|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-20a promotes proliferation and invasion by targeting APP in human ovarian cancer cells显示文摘MicroRNAs (miRNAs ) 作为小调整 RNA 的一个班正在出现,并且 miRNAs 的改变在人的癌症的开始和前进被含有。我们的学习在房间线能压制的 OVCAR3 卵巢的癌症显示出 miR-20a 的那抑制,而 miR-20a 的 overexpression 能提高房间长期的增长和侵略。我们也作为 miR-20a 的直接目标基因证实了淀粉的先锋蛋白质(应用软件) 。而且,应用软件表示的抑制能也支持卵巢的癌症房间增长和侵略,它与 miR-20a overexpression 的结果一致。因此,我们断定应用软件的规定是重要机制让 miR-20a 在卵巢的癌症房间支持增长和侵略。 | Xingxing Fan Yankun Liu Jiechun Jiang Zhuoya Ma Haidong Wu Tao Liu Min Liu Xin Li Hua Tang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 20 |
| 2 | A Novel Mitogen-Activated Protein Kinase Gene in Maize (Zea mays),ZmMPK3,is Involved in Response to Diverse Environmental Cues显示文摘In search for components of mitogen-activated protein kinase (MAPK) cascades in maize (Zea mays) involved in response to abscisic acid (ABA) stimulus,a novel MAPK gene,ZmMPK3,from ABA-treated maize leaves cDNA was isolated and characterized.The full length of the ZmMPK3 gene is 1 520 bp and encodes a 376 amino acid protein with a predicted molecular mass of 43.5 kD and a pI of 5.83.ZmMPK3 contains all 11 MAPK conserved subdomains and the phosphorylation motif TEY.Amino acid sequence alignment revealed that ZmMPK3 shared high identity with group-A MAPK in plants.A time course (30–360 min) experiment using a variety of signal molecules and stresses revealed that the transcripts level of ZmMPK3 accumulated markedly and rapidly when maize seedlings were subjected to exogenous signaling molecules: ABA,H2O2,jasmonic acid and salicylic acid,various abiotic stimuli such as cold,drought,ultraviolet light,salinity,heavy metal and mechanical wounding.Its transcription was also found to be tissue-specific regulated.Here,we show that ABA and H2O2 induced a significant increase in the ZmMPK3 activity using immunoprecipitation and in-gel kinase assay.Furthermore,the results showed that the ZmMPK3 protein is localized mainly to the nucleus.These results suggest that the ZmMPK3 may play an important role in response to environmental stresses. | Jinxiang Wang Haidong Ding Aying Zhang Fangfang Ma Jianmei Cao Mingyi Jiang | 2010 | Journal of Integrative Plant Biology2010，52，5： | 16 |
| 3 | Occurrence and distribution of hexabromocyclododecane in sediments from seven major river drainage basins in China显示文摘The concentrations and geographical distribution of hexabromocyclododecane (HBCD) were investigated in 37 composite surface sediments from seven major river drainage basins in China, including Yangtze River, Yellow River, Pearl River, Liaohe River, Haihe River, Tarim River and Ertix River. The detection frequency of HBCD was 54%, with the concentrations ranged from below limit of detection (LOD) to 206 ng/g dry weight. In general, the geographical distribution showed increasing trends from the upper reaches to the lower reaches of the rivers and from North China to Southeast China. Compared to other regions in the world, the average concentration of HBCD in sediments from Yangtze River drainage basin was at relatively high level, whereas those from other six river drainage basins were at lower or similar level. The highest HBCD concentration in sediment from Yangtze River Delta and the highest detection frequency of HBCD in Pearl River drainage basins suggested that the industrial and urban activities could evidently affect the HBCD distribution. HBCD diastereoisomer profiles showed that γ-HBCD dominated in most of the sediment samples, followed by α- and β-HBCD, which was consistent with those in the commercial HBCD mixtures. Further risk assessment reflected that the average inventories of HBCD were 18.3, 5.87, 3.92, 2.50, 1.77 ng/cm 2 in sediments from Pearl River, Haihe River, Tarim River, Yellow River and Yangtze River, respectively. | Honghua Li Hongtao Shang Pu Wang Yawei Wang Haidong Zhang Qinghua Zhang Guibin Jiang | 2013 | Journal of Environmental Sciences2013，25，1： | 11 |
| 4 | Archimedean copula estimation of distribution algorithm based on artificial bee colony algorithm显示文摘The artificial bee colony(ABC) algorithm is a competitive stochastic population-based optimization algorithm. However, the ABC algorithm does not use the social information and lacks the knowledge of the problem structure, which leads to insufficiency in both convergent speed and searching precision.Archimedean copula estimation of distribution algorithm(ACEDA)is a relatively simple, time-economic and multivariate correlated EDA. This paper proposes a novel hybrid algorithm based on the ABC algorithm and ACEDA called Archimedean copula estimation of distribution based on the artificial bee colony(ACABC)algorithm. The hybrid algorithm utilizes ACEDA to estimate the distribution model and then uses the information to help artificial bees to search more efficiently in the search space. Six benchmark functions are introduced to assess the performance of the ACABC algorithm on numerical function optimization. Experimental results show that the ACABC algorithm converges much faster with greater precision compared with the ABC algorithm, ACEDA and the global best(gbest)-guided ABC(GABC) algorithm in most of the experiments. | Haidong Xu Mingyan Jiang Kun Xu | 2015 | Journal of Systems Engineering and Electronics2015，26，2： | 8 |
