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| 1 | Sini powder ameliorates the inflammatory response in rats with stress-induced non-alcoholic fatty liver disease by inhibiting the nuclear factor kappa-B/pyrin domain-containing protein 3 pathway显示文摘OBJECTIVE: To evaluate the effectiveness of Sini powder for the treatment of non-alcoholic fatty liver disease(NAFLD) in rats and the molecular mechanisms involved.METHODS: A rat model of stress-induced NAFLD was established by a combination of long-term tethering and feeding of a high-fat, high-calorie diet. These rats were then intragastrically administered with either simvastatin, Sini powder, or vehicle for 1 week. The body mass and field test scores for each group were recorded weekly. Serum aspartate aminotransferase and alanine aminotransferase activities, and triglyceride, total cholesterol,and free fatty acid concentrations were measured.Liver tissue histopathology was examined on hematoxylin and eosin-stained paraffin sections and oil red O-stained frozen sections. The hepatic m RNA expression of nuclear factor kappa-B(NF-κB),NOD-, LRR-, and pyrin domain-containing protein 3(NLRP3), apoptosis-associated speck-like protein containing CARD(ASC), and caspase-1 were measured by reverse transcription-polymerase chain reaction(RT-PCR). The hepatic protein concentrations of NF-κB and NLRP3, ASC, caspase-1, interleukin-1β(IL-1β), interleukin-6(IL-6), and the serum concentrations of IL-1β and IL-6 were measured by enzyme-linked immunosorbent assay.RESULTS: Compared with the Blank group, rats in the Compound model group showed significant pathologic manifestations of NAFLD, and the expression of NF-κB, NLRP3, ASC, caspase-1, IL-1βand IL-6 were significantly higher(all P < 0.01). Both simvastatin and Sini powder significantly ameliorated the NAFLD pathology and the abnormal expression of NF-κB, NLRP3, ASC, caspase-1, IL-1β, and IL-6(all P < 0.01).CONCLUSION: Sini powder inhibits the inflamma-tory response in rats with NAFLD, which is mediated by NF-κB/NLRP3, IL-1β, and IL-6, reduces the effects of psychological stress, and improves lipid metabolism. Therefore, Sini powder may be effective for the treatment of stress-related NAFLD through multiple mechanisms. | Mu Jie Cheng Fafeng Wang Qingguo Wang Xueqian Zhu Wenxiang Ma Chongyang Yin Xiangjun Ren Beida Lian Yajun Du Xin Zhang Haixia Liu Shuling Zhang Shuang | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 9 |
| 2 | PDE-BASED MEDIAL AXIS EXTRACTION AND SHAPE MANIPULATION OF ARBITRARY MESHES显示文摘形状 skeletonization (即,中间的轴抽取) 在许多视觉计算应用程序是强大的例如模式识别,反对分割,登记,和动画。在这篇论文,作者扩展与距离地信息相结合到多角形的网孔基于他们的微分性质代表的任意的 3D 固体的近似中间的斧子的散开方程的使用。它为通常使用的 3D 为中间的轴抽取提供一个其他却自然的方法多角形的模型。由沿着时间轴解决 PDE,这个系统不能仅仅快速提取输入网孔的基于散开的中间的斧子,而且允许用户设想抽取进程在每次走。另外,建议模型提供用户雕刻提取中间的斧子的一套操作工具箱,然后使用基于散开的技术根据原来的输入数据集恢复相应使变形的形状。这基于骨骼的形状操作为复杂网孔对象的动画和变丑提供一个快、容易的方法。 | Haixia DU Terry YOO Hong QIN | 2008 | Journal of Systems Science & Complexity2008，21，4： | 3 |
| 3 | An above-room-temperature switchable molecular dielectric with a large dielectric change between high and low dielectric states显示文摘Dielectric anisotropy of anilinium perchlorate is investigated at various temperatures. Crystal structures at different temperatures reveal that significant dielectric change between low and high dielectric states is closely related to the disorder of the anilinium cation and perchlorate anion at high dielectric state; meanwhile, the conductivity after phase transition also contributes a lot to the high dielectric state. | DU Yang HAO HuiMin ZHANG QianChong ZHAO HaiXia LONG LaSheng HUANG RongBin ZHENG LanSun | 2013 | Science China Chemistry2013，56，7： | 2 |
| 4 | Reverse Apolipoprotein A-I Mimetic Peptide R-D4F Inhibits Neointimal Formation Following Carotid Artery Ligation in Mice显示文摘 | Lin Du Xinkai Qu Haixia Zhen Rujun Li Jun Wang Mingxing Chen Pei Zhao Zhengang Zhang Kaizheng Gong | 2013 | The American Journal of Pathology2013，，： | 1 |
| 5 | EGF enhances the migration of cancer cells by up-regulation of TRPM7显示文摘 | Haixia Gao Xingjuan Chen Xiaona Du Bingcai Guan Yani Liu Hailin Zhang | 2011 | Cell Calcium2011，，6： | 1 |
| 6 | EGF enhances the migration of cancer cells by up-regulation of TRPM7显示文摘 | Haixia Gao Xingjuan Chen Xiaona Du Bingcai Guan Yani Liu Hailin Zhang | 2011 | Cell Calcium2011，，6： | 1 |
