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| 1 | Targeting the SUMO pathway for neuroprotection in brain ischaemia显示文摘Small ubiquitin-like modifier(SUMO)conjugation(SUMOylation)is a post-translational protein modification that modulates almost all major cellular processes,and has been implicated in many human diseases.A growing body of evidence from in vitro and in vivo studies demonstrates that increasing global levels of SUMO conjugated proteins(global SUMOylation)protects cells against ischaemia-induced damage,while suppressing global SUMOylation promotes cell injury after ischaemia.Indeed,SUMOylation has emerged as a potential therapeutic target for neuroprotection in brain ischaemia,including global brain ischaemia and focal brain ischaemia(ischaemic stroke).Here,we summarise findings on the role of SUMOylation in human diseases,brain ischaemia in particular,and review recent developments in drug discovery targeting SUMOylation with a major focus on its neuroprotective applications. | Wei Yang Huaxin Sheng Haichen Wang | 2016 | Stroke & Vascular Neurology2016，1，3： | 8 |
| 2 | Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes显示文摘Traumatic brain injury(TBI)is a global cause of morbidity and mortality.Initial management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a widely available,noninvasive diagnostic biomarker.In particular,a blood-based biomarker assay could provide a quick and minimally invasive process to stratify risk and guide early management strategies in patients with mild TBI(mTBI).Analysis of circulating exosomes allows the potential for rapid and specific identification of tissue injury.By applying acoustofluidic exosome separation—which uses a combination of microfluidics and acoustics to separate bioparticles based on differences in size and acoustic properties—we successfully isolated exosomes from plasma samples obtained from mice after TBI.Acoustofluidic isolation eliminated interference from other blood components,making it possible to detect exosomal biomarkers for TBI via flow cytometry.Flow cytometry analysis indicated that exosomal biomarkers for TBI increase in the first 24 h following head trauma,indicating the potential of using circulating exosomes for the rapid diagnosis of TBI.Elevated levels of TBI biomarkers were only detected in the samples separated via acoustofluidics;no changes were observed in the analysis of the raw plasma sample.This finding demonstrated the necessity of sample purification prior to exosomal biomarker analysis.Since acoustofluidic exosome separation can easily be integrated with downstream analysis methods,it shows great potential for improving early diagnosis and treatment decisions associated with TBI. | Zeyu Wang Haichen Wang Ryan Becker Joseph Rufo Shujie Yang Brian E.Mace Mengxi Wu Jun Zou Daniel T.Laskowitz Tony Jun Huang | 2021 | Microsystems & Nanoengineering2021，7，2： | 3 |
| 3 | Perspective on Etiology and Treatment of Bipolar Disorders in China: Clinical Implications and Future Directions显示文摘Bipolar disorder (BD) is a chronic, recurrent, disabling disease, even when given currently-available pharmacological and psychological treatments. Currently, the etiology and pathogenesis of BD remain unclear. As a consequence, patients with BD are frequently unrecognized, misdiagnosed, and inappropriately treated, which often yields a low treatment response and poor outcome. | Zuowei Wang Chen Jun Kerning Gao Haichen Yang Yiru Fang | 2019 | Neuroscience Bulletin2019，35，4： | 2 |
