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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | A Study on Anti-oxidative Activity of Soybean Peptideswith Linoleic Acid Peroxidation Systems显示文摘Soybean bioactive peptides(SBPs) were prepared from the isolated soybean protein by proteolysis with an alkaline protease, alcalase, at 50 ℃ and pH=8.0. The dependence of hydrolysis time on hydrolysis degree and molecular weight distribution were examined. The hydrolysate was fractionated on a Sephadex G-25 column and the anti-oxidative activities of the fractions were detected by the method of pyrogallol auto-oxidation. The average chain length of soybean peptides that have anti-oxidative activity was estimated to be about 7. The anti-oxidative properties of the soybean peptide were also studied by using linoleic acid peroxidation systems. The optimal condition of the peroxidation system was set up, Vc/Cu 2+ as the inducer at pH=7.4 and 25 ℃. In addition, soybean peptides show higher anti-oxidative activity compared with GSH. | XU Li LI Hong-mei HUANG Yi-bing WANG Hua NIE Guang-jun ZHANG Xue-zhong | 2006 | Chemical Research in Chinese Universities2006，22，2： | 13 |
| 3 | Plasma neutrophil-gelatinase-associated lipocalin and cystatin C could early diagnose contrast-induced acute kidney injury in patients with renal insufficiency undergoing an elective percutaneous coronary intervention显示文摘 | LIU Xiao-li WANG Zhi-jian YANG Qing YU Miao SHEN Hua NIE Bin HAN Hong-ya GAO Fei ZHOU Yu-jie | 2012 | Chinese Medical Journal2012，，6： | 12 |
| 4 | The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses,cell differentiation and proliferation显示文摘p204 is a member of the interferon-inducible p200 family proteins in mice.The p200 family has been reported to be multifunctional regulators of cell proliferation,differentiation,apoptosis and senescence.Interferon-inducible protein 16(IFI16)is regarded as the human ortholog of p204 in several studies.This is possibly due to the similarity of their structures.However the consistency of their functions is still elusive.Currently,an emerging focus has been placed upon the role of the p200 proteins as sensors for microbial DNA in innate immune responses and provides new insights into infections as well as autoimmune diseases.This review specially focuses on IFI16 and p204,the member of p200 family in human and murine respectively,and their pathophysiological roles in innate immune responses,cell differentiation and proliferation. | Hua Zhao Elena Gonzalezgugel Lei Cheng Brendon Richbourgh Lin Nie Chuanju Liu | 2015 | Genes & Diseases2015，2，1： | 7 |
| 5 | An Improved Barcoded Oligonucleotide Primers-based Next-generation Sequencing Approach for Direct Identification of Viral Pathogens in Clinical Specimens显示文摘Objective To provide a feasible and cost-effective next-generation sequencing(NGS) method for accurate identification of viral pathogens in clinical specimens, because enormous limitations impede the clinical use of common NGS, such as high cost, complicated procedures, tremendous data analysis, and high background noise in clinical samples. Methods Viruses from cell culture materials or clinical specimens were identified following an improved NGS procedure: reduction of background noise by sample preprocessing, viral enrichment by barcoded oligonucleotide(random hexamer or non-ribosomal hexanucleotide) primer-based amplification, fragmentation-free library construction and sequencing of one-tube mixtures, as well as rapid data analysis using an in-house pipeline. Results NGS data demonstrated that both barcoded primer sets were useful to simultaneously capture multiple viral pathogens in cell culture materials or clinical specimens and verified that hexanucleotide primers captured as many viral sequences as hexamers did. Moreover, direct testing of clinical specimens using this improved hexanucleotide primer-based NGS approach provided further detailed genotypes of enteroviruses causing hand, foot, and mouth disease(HFMD) and identified other potential viruses or differentiated misdiagnosis events. Conclusion The improved barcoded oligonucleotide primer-based NGS approach is simplified, time saving, cost effective, and appropriate for direct identification of viral pathogens in clinical practice. | WANG Churl Hua NIE Kai ZHANG Yi WANG Ji ZHOU Shuai Feng LI Xin Na ZHOU Hang Yu QI Shun Xiang MA Xue Jun | 2017 | Biomedical and Environmental Sciences2017，30，1： | 7 |