| 7 | Land use and land cover change processes in China's eastern Loess Plateau显示文摘Using Landsat remote sensing images, we analyzed changes in each land use type and transitions among different land use types during land use and land cover change(LUCC) in Ningwu County, located in the eastern Loess Plateau of China, from 1990 to 2010. We found that grassland, woodland, and farmland were the main land use types in the study area, and the area of each type changed slightly from 1990 to 2010, whereas the area of water, construction land, and unused land increased greatly. For the whole area, the net change and total change were insignificant due to weak human activity intensity in most of the study area, and the LUCC was dominated by quasi-balanced two-way transitions from 1990 to 2010. The insignificant overall amount of LUCC appears to have resulted from offsetting of rapid increases in population, economic growth, and the implementation of a program to return farmland to woodland and grassland in 2000. This program converted more farmland into woodland and grassland from 2000 to 2010 than from 1990 to 2000, but reclamation of woodland and grassland for use as farmland continued from 2000 to 2010, and is a cause for concern to the local government. | JinChang Li HaiXia Liu Yong Liu ZhiZhu Su ZiQiang Du | 2015 | Research in Cold and Arid Regions2015，7，6： | 1 |
| 8 | Electrochemical bisphenol A sensor based on N-doped graphene sheets显示文摘 | Haixia Fan Yan Li Dan Wu Hongmin Ma Kexia Mao Dawei Fan Bin Du He Li Qin Wei | 2011 | Analytica Chimica Acta2011，，： | 1 |
| 9 | The Improved Simulated Annealing Algorithm and Application in the Surface Wave Dispersion Inversion显示文摘The velocity distribution of layers from surface wave dispersion curve is a severely nonlinear program. Base on the Metropolis rule,we improved the simulated annealing algorithm to simultaneously inverse the velocities and thicknesses using the dispersion data and identified the Moho and the bottom of lithosphere. The application to the numerical examples with 5% noise shows the velocity RMS is 1. 56% between the non-linear results and the original models when the condition of selecting method for temperature parameters and initial temperature are satisfied. Using the pure dispersions of Rayleigh wave,the nonlinear inversion has been carried out for S-wave velocities and thicknesses of the vertical profile crossing the Indian Plate,the Qinghai-Tibetan Plateau,and the Tarim Basin. It indicated that the crustal thickness is about 70 km in the Qiangtang block,while in the hinterland of the Qinghai-Tibetan Plateau the lithosphere is relatively thin(~ 130 km)from the velocity values and their offsets. | ZHANG Xuemei YANG Zhigao SHI Haixia DU Guangbao YANG Wen WEI Xing HAN Yanyan LI Fei HUANG Zhibin LIU Jie | 2019 | Earthquake Research in China2019，33，3： | 1 |
| 10 | A shape design system using volumetric implicit PDEs显示文摘 | Haixia Du Hong Qin | 2004 | Computer-Aided Design2004，，11： | 1 |
| 11 | A shape design system using volumetric implicit PDEs显示文摘 | Du Haixia Qin Hong | 2004 | Computer-Aided Design2004，36，11： | 1 |
| 12 | PVP-assisted preparation of nitrogen doped mesoporous carbon materials for supercapacitors显示文摘The rich porous structure,high surface area and surface doping make nitrogen doping mesoporous carbon materials(N-MPC)attractive in various areas,including adsorption separation,electrochemical energy storage,catalysis and other fields.Herein,polyvinylpyrrolidone(PVP)is introduced into the polymerization process of assembly of phenol/formaldehyde(PF)resin by means of hydrogen bonds and electrostatic interaction,which not only leads to the formation of uniform mesopores,but also leads to the increase of specific surface area and nitrogen doping.The amount of PVP and annealing temperature has no obvious effect on morphology,but subsequently has effect on the specific surface area and pore volume.When appropriate PVP dosage and annealing temperature are adopted,the obtained N-MPC shows abundant mesoporous,high surface area and suitable nitrogen doping.As electrode materials in supercapacitor,the N-MPC shows good performance with high capacitance good stability and rate performance,presenting its excellent promising in energy storage. | Juan Du Aibing Chen Yue Zhang Shuang Zong Haixia Wu Lei Liu | 2020 | Journal of Materials Science & Technology2020，58，23： | 0 |
| 13 | TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNAPKcs cytosolic retention and DNA damage显示文摘Clinical application of doxorubicin(DOX)is heavily hindered by DOX cardiotoxicity.Several theories were postulated for DOX cardiotoxicity including DNA damage and DNA damage response(DDR),although the mechanism(s)involved remains to be elucidated.This study evaluated the potential role of TBC domain family member 15(TBC1D15)in DOX cardiotoxicity.Tamoxifen-induced cardiac-specific Tbcldi5 knockout(Tbcldi5^(CKO))or Tbcldi5 knockin(Tbcldi5^(CKI))male mice were challenged with a single dose of DOx prior to cardiac assessment 1 week or 4 weeks following DOX challenge.Adenoviruses encoding TBC1D15 or containing shRNA targeting Tbcld15 were used for Tbcld15 overexpression or knockdown in isolated primary mouse cardiomyocytes.Our results re-vealed that DOX evoked upregulation of TBC1D15 with compromised myocardial function and overt mortality,the effects of which were ameliorated and accentuated by Tbcldi5 deletion and Tbcld15 overexpression,respectively.DOX overtly evoked apoptotic cell death,the effect of which was alleviated and