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| 1 | Seroprevalence of Toxoplasma gondii infection among patients with hand, foot and mouth disease in Henan, China: a hospital-based study显示文摘Background:The prevalence of infection with Toxoplasma gondii(T.gondii)in humans has been increasing in China due to the growing number of cats in the country.Hand,foot and mouth disease(HFMD)is a serious public health issue in China and still one of the leading causes of child mortality.However,little is known about the epidemiology of T.gondii infection among HFMD patients.Methods:A case–control study of 281 HFMD patients from the First People’s Hospital of Pingdingshan in Pingdingshan city,Henan province,central China,and 222 controls from Pingdingshan city was conducted.Anti-T.gondii antibodies were serologically detected using the enzyme-linked immunosorbent assay.Results:We found that the overall anti-T.gondii immunoglobulin G(IgG)antibody prevalence among HFMD patients was 12.46%,which was significantly higher than that in clinically healthy children(1.80%).The highest T.gondii seroprevalence was detected in critical cases(22.58%),followed by severe cases(11.50%),and the lowest was detected in mild cases(8.33%).Conclusion:The present study is the first survey of T.gondii seroprevalence among HFMD patients in China;12.46%were defined as seropositive.It is imperative that improved integrated measures are taken to prevent and control T.gondii infection among HFMD patients. | Shuai Wang Chunwei Lan Luwen Zhang Haizhu Zhang Zhijun Yao Dong Wang Jingbo Ma Jiarong Deng Shiguo Liu | 2015 | Infectious Diseases of Poverty2015，4，1： | 5 |
| 2 | Base editing-mediated splicing correction therapy for spinal muscular atrophy显示文摘Dear Editor,Spinal muscular atrophy(SMA)is a devastating autosomal recessive motor neuron disease.1,2 Infants with more severe forms of type I SMA die before the age of 2 if no intervention is provided.1,2 Spinraza and zolgensma have been approved by the FDA as SMA therapeutics for pediatric patients.1,2 However,as an antisense oligonucleotide(ASO)based therapy,spinraza requires four loading doses,followed by three annual maintenance doses.The patients would be subjected to repeated intrathecal injections in the procedure.Zolgensma is a single-dose gene-replacement therapy for SMA,but unfortunately is unreliable in maintaining a high,stable level of gene expression.These issues have limited the therapeutic effects of the two approved drugs for SMA. | Xiang Lin Haizhu Chen Ying-Qian Lu Shunyan Hong Xinde Hu Yanxia Gao Lu-Lu Lai Jin-Jing Li Zishuai Wang Wenqin Ying Lixiang Ma Ning Wang Erwei Zuo Hui Yang Wan-Jin Chen | 2020 | Cell Research2020，30，6： | 5 |
| 3 | Shale gas exploitation with supercritical CO_2 technology显示文摘This paper analyzes the physicochemical properties of supercritical CO2, the characteristic of shale gas and shale gas reservoirs. The technologies of drilling, production, fracturing using the supercritical CO2 in shale gas exploration are proposed, to increase the penetration rate, decrease the damage to formation while fracturing, and enhance the recovery of shale gas. It is believed that the huge economic benefits of shale gas exploration with the supercritical CO2 fluid will be obtained, and it also can initiate a new technology field of CO2 in the petroleum engineering. | Wang Haizhu Shen Zhonghou Li Gensheng Tian Shouceng Cheng Yuxiong | 2012 | Engineering Sciences2012，10，4： | 5 |
| 4 | Research and applications of novel jet techniques in well drilling,completion and fracturing显示文摘Oil and gas have long been regarded as key elements for any industrialized country.China's economy and social security are largely dependent on oil and gas exploration and development.Nowadays,a great deal of attention has been paid to various ways of efficiently developing oil and gas reserves.This paper presents an overview of research and applications of novel jet techniques in well-drilling,well-completion and fracturing.Supported by the National Natural Science Foundation of China,through years of effort,significant achievements have been made in this area.Not only has the systematic theory of novel jetting been established,but also its application has been proved practical in petroleum engineering.This paper focuses on the topics of the self-resonating cavitating jet,the abrasive water jet,and the supercritical CO_2 jet,in respect of theories,applications and prospects. | LI GenSheng SHEN ZhongHou HUANG ZhongWei TIAN ShouCeng SHI HuaiZhong SONG XianZhi WANG HaiZhu | 2014 | Science Foundation in China2014，22，2： | 3 |
