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| 1 | Lean heart: Role of leptin in cardiac hypertrophy and metabolism显示文摘Leptin is an adipokine that has been linked with the cardiovascular complications resulting from obesity such as hypertension and heart disease. Obese patients have high levels of circulating leptin due to increased fat mass. Clinical and population studies have correlated high levels of circulating leptin with the development of cardiac hypertrophy in obesity. Leptin has also been demonstrated to increase the growth of cultured cardiomyocytes. However, several animal studies of obese leptin deficient mice have not supported a role for leptin in promoting cardiac hypertrophy so the role of leptin in this pathological process remains unclear. Leptin is also an important hormone in the regulation of cardiac metabolism where it supports oxidation of glucose and fatty acids. In addition, leptin plays a critical role in protecting the heart from excess lipid accumulation and the formation of toxic lipids in obesity a condition known as cardiac lipotoxicity. This paper focuses on the data supporting and refuting leptin's role in promoting cardiac hypertrophy as well as its important role in the regulation of cardiac metabolism and protection against cardiac lipotoxicity. | Michael E Hall Romain Harmancey David E Stec | 2015 | World Journal of Cardiology2015，7，9： | 7 |
| 2 | Less common etiologies of exocrine pancreatic insufficiency显示文摘Exocrine pancreatic insufficiency(EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases(diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin(CCK); celiac or inflammatory bowel disease(IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery(asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food). This paper reviews such conditions that have less straightforward associations with EPI and examines the role of pancreatic enzyme replacement therapy(PERT). Relevant literature was identified by database searches. Most patients with inoperable pancreatic cancer develop EPI(66%-92%). EPI occurs in patients with type 1(26%-57%) or type 2 diabetes(20%-36%) and is typically mild to moderate; by definition, all patients with type 3 c(pancreatogenic) diabetes have EPI. EPI occurs in untreated celiac disease(4%-80%), but typically resolves on a gluten-free diet. EPI manifests in patients with IBD(14%-74%) and up to 100% of gastrointestinal surgery patients(47%-100%; dependent on surgical site). With the paucity of published studies on PERT use for these conditions, recommendations for or against PERT use remain ambiguous. The authors conclude that there is an urgent need to conduct robust clinical studies to understand the validity and nature of associations between EPI and medical conditions beyond those with proven mechanisms, and examine the potential role for PERT. | Vikesh K Singh Mark E Haupt David E Geller Jerry A Hall Pedro M Quintana Diez | 2017 | World Journal of Gastroenterology2017，23，39： | 5 |
| 3 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 4 | HA receptors: regulators of signaling to the cytoskeleton显示文摘 | Entwistle J Hall C L Turley E A | 1996 | J Cell Biochem1996，61，4： | 2 |
| 5 | GATA3 controls Foxp3^sup +^ regulatory T cell fate during inflammation in mice显示文摘 | Wohlfert Elizabeth A Grainger John R Bouladoux Nicolas Konkel Joanne E Oldenhove Guillaume Ribeiro Carolina Hager Hall Jason A Yagi Ryoji Naik Shruti Bhairavabhotla Ravikiran Paul William E Bosselut Remy Wei Gang Zhao Keji Oukka Mohamed Zhu | 2011 | Journal of Clinical Investigation2011，，11： | 2 |
| 6 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | A new approach to using anisotropically conductive adhesives for flip-chip assembly显示文摘 | Lyons A M Hall E Wong Y H | 1996 | IEEE Trans Compon Packg Manuf Techn Part A1996，19，1： | 2 |
| 8 | Estimated risks of radiation- induced fatal cancer from pediatric C显示文摘 | Brenner D Elliston C Hall E | 2001 | A JR Am J Roentgenol2001，176，2： | 1 |
| 9 | Sevoflurane(12% and 8%)inhalational induction in children显示文摘 | Chawathe M Zatman T Hall J E | 2005 | Paediatr Anaesth2005，15，6： | 1 |
| 10 | Three dimensional transonic aeroelasticity using proper orthogonal decompo- sition-based reduced order models显示文摘 | Thomas J P Dowell E H Hall K C | 2003 | Journal of Aircraft2003，40，3： | 1 |
| 11 | (h2chocerca volvulus keralilis (river blindness) is exacerbated in BALB/c IL-4 gene knockout mice显示文摘 | Hall LR Berger RB Diaeonu E | 2002 | Celllmmunol2002，216，： | 1 |
| 12 | Objective methods for registration landmarks and determining cloud motions from satellite data显示文摘 | Endlich R M Wolf D E and Brain A E | 1972 | IEEE Trans1972，21，： | 1 |
| 13 | Analytical perspective on trace element species of interest in exploration 显示文摘 | Hall G E M | 1998 | Journal of Geochemical Exploration1998，61，13： | 1 |
| 14 | Characterization of randomly-obtained matrix attachment regions (MARs) from higher plants显示文摘 | Michalowski S M Alien G C Hall G E Thompson W F Spiker S | 1999 | Biochemistry1999，38，12： | 1 |
| 15 | The effects of increasingplasma concentrations of dexmedetomidine in humans显示文摘 | Ebert T J Hall J E Barney J A | 2000 | Anesthe-siology2000，93，2： | 1 |
| 16 | Recent developments in inductively coupled plasma magnetic sector multiple collector mass spectrometry 显示文摘 | Halliday A N Lee D C Christensen J N Walder A J Freedman P A Jones C E Hall C M Yi W Teagle D | 1995 | Int J Mass Spec Ion Proc1995，，： | 1 |
| 17 | Soil ingestion of sewage sluge annd animal slurries显示文摘 | Hall J E | 1988 | Fertilizer1988，，4： | 1 |
| 18 | Relative deficiency in IgA production by duodenal explants from german shepherd dogs with small intestinal Disease显示文摘 | GERMAN A J HALL E J DAYM J | 2000 | Vet Immunol Immunopatho2000，76，12： | 1 |
| 19 | The Square Kilometere Array 显示文摘 | DEWENEY PETER E HALL PETER J SCHILIZZI RICHARD T | 2009 | Proceedings of the IEEE2009，97，8： | 1 |
| 20 | On bias reduction in local linear smoothing显示文摘 | Choi E Hall P | 1998 | Biometrika1998，85，2： | 1 |
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