exacerbated by Tbcld15 knockout and overexpression,respectively.Meanwhile,DOX provoked mitochondrial membrane potential collapse,oxidative stress and DNA damage,the effects of which were mitigated and exacerbated by Tbcld15 knockdown and overexpression,respectively.Further scrutiny revealed that TBC1D15 fostered cytosolic accumulation of the cardinal DDR element DNA-dependent protein kinase catalytic subunit(DNA-PKcs).Liquid chromatography-tandem mass spectrometry and coimmunoprecipitation denoted an interaction between TBCID15 and DNA-PKcs at the segment 594-624 of TBC1D15.Moreover,overexpression of TBC1D15 mutant(A594-624,deletion of segment 594-624)failed to elicit accentuation of DOX-induced cytosolic retention of DNA-PKcs,DNA damage and cardiomyocyte apoptosis by TBC1D15 wild type.However,Tbcld15 deletion ameliorated DOXinduced cardiomyocyte contractile anomalies,apoptosis,mitochondrial anomalies,DNA damage and cytosolic DNA-PKcs accumulation,which were canceled off by DNA-PKcs inhibition or ATM activation.Taken together,our findings denoted a pivotal role for TBCID15 in DOX-induced DNA damage,mitochondrial injury,and apoptosis possibly through binding with DNA-PKcs and thus gate-keeping its cytosolic retention,a route to accentuation of cardiac contractile dysfunction in DOX-induced cardiotoxicity. | Wenjun Yu Haixia Xu Zhe Sun Yuxin Du Shiqun Sun Miyesaier Abudureyimu Mengjiao Zhang Jun Tao Junbo Ge Jun Ren Yingmei Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 14 | 4-29 Step-target Design for High Energy Electron Radiography Research显示文摘High energy proton beam has the long penetration length in solid matter and it could produce the radiographsand indicate the tomography and material properties inside of the specimen. Considering the expensive coststo construct a high energy proton accelerator, the other candidate of high energy electron beam becomes moreacceptable[1??3]. Due to the high spatial and temperal resolution of high energy electron beam. It is a power tool todiagnose the inner structure change during the high energy density matter production and the inertial confinementfusion process. In order to study the density resolution of the high energy electron beam radiography, a step-targetwas designed and produced. The structure and the target pictures are shown in Fig. 1 and the Si targets withdifferent slot-width were produced by using the microetch technics. | Cheng Rui Zhao Yongtao Zhang Ziming Gai Wei Du Yingchao Cao Shuchun Zhou Xianming Zhao Quantang Shen Xiaokang Zong Yang Wang Yangru Xiao Jiahao Li Haixia | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 15 | Joint User Association and Fair Scheduling for Dual Connectivity Heterogeneous Networks显示文摘Heterogeneous small cell network is one of the most effective solutions to overcome spectrum scarcity for the next generation of mobile networks.Dual connectivity(DC)can improve the throughput for each individual user by allowing concurrent access to two heterogeneous radio networks.In this paper,we propose a joint user association and fair scheduling algorithm(JUAFS)to deal with the resource allocation and load balancing issues for DC heterogeneous small cell networks.Considering different coverage sizes,numbers of users,and quality of experience characteristics of heterogeneous cells,we present a proportional fair scheduling for user association among cells and utilize interference graph to minimize the transmission conflict probability.Simulation results show the performance improvement of the proposed algorithm in spectrum efficiency and fairness comparing to the existing schemes. | Haixia Cui Yongliang Du | 2023 | China Communications2023，20，1： | 0 |
| 16 | Research Progress on the Relationship between Air Pollution and Socio-economic Growth in China显示文摘Air pollution is a hot issue studied by scholars all over the world.Academic circles generally believe that socio-economic factors such as extensive economic growth,unbalanced proportion of industrial structure and unreasonable energy consumption structure are the main'culprits'of serious air pollution in China.Therefore,the relationship between air pollution and socio-economic growth has very important theoretical and practical significance for air pollution prevention and control and promoting the sustainable and healthy development of cities.Through literature research and summary methods,this paper studies the severity and harmfulness of air pollution in China,and deeply studies the research progress of socio-economic influencing factors of air pollution,environmental Kuznets curve hypothesis of air pollution,decoupling relationship between air pollution and socio-economic growth,so as to provide useful reference for the prevention and control of air pollution. | Xiaoming CHUAI Lele DU Haixia ZHOU | 2021 | Meteorological and Environmental Research2021，12，6： | 0 |
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