| 6 | The Effects of Different Sex-Linked Dwarf Variations on Chinese Native Chickens显示文摘Variants in chicken growth hormone receptor (GHR) gene lead to sex-linked dwarf (SLD) chickens, but effects of different variants are distinct. In this study, 11 SLD chicken breeds or strains including 3 Chinese native breeds and 8 breeding strains were studied in order to investigate the effects of different sex-linked dwarf variations on growth performance. The results showed that there were three reasons which could lead to dwarfism in the 11 breeds or strains. Firstly, an about 1.7 kb deletion of growth hormone receptor (GHR) gene leads to dwarfism in Jiangxi dwarf chicken, strains GF24, GF26, N308, N309, and N310. Secondly, a T354C mutation in exon 5 of the GHR gene leads to dwarfism in strains N301 and N305. Thirdly, an unknown variant leads to dwarfism in Guizhou Yellow Dwarf chicken and Yixing Bantam chicken. In addition, all individuals of N303 had the 1.7 kb deletion of the GHR gene, and additionally, some of them also carried the T354C mutation. As far as the performance of individuals were compared among T354C homozygote, deletion homozygote, and heterozygote carrying both T354C and deletion, it was found that the T354C's impacts on body weight of Chinese chickens were maximum, the body weight of chickens with homozygote T354C was 92.12% of those with heterozygote, and the difference of the body weight between deletion homozygote and heterozygote was not significant. There was no significant difference of shank length among three genotypes. | OUYANG Jian-hua XIE Liang NIE Qing-hua ZENG Hua PENG Zhi-jun ZHANG De-xiang ZHANG Xi-quan | 2012 | Journal of Integrative Agriculture2012，11，9： | 7 |
| 7 | Nusap1 is essential for neural crest cell migration in zebrafish显示文摘Microtubules play important roles in mitotic spindle assembly and chromosome segregation to maintain normal cell cycle progression.A number of microtubule-associated proteins have been identified in epithelial and neural cell cultures;however,their physiological significance is not well characterized due to the lack of appropriate in vivo animal models.Nucleolar spindleassociated protein(NuSAP)is a microtubule-binding protein and is reported to be involved in mitosis by cell culture studies.In this report,we identified the zebrafish homologue of human NuSAP and investigated its expression profile and functions.Using in situ hybridization,we demonstrated that transcripts of zebrafish nusap1 are specifically expressed in the retina,forebrain,hindbrain and neural crest.When the in vivo expression of nusap1 was knocked down through antisense oligonucleotide morpholino technology,the morphants of nusap1 showed impaired morphogenesis in the trunk and yolk extension,implying the involvement of Nusap1 in cell migration.Mechanistic studies revealed that nusap1 morphants have an altered expression pattern of neural crest markers crestin and sox9b,but normal expression of blood vessel and notochord markers gata1 and shh.In addition,nusap1 mRNA injection caused serious apoptosis in retina and hindbrain tissue,and these phenotypes can be rescued by co-injection of morpholino against nusap1.These observations not only suggest a role for Nusap1 in connecting apoptosis with cell migration,but also provide strong evidences that Nusap1 is potentially involved in morphogenesis in vertebrates. | Jing Nie Hua Wang Fuchu He Huizhe Huang | 2010 | Protein & Cell2010，1，3： | 7 |
