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| 1 | Micro RNAs Regulating Signaling Pathways:Potential Biomarkers in Systemic Sclerosis显示文摘Systemic sclerosis(SSc) is a multisystem fibrotic and autoimmune disease. Both genetic and epigenetic elements mediate SSc pathophysiology. This review summarizes the role of one epigenetic element, known as micro RNAs(mi RNAs), involved in different signaling pathways of SSc pathogenesis. The expression of key components in transforming growth factor-b(TGF-b)signaling pathway has been found to be regulated by mi RNAs both upstream and downstream of TGF-b. We are specifically interested in the pathway components upstream of TGF-b, while mi RNAs in other signaling pathways have not been extensively studied. The emerging role of mi RNAs in vasculopathy of SSc suggests a promising new direction for future investigation. Elucidation of the regulatory role of mi RNAs in the expression of signaling factors may facilitate the discovery of novel biomarkers in SSc and improve the understanding and treatment of this disease. | Yisha Li Jing Huang Muyao Guo Xiaoxia Zuo | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 3 |
| 2 | A one-for-all strategy of polyimide coating layer for resolving the comprehensive issues of phosphorus anode显示文摘Phosphorus is a promising anode with high capacity (2596 mAh g^(-1)and 6075~6924 mAh cm^(-3)),low lithium-ion diffusion barrier (0.08 e V),and appropriate lithiation potential (~0.7 V vs Li+/Li).However,it faces the problems of huge volume expansion (~300%),low electronic conductivity (10^(-14)~10^(2)S cm^(-1)),soluble intermediates (lithium polyphosphides,Li_(x)Ps),degradation in air,and low thermal stability.In this work,phosphorus/carbon nanotube composites were coated with a polyimide layer,which plays the roles of a buffer layer to relieve the volume expansion of phosphorus,an obstruct layer to confine LixPs,an inert layer to prevent the degradation of phosphorus in air,a heat resistant layer to improve the thermal stability of the anode.The resulting composites (P/CNT@PI) display high capacity retention of798.1 m Ah g^(-1)after 150 cycles at 1 A g^(-1),achieving 17 times as much as the control sample (P/CNT). | Muyao Han Shaojie Zhang Yu Cao Chengyu Han Xu Li Yiming Zhang Zhanxu Yang Jie Sun | 2022 | Journal of Energy Chemistry2022，31，7： | 2 |
| 3 | Opposed arsenic - induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells显示文摘 | Andy T Y Lau Muyao Li | 2004 | Carcinogenesis2004，25，1： | 1 |
| 4 | Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging显示文摘Iron oxide nanoparticle(IONP)with unique magnetic property and high biocompatibility have been widely used as magnetic resonance imaging(MRI)contrast agent(CA)for long time.However,a review which comprehensively summarizes the recent development of IONP as traditional T_(2) CA and its new application for different modality of MRI,such as T_(1) imaging,simultaneous T_(2)/T_(1) or MRI/other imaging modality,and as environment responsive CA is rare.This review starts with an investigation of direction on the development of high-performance MRI CA in both T_(2) and T_(1) modal based on quantum mechanical outer sphere and Solomon-Bloembergen-Morgan(SBM)theory.Recent rational attempts to increase the MRI contrast of IONP by adjusting the key parameters,including magnetization,size,effective radius,inhomogeneity of surrounding generated magnetic field,crystal phase,coordination number of water,electronic relaxation time,and surface modification are summarized.Besides the strategies to improve r2 or r1 values,strategies to increase the in vivo contrast efficiency of IONP have been reviewed from three different aspects,those are introducing second imaging modality to increase the imaging accuracy,endowing IONP with environment response capacity to elevate the signal difference between lesion and normal tissue,and optimizing the interface structure to improve the accumulation amount of IONP in lesion.This detailed review provides a deep understanding of recent researches on the development of high-performance IONP based MRI CAs.It is hoped to trigger deep thinking for design of next generation MRI CAs for early and accurate diagnosis. | Zhenghuan Zhao Muyao Li Jie Zeng Linlin Huo Kun Liu Ruixue Wei Kaiyuan Ni Jinhao Gao | 2022 | Bioactive Materials2022，7，6： | 1 |
| 5 | Identification and characterization of an Nrf2-mediated ARE upstream of the rat glutamate cysteine ligase catalytic subunit gene (GCLC) 显示文摘 | Li Muyao Chiu JF Kelsen A | 2009 | J Cell Biochem2009，107，5： | 1 |
| 6 | Development of a molecular feature-based survival prediction model of ovarian cancer using the deep neural network显示文摘Ovarian cancer(OC)is one of the most lethal gynecologic cancer worldwide,and survival prediction is meaningful for personalized treatment.^(1)The survival outcome of cancer patients mainly depended on the malignancy of the primary tumor which is tightly linked with the expression profile of the molecular features.^(2)Therefore,in this study,we developed a molecular feature-based survival prediction model of OC using a deep neural network(DNN). | Tingyuan Lang Muyao Yang Yunqiu Xia Jingshu Liu Yunzhe Li Lingling Yang Chenxi Cui Yunran Hu Yang Luo Dongling Zou Lei Zhou Zhou Fu Qi Zhou | 2023 | Genes & Diseases2023，10，4： | 0 |
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