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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Update on surgical treatment of pancreatic neuroendocrine neoplasms显示文摘Pancreatic neuroendocrine neoplasms(PNENs) are rare and account for only 2%-4% of all pancreatic neoplasms. All PNENs are potential(neurendocrine tumors PNETs) or overt(neuroendocrine carcinomas PNECs) malignant,but a subset of PNETs is low-risk. Even in case of low-risk PNETs surgical resection is frequently required to treat hormone-related symptoms and to obtain an appropriate pathological diagnosis. Low-risk PNETs in the body and the tail are ideal for minimallyinvasive approaches which should be tailored to the individual patient. Generally,surgeons must aim for parenchyma sparing in these cases. In high-risk and malignant PNENs,indications for tumor resection are much wider than for pancreatic adenocarcinoma,in many cases due to the relatively benign tumor biology. Thus,patients with locally advanced and metastatic PNETs may benefit from extensive resection. In experienced hands,even multi-organ resections are accomplished with acceptable perioperative morbidity and mortality rates and are associated with excellent long term survival. However,poorly differentiated neoplasms with high proliferation rates are associated with a dismal prognosis and may frequently only be treated with chemotherapy. The evidence on surgical treatment of PNENs stems from reviews of mostly singlecenter series and some analyses of nation-wide tumor registries. No randomized trial has been performed to compare surgical and non-surgical therapies in potentially resectable PNEN. Though such a trial would principally be desirable,ethical considerations and the heterogeneity of PNENs preclude realization of such a study. In the current review,we summarize recent advances in the surgical treatment of PNENs. | Jan G D’Haese Chiara Tosolini Güralp O Ceyhan Bo Kong Irene Esposito Christoph W Michalski J?rg Kleeff | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 3 | Pancreatic Enzyme Replacement Therapy in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: A 1-Year Disease Management Study on Symptom Control and Quality of Life显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Peter Layer Waldemar Uhl Matthias L?hr Reinhard Rychlik Konstantinos Pirilis York Z?llner Birgit Gradl Douglas Foerster Julia M?bius Friederike Henniges Helmut Friess | 2014 | Pancreas2014，，： | 2 |
| 4 | Chromosomal aberrations in follicular non-Hodgkin lymphomas of Japanese patients,detected with comparative genomic hybridization and polymerase chain reaction analysis显示文摘 | D'Haese J G Tsukasaki K Cremer F W | 2005 | Cancer Genet Cytogenet2005，162，2： | 1 |
| 5 | Treatment options in painful chronic pancreatitis: a systematic review显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Elke Tieftrunk Helmut Friess | 2014 | HPB2014，，6： | 1 |
| 6 | Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential显示文摘 | Jan G D’Haese Ihsan Ekin Demir Helmut Friess Güralp O Ceyhan | 2010 | Expert Opinion on Therapeutic Targets2010，，2： | 1 |
| 7 | Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential显示文摘 | Jan G D’Haese Ihsan Ekin Demir Helmut Friess Güralp O Ceyhan | 2010 | Expert Opinion on Therapeutic Targets2010，，2： | 1 |
| 8 | Multicenter European external validation of a prostate health indexbased nomogram for predicting prostate cancer at extended biopsy显示文摘 | Lughezzani G Lazzeri M Haese A | 2014 | Eur Urol2014，66，5： | 1 |
| 9 | Removal of covered self-expandable metallic airway stents in benign disorders 显示文摘 | Noppen M Stratakos G D'Haese J | 2005 | Chest2005，127，： | 1 |
| 10 | Experimental and Numerical Investigation of a Hollow Brick Filled with Perlite Insulation 显示文摘 | Zukowski M Haese G | 2010 | Energy and Buildings2010，42，9： | 1 |
| 11 | A multicenter study on the effects of lanthanum carbonate(Fosrenol)and calcium carbonate on renal bone disease in dialysis patients显示文摘 | D'HAESE P C SPASOVSKI G B SIKOLE A | 2003 | Kidney Int Suppl2003，85，： | 1 |
| 12 | Removal of covered self- expandable metallic airway stents in benign disorder indications,technique, and outeomes显示文摘 | Noppen M Stratakos G D 'haese J | 2005 | Chest2005，127，： | 1 |
| 13 | Removal of covered self expandable metallic airway stents in benign disorders: indications, technique, and outcomes显示文摘 | Noppen M Stratakos G D'Haese J | 2005 | Chest2005，127，： | 1 |
| 14 | Removal of covered self expandable metallic airway stents in benign disorders:in- dications, technique, and outcomes 显示文摘 | Noppen M Stratakos G D' Haese J | 2005 | Chest2005，127，2： | 1 |
| 15 | Experimental and numerical investigation of a hollow brick filled with perlite insulation显示文摘 | Zukowski M Haese G | 2010 | Energy and Buildings2010，42，9： | 1 |
| 16 | Muticenter european external valdation of a prostate health index-based nomogram for predicting prostate cancer at extended biopsy显示文摘 | Lughezzani G Lazzeri M Haese A | 2014 | Eur Urol2014，66，5： | 1 |
| 17 | Pore Water Geochemistry of Eastern Mediterranean Mud Volcanoes:Implications for Fluid Transport and Fluid Origin显示文摘 | Haese R R Hensen C Lange G J | 2006 | Marine Geology2006，225，14： | 1 |
| 18 | Removal of covered self expandable metallic airway stents in benign disorders:indications,technique,and outcomes显示文摘 | Noppen M Stratakos G D'Haese J | 2005 | Chest2005，127，2： | 1 |
| 19 | Pore Water Geochemistry of Eastern Mediterranean Mud Volcanoes:Implications for Fluid Transport and Fluid Origin显示文摘 | Haese R R Hensen C Lange G J | 2006 | Marine Geology2006，225，14： | 1 |
| 20 | Pancreatic panniculitis and elevated serum lipase in metastasized acinar cell carcinoma of the pancreas: A case report and review of literature显示文摘BACKGROUND Pancreatic panniculitis is an extremely rare condition associated with different underlying pancreatic disorders and characterized by subcutaneous fat necrosis induced by elevated serum lipase levels.These lesions usually affect the lower extremities and may precede abdominal symptoms of pancreatic disease.Acinar cell carcinoma(ACC)of the pancreas is a rare pancreatic neoplasm,accounting for only 1%-2%of pancreatic tumors in adults.We present the case of a 72-year-old man with ACC of the pancreatic head and synchronous liver metastases.Both the primary tumor and liver metastases were resected.Serum lipase was elevated before surgery and decreased to normal postoperatively.Rising serum lipase levels at follow-up led to the diagnosis of hepatic recurrence.This disease progression was then accompanied by pancreatic panniculitis,with subcutaneous fat necrosis and acute arthritis.To the best of our knowledge,only 4 cases have been reported in the literature and each showed a similar association of serum lipase levels with pancreatic panniculitis and progression of ACC.CONCLUSION Clinical symptoms and progression of ACC may correlate with serum lipase levels,suggesting potential usefulness as a follow-up biomarker. | Rainer Christoph Miksch Tobias S Schiergens Maximilian Weniger Matthias Ilmer Philipp M Kazmierczak Markus O Guba Martin K Angele Jens Werner Jan G D'Haese | 2020 | World Journal of Clinical Cases2020，8，21： | 0 |
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