| 8 | Risk Factors for Strangulated Ovarian Hernia in Female Infants:the Role of Ovarian Volume显示文摘The risk factors associated with strangulated ovarian hernia (SOH)in female patients (<1 year old)were identified.A retrospective analysis was conducted regarding the data from 2006 to 2017.The patients were divided into 2groups:SOH group (n=9)and non-SOH group (n=23). Patient demographics,clinical signs,preoperative examinations and intraoperative findings were compared between the two groups,and risk factors for SOH were tested using a binary logistic regression model.To explore whether greater ovary was more likely to be twisted,leading to SOH, all the patients were divided into ovary volume <5cm^3 and ≥5cm^3 groups and the association between ovarian volume and ovary torsion was assessed.Among a total of 32 female patients (<1year old)with incarcerated ovarian herniation,9 patients developed SOH.The single variate analysis revealed that times of manual reduction,ovarian volume,ovary with or without multiple cysts,ovary torsion or not and angle of ovary torsion were found to be significant factors associated with SOH.The multivariate analysis showed ovarian volume was evidenced as an independent risk factor for SOH.Furthermore,the incidence of ovary torsion was significantly higher in ovarian volume ≥5cm^3 group than in ovarian volume <5cm^3 group,indicating that larger ovary was more likely to result in ovary torsion,leading to SOH.Our study demonstrated that the odds of SOH increased with increasing ovarian volume in female patients (<1 year old)because the relatively greater ovary at this age was more likely to be incarcerated and twisted,leading to SOH. | Yu CHEN Xiang-zhi PENG Wei LU Kai ZHENG Jian GUO Hua NIE Xiao-jie SONG Yan ZHANG Jing YANG | 2018 | Current Medical Science2018，38，6： | 6 |
| 9 | Chromatin accessibility analysis reveals that TFAP2A promotes angiogenesis in acquired resistance to anlotinib in lung cancer cells显示文摘Anlotinib,a multitarget tyrosine kinase inhibitor,is effective as a third-line treatment against non-small cell lung cancer(NSCLC).However,acquired resistance occurs during its administration.To understand the molecular mechanisms of anlotinib resistance,we characterized chromatin accessibility in both the parental and anlotinib-resistant lung cancer cell line NCI-H1975 through ATAC-seq.Compared with the parental cells,we identified 2666 genomic regions with greater accessibility in anlotinib-resistant cells,in which angiogenesis-related processes and the motifs of 21 transcription factors were enriched.Among these transcription factors,TFAP2A was upregulated.TFAP2A knockdown robustly diminished tumor-induced angiogenesis and partially rescued the anti-angiogenic activity of anlotinib.Furthermore,transcriptome analysis indicated that 2280 genes were downregulated in anlotinib-resistant cells with TFAP2A knocked down,among which the PDGFR,TGF-β,and VEGFR signaling pathways were enriched.Meanwhile,we demonstrated that TFAP2A binds to accessible sites within BMP4 and HSPG2.Collectively,this study suggests that TFAP2A accelerates anlotinib resistance by promoting tumor-induced angiogenesis. | Le-le Zhang Jun Lu Rui-qi Liu Min-juan Hu Yi-ming Zhao Sheng Tan Shu-yuan Wang Bo Zhang Wei Nie Yu Dong Hua Zhong Wei Zhang Xiao-dong Zhao Bao-hui Han | 2020 | Acta Pharmacologica Sinica2020，41，10： | 6 |