| 4 | Twinning,phase boundary structure and development of high coercivity in Fe-rich Sm_(2)Co_(17)-type magnets显示文摘The microstructure of twinning as well as the phase boundary between 1:5 H and 2:17 R phase in Fe-rich Sm_(2)Co_(17)-type magnets was characterized at atomic scale using nanobeam diffraction and highresolution STEM-HAADF imaging,and the reason for the dramatic increase of coercivity during slow cooling was investigated based on the microchemistry analysis.The twinning relationship in the 2:17 R phase originates from ordered substitution of Sm atoms by Co-Co atomic pairs on every three(3033)and(3033)planes,leading to formation of two corresponding equivalent twin variants.The basal plane of the 2:17 R phase,the 1:3 R platelet phase across the 2:17 R cell and the 1:5 H cell boundary phase between two adjacent 2:17 R cells all can act as effective twin boundary.The cell boundary phase is precipitated along the pyramidal habit plane,and a fully coherent phase boundary(PB)is formed between the 1:5 H and 2:17 R phases with the orientation relationship to be PB//(1121)1:5 H//(1011)_(2):17 R.The phase boundary may either be parallel to or intersect with the pyramidal planes occupied by Co-Co atomic pairs.The substantial increase of coercivity during slow cooling is ascribed to the development of large gradient of the elements concentration within the cell boundary phase,resulting in large gradient of domain wall energy,and thus the pinning strength of the cell boundary phase against magnetic domain wall motion is significantly enhanced. | Haichen Wu Zhuang Liu Chaoyue Zhang Qiqi Yang Huanming Lu Guoxin Chen Xinming Wang Yong Li Renjie Chen Aru Yan | 2022 | Journal of Rare Earths2022，40，1： | 1 |
| 5 | Enhancement of catalytic and anti-carbon deposition performance of SAPO-34/ZSM-5/quartz films in MTA reaction by Si/Al ratio regulation显示文摘In order to further improve the catalytic performance of zeolite catalyst for methanol to aromatics(MTA)technology, the double-tier SAPO-34/ZSM-5/quartz composite zeolite films were successfully synthesized via hydrothermal crystallization. The Si/Al ratio of SAPO-34 film was used as the only variable to study this material. The composite zeolite material with 0.6Si/Al ratio of SAPO-34 has the largest mesoporous specific surface area and the most suitable acid distribution. The catalytic performance for the MTA process showed that 0.6-SAPO-34/ZSM-5/quartz film has as high as 50.3% benzene-toluenexylene selectivity and 670 min lifetime. The MTA reaction is carried out through the path we designed to effectively avoid the hydrocarbon pool circulation of ZSM-5 zeolite, so as to improve the aromatics selectivity and inhibit the occurrence of deep side reactions to a great extent. The coke deposition behavior was monitored by thermogravimetric analysis and gas chromatograph/mass spectrometer, it is found that with the increase of Si/Al ratio, the active intermediates changed from low-substituted methylbenzene to high-substituted methylbenzene, which led to the rapid deactivation of the catalyst. This work provides a possibility to employ the synergy effect of composite zeolite film synthesizing anti-carbon deposition catalyst in MTA reaction. | Jiaxin Wu Chenxiao Wang Xianliang Meng Haichen Liu Ruizhi Chu Guoguang Wu Weisong Li Xiaofeng Jiang Deguang Yang | 2023 | Chinese Journal of Chemical Engineering2023，56，4： | 1 |
| 6 | Infants with congenital heart disease with severe pulmonary hypertension, in the surgical treatment of 显示文摘 | Haichen W Yang Y Yanhua Y | 2007 | Journal of Xi''an Jiao Tong University (Medical Science Edition)2007，2，2： | 1 |
| 7 | Early Diagnosis of Bipolar Disorder Coming Soon:Application of an Oxidative Stress Injury Biomarker(BIOS)Model显示文摘Early distinction of bipolar disorder(BD)from major depressive disorder(MDD)is difficult since no tools are available to estimate the risk of BD.In this study,we aimed to develop and validate a model of oxidative stress injury for predicting BD.Data were collected from 1252 BD and 1359 MDD patients,including 64 MDD patients identified as converting to BD from 2009 through 2018.30 variables from a randomly-selected subsample of 1827(70%)patients were used to develop the model,including age,sex,oxidative stress markers(uric acid,bilirubin,albumin,and prealbumin),sex hormones,cytokines,thyroid and liver function,and glycolipid metabolism.Univariate analyses and the Least Absolute Shrinkage and Selection Operator