| 5 | Tim-3 promotes cell aggressiveness and paclitaxel resistance through NF-κB/STAT3 signalling pathway in breast cancer cells显示文摘Objective:Although T-cell immunoglobulin and mucin-domain containing molecule-3(Tim-3)has been recognized as a promising target for cancer immunotherapy,its exact role in breast cancer has not been fully elucidated.Methods:Tim-3 gene expression in breast cancer and its prognostic significance were analyzed.Associated mechanisms were then explored in vitro by establishing Tim-3-overexpressing breast cancer cells.Results:In a pooled analysis of The Cancer Genome Atlas(TCGA)database,Tim-3 gene expression levels were significantly higher(P<0.001)in breast cancer tissue,compared with normal tissues.Tim-3 was a prognosis indicator in breast cancer patients[relapse-free survival(RFS),P=0.004;overall survival(OS),P=0.099].Tim-3 overexpression in Tim-3 low breast cancer cells promoted aggressiveness of breast cancer cells,as evidenced by enhanced proliferation,migration,invasion,tight junction deterioration and tumor-associated tubal formation.Tim-3 also enhanced cellular resistance to paclitaxel.Furthermore,Tim-3 exerted its function by activating the NF-κB/STAT3 signalling pathway and by regulating gene expression[cyclin D1(CCND1),C-Myc,matrix metalloproteinase-1(MMP1),TWIST,vascular endothelial growth factor(VEGF)upregulation,concomitant with Ecadherin downregulation).Lastly,Tim-3 downregulated tight junction-associated molecules zona occludens(ZO)-2,ZO-1 and occludin,which may further facilitate tumor progression.Conclusions:Tim-3 plays an oncogenic role in breast cancer and may represent a potential target for antitumor therapy. | Yizi Cong Yuxin Cui Shiguang Zhu Jianqiao Cao Haidong Zou Tracey AMartin Guangdong Qiao Wenguo Jiang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 7 |
| 6 | 肿瘤浸润髓系细胞上表达的共抑制分子B7S1抑制抗肿瘤CD8 T细胞的功能显示文摘文章简介近年来,肿瘤免疫治疗蓬勃发展,为人类战胜癌症带来了一线曙光。阻断PD-1/PD-L1通路的抗体药物可以提高CD8 T细胞的抗肿瘤活性,疗效显著优于传统治疗手段。然而,只有小部分实体瘤病人可以对PD-1/PD-L1免疫治疗产生应答. | 黎静 Younghee Lee Yanjian Li Yu Jiang Huiping Lu Wenjuan Zang Xiaohong Zhao Liguo Liu Yang Chen Haidong Tan 杨志英 Michael Q Zhang Tak W.Mak Ling Ni 董晨 | 2019 | 科学新闻2019，0，2： | 6 |
| 7 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet . 2013 (9882)2013，，9882： | 4 |
| 8 | Sand wave deposition in the Taiwan Shoal of China显示文摘The Taiwan Shoal is the convex terrain in the southern Taiwan Strait, the largest strait in China. In 2006 and 2007, 21 samples and more than 200-km sub-bottom data as well as 80-km near shore side-scan sonar data were gotten, which gave an initial image of the boundaries of the Taiwan Shoal and revealed the internal structure of the sand waves in this area. The results showed that the major component of the sediment samples was sand, and sand waves occurred everywhere in this area, which closely followed the range of the Taiwan Shoal as we know. The western boundary of the Taiwan Shoal thus reaches the 30 m isobaths near the shore, and as a result, its area potentially covers approximately 12 800-14 770 km 2 . The sand waves have different shapes under the complex ocean dynamics, and the height of sand waves in the near shore is usually smaller than that in the Taiwan Shoal. The number of sand waves ranged from 1-5 per kilometer, with more waves in the isobath-intensive area, suggesting the importance of topography for the formation of sand waves. The stratigraphic structure under the seabed has parallel bedding or cross bedding, and large dipping groove bedding can be seen locally in different parts, which may be the result of terrestrial deposition since the Late Pleistocene. | HU Yi CHEN Jian XU Jiang WANG Liming LI Haidong LIU Huaishan | 2013 | Acta Oceanologica Sinica2013，32，8： | 3 |
| 9 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet2013，，9882： | 3 |
| 10 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | 2013 (9882)2013，，9882： | 3 |
