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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Recent developments in inductively coupled plasma magnetic sector multiple collector mass spectrometry 显示文摘 | Halliday A N Lee D C Christensen J N Walder A J Freedman P A Jones C E Hall C M Yi W Teagle D | 1995 | Int J Mass Spec Ion Proc1995，，： | 1 |
| 3 | Development and validation of a measure of emotional intelligence显示文摘 | SCHUTTE N S MALOUFF J M HALL L E | 1998 | Personality and Individual Differences1998，，2： | 1 |
| 4 | Phase relationships between millennial-scale events 64000 -24000 years ago 显示文摘 | Shackleton N J Hall M A Vincent E | 2000 | Paleoceanography2000，15，6： | 1 |
| 5 | Earliness-tardiness scheduling problems, h weighted deviation of completion times about a common due date显示文摘 | HALL N G POSNER M E | 1991 | Operations Research1991，39，5： | 1 |
| 6 | First principles predictions of the structure and function of G-protein-cou- pled receptors: validation for bovine rhodopsin显示文摘 | Trabanino RJ Hall E Vaidehi N | 2004 | Biophys J2004，86，4： | 1 |
| 7 | Logistic model trees显示文摘 | LANDWEHR N HALL M FRANK E | 2005 | Machine Learning2005，59，12： | 1 |
| 8 | Development and validatlor of a measure of Emotional intelligenee显示文摘 | Schutte N S Malouff M Hall L E | 1998 | Personality and lndividua Differences1998，25，： | 1 |
| 9 | The crystal structure of metanilic acid显示文摘 | Hall S R Maslen E N | 1965 | Acta Cryst1965，18，： | 1 |
| 10 | Safety and immunogenicity of a prototype enterotoxigenic Esche- richia coil vaccine administered transeutaneously 显示文摘 | GURENA-BURGLENO F HALL E H TAYLOR D N | 2002 | Infect Im- mun2002，70，4： | 1 |
| 11 | An analysis of pediatric vaccine formulary selection problems显示文摘 | Hall S N Jacobson S H Sewell E C | 2008 | Operations Re?search2008，56，6： | 1 |
| 12 | Formalism,Analyticalmodel,and a Priori Green,s-function-based Calculations of the Current-voltage Characteristics of Molecular Wires显示文摘 | Reimers J R Hush N S | 2000 | J Chem Phys2000，112，3： | 1 |
| 13 | Temperature and the expression of seven muscle-specific protein genes during embryogenesis in the Atlantic cod Gadusmorhua L 显示文摘 | Hall T E Cole N J Johnston I A | 2003 | The Journal of Experimental Biology2003，206，18： | 1 |
| 14 | An internationaloutbreak of Salmonella in fections caused by alfalfa sprouts grownfrom contaminated seeds显示文摘 | MAHON B E PONKA A HALL W N | 1997 | The Journal of Infectious Diseases1997，175，4： | 1 |
| 15 | Genome sequence of the human malaria parasite Plasmodium falciparum 显示文摘 | Gardner M J Hall N Fung E | 2002 | Na- ture2002，419，： | 1 |
| 16 | The expanding TOR signaling network显示文摘 | Martin D E Hall M N | 2005 | Curt Opin Cell Biol2005，17，： | 1 |
| 17 | The expanding TOR signaling network 显示文摘 | MARTIN D E HALL M N | 2005 | Curr Opin Cell Biol2005，17，： | 1 |
| 18 | The expanding TOR signaling network显示文摘 | Dietmar E Martin Michael N Hall | 2005 | Current Opinion in Cell Biology2005，，2： | 1 |
| 19 | Earliness-tardiness scheduling prob-lems,I:weighted deviation of completion times about a common due date 显示文摘 | HALL N G POSNER M E | 1991 | Operations Research1991，39，5： | 1 |
| 20 | Investigating polymers and conducting metals as transduction mediators or immobilization matrices显示文摘 | Hall E A H Skinner N G Jung C | 1995 | Electroanalysis1995，7，9： | 1 |
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