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| 1 | Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes:current strategies and future perspectives显示文摘mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium(TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Other moieties, including short peptides,dequalinium, guanidine, rhodamine, and F16, are also known to be promising mitochondrial targeting agents. Direct conjugation of mitochondrial targeting moieties to anticancer drugs, antioxidants and sensors results in increased cytotoxicity, anti-oxidizing activity and sensing activity, respectively,compared with their non-targeting counterparts, especially in drug-resistant cells. Although many mitochondria-targeted anticancer drug conjugates have been investigated in vitro and in vivo, further clinical studies are still needed. On the other hand, several mitochondria-targeting antioxidants have been analyzed in clinical phases I, II and III trials, and one conjugate has been approved for treating eye disease in Russia. There are numerous ongoing studies of mitochondria-targeted sensors. | Gantumur Battogtokh Yeon Su Choi Dong Seop Kang Sang Jun Park Min Suk Shim Kang Moo Huh Yong-Yeon Cho Joo Young Lee Hye Suk Lee Han Chang Kang | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 17 |
| 2 | Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey显示文摘AIM: To investigate prevalence of Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea.METHODS: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire.RESULTS: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis.CONCLUSION: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite. | Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon Jong Ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon | 2009 | World Journal of Gastroenterology2009，15，1： | 15 |
| 3 | Endoscopic characteristics of gastric adenomas suggesting carcinomatous transformation显示文摘 | Min Kyu Jung Seong Woo Jeon Soo Young Park Chang Min Cho Won Young Tak Young Oh Kweon Sung Kook Kim Yong Hwan Choi Han Ik Bae | 2008 | Surgical Endoscopy2008，，12： | 3 |
| 4 | Endoscopic characteristics of gastric adenomas suggesting carcinomatous transformation显示文摘 | Min Kyu Jung Seong Woo Jeon Soo Young Park Chang Min Cho Won Young Tak Young Oh Kweon Sung Kook Kim Yong Hwan Choi Han Ik Bae | 2008 | Surgical Endoscopy2008，，12： | 3 |
| 5 | Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists显示文摘The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of invasion.Although the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic lesions.Korean pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western medicine.Japan is geographically close to Korea,and academic exchanges are active.Additionally,Korean doctors are familiar with Western style medical terminology.As a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in Korea.To solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss of nuclear polarity,thick and irregular nuclear membrane,and nucleoli. | Joon Mee Kim Mee-Yon Cho Jin Hee Sohn Dae Young Kang Cheol Keun Park Woo Ho Kim So-Young Jin Kyoung Mee Kim Hee Kyung Chang Eunsil Yu Eun Sun Jung Mee Soo Chang Jong Eun Joo Mee Joo Youn Wha Kim Do Youn Park Yun Kyung Kang Sun Hoo Park Hye Seung Han Young Bae Kim Ho Sung Park Yang Seok Chae Kye Won Kwon Hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists | 2011 | World Journal of Gastroenterology2011，17，21： | 2 |
| 6 | Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment显示文摘 | Jae‐Hyun Park Sang Won Seo Changsoo Kim Geon Ha Kim Hyun Jin Noh Sung Tae Kim Ki‐Chang Kwak Uicheul Yoon Jong Min Lee Jong Weon Lee Ji Soo Shin Chi Hun Kim Young Noh Hanna Cho Hee Jin Kim Cindy W. Yoon Seung Jun Oh Jae Seung Kim Yearn Seong Choe Kyung‐Han | 2013 | Ann Neurol2013，，5： | 1 |
| 7 | Studies on the structure and equilibration of (π-allyl) palla-dium complexes of phosphino (oxazolinyl) ferrocene lig-ands 显示文摘 | Cho Chang Woo Son Jeong Ho Ahn Kyo Han | 2006 | Tetrahedron:Asymmetry2006，，17： | 1 |
| 8 | Laparoscopic approach for treatment of multiple hepatocellular carcinomas显示文摘 | Yoo-Seok Yoon Ho-Seong Han Jai Young Cho Chang Jin Yoon Ji Hoon Kim | 2012 | Surgical Endoscopy2012，，11： | 1 |
| 9 | Electrochemical properties of LiNi 0.8 Co 0.2? x Al x O 2 prepared by a sol–gel method显示文摘 | Chang Joo Han Jang Hyuk Yoon Won Il Cho Ho Jang | 2004 | Journal of Power Sources2004，，1： | 1 |
| 10 | Targeted ablation of the histidine-rich Ca 2+ -binding protein (HRC) gene is associated with abnormal SR Ca 2+ -cycling and severe pathology under pressure-overload stress显示文摘 | Chang Sik Park Shan Chen Hoyong Lee Hyeseon Cha Jae Gyun Oh Sunghee Hong Peidong Han Kenneth S. Ginsburg Sora Jin Inju Park Vivek P. Singh Hong-Sheng Wang Clara Franzini-Armstrong Woo Jin Park Donald M. Bers Evangelia G. Kranias Chunghee Cho Do Han Kim | 2013 | Basic Research in Cardiology2013，，3： | 1 |