| 11 | Involvement of Protein Phosphorylation in Water Stress-induced Antioxidant Defense in Maize Leaves显示文摘Using pharmacological and biochemical approaches,the role of protein phosphorylation and the interrelationship between water stress-enhanced kinase activity,antioxidant enzyme activity,hydrogen peroxide(H2O2) accumulation and endogenous abscisic acid in maize(Zea mays L.) leaves were investigated.Water-stress upregulated the activities of total protein phosphorylation and Ca2+-dependent protein kinase,and the upregulation was blocked in abscisic acid-deficient vp5 mutant.Furthermore,pretreatments with a nicotinamide adenine dinucleotide phosphate oxidase inhibitor and a scavenger of H2O2 significantly reduced the increased activities of total protein kinase and Ca2+-dependent protein kinase in maize leaves exposed to water stress.Pretreatments with different protein kinase inhibitors also reduced the water stress-induced H2O2 production and the water stress-enhanced activities of antioxidant enzymes such as superoxide dismutase,catalase,ascorbate peroxidase and glutathione reductase.The data suggest that protein phosphorylation and H2O2 generation are required for water stress-induced antioxidant defense in maize leaves and that crosstalk between protein phosphorylation and H2O2 generation may occur. | Shucheng Xu Haidong Ding Fengxia Su Aying Zhang Mingyi Jiang | 2009 | Journal of Integrative Plant Biology2009，51，7： | 2 |
| 12 | Comparison of results and complications of surgical and Amplatzer device closure of perimembranous ventricular septal defects显示文摘 | Cheng Xunmin Jiang Shisen Gong Jianbin Wang Haidong Wang Lijun | 2006 | International Journal of Cardiology2006，，1： | 2 |
| 13 | Roles of Co element in Fe-based bulk metallic glasses utilizing industrial FeB alloy as raw material显示文摘A series of Fe-based bulk metallic glasses were fabricated by a conventional copper mold casting method using a kind of Fe-B industrial raw alloy. It is found that Fe-B-Y-Nb bulk metallic glass with 3 at% of Co addition possesses the best glass forming ability, thermal stability, hardness, magnetic property and anti-corrosion property. The hardness test result indicates a synchronically trend with glass-forming ability parameters. The excellent glass-forming ability and a combination of good mechanical and functional properties suggest that the alloys in this work might be good candidates for commercial use. | Shouyuan Wang Wei Jiang Haidong Hu Pengfeng Liu Jili Wu Bo Zhang | 2017 | Progress in Natural Science:Materials International2017，27，4： | 2 |
| 14 | Effects of greenness on preterm birth: A national longitudinal study of 3.7 million singleton births显示文摘Exposure to greenness may lead to a wide range of beneficial health outcomes.However,the effects of greenness on preterm birth(PTB)are inconsistent,and limited studies have focused on the subcategories of PTB.A total of 3,751,672 singleton births from a national birth cohort in China's Mainland were included in this study.Greenness was estimated using the satellitebased Normalized Difference Vegetation Index(NDVI)and Enhanced Vegetation Index with 500-m and 1,000-m buffers around participants’addresses.The subcategories of PTB(20-36 weeks)included extremely PTB(EPTB,20-27 weeks). | Lina Zhang Shuyan Shi Shenpeng Wu Ying Yang Jihong Xu Ya Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai Yan Zuoqi Peng Cong Liu Weidong Wang Yixuan Jiang Su Shi Renjie Chen Haidong Kan Yuan He Xia Meng Xu Ma | 2022 | The Innovation2022，3，3： | 2 |
| 15 | Differentiating the effects of fine and coarse particles on daily mortality in Shanghai, China显示文摘 | Haidong Kan Stephanie J. London Guohai Chen Yunhui Zhang Guixiang Song Naiqing Zhao Lili Jiang Bingheng Chen | 2006 | Environment International2006，，3： | 2 |
| 16 | Spatio-temporal variability of soil moisture and its effect on vegetation in a desertified aeolian riparian ecotone on the Tibetan Plateau, China显示文摘 | Haidong Li Weishou Shen Changxin Zou Jiang Jiang Lina Fu Guanghui She | 2012 | Journal of Hydrology2012，，： | 2 |
| 17 | Maize Gene Regulatory Network for Phenolic Metabolism显示文摘 | Fan Yang Wei Li Nan Jiang Haidong Yu Kengo Morohashi Wilberforce Zachary Oumal Daniel E. Morales-Mantilla Fabio Andres Gomez-Canol Eric Mukundi Luis Daniel Prada-Salcedo Roberto Alers Velazquez Jasmin Valentin Maria Katherine Mejia-Guerra John Gray Andrea I. Doseff Erich Grotewold | 2017 | Molecular Plant2017，10，3： | 1 |
| 18 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet2013，，9882： | 1 |
| 19 | Season, Sex, Age, and Education as Modifiers of the Effects of Outdoor Air Pollution on Daily Mortality in Shanghai, China: The Public Health and Air Pollution in Asia (PAPA) Study显示文摘 | Kan Haidong London Stephanie J Chen Guohai Zhang Yunhui Song Guixiang Zhao Naiqing Jiang Lili Chen Bingheng | 2008 | Environmental Health Perspectives2008，，9： | 1 |
| 20 | Visibility, air quality and daily mortality in Shanghai, China显示文摘 | Wei Huang Jianguo Tan Haidong Kan Ni Zhao Weimin Song Guixiang Song Guohai Chen Lili Jiang Cheng Jiang Renjie Chen Bingheng Chen | 2009 | Science of the Total Environment2009，，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员