| 10 | Research Data Management Implementation at Peking University Library:Foster and Promote Open Science and Open Data显示文摘Research Data Management(RDM)has become increasingly important for more and more academic institutions.Using the Peking University Open Research Data Repository(PKU-ORDR)project as an example,this paper will review a library-based university-wide open research data repository project and related RDM services implementation process including project kickoff,needs assessment,partnerships establishment,software investigation and selection,software customization,as well as data curation services and training.Through the review,some issues revealed during the stages of the implementation process are also discussed and addressed in the paper such as awareness of research data,demands from data providers and users,data policies and requirements from home institution,requirements from funding agencies and publishers,the collaboration between administrative units and libraries,and concerns from data providers and users.The significance of the study is that the paper shows an example of creating an Open Data repository and RDM services for other Chinese academic libraries planning to implement their RDM services for their home institutions.The authors of the paper have also observed since the PKU-ORDR and RDM services implemented in 2015,the Peking University Library(PKUL)has helped numerous researchers to support the entire research life cycle and enhanced Open Science(OS)practices on campus,as well as impacted the national OS movement in China through various national events and activities hosted by the PKUL. | Hua Nie Pengcheng Luo Ping Fu | 2021 | Data Intelligence2021，3，1： | 5 |
| 11 | Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke显示文摘Stroke at the acute stage is a major cause of disability in adults, and is associated with dysfunction of brain networks. However, the mechanisms underlying changes in brain connectivity in stroke are far from fully elucidated. In the present study, we investigated brain metabolism and metabolic connectivity in a rat ischemic stroke model of middle cerebral artery occlusion(MCAO)at the acute stage using18 F-fluorodeoxyglucose positron emission tomography. Voxel-wise analysis showed decreased metabolism mainly in the ipsilesional hemisphere, and increased metabolism mainly in the contralesional cerebellum. We used further metabolic connectivity analysis to explore the brain metabolic network in MCAO.Compared to sham controls, rats with MCAO showed most significantly reduced nodal and local efficiency in the ipsilesional striatum. In addition, the MCAO group showed decreased metabolic central connection of the ipsilesional striatum with the ipsilesional cerebellum, ipsilesional hippocampus, and bilateral hypothalamus. Taken together,the present study demonstrated abnormal metabolic connectivity in rats at the acute stage of ischemic stroke, which might provide insight into clinical research. | Shengxiang Liang Xiaofeng Jiang Qingqing Zhang Shaofeng Duan Tianhao Zhang Qi Huang Xi Sun Hua Liu Jie Dong Weilin Liu Jing Tao Shujun Zhao Binbin Nie Lidian Chens Baoci Shan | 2018 | Neuroscience Bulletin2018，34，5： | 5 |
| 12 | Protective effects of medical ozone combined with traditional Chinese medicine against chemically-induced hepatic injury in dogs显示文摘AIM: To investigate the protective effect of medical ozone (O3) combined with Traditional Chinese Medicine (TCM) Yigan Fuzheng Paidu Capsules (YC) against carbon tetrachloride (CCl4)-induced hepatic injury in dogs. METHODS: Thirty healthy dogs were divided randomly into fi ve groups (n = 6 in each group), namely control, oleanolic acid tablet (OAT), O3, YC and O3 + YC, given either no particular pre-treatment, oral OAT, medical ozone rectal insulfflation every other day, oral YC, or oral YC plus medical ozone rectal insulfflation every other day, respectively, for 30 consecutive days. After pre-treatment, acute hepatic injury was induced in all dogs with a single-dose intraperitoneal injection of CCl4. General condition and survival time were recorded. The biochemical and hematological indexes of alanine aminotransferase (ALT), aspartate aminotransferase/ alanine aminotransferase (AST/ALT), serum total bilirubin (TBIL), prothrombin time (PT), blood