| 5 | Throttle characteristics of multi-stage circumfluence nozzle during the separate-layer injection of CO_(2)显示文摘Separate-layer injection of CO2 is an important method to improve oil and gas production and recovery.Conventional single-stage nozzle is usually blocked by impurities,and the ice-barrier phenomenon is very common.To solve this problem,large-diameter multi-stage circumfluence nozzle was designed to release pressure stage by stage.In order to illuminate the throttle characteristics of the CO2 multi-stage circumfluence nozzles,numerical simulation was performed to test several nozzles with different diameters and stage numbers.Furthermore,we tested the throttle characteristics through laboratory experiments and obtained the effects of several critical parameters such as nozzle diameter,number of stage and pressure drop on the throttle characteristics.The results show that the flow rate decreases as the nozzle stage increases on the condition of constant pressure and nozzle diameter.And pressure difference increases as nozzle stage number increases under the constant flow rate.The throttle capability of multi-stage circumfluence nozzles was much better than the concentric nozzles.Large-diameter multi-stage nozzle is recommended rather than small-diameter single-stage nozzle during the process of separate-layer injection,which can efficiently prevent impurities and ice blocking.The results are expected to provide a theoretical support for the nozzle choice of separate-layer injection of CO2. | Haizhu Wang Gensheng Li Lichuan Zhao Youwen Wang Yun Liu Qingling Liu Meng Wang Fei Gao Meng Cai | 2018 | Petroleum2018，4，2： | 2 |
| 6 | Key problems and solutions in supercritical CO2 fracturing technology显示文摘Supercritical CO2 fracturing is considered to be a new method for efficient exploitation of unconventional reservoirs,such as shale gas,coal bed methane,and tight sand stone gas.Supercritical CO2 has many special properties including low viscosity,high diffusion coefficient,and lack of surface tension,which brings about great advantages for fracturing.However,these properties also cause several problems,such as difficulty in proppant transportation,high friction loss,and high pump displacement.In this paper,the above problems were analyzed by combining field test with laboratory study and specific solutions to these problems are given.The high frictionloss in the pipeline could be reduced by developing a new drag reducing agent and selecting large-size casing.Besides,for the problem of poor capacity in proppant carrying and sand plug,the methods of adding tackifier into supercritical CO2,increasing pump displacement and selecting ultralow density proppants are proposed.Moreover,for the problem of fast leak-off and high requirement for pump displacement,the displacement can be increased or the pad fluid can be injected into the reservoir.After solving the above three problems,the field test of supercritical CO2 fracturing can be conducted.The research results can promote the industrialization process of supercritical CO2 fracturing. | Haizhu WANG Gensheng LI Bin ZHU Kamy SEPEHRNOORI Lujie SHI Yong ZHENG Xiaomei SHI | 2019 | Frontiers in Energy2019，13，4： | 2 |
| 7 | Polyvinylpyrrolidone (PVP) assisted synthesized nano-LiFePO 4 /C composite with enhanced low temperature performance显示文摘 | Guolong Huang Wei Li Haizhu Sun Jiawei Wang Jingping Zhang Huixin Jiang Fei Zhai | 2013 | Electrochimica Acta2013，，： | 1 |
| 8 | Noble and valuable: atomically precise gold nanoclusters显示文摘Atomically precise gold nanoclusters have recently attracted intensive attention due to their significance in catalysis,chemical sensing,and bio-application.These nanoclusters often possess unique optical,chemical or physical properties originated from the quantum size effect(i.e.size | Shuxin Wang Haizhu Yu Manzhou Zhu | 2016 | Science China Chemistry2016，59，2： | 1 |
