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| 1 | Analysis on the risk factors of intracranial infection secondary to traumatic brain injury显示文摘 | Chao Lin Xin Zhao Haichen Sun | 2015 | Chinese Journal of Traumatology2015，18，2： | 29 |
| 2 | B-doped and La_(4)NiLiO_(8)-coated Ni-rich cathode with enhanced structural and interfacial stability for lithium-ion batteries显示文摘Ni-rich layered oxides are considered promising cathodes for advanced lithium-ion batteries(LIBs)in the future,owing to their high capacity and low cost.However,the issues on structural and interfacial stability of Ni-rich cathodes still pose substantial obstacles in the practical application of advanced LIBs.Here,we employ a one-step method to synthesize a B-doped and La_(4)NiLiO_(8)-coated LiNi_(0.82)5Co_(0.115)Mn_(0.06)O_(2)(BL-1)cathode with reliable structure and interface,for the first time.The La_(4)NiLiO_(8)coating layer can prevent cathodes from electrolyte assault and facilitate Li+diffusion kinetics.Moreover,B-doping can effectively restrain the pernicious H_(2)-H_(3) phase transition and adjust the orientation of primary particles to a radial alignment,which is obstructive to the arise of microcracks induced by the change of anisotropic volume.Specifically,when tested in pouch cells,the BL-1 cathode exhibits outstanding capacity retention of 93.49%after 500 cycles at 1 C.This dual-modification strategy dramatically enhances the stability of the structure and interface for Ni-rich cathode materials,consequently accelerating the commercialization process of high-energy–density LIBs. | Lingjun Li Lizhi Fu Miao Li Chu Wang Zixiang Zhao Shangchen Xie Haichen Lin Xianwen Wu Haodong Liu Li Zhang Qiaobao Zhang Lei Tan | 2022 | Journal of Energy Chemistry2022，31，8： | 10 |
| 3 | Targeting the SUMO pathway for neuroprotection in brain ischaemia显示文摘Small ubiquitin-like modifier(SUMO)conjugation(SUMOylation)is a post-translational protein modification that modulates almost all major cellular processes,and has been implicated in many human diseases.A growing body of evidence from in vitro and in vivo studies demonstrates that increasing global levels of SUMO conjugated proteins(global SUMOylation)protects cells against ischaemia-induced damage,while suppressing global SUMOylation promotes cell injury after ischaemia.Indeed,SUMOylation has emerged as a potential therapeutic target for neuroprotection in brain ischaemia,including global brain ischaemia and focal brain ischaemia(ischaemic stroke).Here,we summarise findings on the role of SUMOylation in human diseases,brain ischaemia in particular,and review recent developments in drug discovery targeting SUMOylation with a major focus on its neuroprotective applications. | Wei Yang Huaxin Sheng Haichen Wang | 2016 | Stroke & Vascular Neurology2016，1，3： | 8 |
| 4 | Comparison of fondaparinux sodium and low molecular weight heparin in the treatment of hypercoagulability secondary to traumatic infection显示文摘 | Baiqiang Li Kang Wang Xin Zhao Chao Lin Haichen Sun | 2015 | Chinese Journal of Traumatology2015，18，3： | 3 |
| 5 | Reduced graphene oxide decorated with Bi2O2.33 nanodots for superior lithium storage显示文摘 | Haichen Liang Xiyan Liu Dongliang Gao Jiangfeng Ni Yan Li | 2017 | Nano Research2017，10，11： | 3 |
| 6 | Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes显示文摘Traumatic brain injury(TBI)is a global cause of morbidity and mortality.Initial management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a widely available,noninvasive diagnostic biomarker.In particular,a blood-based biomarker assay could provide a quick and minimally invasive process to stratify risk and guide early management strategies in patients with mild TBI(mTBI).Analysis of circulating exosomes allows the potential for rapid and specific identification of tissue injury.By applying acoustofluidic exosome separation—which uses a combination of microfluidics and acoustics to separate bioparticles based on differences in size and acoustic properties—we successfully isolated exosomes from plasma samples obtained from mice after TBI.Acoustofluidic isolation eliminated interference from other blood components,making it possible to detect exosomal biomarkers for TBI via flow cytometry.Flow cytometry analysis indicated that exosomal biomarkers for TBI increase in the first 24 h following head trauma,indicating the potential of using