were applied for data dimension reduction and variable selection.Multivariable logistic regression was used to construct a model for predicting bipolar disorder by oxidative stress biomarkers(BIOS)on a nomogram.Internal validation was assessed in the remaining 784 patients(30%),and independent external validation was done with data from 3797 matched patients from five other hospitals in China.10 predictors,mainly oxidative stress markers,were shown on the nomogram.The BIOS model showed good discrimination in the training sample,with an AUC of 75.1%(95%CI:72.9%–77.3%),sensitivity of 0.66,and specificity of 0.73.The discrimination was good both in internal validation(AUC 72.1%,68.6%–75.6%)and external validation(AUC 65.7%,63.9%–67.5%).In this study,we developed a nomogram centered on oxidative stress injury,which could help in the individualized prediction of BD.For better real-world practice,a set of measurements,especially on oxidative stress markers,should be emphasized using big data in psychiatry. | Zhiang Niu Xiaohui Wu Yuncheng Zhu Lu Yang Yifan Shi Yun Wang Hong Qiu Wenjie Gu Yina Wu Xiangyun Long Zheng Lu Shaohua Hu Zhijian Yao Haichen Yang Tiebang Liu Yong Xia Zhiyu Chen Jun Chen Yiru Fang | 2022 | Neuroscience Bulletin2022，38，9： | 1 |
| 8 | Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat?显示文摘 | Qiaoming Zhi Haichen Sun Xiaoming Qian Litao Yang | 2010 | International Immunopharmacology2010，，1： | 1 |
| 9 | Inhibitory effects of HS014 on glutamate release in astrocytes chronically treated with morphine显示文摘Previous studies have confirmed that the number of glial fibrillary acidic protein-positive cells significantly increases during morphine tolerance.However,morphine tolerance is reversed with melanocortin receptor antagonists,and analgesic action is enhanced accordingly.However,these mechanisms remain unclear.In the present study,following addition of morphine to Wistar rat spinal cord astrocytes,glutamate levels in the supernatant significantly increased(P < 0.05).At 30-120 minutes following addition of intervention agent to spinal cord astrocytes,naloxone significantly increased glutamate release in morphine-tolerant model cells(P < 0.05),while melanocortin receptor antagonist HS014 decreased glutamate release(P < 0.05).Additional naloxone and HS014 to astrocytes significantly decreased glutamate release compared with additional naloxone alone(P < 0.01).Results from the present study demonstrated that glutamate release was increased in spinal cord astrocytes co-cultured with morphine.Naloxone increased glutamate release,and HS014 reduced glutamate release. | Haichen Chu Zejun Niu Zhao Yang Xuefeng Zhang | 2010 | Neural Regeneration Research2010，5，19： | 1 |
| 10 | From sawdust waste to high-value hierarchical ceramics-based phase change materials: Efficient dual functional thermal and solar energy storage显示文摘Latent heat thermal energy storage(LHTES) technology is gaining extensive attention due to its capability to balance supply and demand mismatch in solar energy utilization. However, phase change material as the core of storing latent heat still suffers from low thermal conductivity and poor shape stability, which severely restricts its practical application. Here, an eco-friendly strategy for achieving high-performance dual functional thermal and solar energy storage is proposed via turning wood processing waste into high-value hierarchical porous SiC ceramic-based composite phase change materials. The porosity of prepared porous SiC skeletons is highly adjustable from 59.4% to 90.2%, overcoming low porosity limitations of traditional wood materials and enabling tunable energy storage density for various applications. High thermal conductivity is achieved by benefiting from large grains and continuous skeletons with a value up to 37.93 and 1.87 W/(m K) for porosity of 59.4% and 90.2%, respectively.Excellent stabilities are demonstrated with only slight decreases of thermal conductivity and energy storage density over 1000 cycles and good anti-leakage properties are confirmed due to capillary adsorption forces induced by hierarchical pores. Benefiting from high thermal conductivity and high solar absorptance, fast and efficient solar thermal energy storage is successfully demonstrated. This work provides a new strategy for the high-value utilization of wood processing waste and efficient thermal/solar energy storage. | LIU XiangLei WEI PeiDong LUO QingYang XU Qiao WANG JianGuo LV ShuShan TIAN Yang YAO HaiChen XUAN YiMin | 2023 | Science China(Technological Sciences)2023，66，9： | 0 |
