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| 1 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 2 | Design ofL-Cysteine Functionalized Au@SiO2@Fe3O4/Nitrogen-doped Graphene Nanocomposite and Its Application in Electrochemical Detection of Pb2+显示文摘 | NIE Jing HE Bin CHENG Yanmei YIN Wei HOU Changjun HUO Danqun QIAN Linlin QIN Yunan FA Huanbao | 2017 | Chemical Research in Chinese Universities2017，33，6： | 3 |
| 3 | A Dual Read-out Molecularly Imprinted Composite Membrane Sensor Based on Zinc Porphyrin for the Detection of Dimethyl Methylphosphonate显示文摘 | ZHANG Ya QIAN Linlin YIN Wei HE Bin LIU Fangmei HOU Changjun HUO Danqun FA Huanbao | 2016 | Chemical Research in Chinese Universities2016，32，5： | 2 |
| 4 | Estimation of Fracture Geometry Parameters and Characterization of Rock Mass Structure for the Beishan Area,China显示文摘The accurate estimation of fracture geometry parameters and the characterization of rock mass structure are two important topics in the geological disposal system of high-level radioactive waste(HLW).The Beishan area,as the current preselected area for China’s HLW disposal,has three subareas considered to be the key survey area at the stage of site selection.In this paper,a comprehensive survey method conducted on the outcrop is developed to estimate fracture geometry parameters.Results show that fracture occurrence obeys a Fisher distribution,fracture trace length obeys a normal distribution,and the distribution of spacing obeys a negative exponential distribution.An evaluation index,Rock Mass Structure Rating(RMSR),is proposed to characterize rock mass structure for the three subareas.The results show that the Xinchang area is more suitable to act as China’s HLW disposal repository site.At the same time,the index can also be applied to characterize surface rock mass structure and rock mass integrity at the site selection phase of HLW disposal. | WEI Xiang GUO Ying CHENG Hanlie WEI Jianfei ZHANG Linlin HUO Liang HOU Zhenkun | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 1 |
| 5 | Molecular level understanding of CO_(2) capture in ionic liquid/polyimide composite membrane显示文摘Ionic liquid(IL)/polyimide(PI)composite membranes demonstrate promise for use in CO_(2)separation applications.However,few studies have focused on the microscopic mechanism of CO_(2)in these composite systems,which is important information for designing new membranes.In this work,a series of systems of CO_(2)in 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide composited with 4,4-(hexafluoroisopropylidene)diphthalic anhydride(6FDA)-based PI,6FDA-2,3,5,6-tetramethyl-1,4-phenylene-diamine,at different IL concentrations were investigated by all-atom molecular dynamics simulation.The formation of IL regions in PI was found,and the IL regions gradually became continuous channels with increasing IL concentrations.The analysis of the radial distribution functions and hydrogen bond numbers demonstrated that PI had a stronger interaction with cations than anions.However,the hydrogen bonds among PI chains were destroyed by the addition of IL,which was favorable for transporting CO_(2).Furthermore,the self-diffusion coefficient and free energy barrier suggested that the diffusion coefficient of CO_(2)decreased with increasing IL concentrations up to 35 wt-%due to the decrease of the fractional free volume of the composite membrane.However,the CO_(2)selfdiffusion coefficients increased when the IL contents were higher than 35 wt-%,which was attributed to the formation of continuous IL domain that benefitted the transportation of CO_(2). | Linlin You Yandong Guo Yanjing He Feng Huo Shaojuan Zeng Chunshan Li Xiangping Zhang Xiaochun Zhang | 2022 | Frontiers of Chemical Science and Engineering2022，16，2： | 1 |
| 6 | Extended 9-Intersection Model for Description of Topological Relations between Regions with Holes显示文摘 | OUYANG Jihong HUO Linlin LIU Dayou | 2009 | Journal of Jilin University(Engineering and Technology Edition)2009，39，6： | 1 |
| 7 | Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging显示文摘Iron oxide nanoparticle(IONP)with unique magnetic property and high biocompatibility have been widely used as magnetic resonance imaging(MRI)contrast agent(CA)for long time.However,a review which comprehensively summarizes the recent development of IONP as traditional T_(2) CA and its new application for different modality of MRI,such as T_(1) imaging,simultaneous T_(2)/T_(1) or MRI/other imaging modality,and as environment responsive CA is rare.This review starts with an investigation of direction on the development of high-performance MRI CA in both T_(2) and T_(1) modal based on quantum mechanical outer sphere and Solomon-Bloembergen-Morgan(SBM)theory.Recent rational attempts to increase the MRI contrast of IONP by adjusting the key parameters,including magnetization,size,effective radius,inhomogeneity of surrounding generated magnetic field,crystal phase,coordination number of water,electronic relaxation time,and surface modification are summarized.Besides the strategies to improve r2 or r1 values,strategies to increase the in vivo contrast efficiency of IONP have been reviewed from three different aspects,those are introducing second imaging modality to increase the imaging accuracy,endowing IONP with environment response capacity to elevate the signal difference between lesion and normal tissue,and optimizing the interface structure to improve the accumulation amount of IONP in lesion.This detailed review provides a deep understanding of recent researches on the development of high-performance IONP based MRI CAs.It is hoped to trigger deep thinking for design of next generation MRI CAs for early and accurate diagnosis. | Zhenghuan Zhao Muyao Li Jie Zeng Linlin Huo Kun Liu Ruixue Wei Kaiyuan Ni Jinhao Gao | 2022 | Bioactive Materials2022，7，6： | 1 |
