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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 3 | Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue显示文摘 | Deng W Han Q Liao L Li C Ge W Zhao Z You S Deng H Murad F Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 4 | HLA 2DRB and 2DQB alle contribution to narcolep sy suscep tibility in Chinese patients with narcolep sy显示文摘 | Han F Chene Z Weih L | 2003 | Natl Med J Chinam2003，83，： | 1 |
| 5 | Optimization of an impact drive mechanism based on real-coded genetic algorithm 显示文摘 | Ha J L Fung R F Han C F | 2005 | Sensors and Actuators2005，121，2： | 1 |
| 6 | The effect of temperature onthe interfacial tension between crude oil and gemini sur-factant solution显示文摘 | Ye Z Zhang F Han L | 2008 | Colloids and Surfaces A2008，322，： | 1 |
| 7 | Remote measurement of algal chlorophyll in surface waters:the case for the first derivative of reflectance near 690nm显示文摘 | Rundquitst D C Han L Schalles J F | 1996 | Photogramm Eng Remote Sens1996，62，： | 1 |
| 8 | Rare earth elements (REE) of dissolved and suspended loads in the Xijiang River,South China显示文摘 | Xu Z F Han G L | 2009 | Appl Geochem2009，24，9： | 1 |
| 9 | Thrombospondin, a negative modulator of megakaryocytopoiesis显示文摘 | Chen Y Z Incardona F Legrand C Momeux L Caen J Han Z C | 1997 | J Lab Clin Med1997，129，： | 1 |
| 10 | Optimization of an impact drive mechanism based on real-coded genetic algorithm显示文摘 | Ha J L Fung R F Han C F | | 0，，02： | 1 |
| 11 | Performance of reinforced concrete shear walls with steel reinforced concrete boundary columns显示文摘 | Liao F Y Han L H Tao Z | 2012 | Engineering Structures2012，44，： | 1 |
| 12 | Integral Boundary Value Problems for First Order Integro-Differential Equations with ImpulsiveIntegral Conditions 显示文摘 | Liu Z H Han J F Fang L J | 2011 | Computers and Mathematics with Applications2011，61，10： | 1 |
| 13 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 14 | Molecular basis for the herbicide resistance of roundup ready crops显示文摘 | Todd F Han H J Healy-Fried M L Fischer M Schnbrunn E | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，，13： | 1 |
| 15 | 8-Hydroxyquinoline benzoates as highly sensitive fluorescent chemosensors for transition metal ions 显示文摘 | Zhang H Han L F Zachariasse K A | 2005 | Org Lett2005，7，19： | 1 |
| 16 | Distribution and pathogenicity of bacteria species carried by Bursaphelenchus xylophilus in China显示文摘 | Zhao B G Wang H L Han S F | 2003 | Nematology2003，5，6： | 1 |
| 17 | High-efficiency-sensitized solar cell with a novel co-adsorbent显示文摘 | Han L Y Islam A Chen H Malapaka C Chiranjeevi B Zhang S F Yang X D Yanagida M | | 0，，03： | 1 |
| 18 | Molecular evolution and functional specialization of chalcone synthase superfamily from Phalaenopsis orchid显示文摘 | Han Y Y Ming F Wang W Wang J W Ye M M Sheng D L | 2006 | Genetica2006，128，123： | 1 |
| 19 | Present situation Chinese sweet-maize and the way to deal with a situation显示文摘 | Yao W H Han X L Wang Y F | 2011 | Journal of AgriculturalScience and Technology2011，13，2： | 1 |
| 20 | Prediction of flow-induced structure vibration and sound radiation using energy flow analysis显示文摘 | BERNHARD R J MONGEAU L G | 1999 | Journal of Sound and Vibration1999，227，4： | 1 |
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