| 11 | Space advanced technology demonstration satellite显示文摘The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch Centre.Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,etc.This paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance. | ZHANG XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE JunWang BI XingZi ZHANG YongHe SHI Qi LI Fei LIU Rui FENG ZhengGong LIU Liu LI JinSong WU HaiChen XU DongXiao LI TaiJie HUANG JiangJiang LIU Shuo LI TianTong YU XianSheng GAO Yang ZHOU Heng BAN HanYu ZHANG YanLi ZHANG YueTing YANG YingQuan HE Tao DUAN XuLiang CHEN Xin WANG YaMin SUN AnTai ZHANG KuoXiang SUN Ying WANG YaoBin FAN ChengCheng XIONG ShaoLin LI XinQiao WEN XiangYang LING ZhiXing SUN XiaoJin ZHANG Chen BAI XianYong WANG ZhanShan DENG YuanYong TIAN Hui YANG JianFeng XUE HongBo SANG Peng LIU JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui XU LuXiang XU ShuYan CHEN WenWu LIU ZhenDong WANG ZhaoLi MAO XiangLong GAO Rong LI ZongXuan DING GuoPeng WANG XinYu DOU RunJiang WENG LuBin LUO Hao WANG YaPing LIANG XianFeng FANG ZiRuo | 2024 | Science China(Technological Sciences)2024，67，1： | 0 |
| 12 | Artificial“honeycomb-honey”decorated with non-noble plasmonic nanoparticles for superior solar capture and thermal energy storage显示文摘Phase change materials(PCMs)are popular solutions to tackle the unbalance of thermal energy supply and demand,but suffer from low thermal conductivity and leakage problems.Inspired by how honeybees store honey,we propose artificial“honeycombhoney”for excellent solar and thermal energy storage capacity based on TiN nanoparticles decorated porous AlN skeletonsPCMs composites.The thermal conductivity of composites achieves 21.58 W/(m·K)at AlN loading of 20 vol.%,superior to the state-of-the-art ceramic-based composites.The charging/discharging time is reduced to about half of pure PCMs with shapestability and thermal reliability well maintained over 500 melting/freezing cycles.The underlying mechanism can be attributed to the combination of single-crystal AlN whiskers with few crystal defects and reduced phonon scattering,as well as vertically arranged three-dimantional(3D)heat conduction channels.A rapid and efficient solar thermal storage is also demonstrated with solar thermal storage efficiency achieving a high value of 92.9%without employing additional spectrum selective coatings.This is benefited from high thermal conductivity and full-spectrum solar absorptance of up to 95%induced by plasmonic resonances of TiN nanoparticles.In addition,by embedding LiNO3-NaCl eutectics,the phase change enthalpy of composites reaches as high as 208 kJ/kg,making high energy storage density and fast energy storage rate compatible.This work offers new routes to achieve rapid,efficient,stable,and compact solar capture and thermal energy storage. | Haolei Wang Xianglei Liu Qingyang Luo Haichen Yao Qiao Xu Yang Tian Jianguo Wang Yimin Xuan | 2022 | Nano Research2022，15，9： | 0 |