circulating exosomes for the rapid diagnosis of TBI.Elevated levels of TBI biomarkers were only detected in the samples separated via acoustofluidics;no changes were observed in the analysis of the raw plasma sample.This finding demonstrated the necessity of sample purification prior to exosomal biomarker analysis.Since acoustofluidic exosome separation can easily be integrated with downstream analysis methods,it shows great potential for improving early diagnosis and treatment decisions associated with TBI. | Zeyu Wang Haichen Wang Ryan Becker Joseph Rufo Shujie Yang Brian E.Mace Mengxi Wu Jun Zou Daniel T.Laskowitz Tony Jun Huang | 2021 | Microsystems & Nanoengineering2021，7，2： | 3 |
| 7 | Research progress of acute coagulopathy of trauma-shock显示文摘 | Baiqiang Li Haichen Sun | 2015 | Chinese Journal of Traumatology2015，18，2： | 3 |
| 8 | Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference,and delays morphine extinction in rats显示文摘Objective It is well established that glutamate and its receptors, particularly the N-methyl-D-aspartate receptor (NMDAR), play a significant role in addiction and that the inhibition of glutamatergic hyperfunction reduces addictive behaviors in experimental animals. Specifically, NMDAR antagonists such as MK-801, and an inducer of the expression of glutamate transporter subtype-1 (GLT-1) (ceftriaxone) are known to inhibit addictive behavior. The purpose of this study was to determine whether the combined action of a low dose of MK-801 and a low dose of ceftriaxone provides better inhibition of the acquisition, extinction, and reinstatement of morphine-induced conditioned place preference (CPP) than either compound alone. Methods A morphine-paired CPP experiment was used to study the effects of low doses of MK-801, ceftriaxone and a combination of both on reward-related memory (acquisition, extinction, and reinstatement of morphine preference) in rats. Results A low dose of neither MK-801 (0.05 mg/kg, i.p.) nor ceftriaxone (25 mg/kg, i.p.) alone effectively impaired CPP behaviors. However, when applied in combination, they reduced the acquisition of morphine-induced CPP and completely prevented morphine reinstatement. Their combination also notably impaired the extinction of morphine-induced CPP. Conclusion The combined action of a low dose of an NMDAR antagonist (MK-801) and GLT-1 activation by ceftriaxone effectively changed different phases of CPP behavior. | Yaodong Fan Haichen Niu Joshua D. Rizak Ling Li Guimei Wang Liqi Xu He Ren Hao Lei Hualin Yu | 2012 | Neuroscience Bulletin2012，28，5： | 2 |
| 9 | Perspective on Etiology and Treatment of Bipolar Disorders in China: Clinical Implications and Future Directions显示文摘Bipolar disorder (BD) is a chronic, recurrent, disabling disease, even when given currently-available pharmacological and psychological treatments. Currently, the etiology and pathogenesis of BD remain unclear. As a consequence, patients with BD are frequently unrecognized, misdiagnosed, and inappropriately treated, which often yields a low treatment response and poor outcome. | Zuowei Wang Chen Jun Kerning Gao Haichen Yang Yiru Fang | 2019 | Neuroscience Bulletin2019，35，4： | 2 |
| 10 | In-situ SEM Observation of Monotonic and Cyclic Deformed Structure in Ti-2A1-2.5Zr Alloy显示文摘The SEM observation in situ of monotonic and cyclic deformed structure in Ti-ZA1-2.5Zr alloy was performed. The regularity of slippage, crack nucleation, propagation and the typical dislocation configuration were also investigated. The twin and twist play an important role in maintaining homogeneous deformation in the final plastic deformation stage. | Zhentao YU Lian ZHOU Haichen GU Ju DENG | 2001 | Journal of Materials Science & Technology2001，17，1： | 2 |
| 11 | Carbon nanotube directed three-dimensional porous Li2FeSiO4 composite for lithium batteries显示文摘锂铁硅酸盐(李 2 FeSiO 4) 能够比常规阴极负担得起一个高得多的能力,并且这样,它为高精力的电池应用显示出大诺言。然而,它的能力被差的反应活动不利地经常影响了由于硅酸盐的极其低的电子、离子的传导性。这里,我们第一次向高度积极的李 2 由设计碳 nanotube (CNT ) 的 FeSiO 4 指导了三维(3D ) 多孔的李 2 FeSiO 4 合成。当 CNT 框架启用毛孔给予有效电解质穿入的快速的电子运输,和富人,这唯一的 3D 李 2 FeSiO 4-CNT 合成作为提高并且分别地,保护单位改进钴氧化物的能力和稳定性基本联合起来展出 214 mAher 功能的一个高能力。利用 synergistic 效果吗?? | Wencong Wang Haichen Liang Ling Zhang Serguei V. Savilov Jiangfeng Ni Liang Li | 2017 | Nano Research2017，10，1： | 2 |