| 9 | Application investigations and prospects of supercritical carbon dioxide jet in petroleum engineering 显示文摘 | LI Gensheng WANG Haizhu SHEN Zhonghou | 2013 | Journal of China University of Petroleum ( Edition of Natural Sci- ence)2013，37，5： | 1 |
| 10 | Effects of zero-valent metals together with quartz sand on the mechanochemical destruction of dechlorane plus coground in a planetary ball mill 显示文摘 | WANG Haizhu HUANG Jun ZHANG Kunlun | 2014 | Journal of Hazardous Materials2014，264，： | 1 |
| 11 | Acceleration and mechanistic studies of the mechanochemical dechlorination of HCB with iron powder and quartz sand 显示文摘 | ZHANG Wang WANG Haizhu HUANG Jun | 2014 | Chemical Engineering Journal2014，239，： | 1 |
| 12 | Meehanoehemieal degradation of hexabromoeyelododeeane and approaches for the remediation of its contaminated soil 显示文摘 | ZHANG Kunlun HUANG Jun WANG Haizhu | 2014 | Chemosphere2014，116，： | 1 |
| 13 | , A feasibility analysis on shale gas exploitation with supercritical carbon dioxide 显示文摘 | Wang Haizhu Li Gensheng Shen Zhonghou | 2012 | Energy Sources: Part A2012，34，15： | 1 |
| 14 | Mechanochemical degradation of hexabromocyclododeeane and approaches for the remediation of its contaminated soil 显示文摘 | ZHANG Kunlun HUANG Jun WANG Haizhu | 2014 | Chemosphere2014，116，： | 1 |
| 15 | Effects of zero-valent metals together with quartz sand on the mechanochemical destruction of dechlorane plus coground in a planetary ball mill显示文摘 | WANG Haizhu HUANG Jun ZHANG Kunlun | 2014 | Journal of Hazardous Materials2014，264，： | 1 |
| 16 | Applicationinvestigation and prospects of supercritical carbon dioxide jet inpetroleum engineering显示文摘 | LI Gensheng WANG Haizhu SHEN Zhonghou | 2013 | Journal of China University of Petroleum(Edition of Natural Science)2013，37，5： | 1 |
| 17 | Expulsive force in the development of C02 sequestration:application of SC-C02 jet in oil and gas extraction显示文摘With the rapid development of global economy,an increasing amount of attention has been paid to the emission of greenhouse gases,especially CO2.In recent years,dominated by the governments around the world,several significant projects of CO2 sequestration have been conducted.However,due to the huge investment and poor economic effects,the sustainability of those projects is not satisfactory.Supercritical CO2(SC-CO2)has prominent advantages in well drilling,fracturing,displacement,storage,plug and scale removal within tubing and casing,which could bring considerable economic benefits along with CO2 sequestration.In this paper,based on physicochemical properties of SC-CO2 fluid,a detailed analysis of technical advantages of SC-CO2 applied in oil and gas development is illustrated.Furthermore,the implementation processes of SC-CO2 are also proposed.For the first time,a recycling process is presented in which oil and gas are extracted and the CO2 generated could be restored underground,thus an integrated technology system is formed.Considering the recent interests in the development of enhancing hydrocarbon recoveries and CO2 sequestration,this approach provides a promising techni?que that can achieve these two goals simultaneously. | Haizhu WANG Gensheng LI Zhonghou SHEN | 2019 | Frontiers in Energy2019，13，1： | 1 |
| 18 | 局部热疗联合腔内化疗对恶性胸腔积液的疗效观察(英文)显示文摘Objective: The aim of our study was to assess the efficacy of regional hyperthermia combined with intrapleural chemotherapy and to evaluate the effect on the immunologic cells and vascular endothelial growth factor (VEGF) in patients with malignant pleural effusion. Methods: The 102 patients with malignant pleural effusion were included in this study: 52 patients undergoing regional hyperthermia with intrapleural chemotherapy (HICT), and 50 patients treated with intrapleural chemotherapy (ICT). Chemotherapy was administered into the thoracic cavity weekly through a tube with CDDP (dose = 40 mg/m2), and hyperthermia was performed twice a week for 60 minutes following the ICT. We evaluated the response rates and side-effects after 4 weeks. Before and after the treatment, T cell subsets and NK cells were detected by flow cytometry and VEGF was measured with ELISA kits. Results: Compared HICT to ICT, the overall response