| 13 | Development of the high-strength ductile ferritic alloys via regulating the intragranular and grain boundary precipitation of G-phase显示文摘A typical G-phase strengthened ferritic model alloy(1Ti:Fe-20Cr-3Ni-1Ti-3Si,wt.%)has been carefully studied using both advanced experimental(EBSD,TEM and APT)and theoretical(DFT)techniques.During the classic“solid solution and aging”process,the superfine(Fe,Ni)_(2)TiSi-L2_(1)particles densely precipitate within the ferritic grain and subsequently transform into the(Ni,Fe)_(16)Ti_(6)Si_(7)-G phase.In the meanwhile,the elemental segregation at grain boundaries and the resulting precipitation of a large amount of the(Ni,Fe)_(16)Ti_(6)Si_(7)-G phase are also observed.These nanoscale microstructural evolutions result in a remarkable increase in hardness(100-300 HV)and severe embrittlement.When the“cold rolling and aging”process is used,the brittle fracture is effectively suppressed without loss of nano-precipitation strengthening ef-fect.Superhigh yield strength of 1700 MPa with 4%elongation at break is achieved.This key improvement in mechanical properties is mainly attributed to the pre-cold rolling process which effectively avoids the dense precipitation of the G-phase at the grain boundary.These findings could shed light on the further exploration of the precipitation site via optimal processing strategies. | Mujin Yang Chao Huang Jiajia Han Haichen Wu Yilu Zhao Tao Yang Shenbao Jin Chenglei Wang Zhou Li Ruiying Shu Cuiping Wang Huanming Lu Gang Sha Xingjun Liu | 2023 | Journal of Materials Science & Technology2023，，5： | 0 |
| 14 | Improving superficial microstructure and properties of the laser-processed ultrathin kerf in Ti-6Al-4V alloy by water-jet guiding显示文摘In the present research,the gas-assisted laser(GAL)and water-jet guided laser(WGL)processing technologies were applied to machine the ultrathin kerf in the wrought Ti-6Al-4V alloy.The microstructure,microhardness,and wear properties of the superficial layer were investigated.The results reveal that the GAL processing could machine the kerf with a high depth-to-width ratio of 12–15,but the increased processing times enhance the depth little.Due to the oxygen entrainment and relatively low heat and mass transferring efficiency,the assisted gas promotes the formation of a scaled recast layer containingβ-Ti phase and oxides,which increases the roughness to 20μm.The WGL processed kerf has a low depth-to-width ratio with a value of 1.9–2.5 and the depth could be increased by increasing the WGL processing times.With the assistance of the water jet,the remelted debris and heat could be eliminated immediately,which restrains the formation of the recast layer and heat-affected zone.The ultrathin oxide outer layer with hundreds of nanometers and ultrafineα-Ti grain inner layer are formed on the surface,which decreases the roughness to 12μm.Compared with the as-received Ti-6Al-4V alloy,the microhardness of GAL processed kerf surface is increased to 382.8 HV accompanied by residual tensile stress,while the microhardness of WGL processed kerf surface is increased to 481.6 HV accompanying with residual compressive stress.In addition,the GAL processing increases the wear rate at room temperature but decreases the wear rate at high temperatures.Comparatively,the WGL processing decreases the wear rate at room and high temperatures,simultaneously.Such wear behaviors could be ascribed to their different superficial microstructures and phase constituents. | Yang Chao Yuezhuan Liu Zifa Xu Weixin Xie Li Zhang Wentai Ouyang Haichen Wu Zebin Pan Junke Jiao Shujun Li Guangyi Zhang Wenwu Zhang Liyuan Sheng | 2023 | Journal of Materials Science & Technology2023，，25： | 0 |
| 15 | The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates显示文摘Dear Editor,Neurologic manifestations associated with many COVID-19 patients,including acute infection with severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)and long COVID,have been proven by increasing evidence.1 To date,most studies have focused on how SARS-CoV-2 invades the nervous system and the consequent neuropathological changes.2,3 In contrast,the specific mechanism by which SARS-CoV-2 infection leads to neurological disease remains unclear. | Jiaxin Yang Yan Li Shijin Wang Huili Li Lili Zhang Haichen Zhang Pei-Hui Wang Xiangyu Zheng Xiao-Fang Yu Wei Wei | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
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