| 12 | High resolution Porites Mg/Ca thermometer for the north of the South China Sea显示文摘High resolution Mg/Ca ratios in the skeleton of a Porites lutea from the coastal area in the North of the South China Sea were precisely analyzed by ICP-MS. Compared with the instrument measured SST records, the Mg/Ca ratios strongly correlate with the SSTs, even in time of 1982/83 EI N(?)io. Therefore, a coral Mg/Ca thermometer for the North of the South China Sea was established.Based on ICP-MS technique it can report sea surface temperatures to an accuracy of±0.5℃. | Gangjian Wei Xianhua Li Baofu Nie Min Sun Haichen Liu | 1999 | Chinese Science Bulletin1999，44，3： | 2 |
| 13 | EPMA Study of the Interface of β-Tricalcium Phosphate Ceramics in Vivo显示文摘Electron probe and X-ray energy spectrum were used to investigate the chemical composition of the interface between material and new bone after porous tricalcium phosphate ceramic implanted in tibia of rabbits. The element changes of the interface, the materials transformation and the situation of new bone formation at different implantation period were observed. The results showed that the carbon element content decreased gradually in new bone tissue, and the content of calcium and phosphor element increased by degrees with the implantation time. At the same time, calcium-phosphor ratio in the new bone kept a higher level. New bone grew into the materials interior, material dispersed and degraded simultaneously. Both composition of materials and new bone tended to be consentient. Finally, the materials were substituted by new bone. After implantation, not only the materials itself dissolved and degraded partially, but also new bone formed on the outer and pore surface of β-TCP porous bioceramics, which showed that the degradation products of lifeless calcium phosphate inorganic materials took part in constituting of new bone tissue. | Honglian DAI, Xianying CAO, Haichen SHAO, Chunhua SHEN and Shipu LIBiomedicaI Materials and Engineering Center, Wuhan University of Technology, Wuhan 430070, China | 2004 | Journal of Materials Science & Technology2004，20，6： | 1 |
| 14 | Chemistry of carbon nanotubes in biomedical applications显示文摘 | WU Haichen CHANG Xueling LIU Lei | | 0，，06： | 1 |
| 15 | Chemistry of carbon nanotubes in biomedical applications显示文摘 | WU Haichen CHANG Xuelingf LIU Lei | 2010 | J Mater Chem2010，20，6： | 1 |
| 16 | Twinning,phase boundary structure and development of high coercivity in Fe-rich Sm_(2)Co_(17)-type magnets显示文摘The microstructure of twinning as well as the phase boundary between 1:5 H and 2:17 R phase in Fe-rich Sm_(2)Co_(17)-type magnets was characterized at atomic scale using nanobeam diffraction and highresolution STEM-HAADF imaging,and the reason for the dramatic increase of coercivity during slow cooling was investigated based on the microchemistry analysis.The twinning relationship in the 2:17 R phase originates from ordered substitution of Sm atoms by Co-Co atomic pairs on every three(3033)and(3033)planes,leading to formation of two corresponding equivalent twin variants.The basal plane of the 2:17 R phase,the 1:3 R platelet phase across the 2:17 R cell and the 1:5 H cell boundary phase between two adjacent 2:17 R cells all can act as effective twin boundary.The cell boundary phase is precipitated along the pyramidal habit plane,and a fully coherent phase boundary(PB)is formed between the 1:5 H and 2:17 R phases with the orientation relationship to be PB//(1121)1:5 H//(1011)_(2):17 R.The phase boundary may either be parallel to or intersect with the pyramidal planes occupied by Co-Co atomic pairs.The substantial increase of coercivity during slow cooling is ascribed to the development of large gradient of the elements concentration within the cell boundary phase,resulting in large gradient of domain wall energy,and thus the pinning strength of the cell boundary phase against magnetic domain wall motion is significantly enhanced. | Haichen Wu Zhuang Liu Chaoyue Zhang Qiqi Yang Huanming Lu Guoxin Chen Xinming Wang Yong Li Renjie Chen Aru Yan | 2022 | Journal of Rare Earths2022，40，1： | 1 |