rates of the whole group, breast cancers and lung cancers were 80.8% vs 54% (P < 0.01), 86.7% vs 56.3% (P > 0.05) and 78.4% vs 52.9% (P < 0.05) respectively. The ratios of CD4+, CD4+/CD8+ and NK cells increased and the concentration of VEGF decreased more significantly after HICT. Conclusion: We concluded that combined regional hyperthermia with intrapleural chemotherapy could control the malignant pleural effusion effectively with mild toxicity. The levels of the T cell subset, NK cells and VEGF in both blood and effusion changed obviously. | Haizhu Song Longbang Chen Jinghua Wang Qu Zhang Xiaoyuan Chu Huaicheng Geng Xiaoxiang Guan | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，6： | 0 |
| 19 | Detection and classification of breast lesions using multiple information on contrast-enhanced mammography by a multiprocess deep-learning system: A multicenter study显示文摘Objective: Accurate detection and classification of breast lesions in early stage is crucial to timely formulate effective treatments for patients. We aim to develop a fully automatic system to detect and classify breast lesions using multiple contrast-enhanced mammography(CEM) images.Methods: In this study, a total of 1,903 females who underwent CEM examination from three hospitals were enrolled as the training set, internal testing set, pooled external testing set and prospective testing set. Here we developed a CEM-based multiprocess detection and classification system(MDCS) to perform the task of detection and classification of breast lesions. In this system, we introduced an innovative auxiliary feature fusion(AFF)algorithm that could intelligently incorporates multiple types of information from CEM images. The average freeresponse receiver operating characteristic score(AFROC-Score) was presented to validate system’s detection performance, and the performance of classification was evaluated by area under the receiver operating characteristic curve(AUC). Furthermore, we assessed the diagnostic value of MDCS through visual analysis of disputed cases,comparing its performance and efficiency with that of radiologists and exploring whether it could augment radiologists’ performance.Results: On the pooled external and prospective testing sets, MDCS always maintained a high standalone performance, with AFROC-Scores of 0.953 and 0.963 for detection task, and AUCs for classification were 0.909[95% confidence interval(95% CI): 0.822-0.996] and 0.912(95% CI: 0.840-0.985), respectively. It also achieved higher sensitivity than all senior radiologists and higher specificity than all junior radiologists on pooled external and prospective testing sets. Moreover, MDCS performed superior diagnostic efficiency with an average reading time of 5 seconds, compared to the radiologists’ average reading time of 3.2 min. The average performance of all radiologists was also improved to varying degrees with MDCS assistance.Conclusions: MDCS demonstrated excellent performance in the detection and classification of breast lesions,and greatly enhanced the overall performance of radiologists. | Yuqian Chen Zhen Hua Fan Lin Tiantian Zheng Heng Zhou Shijie Zhang Jing Gao Zhongyi Wang Huafei Shao Wenjuan Li Fengjie Liu Simin Wang Yan Zhang Feng Zhao Hao Liu Haizhu Xie Heng Ma Haicheng Zhang Ning Mao | 2023 | Chinese Journal of Cancer Research2023，35，4： | 0 |
| 20 | Duodenal pseudolymphoma: A case report and review of literature显示文摘We report a rare case of duodenal pseudolymphoma without any symptoms. The lesion located in front of the head of the pancreas was found accidentally during a medical examination. The findings of computed tomography and positron emission tomography-computed tomography suggested a stromal tumor or malignant lymphoma. Surgical resection was performed. The lesions were patho- logically diagnosed as duodenal pseudolymphoma. | Yong-Heng Huang, Tian-Zhu Long, Zhi-Yu Xiao, Hua Ye, Yun-Le Wan, Jie Wang Yong-Heng Huang, Tian-Zhu Long, Zhi-Yu Xiao, Hua Ye, Yun-Le Wan, Jie Wang, Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University Haizhu District, Guangzhou 510260, Guangdong Province, China | 2011 | World Journal of Gastroenterology2011，17，27： | 0 |
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