| 11 | Role of Intravenous Hyoscine N-Butyl Bromide At the Time of Colonoscopic Withdrawal for Polyp Detection Rates: A Randomized, Double-Blinded, Placebo-Controlled Trial显示文摘 | Tae Jun Byun Dong Soo Han Sang Bong Ahn Hyun Seok Cho Tae Yeob Kim Chang Soo Eun Yong Cheol Jeon Joo Hyun Sohn | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 12 | Characterization of Clay Sedimentation Using Piezoelectric Bender Elements显示文摘 | Chang Il Han Cho Gye Chun Lee Joo Gong Kim Lee Hyung | 2006 | Key Engineering Materials2006，，321： | 1 |
| 13 | Phytogenic feed additives alleviate pathogenic Escherichia coli-induced intestinal damage through improving barrier integrity and inhibiting inflammation in weaned pigs显示文摘Background:This study was conducted to investigate the effects of each phytogenic feed additive(PFA;PFA1,bitter citrus extract;PFA2,a microencapsulated blend of thymol and carvacrol;PFA3,a mixture of bitter citrus extract,thymol,and carvacrol;PFA4,a premixture of grape seed,grape marc extract,green tea,and hops;PFA5,fenugreek seed powder)on the growth performance,nutrient digestibility,intestinal morphology,and immune response in weaned pigs infected with Escherichia coli(E.coli).Results:A total of 634-week-old weaned pigs were placed in individual metabolic cages and assigned to seven treatment groups.The seven treatments were as follows:1)NC;basal diet without E.coli challenge,2)PC;basal diet with E.coli challenge,3)T1;PC+0.04%PFA1,4)T2;PC+0.01%PFA2,5)T3;PC+0.10%PFA3,6)T4;PC+0.04%PFA4,7)T5;PC+0.10%PFA5.The experiments lasted in 21 d,including 7 d before and 14 d after the first E.coli challenge.In the E.coli challenge treatments,all pigs were orally inoculated by dividing a total of 10 mL of E.coli F18 for 3 consecutive days.The PFA-added groups significantly increased(P<0.05)average daily gain and feed efficiency and decreased(P<0.05)the fecal score at d 0 to 14 post-inoculation(PI).Tumor necrosis factorαwas significantly lower(P<0.05)in the PFA-added groups except for T1 in d 14 PI compared to the PC treatment.The T3 had a higher(P<0.05)immunoglobulin G and immunoglobulin A concentration compared to the PC treatment at d 7 PI.Also,T3 showed significantly higher(P<0.05)villus height:crypt depth and claudin 1 expression in ileal mucosa,and significantly downregulated(P<0.05)the expression of calprotectin compared to the PC treatment.Conclusions:Supplementation of PFA in weaned pigs challenged with E.coli alleviated the negative effects of E.coli and improved growth performance.Among them,the mixed additive of bitter citrus extract,thymol,and carvacrol showed the most effective results,improving immune response,intestinal morphology,and expression of tight junctions. | Se Yeon Chang Min Ho Song Ji Hwan Lee Han Jin Oh Yong Ju Kim Jae Woo An Young Bin Go Dong Cheol Song Hyun AhCho Seung Yeol Cho Dong Jun Kim Mi Suk Kim Hyeun Bum Kim Jin Ho Cho | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 1 |
| 14 | Incidence, Risk Factors and Clinical Course of Pancreatic Fluid Collections in Acute Pancreatitis显示文摘 | Mei Lan Cui Kook Hyun Kim Ho Gak Kim Jimin Han Hyunsoo Kim Kwang Bum Cho Min Kyu Jung Chang Min Cho Tae Nyeun Kim | 2014 | Digestive Diseases and Sciences2014，，5： | 1 |
| 15 | Stent patency using competing risk model in unresectable pancreatic cancers inserted with biliary self‐expandable metallic stent显示文摘 | Young Ook Eum Yong‐Tae Kim Sang Hyub Lee Sang Wook Park Jin‐Hyeok Hwang Won Jae Yoon Ji Kon Ryu Yong Bum Yoon Joon Koo Han Chang Jin Yoon Jung‐Hwa Cho Yunhee Choi | 2012 | Digestive Endoscopy2012，，1： | 1 |
| 16 | Role of Intravenous Hyoscine N-Butyl Bromide At the Time of Colonoscopic Withdrawal for Polyp Detection Rates: A Randomized, Double-Blinded, Placebo-Controlled Trial显示文摘 | Tae Jun Byun Dong Soo Han Sang Bong Ahn Hyun Seok Cho Tae Yeob Kim Chang Soo Eun Yong Cheol Jeon Joo Hyun Sohn | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 17 | Reasonable Duration of Clopidogrel Use After Drug-Eluting Stent Implantation in Korean Patients显示文摘 | Dong-Ho Shin In-Ho Chae Tae-Jin Youn Sung-Il Cho Dong-A. Kwon Jung-Won Suh Hyuk-Jae Chang Young-Seok Cho Woo-Young Chung Young-Jin Choi Hyeon-Cheol Gwon Kyoo-Rok Han Dong-Ju Choi | 2009 | The American Journal of Cardiology2009，，12： | 1 |
| 18 | Effect of Coal Type on Gasification in Pressurized Drop Tube Furnace 显示文摘 | Han Chang Cho Kil Won Cho | 2001 | International Journal of Energy Research2001，25，： | 1 |
| 19 | Cerebral sparganosis: MR imaging versus CT features显示文摘 | Moon WK Chang KH Cho SY Han MH Cha SH Chi JG | 1993 | Radiology1993，188，3： | 1 |
| 20 | Transcatheter Arterial Embolization of Gastroduodenal Artery Stump Pseudoaneurysms after Pancreaticoduodenectomy: Safety and Efficacy of Two Embolization Techniques显示文摘 | Saebeom Hur Chang Jin Yoon Sung-Gwon Kang Robert Dixon Ho-Seong Han Yoo-Seok Yoon Jai Young Cho | 2011 | Journal of Vascular and Interventional Radiology2011，，： | 1 |
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