| 17 | Achieving high-capacity and long-life K^(+)storage enabled by constructing yolk-shell Sb_(2)S_(3)@N,S-doped carbon nanorod anodes显示文摘As promising anode candidates for potassium-ion batteries(PIBs),antimony sulfide(Sb_(2)S_(3))possesses high specific capacity but suffers from massive volume expansion and sluggish kinetics due to the large K^(+)insertion,resulting in inferior cycling and rate performance.To address these challenges,a yolk-shell structured Sb_(2)S_(3)confined in N,S co-doped hollow carbon nanorod(YS-Sb_(2)S_(3)@NSC)working as a viable anode for PIBs is proposed.As directly verified by in situ transmission electron microscopy(TEM),the buffer space between the Sb_(2)S_(3)core and thin carbon shell can effectively accommodate the large expansion stress of Sb_(2)S_(3)without cracking the shell and the carbon shell can accelerate electron transport and K^(+)diffusion,which plays a significant role in reinforcing the structural stability and facilitating charge transfer.As a result,the YS-Sb_(2)S_(3)@NSC electrode delivers a high reversible K^(+)storage capacity of 594.58 m A h g^(-1)at 0.1 A g^(-1)and a long cycle life with a slight capacity degradation(0.01%per cycle)for 2000 cycles at 1 A g^(-1)while maintaining outstanding rate capability.Importantly,utilizing in in situ/ex situ microscopic and spectroscopic characterizations,the origins of performance enhancement and K^(+)storage mechanism of Sb_(2)S_(3)were clearly elucidated.This work provides valuable insights into the rational design of high-performance and durable transition metal sulfides-based anodes for PIBs. | Bensheng Xiao Hehe Zhang Zhefei Sun Miao Li Yingzhu Fan Haichen Lin Haodong Liu Bing Jiang Yanbin Shen Ming-Sheng Wang Meicheng Li Qiaobao Zhang | 2023 | Journal of Energy Chemistry2023，，1： | 1 |
| 18 | Enhancement of catalytic and anti-carbon deposition performance of SAPO-34/ZSM-5/quartz films in MTA reaction by Si/Al ratio regulation显示文摘In order to further improve the catalytic performance of zeolite catalyst for methanol to aromatics(MTA)technology, the double-tier SAPO-34/ZSM-5/quartz composite zeolite films were successfully synthesized via hydrothermal crystallization. The Si/Al ratio of SAPO-34 film was used as the only variable to study this material. The composite zeolite material with 0.6Si/Al ratio of SAPO-34 has the largest mesoporous specific surface area and the most suitable acid distribution. The catalytic performance for the MTA process showed that 0.6-SAPO-34/ZSM-5/quartz film has as high as 50.3% benzene-toluenexylene selectivity and 670 min lifetime. The MTA reaction is carried out through the path we designed to effectively avoid the hydrocarbon pool circulation of ZSM-5 zeolite, so as to improve the aromatics selectivity and inhibit the occurrence of deep side reactions to a great extent. The coke deposition behavior was monitored by thermogravimetric analysis and gas chromatograph/mass spectrometer, it is found that with the increase of Si/Al ratio, the active intermediates changed from low-substituted methylbenzene to high-substituted methylbenzene, which led to the rapid deactivation of the catalyst. This work provides a possibility to employ the synergy effect of composite zeolite film synthesizing anti-carbon deposition catalyst in MTA reaction. | Jiaxin Wu Chenxiao Wang Xianliang Meng Haichen Liu Ruizhi Chu Guoguang Wu Weisong Li Xiaofeng Jiang Deguang Yang | 2023 | Chinese Journal of Chemical Engineering2023，56，4： | 1 |
| 19 | Fabricating high-performance sodium ion capacitors with P2-Na_(0.67)Co_(0.5)Mn_(0.5)O_2 and MOF-derived carbon显示文摘Sodium ion capacitors(SICs) have been considered as a kind of promising devices to achieve both high power and energy density. However, it is still a challenge to achieve high energy output at elevated power delivery due to the poor rate capability of battery-type electrode materials and the kinetic mismatch with capacitor-type electrode materials. In this work, to fabricate SICs, P2-Na_(0.67)Co_(0.5)Mn_(0.5)O_2(P2-NCM)was chosen as the battery-type cathode material, and a typical metal-organic framework(MOF) material,zeolitic imidazolate framework-8(ZIF-8) derived carbon(ZDC) was utilized as the capacitor-type anode material. Due to the kinetic match and high-rate performance of both electrodes, the ZDC//P2-NCM SICs exhibited an energy output of 18.8 Wh kg^(-1) at a high power delivery of 12.75 kW kg^(-1). | Haichen Gu Lingjun Kong Huijuan Cui Xianlong Zhou Zhaojun Xie Zhen Zhou | 2019 | Journal of Energy Chemistry2019，28，1： | 1 |
| 20 | ApolipoproteinE mimetic peptides improve outcome after focal ischemia显示文摘 | Haichen Wang Lauren G Anderson Christopher D Las- cola | 2013 | Experimental neurology2013，01，241： | 1 |
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