| 8 | A review of research on nanoparticulate flow undergoing coagulation显示文摘Nanoparticulate flows occur in a wide range of natural phenomena and engineering applications and, hence,have attracted much attention. The purpose of the present paper is to provide a review of the research conducted over the last decade. The research covered relates to the Brownian coagulation of monodisperse and polydisperse particles, the Taylor-series expansion method of moment, and nanoparticle distributions due to coagulation in pipe and channel flow,jet flow, and the mixing layer and in the process of flame synthesis and deposition. | Jianzhong Lin Linlin Huo | 2015 | Acta Mechanica Sinica2015，31，3： | 0 |
| 9 | In vitro characterization of a nitro-forming oxygenase involved in 3-(trans-2’-aminocyclopropyl)alanine biosynthesis显示文摘In vitro characterization experiments revealed the formations of 3-(trans-2’-aminocyclopropyl)alanine((3-Acp)Ala)and 3-(trans-2’-nitrocyclopropyl)alanine((3-Ncp)Ala)are originated via two homologous proteins,BelK and HrmI,which regioselectively catalyze the N��-oxygenation of l-lysine.The two enzymes belong to the emerg-ing heme-oxygenase-like diiron oxidase and oxygenase(HDO)superfamily and the catalytic center of BelK is validated by homology modeling and site-directed mutations.Based on the in vitro characterization,the biosyn-thetic pathways of(3-Acp)Ala and(3-Ncp)Ala are proposed. | Linlin Pang Weijing Niu Yuwei Duan Liujie Huo Aiying Li Jiequn Wu Youming Zhang Xiaoying Bian Guannan Zhong | 2022 | Engineering Microbiology2022，2，1： | 0 |
| 10 | Low-rank matrix recovery with total generalized variation for defending adversarial examples显示文摘Low-rank matrix decomposition with first-order total variation(TV)regularization exhibits excellent performance in exploration of image structure.Taking advantage of its excellent performance in image denoising,we apply it to improve the robustness of deep neural networks.However,although TV regularization can improve the robustness of the model,it reduces the accuracy of normal samples due to its over-smoothing.In our work,we develop a new low-rank matrix recovery model,called LRTGV,which incorporates total generalized variation(TGV)regularization into the reweighted low-rank matrix recovery model.In the proposed model,TGV is used to better reconstruct texture information without over-smoothing.The reweighted nuclear norm and Li-norm can enhance the global structure information.Thus,the proposed LRTGV can destroy the structure of adversarial noise while re-enhancing the global structure and local texture of the image.To solve the challenging optimal model issue,we propose an algorithm based on the alternating direction method of multipliers.Experimental results show that the proposed algorithm has a certain defense capability against black-box attacks,and outperforms state-of-the-art low-rank matrix recovery methods in image restoration. | Wen LI Hengyou WANG Lianzhi HUO Qiang HE Linlin CHEN Zhiquan HE Wing W.Y.Ng | 2024 | Frontiers of Information Technology & Electronic Engineering2024，25，3： | 0 |
| 11 | Re-Os isotopic dating and geological significance of molybdenite from Xintian Cu-Mo polymetallic deposit in Yanbian,Jilin显示文摘Xintian polymetallic deposit is a hydrothermal vein type Cu-Mo deposit. Analysis on Re-Os isotopic dating for the molybdenite from this deposit is undertaken to determine metallogenic epoch and dynamics setting of the deposit. Re-Os isotopic dating for the molybdenite yields model ages ranging from 123. 9 ± 1. 9 Ma to 124. 7 ± 1. 8 Ma,with a weighted mean age of 123. 4 ± 0. 81 Ma,and an isochron age of 127 ± 16 Ma,MSWD= 0. 25,indicating that the metallization was at late Yanshanian. The content of Re in molybdenite is( 330. 1± 4. 0--367. 9 ± 3. 1) × 10^(-6),which demonstrates mantle derived metallogenic sources. Integrating the regional tectonic evolution and the metallogenic characteristics of other contemporaneous Cu-Mo deposits in the region,it is suggested that the Cu-Mo mineralization of this deposit occurred in an active epicontinental environment under lithospheric extension resulted from the subduction of the Izanagi plate to the Paleo-Asia continental margin at late Yanshanian. The Mantle wedge was partially melted with large amount of metallogenic elements dissolved in it. Under the favorable conditions of crust-mantle interaction,large-scale magmatic activity turns out to be the important mechanism of the mineralization of many Cu-Mo deposits in the Xiaoxingan Range--Zhangguangcai Mountain metallogenic belt,including the Xintian Cu-Mo polymetallic deposit. | YIN Yue CUI Bo WANG Li WANG Linlin HUO Liang LI Liang DUAN Hongchang | 2018 | Global Geology2018，21，3： | 0 |
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