ammonia (AMMO), and blood urea nitrogen (BUN) were measured after CCl4 injection. Hepatic pathological changes were also observed.RESULTS: Compared to the other four groups, the changes of group O3 + YC dogs’ general conditions (motoricity, mental state, eating, urination and defecation) could be better controlled. In group O3 + YC the survival rates were higher (P < 0.05 vs group control). AST/ALT values were kept within a normal level in group O3 + YC. Hepatic histopathology showed that hepatic injury in group O3 + YC was less serious than those in the other four groups. CONCLUSION: Medical ozone combined with TCM YC could exert a protective effect on acute liver injury induced by CCl4. | Li-Jie Li Yun-Gao Yang Zhi-Ling Zhang Sui-Feng Nie Ze Li Feng Li He-Yu Hua Yan-Jun Hu Hong-Shuan Zhang Ya-Bing Guo | 2007 | World Journal of Gastroenterology2007，13，45： | 4 |
| 13 | Lipase-catalyzed synthesis of novel galactosylated cholesterol显示文摘In an organic phase system,an enzymes lipase was used as a catalyst to synthesize galactosylated cholesterol,(5-cholesten-3b-yl)[(4-O-β-D-galactopyranosyl)D-glucitol-6]sebacate(CHS-SE-LA),which contains galactose residues.Its chemical structure was characterized by ESI-MS,and NMR.For HepG2 cells,the cellular fluorescence intensities of liposomes modified with CHS-SE-LA(GAL-FL) were as much as 2.6-fold(p < 0.01) control liposomes(FL).Moreover,the presence of excess galactose significantly inhibited the uptake of GAL-FL suggesting ASGPR mediated uptake.In conclusion,the novel galactosylated ligand CHS-SE-LA was synthesized by lipase-catalyzation and revealed a great potential as drug carrier materials for hepatocyte-selective targeting. | Hua Nie Yi Cheng Pin-Jing Zheng Li-Hua Luo Sheng-Yuan Zhang | 2015 | Chinese Chemical Letters2015，26，5： | 4 |
| 14 | Matrix Effects and Behaviors of Elements in Oxalic Acid Medium by Inductively Coupled Plasma Mass Spectrometry显示文摘The influence of different concentration of oxalic acid matrix on elemental inductively coupled plasma mass spectrometry (ICP-MS) has been investigated. It has been proved that the sensitivity of analytes can be significantly enhanced by adding small amounts of oxalic acid medium with adjusted nebulizer flow-rate gas,especially for the elements with ionization potential between 9 and 11 eV. Oxalic acid,as an enhancement agent,can be used to compensate the signal depression caused by inorganic matrix and to improve the detection limits about two to eight times,for the hard-to-ionize elements in ICP-MS determination. | Hua Lin XIE Yu Jie LI Xi Du NIE Li Bo LI | 2006 | Chinese Chemical Letters2006，17，7： | 4 |
| 15 | 断肢再植术后感染患者甲襞微循环及血流指标的变化观察显示文摘目的分析断肢再植术后感染患者甲襞微循环及血流变指标的变化,为断肢再植术后感染患者的诊治及预防控制提供依据。方法选取2012年1月-2015年9月收治的56例断肢再植术后感染患者为观察组,同时间段56例断肢再植术后未发生感染患者为对照组,将两组患者的甲襞微循环及血流变指标进行检测与比较,并比较观察组中浅层感染及深部感染者的检测结果。结果观察组甲襞微循环加权积分中的襻周积分、流态积分、管襻积分及总积分分别为(1.64±0.21)、(2.31±0.27)、(1.25±0.14)及(3.32±0.32),其均高于对照组(0.88±0.12)、(1.18±0.15)、(0.64±0.06)及(2.30±0.24),其他甲襞微循环指标及血流变指标也均高于对照组,且观察组中深部感染患者的检测结果高于浅层感染的患者,各个比较指标间差异均有统计学意义(P<0.05)。结论断肢再植术后感染患者甲襞微循环及血流变指标均较高,且浅部感染与深部感染患者的检测结果也存在明显差异,因此应重视对此类患者进行微循环状态的改善。 | 张全英 朱玉花 李琼 李中锋 王丽娜 NIE Xing-guo QIN Hua | 2016 | 中华医院感染学杂志2016，26，13： | 4 |
| 16 | Quantification of Trace Amounts of Impurities in High Purity Cobalt by High Resolution Inductively Coupled Plasma Mass Spectrometry显示文摘An analytical method using high resolution inductively coupled plasma mass spectrometry (HR-ICP-MS) for rapid simultaneous determination of Be, Mg, Al, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Ga, Ge, As, Se, Mo, Ag, Cd, Sn, Sb, Ba, Pt, Au and Pb in high purity cobalt was described. Sample digestions were performed in closed microwave vessels using HNO3 and HCl. The matrix effects due to the presence of excess HCl and Co were evaluated. The usefulness of high mass resolution for overcoming some spectral interference was demonstrated. The optimum conditions for the determination was tested and discussed. Correction for matrix effects, Sc, Rh and Bi were used as internal standards. The detection limits is 0.003-0.57 μg/g, the recovery ratio is 92.2%-111.2%, and the RSD is less than 3.6%. The method is accurate, quick and convenient. It has been applied to the determination of trace impurities in high purity cobalt with satisfactory results. | Hua Lin XIE Xi Du NIE You Gen TANG | 2006 | Chinese Chemical Letters2006，17，8： | 3 |
