |
| 14 | Information Propagation with Retweet Probability on Online Social Network显示文摘The rapid development of online social network has attracted a lot of research attention. On online social network, people can discuss their ideas, express their interests and opinions, all of which are demonstrated by information propagation. So how to model the information propagation cascade accurately has become a hot topic. In this paper, we firstly incorporate the retweet probability into the traditional propagation models. To find the accurate retweet probability, we introduce the logistic regression model for every user based on the extracted features. With the crawled real dataset, simulation is conducted on the real online social network and moreover some novel results have been obtained. The homogenous retweet probability in the original model has underestimated the speed of information propagation, despite the scale of information propagation is almost at the same level. Besides, the initial information poster is really important for a certain propagation, which enables us to make effective strategies to prevent epidemics of rumor on social network. | Xing Tang Yining Quan Qiguang Miao Ruihong Hou Kai Deng | 2015 | 国际计算机前沿大会会议论文集2015，，1： | 0 |
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