| 17 | Effect of calcium citrate on bone integration in a rabbit femur defect model显示文摘Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study. Methods:Twenty-four male Japanese white rabbits were randomly divided into three groups (Group A.B.C)in this study.Under anesthesia,defects of four sizes(1.2,1.5,2.0 and 2.5 mm) were created in each of the rabbits.Commercially pure calcium citrate powder was placed inside the medullary compartment of the femur(Experimental),while in the contralateral femur(Control) nothing was implanted.The defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A),6th(Group B) and 8th(Group C) weeks postoperatively.Four samples were analyzed for each size of defect and each healing period.Results:The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks,It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 mm.No statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th week.Conclusions:Calcium citrate affects the early periods of hone defects healing mechanism in Japanese white rabbits positively,especially when the defect is not too large,We suggest further studies on calcium citrate to determine the effects of various dosages,administration ways and the experimental time on the bone defects. | Wei Zhang Wei Wang Qing-Yu Chen Zhong-Qin Lin Shao-Wen Cheng Dong-Quan Kou Xiao-Zhou Ying Yue Shen Xiao-Jie Cheng Peng-Fei Nie Xiu-Cui Li Ferdinand An Rompis Hang Huang Hua Zhang Zhong-Lin Mu Lei Peng | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 3 |
| 18 | Decreased expression of β-nerve growth factor correlated with histological changes in a cryptorchidism rat model显示文摘背景神经生长因素( NGF )为它在有它的神经营养的角色的紧张的 system.Along 的发展和维护的重要角色是著名的, NGF 在老鼠,老鼠和人的睾丸被检测了,建议在在 undescended 睾丸( cryptorchidism )的 -NGF 的男繁殖 system.The 表示的另外的非神经营养的效果没在这研究的 present.The 目的被检测是在 experimenta 计算神经生长因素 mRNA | XIAN Hua XIAN Yun JIANG Chun-yi NIE Xiao WANG Xu-dong CHENG Hong-xia HE Jiang-hong WANG Yong-jun ZHOU Yan HUANG Jian-fei | 2012 | Chinese Medical Journal2012，，4： | 3 |
| 19 | Primary human hepatocyte transplantation in the therapy of hepatic failure:2 cases report显示文摘Liver failure is the end stage of hepatopathy with unfavorable prognosis.In two patients with liver failure,viable primary human hepatocytes,obtained from resected liver tissue of patients with hepatolithiasis.were transplanted into the spleen by interventional therapy through femoral arterial cannula.After transplantation,the patients’ clinical symptoms and liver function were significantly improved.However,their bilirubin increased within six days following transplantation.One suffered from hepatic coma and give up treatment and the other patient died forteen days after transplantation.It is technically safe to treat liver failure by intrasplenic transplantation of adult hepatocytes and the clinical efficacy has been confirmed.How to make transplanted hepatic cells proliferate and functionally survive is the key point to maintain continuous improvement of the recipient’s hepatic function. | Zhuo-Ri Li Xian-Hai Mao Xiao-Xuan Hu Sheng-Dan Nie Yong-Zhong Shi Hua Xiang Jian-Hui Yang Ou-De Cao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 3 |
| 20 | Innovative Design and Performance Evaluation of a High-speed Bionic Mechanical Leg显示文摘 | Hua Nie Ronglei Sun Chaoke Guo Guohua Qin Huiyang Yu | 2015 | Journal of Bionic Engineering2015，12，3： | 3 |
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